LOCUS       BGC0001534              5762 bp    DNA     linear   BCT 21-FEB-2018
DEFINITION  Streptomyces filamentosus bkdA2B2C2 gene cluster, complete sequence.
ACCESSION   BGC0001534
VERSION     BGC0001534
KEYWORDS    .
SOURCE      Streptomyces filamentosus (Streptomyces roseosporus)
  ORGANISM  Streptomyces filamentosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:46:08
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..5762
                     /db_xref="taxon:67294"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces filamentosus"
                     /strain="L30"
     subregion       1..5762
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001534"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..5762
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(800..2254)
                     /gene="bkdC2"
     CDS             complement(800..2254)
                     /EC_number="2.3.1.168"
                     /codon_start=1
                     /gene="bkdC2"
                     /note="dihydrolipoamide acyltransferase component of
                     branched-chain alpha-keto acid dehydrogenase complex"
                     /product="BkdC2"
                     /protein_id="AVE17169.1"
                     /transl_table=11
                     /translation="MGGGQLMAQVLEFKLPDLGEGLTEAEIVRWLVEVGDVVAIDQPVV
                     EVETAKAMVEVPCPYGGVVTARFGEEGTELPVGAPLLTVAVGAPEGASGSAASPSSSSS
                     PSPSPSPSSSSSGKGSGSGAESSGGSGNVLVGYGTGAPAARRRRIRPDRLDRAVAEVPV
                     VEVLVAEAPVSDGPVPVVSPLVRRLARQHDIDLRRLAGSGPDGLILRADVDRAIRTAEE
                     TAAATARAARAPMQAQVPAAAPNGVAAAAGAERIPLRGVRGAVADKLSRSRTEIPDATC
                     WVDADATELMAVRAAMNAATGPSAGPKVSVLALLARICTAALARFPELNATVDTEAREI
                     VRLPGVHLGFAAQTERGLVVPVVRDAHTRNAESIGAEIARLTELARTGKLSPAQLTGGT
                     FTLNNYGVFGVDGSTPIINHPEAAMLGVGRIMPKPWVHQGELAVRQVVQLSLTFDHRVC
                     DGGTAGGFLRYVADCVEQPTVLLRTL"
     misc_feature    800..5264
                     /note="bkdA2B2C2 gene cluster"
     gene            complement(2236..3252)
                     /gene="bkdB2"
     CDS             complement(2236..3252)
                     /EC_number="1.2.4.4"
                     /codon_start=1
                     /gene="bkdB2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110:1-deoxy-D-xylulose-5-phosphate synthase (Score:
                     357.1; E-value: 9.6e-109)"
                     /gene_kind="biosynthetic-additional"
                     /note="branched-chain alpha-keto acid dehydrogenase, E1
                     component, beta subunit"
                     /product="BkdB2"
                     /protein_id="AVE17168.1"
                     /transl_table=11
                     /translation="MTADGRPVKAKPATMAQALGRALRDSMAEDPTVHVLGEDVGTLGG
                     VFRITDGLAKEFGDDRCTDTPLAEAGILGAAVGMAMYGLRPVVEMQFDAFAYPAFEQLM
                     SHVAKMRNRTGGAMPLPITVRVPYGGGIGGVEHHSDSSEAYYMATPGLHVVTPATVDDA
                     YGLLRESIASDDPVVFLEPKRLYWSKADWSPEAPAAVEPIGKAVVRRPGRSATLITYGP
                     SLPVCMEAAEAALAEGWDLEVVDLRSLVPFDDETVAASVRRTGRAVVVHESPGFGGPGG
                     EIAARITERCFHHLEAPVLRVAGFDIPYPPPMLERHHLPGVDRVLDAVARLQWEADS"
     gene            complement(3264..4424)
                     /gene="bkdA2"
     CDS             complement(3264..4424)
                     /EC_number="1.2.4.4"
                     /codon_start=1
                     /gene="bkdA2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_kind="biosynthetic-additional"
                     /note="branched-chain alpha-keto acid dehydrogenase, E1
                     component, alpha subunit"
                     /product="BkdA2"
                     /protein_id="AVE17167.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 1e-09, bitscore:
                     26.0, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQELPGAAAYRPTPPPAWKPITDPAPLLPDPEPYRVLGTDAVA
                     DVDPELLLRLHAELVRGRRYNAQATALTKQGRLAVYPSSTGQEACEIAAALVLEERDWL
                     FPSYRDTLAAVARGLDPVEALTLLRGDRHTGYDPREHRIAPLCTPLATQLPHAVGLAHA
                     ARLKGDDVVALAMVGDGGTSEGDFHEALNFAAVWKAPVVFFVQNNGFAISVPLAKQTAA
                     PSLAHKAVGYGMPGRLVDGNDAAAVHQVLSEAVARARRGEGPTLVEAVTYRMEAHTNAD
                     DATRYRVDSEVEAWKAHDPVRLLERELTERGLLDDAGIEQAKEAAERMAAALRDRMNAD
                     PELTPMDLFTHVYAEQTSQLREQAAALRAELDAEQDHDEHGPEAGR"
     gene            4686..5264
                     /gene="bkdR"
     CDS             4686..5264
                     /codon_start=1
                     /gene="bkdR"
                     /gene_functions="regulatory (smcogs) SMCOG1120:AsnC family
                     transcriptional regulator (Score: 129.1; E-value: 1.7e-39)"
                     /gene_kind="regulatory"
                     /note="leucine-responsive regulatory protein; regulator for
                     leucine (or lrp) regulon and high-affinity branched-chain
                     amino acid transport system"
                     /product="BkdR"
                     /protein_id="AVE17166.1"
                     /transl_table=11
                     /translation="MAAEQMADKGEEPDRTPPTAAPSAAAPAGPEPVPVPPARPLDAID
                     RDILRILQTDGRASIRSVAERVHVSRANAYARINRLVEDGVIRGFGARVDHERAGQGAS
                     AYITLKIVQNSWRTVREQLQALPGATHIALVSGDFDVLLLVHTPDNRALRELVLTRIQS
                     IPEVLSTRTLLVFEETDLGPRPDRPAELA"
ORIGIN
        1 cgtgcgcggc gtcacgggcg aggtcgagca ggacaccggt gtcgacgtcg aggtcgattc
       61 ccagttcgtt cttgaccgag gtgatccatt cgtccagcac ggccccatgc tccctgatcc
      121 gggcgcgggc ggcggcgatg tcgtcccaag tgtcgcagtc gaacgcggcg tcaggacccg
      181 cctcgacccg ggcgaggtcc agctccgccg tcagaagccg gagcggaagc ccggcgaggt
      241 ttccgtgctc ggtggcgatc agggccagct cccggcggag cggctcggcg cggtacgcgg
      301 ccacgagcgg ctggtcgcgc ccgtcgggat cggtgcacag ggccccttcc cggccgggct
      361 gtacggcggc ggcgagcagc gcgtcgaccg tgcccgggcc gaggaacgga aggtcggcgg
      421 agagaacgag aacgtggtcc gccgtcgtca gccgcagccc cgcgcccagc gccgccaacg
      481 ggccgccgcc ctgcggtact tcccgggtcc agaggaccgg ccgggcggtc ggtcgacggt
      541 cgcccaccac gacggtacga gccgcgccgt cgcacgccgc gaggacccgg tcgagcaggg
      601 cccggccgcc cacccggact cctggcttgt cggcgccgcc gagccgcttc gcggcccctc
      661 cggcaaggac gatcacgtcg taggcggtca tacgtcgagt atgggcggcg ccccgcggcg
      721 acgcccccgc cggggtggcc ggacgaccgg acaccgcgac gggggcgtgt cgggggagcc
      781 cccgaaggcg taagcgtgac tacagcgtgc gcagcagcac cgtcggctgc tccacgcagt
      841 ccgccacgta ccggaggaag ccgcccgccg ttccgccgtc gcacacccgg tggtcgaagg
      901 tgagggacag ctggacgacc tgacgtacgg ccagttcgcc ctggtgaacc cagggtttgg
      961 gcatgatccg gccgaccccg agcatcgccg cctccgggtg gttgatgatc ggcgtcgaac
     1021 cgtcgacccc gaacaccccg tagttgttca gcgtgaacgt gcccccggtc agctgcgccg
     1081 ggctgagctt cccggtgcgc gccagctcgg tcagccgggc gatctcggcc ccgatcgact
     1141 cggcgttgcg ggtgtgcgcg tcccggacga ccgggacgac gaggccccgc tcggtctggg
     1201 ccgcgaaccc gaggtgcacg ccgggcagcc ggacgatctc gcgggcttcc gtgtccacgg
     1261 tggcgttgag ctcggggaac cgggccagcg ccgccgtgca gatcctcgcc agcagggcca
     1321 ggaccgacac cttcggcccg gcggacgggc ccgtggcggc gttcatcgcg gccctgaccg
     1381 ccatcagctc ggtggcgtcg gcgtcgaccc agcaggtggc gtcgggaatc tcggtccggc
     1441 tgcgcgacag cttgtcggcg accgctccgc gcaccccgcg cagcggaatc cgctcggcgc
     1501 ccgcagcggc ggctacgccg ttcggggctg cggccggtac ctgggcctgc atcggtgccc
     1561 gggccgcacg tgccgtcgcc gcagcggtct cctccgccgt ccggatcgcc cggtcgacgt
     1621 cggcgcgcag gatcagcccg tcggggcccg aacccgccag ccgccgcaga tcgatgtcgt
     1681 gctgccgggc cagccggcgt accagcggag agaccaccgg cacgggcccg tcggacaccg
     1741 gagcttcggc aaccaggacc tcgaccacag ggacctcggc caccgcccgg tcgagccggt
     1801 ccggacggat gcgccgacga cgcgcggccg gcgcgccggt cccgtacccc acgagcacgt
     1861 tccccgagcc gcccgaggac tccgcgccgg agccggaacc cttgccggag gaggaggagg
     1921 agggggaagg ggaaggggaa ggggaagaag aggaggaagg ggacgcggcg gagccggaag
     1981 ccccctccgg tgccccgacg gcgaccgtca gcagcggtgc gccgacggga agttccgtgc
     2041 cctcctcgcc gaaccgcgcg gtcaccacgc ccccgtaggg acagggcacc tccaccatcg
     2101 ccttggccgt ctcgacctcg acgacgggct ggtcgatggc gacgacatcg ccgacctcca
     2161 ccagccagcg gacgatctcc gcctcggtca gaccctcacc gaggtccggc agcttgaatt
     2221 ccagcacctg ggccatcagc tgtccgcctc ccactgcaac cgggccaccg cgtcgagcac
     2281 ccggtcgact cccggcagat ggtgccgctc cagcatgggc ggcgggtagg ggatgtcgaa
     2341 cccggccacc cgcagcaccg gagcctccag atggtggaag caccgctcgg tgatccgggc
     2401 cgcgatctcg ccgccgggcc cgccgaatcc gggggactcg tgcacgacga ccgcccgccc
     2461 ggtgcggcgc accgacgcgg ccaccgtctc gtcgtcgaac ggcaccagcg agcgcaggtc
     2521 gaccacttcg aggtcccagc cctcggcgag ggccgcctcg gcggcttcca tgcagaccgg
     2581 cagcgagggc ccgtacgtga tcagggtggc gctgcgcccg ggccggcgca ccacggcctt
     2641 gccgatcggc tcgaccgcgg cgggggcctc gggcgaccag tcggccttgg accagtagag
     2701 ccgcttcggc tccaggaaga ccaccgggtc gtccgaggcg atcgactccc gcagcagccc
     2761 gtaggcgtcg tcgaccgtgg ccggcgtgac gacgtgcagg ccgggggtgg ccatgtagta
     2821 cgcctcggag gagtcgctgt ggtgctcgac cccgccgatc ccgccgccgt aaggcacccg
     2881 cacggtgatc ggcagcggca tggccccgcc ggtgcggttg cgcatcttgg cgacatggct
     2941 catcagctgc tcgaatgccg ggtaggcgaa cgcgtcgaac tgcatctcca ccacggggcg
     3001 cagcccgtac atcgccatgc cgacggccgc gccgagaatg ccggcctcgg ccagcggggt
     3061 gtcggtgcag cggtcgtcgc cgaactcctt cgccagcccg tcggtgatcc ggaagacccc
     3121 gccgagcgtg cccacgtcct caccgagcac atggacggtg gggtcctcgg ccatcgagtc
     3181 gcggagcgca cgcccgaggg cctgcgccat cgtggccggt ttcgccttca cggggcggcc
     3241 gtcggccgtc actgccgccg tggtcatcgt cctgcctccg ggccgtgctc gtcgtggtcc
     3301 tgctcggcgt ccagctcggc gcgcagggcg gcggcctgct cccggagctg gctcgtctgc
     3361 tcggcgtaca catgggtgaa gaggtccatc ggggtcagct ccggatccgc gttcatccgg
     3421 tcgcgcaggg cggcggccat gcgttcggcg gcctccttcg cctgctcgat gcccgcgtcg
     3481 tccagcagcc cgcgctccgt cagctcacgc tccagcagcc gcaccgggtc gtgcgccttc
     3541 cacgcctcga cctcgctgtc gacccggtag cgggtggcgt cgtcggcgtt ggtgtgggcc
     3601 tccatgcggt aggtgaccgc ctcgaccagc gtcggaccct cgccgcgccg ggcccgcgcc
     3661 acggcctcgc tcagcacctg gtgcaccgcg gcggcgtcgt tgccgtcgac gaggcggccc
     3721 ggcatcccgt atccgacggc cttgtgggcg agggaggggg cggcggtttg cttggccagc
     3781 ggcacggaga tcgcgaagcc gttgttctgg acgaagaaga cgaccggggc tttccagacg
     3841 gccgcgaaat tcagcgcctc gtggaagtcg ccctcgctgg tgccgccgtc gccgaccatg
     3901 gcgagcgcca ccacgtcgtc gcccttgagc cgggcggcgt gcgccagccc cacggcgtgc
     3961 gggagctggg tggcgagcgg ggtgcacagc ggggcgatgc ggtgctcgcg cgggtcgtaa
     4021 ccggtgtgcc ggtcgccgcg cagcagggtc agcgcctcga ccgggtccag accgcgcgcg
     4081 actgccgcga gcgtgtcgcg gtagctgggg aagagccagt cgcgctcctc cagcaccagg
     4141 gcggcggcga tctcgcacgc ctcctgaccg gtgctcgacg ggtagaccgc cagccggccc
     4201 tgcttcgtca gcgcggtggc ctgggcgttg tagcgacgcc cgcgcaccag ctccgcgtgg
     4261 aggcggagca gcagctcggg gtcgacatcg gcgaccgcgt ccgtaccgag cacccggtag
     4321 ggctccgggt ccgggagcag cggggcgggg tcggtgatcg gcttccaggc cgggggcggc
     4381 gtgggccggt atgcggccgc gccgggcagc tcttggaccg tcatgagaag cacctcctgg
     4441 catcgaggga gatcgagggg tgtcgatcgg cggtttcgag tcgatcggcg gtgtcgatgg
     4501 gtgtcgatgg tgtcgatcgg gagcgagaca tcgcgagctg ggcgaggcgc cggtgtggtg
     4561 tgcctcacct accgattgtt cggtcgcaag cgcattttgg ctacaggcac cgccagcctg
     4621 tggacaaacg gttctccaca gcctgggatg ggtacaggtc gtccacgaca gggaggcgcg
     4681 ggccgatggc agctgaacaa atggccgaca agggcgagga gccggaccgg accccgccca
     4741 ccgccgcacc gtcggccgcc gcccccgcgg gcccggagcc ggtcccggtt ccgcccgcgc
     4801 ggccgctgga cgccatcgac cgcgacatcc tgcggatcct ccagacggac ggccgcgcct
     4861 cgatacggtc cgtggccgag cgggtccacg tctcgcgcgc caacgcctac gcccggatca
     4921 accggctcgt cgaggacggc gtgatccgcg gcttcggcgc ccgggtcgac cacgagcggg
     4981 ccggccaggg agcgtccgcg tacatcacgc tcaagatcgt gcagaactcc tggcgcaccg
     5041 tgcgcgagca gctccaggcg ctgcccgggg ccacgcacat cgccctggtc agcggcgact
     5101 tcgacgtact gcttctggtg cacacgccgg acaaccgggc gctgcgcgag ctggtcctca
     5161 cccggatcca gtccatcccc gaggtgctct cgacgcgcac gctgctggtg ttcgaggaga
     5221 cggacctcgg accgcgcccg gaccggccgg ccgaactcgc ctgaccgtgc cgtgcgcggc
     5281 agcccgatgc ccggcgggct cggcgggctc agcgggctcg gtgggctcgg tgggctcggt
     5341 gggctcggtg ggctcggtgg gctcggtggg ctcggtgggc tcagcgggag ccgttcgccc
     5401 gcattccctc gaaggccagc tgcacgaccg tgtccgcgag ctgctcctcc ccggggaaac
     5461 cgcccggctg cggccggtac cactcgacca gcgagttcac catgccgaac agcagccggg
     5521 tcgccagccg tatgtccacg tcggcccgga ggtcgccctc ggcgacggcg gcctggagca
     5581 gctccgccac ccgctggtcg aactcgcggc gccgctccag cgcccagcgc tccgtcttcg
     5641 tgttgccgcg cacccgcagc agcagggtga cgtaggggac ctccgccatc agcacgtcga
     5701 cggtccggcg cgtgacgtac tcgacccgct cgaccgcgcg cccgcgctgc gcccccggct
     5761 cg
//
