LOCUS       BGC0001525             16392 bp    DNA     linear   BCT 05-OCT-2015
DEFINITION  Synechocystis salina LEGE 06155 glycosyltransferase, haemolysin-type
            calcium-binding repeat, dialkylresorcinol condensing enzyme
            (aromatase), dialkylresorcinol condensing enzyme (ketosynthase),
            glycosyltransferases, DevB family protein, DevC family protein, DevA
            family protein, and hypothetical proteins genes, complete cds.
ACCESSION   BGC0001525
VERSION     BGC0001525
KEYWORDS    .
SOURCE      Synechocystis salina LEGE 06155
  ORGANISM  Synechocystis salina LEGE 06155
            Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae;
            Synechocystis.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:20:41
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1674)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 96.5;
                     E-value: 3.3e-29)"
                     /gene_kind="biosynthetic-additional"
                     /note="BrtA"
                     /product="glycosyltransferase"
                     /protein_id="AKV71846.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.9e-18,
                     bitscore: 56.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTSNTALSPAIFYESEGYRTSGSRLMGRHSAGEAFLRAVIQGTP
                     PSNPIFGYCRDAEGFGAFKADVLRHDPTNGDRLMRWLPRHQPEKLGNASILYLPGPGLL
                     NEAQRRLGSGQEQSYSLCGITHTISSAGAMQSIRDLLIAPVHGWDAIICTSKAVKASLE
                     TIIAEQAEYLRVRLGARFCEMPQFPVIPLGVHCQDFQFTTAEKQAARKRLGIAPEAVVV
                     LFVGRLVFHAKAHPLPLYLALERAAEKKSVTLIECGWFPNEPVARSYDQARNLAAPNIG
                     SIVLDGRQPSQRRDAWAAADIFTSLSDNIQESFGLTPIEAMAAGLPSVVSDWDGYKDTV
                     RHGIDGFRIPTTMPSDGGDDFALRHLLDIDSYDFYIGHVSQTVAVDIEAATLAFHQLLH
                     QPELRQRMGDAAKEQAQTVFDWSCIYGRYQELWHHLTEKRRQVSGDRQLPRGGAMIDPY
                     KLFANYPTNAMGNLQFALRENVTLAEIETISQLESVKFASYMLPPMALVDQIVQNLNKS
                     QPLSLEELQSFVSVPMATLEKAISWLLKYGLIKSELILKD"
     source          1..16392
                     /db_xref="taxon:945782"
                     /isolation_source="intertidal zone, Sao Bartolomeu do Mar
                     beach"
                     /mol_type="genomic DNA"
                     /organism="Synechocystis salina LEGE 06155"
                     /strain="LEGE 06155"
     protocluster    1..16392
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[6021:7173]"
                     /cutoff="20000"
                     /detection_rule="DarB"
                     /neighbourhood="20000"
                     /product="resorcinol"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6022..7173
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="DarB"
                     /neighbourhood="20000"
                     /product="resorcinol"
                     /protocluster_number="1"
     cand_cluster    1..16392
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="DarB"
                     /kind="single"
                     /product="resorcinol"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..16392
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001525"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..16392
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="resorcinol"
                     /region_number="1"
                     /rules="DarB"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             2260..4764
                     /codon_start=1
                     /note="BrtB"
                     /product="haemolysin-type calcium-binding repeat"
                     /protein_id="AKV71847.1"
                     /transl_table=11
                     /translation="MANPFDVALTNLNSLYSGIPDVPVLQTYNSLNPYDISLTNLNNLS
                     NFIIEPALLPEAAGTYGPTLGQLAFAVGGGILSGVLANELGIENEILITKFLSFWTPGS
                     DYALGQDYIEFIGGREGFDTIIGYDPGLNSAFAPVQIDFTIAGPSLVNPFAPLNEPARY
                     VLGDWRKPYYVDNNIYSEGLSDFMYVSIISFNPVDFSPQNNRLQLHGSLNDYYFVATDV
                     VIDLSSLAPGQPPIIFPGTEIYYKTGQVFADLIAVVPFQDPTDPNLISAWIDFEGYTPP
                     ELADLNPLTSTSYQETAALFLSSPLLQLGYEGIDIGGATALAPDGDIYVAGSTSSLLGP
                     FPRGGSDNFIARYNDDGSLEWIVQFGSTEFDILTDIVSDAAGNVYATGWTRGNVETGSG
