BGC0001533 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001533 (Streptomyces rochei)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	63,657	borrelidin	PKS	100%

BGC0001533 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 63,657 nt. (total: 63,657 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 63,658
Label		BGC0001533

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001533	1.00	Polyketide	borrelidin	Streptomyces rochei
BGC0000031	0.82	Polyketide	borrelidin	Streptomyces parvulus
BGC0000016	0.39	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.33	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002266	0.32	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002404	0.32	Other	falcarindiol	Solanum lycopersicum
BGC0002211	0.31	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0002228	0.31	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0002729	0.31	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001504	0.31	Polyketide	amycomicin	Amycolatopsis sp. AA4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001533	1.00	Polyketide	borrelidin	Streptomyces rochei
BGC0000031	0.94	Polyketide	borrelidin	Streptomyces parvulus
BGC0000016	0.71	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002266	0.65	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002404	0.65	Other	falcarindiol	Solanum lycopersicum
BGC0002211	0.65	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0002228	0.65	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0002729	0.65	Polyketide	sordarial	Neurospora crassa OR74A
BGC0001504	0.64	Polyketide	amycomicin	Amycolatopsis sp. AA4

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 63657:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ohmal) + (ccmal - Me-ccmal) + (Me-ohmal) + (Me-redmal) + (ohmal)
Non-colinear ordering:: bor2A1 + bor2A2 + bor2A3 + bor2A4 + bor2A5 + bor2A6

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

bor2A1

PKS_AT (285..584): pk

ATSignature: trans-1,2-CPDA

Top 3 matches:: trans-1,2-CPDA: 95.8%; Ethylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 285.0
Ethylmalonyl-CoA: 175.2
Methylmalonyl-CoA: 167.0
Methoxymalonyl-CoA: 151.3
2-Methylbutyryl-CoA: 117.2
Propionyl-CoA: 104.0
CHC-CoA: 94.8
Malonyl-CoA: 64.9
Acetyl-CoA: 56.4
Benzoyl-CoA: 53.9
Isobutyryl-CoA: 52.1
fatty_acid: 31.3
3-Methylbutyryl-CoA: 28.5
inactive: 13.4

bor2A2

PKS_AT (560..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.9
inactive: 95.6
Methoxymalonyl-CoA: 56.6
Propionyl-CoA: 38.1
Methylmalonyl-CoA: 37.7
Isobutyryl-CoA: 18.7
fatty_acid: 14.4
Ethylmalonyl-CoA: 14.2
Acetyl-CoA: 10.8
Benzoyl-CoA: 7.3
trans-1,2-CPDA: 6.2
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

bor2A3

PKS_AT (560..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.9
inactive: 95.6
Methoxymalonyl-CoA: 56.6
Propionyl-CoA: 38.1
Methylmalonyl-CoA: 37.7
Isobutyryl-CoA: 18.7
fatty_acid: 14.4
Ethylmalonyl-CoA: 14.2
Acetyl-CoA: 10.8
Benzoyl-CoA: 7.3
trans-1,2-CPDA: 6.2
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2246..2535): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.6
Ethylmalonyl-CoA: 184.3
Methoxymalonyl-CoA: 160.9
2-Methylbutyryl-CoA: 128.6
Propionyl-CoA: 111.1
trans-1,2-CPDA: 109.9
CHC-CoA: 98.7
Malonyl-CoA: 94.2
Isobutyryl-CoA: 69.4
Benzoyl-CoA: 68.0
Acetyl-CoA: 56.0
3-Methylbutyryl-CoA: 43.0
inactive: 35.2
fatty_acid: 28.9

bor2A4

PKS_AT (556..845): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.6
Ethylmalonyl-CoA: 184.3
Methoxymalonyl-CoA: 160.9
2-Methylbutyryl-CoA: 128.6
Propionyl-CoA: 111.1
trans-1,2-CPDA: 109.9
CHC-CoA: 98.7
Malonyl-CoA: 94.2
Isobutyryl-CoA: 69.4
Benzoyl-CoA: 68.0
Acetyl-CoA: 56.0
3-Methylbutyryl-CoA: 43.0
inactive: 35.2
fatty_acid: 28.9

bor2A5

PKS_AT (554..848): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.4
Ethylmalonyl-CoA: 189.7
Methoxymalonyl-CoA: 169.9
2-Methylbutyryl-CoA: 136.2
trans-1,2-CPDA: 120.6
Propionyl-CoA: 115.8
CHC-CoA: 104.2
Malonyl-CoA: 102.2
Benzoyl-CoA: 74.2
Isobutyryl-CoA: 73.4
Acetyl-CoA: 59.2
3-Methylbutyryl-CoA: 54.4
inactive: 39.6
fatty_acid: 32.1

bor2A6

PKS_AT (556..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.9
inactive: 95.6
Methoxymalonyl-CoA: 56.6
Propionyl-CoA: 38.1
Methylmalonyl-CoA: 37.7
Isobutyryl-CoA: 18.7
fatty_acid: 14.4
Ethylmalonyl-CoA: 14.2
Acetyl-CoA: 10.8
Benzoyl-CoA: 7.3
trans-1,2-CPDA: 6.2
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0