BGC0001516 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001516 (Aspergillus flavus NRRL3357)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	14,978	aspergillic acid	NRPS:Type I	100%

BGC0001516 - Region 1 - NRPS-like

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Location: 1 - 14,978 nt. (total: 14,978 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,979
Label		BGC0001516

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001516	1.00	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0002602	0.72	Alkaloid	aspergillic acid	Aspergillus flavus
BGC0001168	0.33	NRP	livipeptin	Streptomyces lividans 1326
BGC0002321	0.32	Other	pulcherriminic acid, pulcherrimin, cyclodileucine, compound 3	Metschnikowia aff. pulcherrima
BGC0001989	0.32	Other	pulcherrimin	Kluyveromyces lactis
BGC0002278	0.24	Alkaloid, NRP	brasiliamide I, brasiliamide A, brasiliamide B, 2,2-dibenzylpiperazine, brasiliamide D	Penicillium brasilianum
BGC0002582	0.22	NRP	guanipiperazine A, guanipiperazine B	Streptomyces chrestomyceticus
BGC0000375	0.21	NRP	indigoidine	Streptomyces chromofuscus
BGC0002286	0.18	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128	0.18	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001516	1.00	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0002602	0.90	Alkaloid	aspergillic acid	Aspergillus flavus
BGC0001168	0.66	NRP	livipeptin	Streptomyces lividans 1326
BGC0002321	0.65	Other	pulcherriminic acid, pulcherrimin, cyclodileucine, compound 3	Metschnikowia aff. pulcherrima
BGC0001989	0.65	Other	pulcherrimin	Kluyveromyces lactis
BGC0002278	0.57	Alkaloid, NRP	brasiliamide I, brasiliamide A, brasiliamide B, 2,2-dibenzylpiperazine, brasiliamide D	Penicillium brasilianum
BGC0002582	0.55	NRP	guanipiperazine A, guanipiperazine B	Streptomyces chrestomyceticus
BGC0000375	0.54	NRP	indigoidine	Streptomyces chromofuscus
BGC0002286	0.50	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128	0.50	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14978:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

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NRPS/PKS substrate predictions

AFLA_023020

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AMP-binding (16..418): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFLLGAIIK
Nearest Stachelhaus code(s):: Val DAFWLGATFK (68% 8Å match)
Stachelhaus code match:: 70% (weak)