                     LAPGVQDNWVAKFDASGNQLWVEQFTIDGYLDRSMGIALDGTSGTVYLTGHSNTDGTVA
                     DTDNPGGFNPIGTVVTWIASFDANTGAENYRNIFEVSITNNDGGVPGEPGLFDEGFGVA
                     VDNSGNLFATGWAGENAYDVYLTKFDTTTDPSTSTELWSKSFGTGSNATQSYSWDVASD
                     GTNAYVLGWTQDTLDKFRDQGTGLYSDLTQSQPVISSYNGGAFDAYIAAFTDQGVLSWI
                     TYIGGNGDDGTFMGKIVADGDFVYATGYTNGFIGTLDQEGSNAGDYDAWIGKFDKLTGE
                     TAWIQQIGSTKLDYATGISIDGDDIFVTGFTEGSLGGLNGGASDAWVAKLNQAGALEAF
                     NVSAPIAPPAPFAPPAPPAPPAPDLSGLQLQSLGSTPQPTYPALGDSYGTNPFGTQPTY
                     DLSAMYQNAYYGGFGGYSGYGY"
     CDS             4995..5936
                     /codon_start=1
                     /note="BrtC"
                     /product="dialkylresorcinol condensing enzyme (aromatase)"
                     /protein_id="AKV71848.1"
                     /transl_table=11
                     /translation="MTDPAATNVLVLYYSQSGDTERLVRNFVEPVASAGANITWANIEP
                     AQPYPYPWNLSHFFDVFPDCINGDTPEILTPSFEPDQHFDLIILAYQVWFLAPSLPIQA
                     FMKSPYAQVLRDTPIITLIACRNMWHSASEQLQQTLIDLGAHLIGKIVVTHQGSPLATF
                     ITTPRLLLTGKKDSALGVLPPGGFAEEDIKSVSQFGKQLADYLPQLSLPQKTPIFTDLH
                     PVQVNKRYILPEWVGITLYRPWARLIRLGGPSGSPVRTLLVWLFALQLVVALPIVLFLC
                     TITRILLYPVLNPVLEGYALKLQEQSFDNSVG"
     CDS             6022..7173
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     resorcinol: DarB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 187.9; E-value: 4e-57)"
                     /gene_kind="biosynthetic"
                     /note="BrtD"
                     /product="dialkylresorcinol condensing enzyme
                     (ketosynthase)"
                     /protein_id="AKV71849.1"
                     /sec_met_domain="DarB (E-value: 5.5e-164, bitscore: 534.8,
                     seeds: 92, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSISVYINGMGAFLPNEPVDNTQIENVLGLINGKPSRAKKMVLRN
                     NAIKTRYYAINPANGSMTHTNVELTVEAINALVKNSGFDLNQLDCLACGTSGPDQMIPN
                     HALMVHGALGNKPCEVIATSGVCCSGVAAFKYAYMNVSLGFARNAVVTGSEQVSSILRG
                     QYFQPEIDAQIARLDDKPIVGFERDFLRWMLSDAAGAALIENKPNENSISLRVDWVDYI
                     SFANELETCMYEACIKLEDGTVQSWRHVNNIKDAFEEGYFDLSQDVKLLGENIIRMGQR
                     GLKNVKEKYNLDSDKIDWFLPHISSGYFKKDLGLQMEEIGIFIPQERWFTNLEYKGNTG
                     AASIWIMLEELFNSGRLEKGQKIFCIIPESARFSYAYMHLTVV"
     CDS             7260..8522
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 249.9;
                     E-value: 8.8e-76)"
                     /gene_kind="biosynthetic-additional"
                     /note="BrtE"
                     /product="glycosyltransferase"
                     /protein_id="AKV71850.1"
                     /sec_met_domain="MGT (E-value: 2.1e-44, bitscore: 141.8,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHFGLICPQSTGHLNPMVALGKALFKKGHQVTLFSVDDLREKFP
                     PSAIQVQVIGKEEFPKGTLPAFFQKLGHLEGIKAALYTRDSLLAFAQVVLKELPPIIKS
                     HGIEVLLVDQLCPEAGSIAEYLQIPFVTTCAISPLNYELQVPPCFTDWAFHKEGWALAR
                     NRMGYFMYYQARRPIHQLINQSRRDWGLPPLNHPDDAFSSMAQICQVPQSFEFPRHQLP
                     PQFVFTGPFLDGASRPHIPFPFEELDGRPLIYASLGTAHNLHRTLFQSIATAVKDLDAQ
                     TVISLGGGLNPGDLDDVPDNVILVNYAPQLDLLQKASLTITHAGINTTLESLSNGVPLV
                     ALPVAGDQPSVAARIAWTNSGEVLPPARRSSRDLRATIEKVLHNSIYNQNAQRIQNDIE
                     QAGGLRKAVEVIERCLVTKSQ"
     CDS             8598..9845
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 230;
                     E-value: 9.4e-70)"
                     /gene_kind="biosynthetic-additional"
                     /note="BrtF"
                     /product="glycosyltransferase"
                     /protein_id="AKV71851.1"
                     /sec_met_domain="MGT (E-value: 2.9e-45, bitscore: 144.7,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHFGLICPQSTGHLNPMVSLGLALINNGHEVTLFCVEDVQQKFS
                     HSALNLEIIGRKEIPLGTVPRFLKNLGNPQRSLADILNQDVFSVFCKVVLKEVPSITRS
                     LGIDVLLVDQLCPEGGTIAEYLGIPFISICTILPLNYELLVPPCFTNWSYRTDNLAKLR
                     NHLGYFLFYLLRRPVFQIIAEFRSRWALPPLKYSDEAFSPIAQISALPPSFEFPRHHLP
                     KQFVFTGPWINEVNSQVIPLPYERLDGRPLIYVSFGTIFNRNKTLFQRIATALTNLEVQ
                     AVITLGNSLSVSDFPDYPKNILFVDYAPQYELLQHASLTIAHAGMNTALDSLYFGVPVL
                     ALPISGDQHGVAARIAWTQTGETLSPRQRSLKNLETTIGRVLSSPIYRHNVLRIQSDMK
                     QAGGLKKAVEVIERCI"
     CDS             10081..11433
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 173.6; E-value:
                     9.3e-53)"
                     /gene_kind="transport"
                     /note="BrtG"
                     /product="DevB family protein"
                     /protein_id="AKV71852.1"
                     /transl_table=11
                     /translation="MKSVFPNNSSNSKFVIFLVVGGIVAGLGTLGWLSYPQGWMTNSQT
                     KSTEDKQSQSLTATALEGQNPQQLSRVAAIGYLEPKGEVRSLSAPIGPDGKGGRIEKLL
                     VKEGDVVRSGQIIAILDNYATVDSKVKIAQSQLRTAQAKLMQVQAGAKQGQISAQKARL
                     SGVVSELEGQIDIQNATIQRISAELAGEKIAQEKFIEKLEIEYSNASSECQRYQSLFEQ
                     GGTSASEYDRICLVPKQLERELAEAQANLQRIVSSRQEELAEARANLSRTVQTLNDQQN
                     QNQGTLDEISEVREVDVAVAEAQVQEAQAQLRQAQAEFNLTKIISPTDGQVLKIYTYPG
                     ERINDKGILDIGRTQAMYVRAEVYETDILNVKKGQRAYISSPALSSNLEGIVESVGHQI
                     GRRDILDNDPVADIDARVVEVNIRLLEESQNEIDLSRLTNLKTRVIIETSP"
     CDS             11596..12765
                     /codon_start=1
                     /note="BrtH"
                     /product="DevC family protein"
                     /protein_id="AKV71853.1"
                     /transl_table=11
                     /translation="MNVPTAWLQLKFYPLRLTVAVAGVCFSIFLIFMQLSFQDALFDSA
                     VSFYEALDADIFILNSRSSALIAMENFPERRLNQALAVDNVAEVIPIYLGFAQWRNPVK
                     KNVWRNIYLIGIEPSQSVFNIEAVEENRFKLKLPDTVLFNQTSRSEFGPIAELFRQEGE
                     VKTEVGDRGPSNRLITVVGLFPLGASFGSDGTIITSDLNFQRILPGSRKGFINLGGIKL
                     QDKNKLDITLAALRDYLPNDVKIFSKAEVFAFEKNYWATGSPIGFVFALGVGIGMAVGV
                     VITYQVLYSSIAQHLSEYATLRAVGYRQRYLLGVVFQEAVFLALFAYVPGIIFAGFVTK
                     LARDATSLPVYINVNKAIIVLLLSCLMCFISGGIAIRKLQDADPADVFY"
     CDS             12818..13495
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 196.6; E-value:
                     8e-60)"
                     /gene_kind="transport"
                     /note="BrtI"
                     /product="DevA family protein"
                     /protein_id="AKV71854.1"
                     /transl_table=11
                     /translation="MNDAVFVSNLNHYYGHRQLRQQVLFDINLVINEGEIVLLTGESGS
                     GKTTLLSLIGALRSITEGNVVVLNRQLYRANEARLVDVRRRVGYIFQSHNLLQFMTALQ
                     NVRMSAELLEEPYLGPAIERAHRILDAVGLKSRKDYYPHELSGGQKQRVAIARALVNSP
                     KLILADEPTASLDSKTGREIINLIQRLAQEQGSAVLLVTHDNRIFDIAHRILSMEDGRL
                     YET"
     CDS             13578..14783
                     /codon_start=1
                     /note="BrtJ"
                     /product="hypothetical protein"
                     /protein_id="AKV71855.1"
                     /transl_table=11
                     /translation="MVSVTPSSVESLDFSHLRGKERKITQIIEKTYHNNTESDYTEKIE
                     QLEKAFNYSVEKDYYWGSPELSFLYGTPLYEKASESQKKVLNHLYWIGQYNLVAASEKS
                     TILFNQVTANVFFSLGGFDSLCHELDLETNQERYHIHAFQNIDRIVQDGIFGDGDANGD
                     QYRKQTLDVLRDGVARYMGSDLTLKFLSFNWGSTPFLASQYYCARYIANISLKNKEQVY
                     SLHCRKLENSGAHVPAPTAISRYHLLDESFHTTISQLLGKELYKEFAKPSAYEKFLMNM
                     VIYNYQKHGAGSLSGLAPGAPLKDELFMPALYGVLRSSVFGMSATEALDWIEKCACTEH
                     QGFHVSLQYVTRLLNDLRRFFSSIDYFWPVNKEWSIMAEAHSIPKTLKANRRAFNKFAR
                     TV"
     CDS             complement(14896..16392)
                     /codon_start=1
                     /note="BrtK"
                     /product="hypothetical protein"
                     /protein_id="AKV71856.1"
                     /transl_table=11
                     /translation="MATFFVNNLNDSGAGSLREALTTANSTPGTDSIVFNVSGQINLID
                     PLVITDDVRINWPAIVFRTPAGIPFFTSPTSTITIDGTGLDDDGVGSSDEEDIFQISNG
                     ATVEMNNLVLNNAGEDAIAIDSGDLKLFRVNIFNSDDDGIDSVSNGGLLQIVRSEIAQN
                     GDDGIDVAASGATIVLEGAKVYDNDDYGIDIEGNDLTITINKSDVYNNDDSGLRLNDIE
                     TDNSFTTLKITNSSFEGNSDGIELESDGLTGFLSAVRANGNDDEGVQIEGDDGIFTIIK
                     SQFSNNGSDGLILVEDDGGDSADNNKLTIIDSLFNDNFNDGLDIDGDFNQVSVFGGSSR
                     GNGDSLLSEDGRGVEVSGTGNRVFLNRILIANNYSGGDGGGIGIFGVDNIVNLMSSVIK
                     NNESLGDGGGIFIRGIVPESVPDETTGNQLIGRFNRIFDNFSGNNGGGISIGQSATASL
                     FANFIRGNTDSNNGSSDLFLAPSANFVDLGANIIGTTISV"
ORIGIN
        1 ctaatccttt agtattaact cagatttgat caagccatat ttcagtagcc aactgatggc
       61 tttttctagg gtagccattg gcacagacac aaatgactgt aattcttcca gagacaacgg
      121 ctgggattta ttgagatttt gtacaatttg gtcaaccaat gccataggtg gcaacatata
      181 gctagcgaat ttaacacttt ctaattggct aattgtctct atttctgcca acgtgacatt
      241 ttccctgagg gcaaattgca gattacccat ggcattggta ggatagttgg cgaataactt
      301 ataagggtcg atcattgctc cccctcgggg taactggcga tcgccgctga cctgccgacg
      361 cttctcggtc agatggtgcc acaattcctg gtaacgacca taaatacatg accaatcaaa
      421 aactgtttgg gcctgttcct tcgctgcgtc ccccatgcgt tgccgtagtt ccggttgatg
      481 taaaagctga tgaaaagcta gggtcgccgc ctcaatatcg accgcaacag tctggctgac
      541 atgaccaatg taaaaatcgt aggaatcaat atccaacaga tgacgtagtg caaaatcatc
      601 acccccatca gagggcatag ttgtgggaat tctaaagcca tcaatcccat gccgcaccgt
      661 atctttgtag ccatcccagt cactaactac agaggggaga cctgcggcca tggcctcaat
      721 gggcgttaaa ccaaagcttt cttgaatatt gtccgatagc gatgtaaaga tatccgccgc
      781 cgcccaggca tctcgacgct gtgacggttg gcgaccatcc agcacaattg agcctatatt
      841 aggtgcagct aaattgcggg cttgatcata actacgggcc accggttcat tcggaaacca
      901 accacattcg atcagcgtaa cggatttttt ctccgccgcc cgttctaagg ccagatacaa
      961 aggtaaggga tgggctttgg catggaagac taatcgaccc acaaataaca ccaccacagc
     1021 ctctggcgca attcccagac gtttacgggc agcctgtttt tccgccgttg taaactgaaa
     1081 atcttgacaa tgcaccccca ggggaatgac tggaaattga ggcatttcac aaaaacgtgc
     1141 ccccaaacga acccgcagat actcagcttg ttctgcgatg atggtttcta aactagcttt
     1201 tacagcttta gacgtacaaa taatcgcatc ccagccatga accggagcaa ttaacaaatc
     1261 tcggattgac tgcattgccc cagcagatga aattgtatgg gtgatgccac acaaactata
     1321 ggactgctct tgaccactac ccaaacgtcg ctgggcttca ttgagcagac ctggtcccgg
     1381 taaataaagt atggatgcat tccctaattt ttccggttga tgacgaggta accaccgcat
     1441 aaggcgatcg ccgttggttg gatcatgtct taaaacatca gccttaaagg cgccaaaacc
     1501 ttctgcatct cgacaatagc caaatatcgg attactaggg ggagttccct ggattacggc
     1561 ccgcaaaaac gcttcacctg cggagtggcg tcccattaac ctggaaccgc tagtacgata
     1621 accctctgac tcatagaaga tggccggaga cagggcagta ttgcttgttg gcatcaatct
     1681 aaaaactcaa tttgccacca tcttagtctg agttgttccc taatcatttt tcgacccaat
     1741 ccccacgcct agctggagcc atggatgacg ggcaattcct tcattggcaa gggagattaa
     1801 gaggataaag tcaagcttaa attaaggact gattaaccat cctttgtcag actgtgtagg
     1861 tcgattagag aacaaccacg gaaagcttct aaggacaaaa gtttcaagaa ctgtacttga
     1921 caaaaagtca atcccatatt tcttgagtca taaaaagcct aaagtgtttt cacagcagaa
     1981 cttttaaagt accaatagtg agtccagctt ccggggttca tgaaaaagtt agatcaaaga
     2041 ctctgaaatg aactgatgct aatcattgcc gtcaacgcga aagataaata agattaatga
     2101 caatttttgg cactatgagt tgcaaacccg gctgaattga ttataatcgc atagtcacac
     2161 tccgtaaata cgaatttttt agtgaaactt tctctgattc tttaagtttc ttctccgtaa
     2221 tcgataatcg ctattcaatt taatcctggt gaggagttta tggccaatcc cttcgacgtc
     2281 gctctgacta atctgaatag tctttacagc ggcatccctg acgtccctgt tctgcagacg
     2341 tacaactctc ttaatcccta cgacatctct ttaactaatc ttaacaatct tagcaacttt
     2401 attattgagc cggccctgct ccccgaggcg gccggtacct acggccctac actcggtcaa
     2461 cttgcttttg ctgtgggggg cggaattctg tcgggtgtgt tggctaacga gctagggatc
     2521 gagaacgaga ttctcataac caagttcctt tccttctgga cgccgggttc tgactacgcc
     2581 cttggccagg attatattga atttattggt ggtcgtgagg gctttgacac catcatcggc
     2641 tacgaccccg gattgaatag tgcatttgct ccggtacaaa ttgattttac cattgctggg
     2701 ccttccttgg ttaacccctt tgctccctta aacgagcccg cacgctacgt cctgggagat
     2761 tggcgcaagc cctactatgt ggataacaat atctacagtg aagggttgag cgatttcatg
     2821 tatgtttcga tcatctcctt caacccagtt gacttttcgc cacagaataa tcgtctccag
     2881 ctccacggca gtctgaacga ttattatttt gttgctacag acgttgtaat tgatctgagc
     2941 agcctagctc cggggcagcc ccccattatt tttcccggta cagagattta ctacaaaacc
     3001 ggccaggtgt ttgccgattt gattgccgtg gtgcctttcc aggatcccac cgacccaaat
     3061 cttatttccg cctggattga ttttgaaggt tacactcccc cagagctggc cgatctcaat
     3121 cccctaacat caacttccta ccaagagact gctgccttgt tcctgagctc tcccctcctg
     3181 caattgggct acgaaggcat cgacataggc ggggcgacag ccctcgcacc cgatggggat
     3241 atctatgttg ctggctccac tagcagtctt ttgggacctt ttccccgggg cggctcggac
     3301 aacttcatcg cccgatacaa cgacgacggc agtttggaat ggattgtcca atttggtagc
     3361 actgagttcg atatcctcac cgacattgtc agcgatgccg ctggtaatgt ttatgccacc
     3421 ggttggactc ggggcaatgt ggagacgggg tccggcctag ccccaggtgt tcaagacaat
     3481 tgggtggcca agtttgacgc cagcggcaac caactctggg tagagcaatt taccattgat
     3541 ggttacctcg atcgttccat gggcattgcc ctcgatggaa ccagtgggac agtttacctg
     3601 acgggtcact ctaataccga tggaacggtt gctgacactg acaaccccgg aggatttaac
     3661 cccatcggca ccgtagtcac ctggattgct agttttgatg ccaacactgg agcagaaaac
     3721 taccgcaaca tttttgaggt tagcataacc aacaatgatg gtggtgtccc cggagaacct
     3781 ggactctttg atgaaggttt cggggtagct gttgataatt ctggcaatct atttgccact
     3841 ggttgggccg gagaaaatgc ctacgatgtc tatctgacca aattcgatac caccactgac
     3901 ccaagtacta gtactgaact ctggtccaag agcttcggaa caggttccaa tgcaacccaa
     3961 agttattcct gggatgtggc cagtgatggt actaatgcat atgtccttgg ctggactcag
     4021 gataccctag acaaattccg cgatcaagga acgggacttt actctgacct aacgcaatca
     4081 cagcccgtaa tttcctccta taacgggggc gccttcgatg cttatattgc cgcctttaca
     4141 gaccagggag tcttaagctg gatcacatat attggcggaa acggtgatga cggtaccttc
     4201 atgggcaaaa ttgtcgctga tggtgacttc gtctatgcca cgggctatac caatggcttt
     4261 attggtactc tagaccaaga gggcagtaac gccggcgact acgatgcctg gatcggcaag
     4321 tttgataaat taaccggtga aactgcctgg atccaacaaa ttggtagcac caagctagac
     4381 tacgccaccg gtatttccat tgatggcgat gacattttcg taacgggctt tacggaaggc
     4441 tccttgggcg gcttgaacgg tggcgcttcc gatgcctggg ttgctaaatt aaatcaagct
     4501 ggcgctttag aagcctttaa tgtttctgcc cccattgctc ccccggctcc ttttgctccc
     4561 ccagctcccc cagctcctcc tgcacctgat ctcagtgggt tgcagttgca atcattaggt
     4621 agtacccctc agcccaccta tcctgccctt ggggacagct atggcaccaa tcccttcggc
     4681 actcagccta cctatgacct cagtgccatg taccaaaatg cttactatgg cggtttcgga
     4741 ggttattccg ggtacggtta ctagaagctg ttcatgacca tgacggacta aacaatctgg
     4801 agggatggta attttatccc tcctttggtc ttagcctctg atactcattc ctgaagctaa
     4861 gataggtgag gctaaatact tataaaatct ccctgtcgta cagaatcccc ccttatcaag
     4921 ggaggttggg gggatagagt gcaaaactta tgcttggttt aattacaccg acctgattac
     4981 aatttgtttt ggtaatgact gacccagccg ccaccaatgt tctcgtgctt tattattccc
     5041 agtccgggga taccgagcga ttagtccgca attttgtaga gccggtagcc tcagcaggag
     5101 ctaacataac ctgggccaac attgagcccg ctcagcccta tccctatccc tggaatctct
     5161 cacacttctt tgatgttttt cccgattgca ttaatggaga cacgccggag attctgacac
     5221 catcatttga accagatcag cattttgacc taattatttt ggcctatcag gtctggttct
     5281 tggccccttc cctgcccatt caggctttca tgaaatcccc ctatgcccag gttctgcggg
     5341 atacccctat tatcaccctc attgcctgcc gcaatatgtg gcattctgct tcagagcaat
     5401 tgcaacaaac cctaattgac ctaggcgccc atttaattgg caaaatagtg gttacccacc
     5461 agggatcccc cttggccacc tttatcacca ctccccgcct actactcacg ggcaaaaaag
     5521 actcggcttt aggggttctc cctcccggag gatttgcaga ggaagatatt aaatctgtgt
     5581 cacagtttgg caagcaatta gcggactatt tgccccaatt gtctctacct caaaaaacac
     5641 cgatcttcac cgatttgcac cccgttcaag tcaataaacg ttatattcta cccgaatggg
     5701 ttggcatcac tctctatcga ccttgggcta gattgatccg cctaggtggc ccctccggat
     5761 ctcccgtcag gactttattg gtttggttat ttgctttaca actggttgtt gccttgccga
     5821 tagtattatt tctatgtaca atcaccagaa tattgcttta tcctgtcttg aacccggttc
     5881 tagaaggcta cgccctaaaa ctacaagaac agtcctttga taactccgta ggctagctca
     5941 ttatatcctt gagttttagt caaggatata cccatgctct gacacacaaa ctaataaccc
     6001 attttagagg agcgacactc aatgagtata agtgtttaca ttaacggaat gggagctttt
     6061 cttcccaatg aaccggttga taacactcaa atcgaaaatg tcttagggtt aattaatggc
     6121 aaaccatccc gagctaagaa gatggttcta agaaataacg caatcaaaac tcgctactat
     6181 gccattaatc ctgcaaatgg aagcatgacc cacacaaatg tggaactgac ggttgaagcg
     6241 attaacgccc ttgtcaaaaa ttcgggcttt gatctcaatc aacttgattg cttggcctgt
     6301 ggaacatctg gccccgacca gatgattcca aaccatgccc tgatggttca tggggctttg
     6361 gggaataagc cctgcgaagt cattgccaca agtggcgttt gctgctcggg ggtcgcggca
     6421 ttcaaatatg cctacatgaa tgttagcctg ggctttgctc gtaatgccgt ggtgacgggt
     6481 tcagagcaag tgtcgagtat tctgcggggc cagtacttcc aaccggaaat agatgcccaa
     6541 atagccagat tagatgataa acccattgtg ggatttgaaa gagacttctt gcgttggatg
     6601 ctttccgatg cggcgggggc tgctctcatt gaaaataaac ccaatgaaaa cagtatttct
     6661 ctacgggttg actgggttga ttatatttcc tttgccaatg aactagaaac ctgtatgtac
     6721 gaagcttgca tcaaactaga agatggcact gttcaaagct ggagacatgt caataatatt
     6781 aaagatgctt ttgaggaagg ctactttgat ctgagccaag atgttaaatt gcttggggaa
     6841 aatattattc gcatgggtca gcgaggttta aaaaatgtca aggaaaagta caatttagac
     6901 tcagataaaa tcgattggtt tcttccccat atttcttctg gctatttcaa aaaagattta
     6961 gggctacaaa tggaagaaat tggcattttt atacctcaag aacgctggtt tactaatctg
     7021 gaatacaaag gcaatacggg agccgcttcg atttggatca tgttagagga attatttaat
     7081 tctggacgac tggagaaggg ccaaaaaatc ttctgcatta ttccagaaag tgcccgcttt
     7141 tcctatgcgt atatgcacct tactgtcgtc taggtagtcc taggaaccat gaggcccgtt
     7201 gatcaattat acatccctga taggacgtct gtttttatct atagccgtag gaattcgcca
     7261 tgacccattt cgggctgatt tgtcctcaat cgacgggcca ccttaatccg atggttgcat
     7321 tgggcaaggc tttgttcaaa aaaggacacc aggtaactct tttttctgtt gacgacctta
     7381 gagaaaagtt tcctccgtcg gccatccaag tgcaagtgat cggaaaagag gagtttccta
     7441 aaggtacatt gcccgctttt tttcaaaaac taggtcatct tgaaggtatt aaagctgctc
     7501 tatatacgcg agacagtcta ctggcctttg ctcaagttgt cttgaaagaa cttcctccca
     7561 ttattaagtc ccatggcatt gaagtattgc tggtggatca actttgcccg gaagctggaa
     7621 gtatagctga gtatttacaa attccctttg tcaccacttg cgctatttct ccgcttaact
     7681 atgagttgca agttccgcct tgcttcacag actgggcttt tcacaaagag ggttgggcat
     7741 tagcccgtaa tcgcatgggg tatttcatgt actaccaggc ccgtcgtcca attcaccaac
     7801 ttataaatca atctcgtcga gattggggtt tacctccctt aaatcaccca gatgacgctt
     7861 tctcctccat ggctcaaatt tgccaagttc cccaatcatt tgagtttccc cgccatcaat
     7921 tacctccgca atttgtcttt acaggtccct ttctagatgg agcaagtcgc ccccatattc
     7981 cttttccttt tgaagaatta gatggccgtc cgcttattta cgcatcttta ggaacagctc
     8041 ataatcttca ccgaacctta tttcaaagta ttgctactgc tgtcaaagat ctggatgcac
     8101 aaacagtgat tagtctgggt ggtggtttga atcctggaga tttagatgat gtgcccgata
     8161 atgtcattct ggtaaattat gcacctcaat tggatctgct acagaaggcc tcgctgacca
     8221 ttacccatgc aggcataaat acaaccctag agtctttaag caatggtgtt cccttagtcg
     8281 ccctgcccgt ggcaggggat cagccgagtg tggcggctcg cattgcctgg acaaattccg
     8341 gtgaagttct gccacccgcc cgccgttctt cccgggacct gagagctaca attgaaaaag
     8401 ttttgcataa ttcaatttat aatcaaaacg cccagcgtat ccagaatgac attgagcaag
     8461 cgggcggctt acggaaagca gtcgaagtca ttgagcgttg tttggtcacc aaaagtcaat
     8521 agtacgaaaa tcgtcgaaaa atttctgact ctgctacact gagcccctag ataaagccta
     8581 atcttcattt tacacatatg acccactttg gtttgatttg tccccagtcc actggtcacc
     8641 tcaatccaat ggtttccctt ggtcttgccc taataaataa tggacatgag gtcactcttt
     8701 tctgcgttga ggatgtccaa caaaaatttt ctcactcagc tttaaacctc gaaatcattg
     8761 gcagaaagga gattcctttg gggacagtgc caagattcct aaaaaatctg ggaaatcccc
     8821 agcgctccct ggcagatatt cttaaccaag atgttttttc agtcttctgc aaagtagtac
     8881 taaaggaggt gcctagtatc actcgatcct tagggattga tgttttgttg gttgaccaac
     8941 tgtgtccaga gggaggaacc atcgcagaat atctaggtat tcctttcatt agtatttgta
     9001 ctatccttcc cctcaattat gaattattgg ttcccccctg ttttaccaac tggtcttacc
     9061 gcacggataa ccttgctaaa ctgcgtaatc accttggtta tttcctgttc tatttacttc
     9121 gtcgccctgt ttttcagatt atcgccgagt tccgaagccg ctgggctctc cctcccctga
     9181 agtattctga tgaagccttc tctcccattg cacaaatcag tgcccttccc cctagctttg
     9241 aatttcctcg tcatcactta cccaagcagt ttgtctttac ggggccatgg attaatgaag
     9301 ttaatagcca ggtcattcct cttccctacg agcgattgga tggacgaccc cttatctatg
     9361 tatcttttgg aacgatattt aataggaata aaactctgtt tcaacgaatt gctacagcac
     9421 taacaaacct tgaagtacag gcagtcatta ccttgggtaa tagcttatcg gtgtcggatt
     9481 ttccagatta tcctaaaaat atcctcttcg ttgattacgc tccgcaatac gaacttctcc
     9541 agcacgcttc cctgactatt gcccacgctg gcatgaatac ggccctggac tctctctatt
     9601 ttggtgttcc tgttcttgcc ttacctattt caggggatca acatggcgtg gcagctcgca
     9661 ttgcctggac tcaaaccggt gaaacccttt ctcccagaca aaggtctttg aagaacttag
     9721 aaaccaccat tggaagagtc ttaagcagtc ccatatatcg acataatgtc ttgagaatcc
     9781 aatctgatat gaagcaagct ggtggtttaa aaaaagcggt agaggtcatt gagcgttgta
     9841 tctagtacct ccaccgacta aaattaacag agagaaaaaa gccacggatt tgcattacta
     9901 atgaactggg gcttaactat gccgtctgtc tccgttcagg tccagccttt tcatttaagc
     9961 ttgtcaagga gtagaagggg ataaccgaca gaaagcaatc agcctagaga tttgtgctag
    10021 cataaactag cttcttttgc gaaagaggag ctttcttcgc gttgcagagg atttatctcc
    10081 atgaagtcag tctttccgaa caactcctcg aatagcaagt ttgttatttt tctggtggtg
    10141 ggaggtatcg tcgcaggact gggtaccttg ggatggttga gttatcctca aggttggatg
    10201 acaaattctc agaccaagtc caccgaggat aaacaaagtc aaagcttgac agcaaccgcc
    10261 ctcgagggac aaaatcccca gcaattatcc cgagttgctg ccattggtta ccttgaaccc
    10321 aaaggagaag tgcgaagttt atcagcgccc atcggccccg atggtaaagg gggaaggatc
    10381 gaaaaacttc tggtcaaaga gggagatgtt gttcgttctg gacagataat tgcaattctg
    10441 gataactacg ctactgtaga ctcgaaagtc aagattgccc agtcccaact gcggacagcc
    10501 caggccaaat tgatgcaagt acaagcaggg gcgaagcaag gacaaatttc agcacaaaaa
    10561 gcccggttgt ctggtgttgt atccgagcta gaggggcaaa ttgatatcca aaatgcaact
    10621 attcagcgga ttagtgcaga attagcaggg gaaaaaattg cccaagaaaa attcatagaa
    10681 aaattagaaa ttgaatacag taatgccagt tcggaatgcc aacgttatca atccctgttt
    10741 gagcaaggag gtacttctgc ttccgaatat gatcgaatct gtttggtgcc caaacaatta
    10801 gagagggaac tagcagaagc ccaagctaac ttacaacgga ttgttagtag tcgccaggaa
    10861 gaacttgcag aagccagggc taacctgagt cggacggtgc aaactctcaa tgatcaacaa
    10921 aatcagaacc aaggaaccct cgatgaaatt tccgaggtca gggaggttga cgtggccgtc
    10981 gcagaagccc aggtacagga agcacaggcc caactcaggc aagcccaggc cgaatttaat
    11041 ttaactaaaa ttatttcacc cacggatgga caagtcctca agatttatac ctatccaggg
    11101 gagcggatta atgacaaggg gattctggat attggacgaa cgcaagcaat gtatgtgagg
    11161 gcggaagtct atgaaacgga tattcttaac gtcaaaaaag gacaaagggc ttacatatcc
    11221 agtcctgcat tgtcaagtaa tttggaaggt attgttgagt cagttggcca tcaaattggt
    11281 cgtcgggata tcctcgacaa tgatcccgtc gctgatattg atgccagagt agtggaagtg
    11341 aatatccgcc tgctggaaga gagtcaaaat gaaattgatc tttcacggct aaccaatctt
    11401 aagactcggg tgattattga aactagtcct taaaattcac aaggttaagc caatgtattc
    11461 agtatgctgg gtaatgttct tgggctatat tgtctattaa attagggcgg ccagcaccat
    11521 attcttttag attgaactgg tgactgccca ggttaaaata aacatctagt atttaaaaaa
    11581 ctgttgattt ttcctgtgaa tgtacccacc gcttggctgc aactcaaatt ttatccattg
    11641 cgtctcacgg ttgcggttgc gggggtctgc ttttcgatat tcttgatttt tatgcaattg
    11701 agcttccagg atgctctctt tgatagtgcc gtttcttttt atgaagctct agatgcagat
    11761 atttttattc taaatagtcg ttcatccgcc ttaatcgcca tggaaaattt cccagagcga
    11821 agacttaatc aggcgttggc tgtagacaat gttgcggaag taattcccat ctatctaggc
    11881 tttgcccagt ggcgtaatcc tgtcaaaaaa aatgtttggc ggaacattta tctgataggc
    11941 attgagccta gccaatcggt ttttaatata gaggcggttg aggaaaaccg atttaaacta
    12001 aaactgcctg atacagtcct tttcaatcag acgtcgaggt ccgaatttgg ccctattgcc
    12061 gagcttttcc gccaagaggg agaagtgaaa acggaagtag gtgatcgagg cccgagtaat
    12121 cgtctaatca ccgttgttgg tttatttccg ctaggcgcat cctttggttc cgatggcacc
    12181 attattacta gtgatctaaa cttccagcgg atattaccag gaagcagaaa aggatttatt
    12241 aacttggggg gcattaaact ccaagacaaa aataagctgg acatcaccct ggcagcactg
    12301 agggattatt taccgaacga tgtcaagatt ttttccaaag cagaggtttt tgccttcgag
    12361 aaaaactact gggccacggg cagtcccatc ggttttgtat tcgctttggg ggtcggcatt
    12421 ggtatggctg tcggtgtggt aattacctat caagtgctct acagtagcat tgcccaacat
    12481 ttgtcggaat atgcaacgct gcgggccgtt ggttatcgac agcgctatct actcggagtt
    12541 gtttttcaag aagctgtttt tttagccctc tttgcctatg ttccgggcat tatatttgct
    12601 ggttttgtta ctaaattggc cagggatgcc actagtcttc cagtctatat caatgtgaac
    12661 aaagcaataa ttgtattgtt actatcctgt cttatgtgct ttatatcggg ggggattgct
    12721 attcggaaac ttcaggatgc tgatccggcg gatgtatttt attaggatta agcagttaat
    12781 gtattgttaa cttcaggagc aatttaactt actttgcatg aatgacgctg tttttgttag
    12841 taatctcaat cactattacg gccatagaca actccggcag caggttttat ttgatattaa
    12901 tctggttatt aatgaagggg aaattgttct actaacgggg gaatcaggtt cgggcaagac
    12961 taccctacta tctttgatag gtgccctacg gagcattact gagggaaatg ttgtagtgct
    13021 caaccgtcaa ttgtatcggg ccaatgaggc cagattggtg gatgtgcgcc ggagagttgg
