BGC0001517 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001517 (Aspergillus terreus NIH2624)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	64,406	High	asperphenamate	NRPS:Type I

BGC0001517 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 64,406 nt. (total: 64,406 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 64,407
Label		BGC0001517

Tailoring functions

Transferases: sulfotransferase

ATEG_09065: Sulfotransferase domain

extras: Sulfotransfer_4: Sulfotransferase domain

Ligases: ligase

ATEG_09064: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

ATEG_09068: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001517.3	0.98	NRPS	asperphenamate	Aspergillus terreus NIH2624
BGC0001249.5	0.74	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0002164.2	0.71	NRPS	peramine	Epichloe festucae
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001240.4	0.67	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.66	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001517.3	0.98	NRPS	asperphenamate	Aspergillus terreus NIH2624
BGC0001249.5	0.74	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0002164.2	0.71	NRPS	peramine	Epichloe festucae
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001240.4	0.67	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.66	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 64406:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Phe) + (X - Phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ATEG_09064: X - Phe

Search NORINE for peptide: strict or relaxed

AMP-binding (184..576): X

nrpys: Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IIFCLAMVCK
Nearest Stachelhaus code(s):: Ala DIFQLALVYK (44% 8Å match); Pro DLFYLALVCK (41% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (1257..1649): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAVVGAAVCK
Nearest Stachelhaus code(s):: Phe DAYVGAAVWK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

ATEG_09068: X - Phe

Search NORINE for peptide: strict or relaxed

AMP-binding (262..612): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -TTSIAIVIK
Nearest Stachelhaus code(s):: Val DFWSIAIVYK (38% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (1290..1674): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DALVVAGVCK
Nearest Stachelhaus code(s):: oh-D-Kyn DAVVVAGVVK (62% 8Å match); S-bohPhe or Phe DALIVAAVCK (59% 8Å match); Tyr DASTVAGVCK (53% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor