BGC0001517 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001517 (Aspergillus terreus NIH2624)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	24,406	asperphenamate	NRPS:Type I	100%

BGC0001517 - Region 1 - NRPS

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Location: 1 - 24,406 nt. (total: 24,406 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 24,407
Label		BGC0001517

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001517	1.00	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0000900	0.33	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.33	NRP	dimethylcoprogen	Alternaria alternata
BGC0002164	0.28	NRP	peramine	Epichloe festucae
BGC0002166	0.28	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi
BGC0001261	0.25	NRP	AM-toxin	Alternaria alternata
BGC0001240	0.23	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001132	0.23	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000307	0.22	NRP	AbT1	Aureobasidium pullulans
BGC0001128	0.22	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001517	1.00	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0002164	0.62	NRP	peramine	Epichloe festucae
BGC0002166	0.61	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi
BGC0001261	0.58	NRP	AM-toxin	Alternaria alternata
BGC0001240	0.56	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001132	0.56	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000307	0.55	NRP	AbT1	Aureobasidium pullulans
BGC0001128	0.55	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 24406:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ATEG_09068

Search NORINE for peptide: strict or relaxed

AMP-binding (262..612): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -TTSIAIVIK
Nearest Stachelhaus code(s):: Val DFWSIAIVYK (38% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (1290..1674): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DALVVAGVCK
Nearest Stachelhaus code(s):: oh-D-Kyn DAVVVAGVVK (62% 8Å match); S-bohPhe or Phe DALIVAAVCK (59% 8Å match); Tyr DASTVAGVCK (53% 8Å match)
Stachelhaus code match:: 80% (moderate)