    13081 ttatattttc caatcccata atcttctcca atttatgacg gctctgcaaa acgtcagaat
    13141 gtcggcggag ctcttggaag aaccttacct tggcccagca atagagcgag cccatcgcat
    13201 cctggatgct gtcggcttaa agtcacgaaa agattattat ccccacgaac tatcgggggg
    13261 acaaaaacag cgggtggcca ttgcccgtgc cctggtgaat agtcccaagc taattttggc
    13321 agatgagccc accgcgtcct tggatagcaa aaccggtcgg gagattatta atctcatcca
    13381 gcgactggcc caagaacaag gaagtgcggt tctcctggtc acccacgaca accgtatttt
    13441 tgacattgcc caccgtatcc ttagcatgga agatggccgt ctgtacgaaa cttagagcag
    13501 tgttatagtg agaggaacat aggacttgcc gcaaaaaaaa ggtctatgcc gtatcttttc
    13561 tatttacact taaagccatg gtttctgtaa cgccatcttc cgtcgaaagt ttggatttta
    13621 gccatctgcg gggtaaagag cgcaagatca ctcagatcat cgaaaaaacc tatcacaaca
    13681 acactgaatc tgactacacc gaaaaaattg aacagttgga aaaggccttc aactactcgg
    13741 ttgaaaaaga ctattattgg ggctctccag aattgtcatt tttgtatgga actcccctct
    13801 atgaaaaggc ttcagagtct cagaaaaagg tgctgaatca cctctactgg attggacagt
    13861 acaatcttgt tgcggctagt gaaaaaagca caattctgtt taatcaggtt accgcaaatg
    13921 tcttcttctc cctgggagga tttgactccc tctgccatga gttggatcta gaaaccaatc
    13981 aagaacggta tcatattcat gctttccaga atattgatcg cattgtccaa gatggtattt
    14041 ttggggatgg ggatgccaat ggggatcaat accgtaaaca aaccctagac gttctgcggg
    14101 atggggttgc tcgatatatg ggatcggact taaccctaaa atttcttagc ttcaattggg
    14161 gaagtacccc atttctggct tctcagtatt actgtgctcg atacattgcc aatatttccc
    14221 tcaaaaacaa ggagcaggtc tactcgctgc actgtcggaa gttagaaaac tccggtgccc
    14281 atgtgccggc accaacggcc atttcccgtt accatctttt ggatgaatca tttcatacta
    14341 ctatttccca gctgcttggc aaggaacttt ataaagagtt tgcgaagcca tctgcctacg
    14401 aaaagttttt gatgaatatg gtcatctata actatcaaaa acatggagct ggtagcttgt
    14461 caggcttggc accgggggcc ccactcaagg atgagttgtt tatgcccgct ctttatggtg
    14521 ttcttcgatc ttcggtgttt gggatgtccg ccacggaagc tttagattgg atcgaaaaat
    14581 gcgcttgtac ggaacaccaa gggtttcatg tgtccctaca gtatgtcact cggctattga
    14641 atgacttgcg gcgtttcttt tcgagtattg attatttctg gccggtaaat aaggagtgga
    14701 gcatcatggc agaagcccat tccattccaa aaaccttaaa ggctaatcgc cgggccttta
    14761 acaaattcgc tagaaccgtg taactcacta tcctgagtgt ccataactat caaaaacctc
    14821 tcctgtaaat ttgtaaattg ggagaggttt ttaaagtttt taaattaggc gataggattc
    14881 ggaattaggg ttttcctaga ctgaaatagt cgtgccgatg atatttgcgc ctaaatccac
    14941 aaaattggca gagggagcaa ggaaaagatc ggaggaacca ttgttggaat ctgtgttccc
    15001 gcggatgaag ttggcaaaca gggaggcagt ggcggactgg ccaatagaaa tgccgccacc
    15061 attattaccg gaaaaattgt cgaaaatacg gttgaagcgg ccaatgagtt gattgccagt
    15121 ggtctcatcg gggacagatt cgggtactat gccccggata aaaataccac caccatctcc
    15181 cagagactca ttatttttga taacactgga catgaggtta acaatattat ctaccccaaa
    15241 aataccaatg ccaccaccat cacccccaga gtaattattg gcgatgagaa tcctgttgag
    15301 gaagacacga ttgccagtac cagagacctc caccccacga ccatcttccg atagcaatga
    15361 gtctccatta ccgcgggacg agccaccaaa aacgctgacc tgattaaagt caccgtcaat
    15421 atcaaggccg tcattgaaat tgtcattgaa caatgagtcg atgatagtta gcttgttgtt
    15481 atcggcacta tcgccgccgt catcctcaac gaggataagg ccatcggaac cgttgttaga
    15541 aaattgactt ttgataatgg tgaaaatccc atcatcacct tcaatctgta caccttcatc
    15601 gtcgttacca ttcgctcgga cagcgctcaa aaatccggtg aggccatcgg attctagttc
    15661 aattccatcg ctattaccct caaaggaact attcgtaatc ttgagggtag taaagctatt
    15721 atcggtctca atatcattca accggagacc gctatcatca ttattgtaaa cgtcgctttt
    15781 gttaatggtg atagttagat catttccttc gatatctatt ccatagtcgt cgttgtcata
    15841 aaccttggct ccttctagga ctatggttgc accggaggcc gctacatcaa taccgtcatc
    15901 gccattttgg gcaatttcgc ttctgacgat ttgcaaaaga cccccattgg agacggaatc
    15961 aatgccatcg tcatcagaat taaaaatgtt gacacgaaat agtttgagat ctccgctatc
    16021 tatggcaatg gcatcctcac cagcgttatt caataccaga ttattcattt caacggtggc
    16081 accgttgcta atctggaaga tgtcttcctc atcggagctg ccaacgccat cgtcatctag
    16141 cccagttccg tcaatggtga tggtagatgt cggactagta aagaaaggga tacctgctgg
    16201 cgttctgaag acaatggccg gccagttgat acggacatca tcggtaatga ccagaggatc
    16261 gatcaagttg atctggccag aaacattgaa aacgatagaa tcagtacccg gggtactgtt
    16321 cgcagttgtc aaggcttctc gaagggagcc tgcaccggag tcattaagat tattaacaaa
    16381 aaaagttgcc at
//
