LOCUS       BGC0001535              4391 bp    DNA     linear   BCT 21-FEB-2018
DEFINITION  Streptomyces filamentosus bkdA1B1C1 gene cluster, complete sequence.
ACCESSION   BGC0001535
VERSION     BGC0001535
KEYWORDS    .
SOURCE      Streptomyces filamentosus (Streptomyces roseosporus)
  ORGANISM  Streptomyces filamentosus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:23:35
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4391
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..4391
                     /db_xref="taxon:67294"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces filamentosus"
                     /strain="L30"
     subregion       1..4391
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001535"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..4391
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(335..1783)
                     /gene="bkdC1"
     CDS             complement(335..1783)
                     /EC_number="2.3.1.168"
                     /codon_start=1
                     /gene="bkdC1"
                     /note="dihydrolipoamide acyltransferase; component of
                     branched-chain alpha-keto acid dehydrogenase complex"
                     /product="BkdC1"
                     /protein_id="AVE17172.1"
                     /transl_table=11
                     /translation="MTTMTETSARFREFKMPDVGEGLTEAEILKWFVQPGDTVTDGQVV
                     CEVETAKAAVELPIPFDGVVHELRFPEGTTVDVGQVIIAIDVAPGSGDAPVPAAAAPVQ
                     EPAAEPEAEAEPKGRTPVLVGYGVAESSTKRRPRKGAATAPEAAAVAAAVQAELNGHGA
                     PAASAPAPAVPVQGGRPLAKPPVRKLAKDLGIDLATVVPTGKDGIITREDVHAAAAPAA
                     PEAPAAVAPPVTSAPAVAEAPAVVSDSARETRIPVRGVRKAIAQAMVGSAFTAPHVTEF
                     VTVDVTRTMKLVAELKEDKDMAGVRVNPLLIIAKALLVAIKRNPEVNAAWDEANQEIVQ
                     KHYVNLGIAAATPRGLIVPNIKDAHDKTLPQLAEALGELVATARDGKTSPAAMAGGTVT
                     ITNVGVFGVDTGTPILNPGESAILAVGAIKLQPWVHKGKVKPRQVTTLALSFDHRLVDG
                     ELGSKVLADVAAILEQPKRLITWA"
     misc_feature    complement(335..3938)
                     /note="bkdA1B1C1 gene cluster"
     gene            complement(1795..2775)
                     /gene="bkdB1"
     CDS             complement(1795..2775)
                     /codon_start=1
                     /gene="bkdB1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110:1-deoxy-D-xylulose-5-phosphate synthase (Score:
                     366.6; E-value: 1.3e-111)"
                     /gene_kind="biosynthetic-additional"
                     /note="branched-chain alpha-keto acid dehydrogenase, E1
                     component, beta subunit"
                     /product="BkdB1"
                     /protein_id="AVE17171.1"
                     /transl_table=11
                     /translation="MAVEKMSIAKALNESLRLALDTDPKVLIMGEDVGKLGGVFRITDG
                     LQKDFGEDRVIDTPLAESGIVGTAIGLALRGYRPIVEIQFDGFVFPAYDQIVTQLAKMH
                     ARALGKVKLPVVVRIPYGGGIGAVEHHSESPEALFAHVAGLKVVSPSNASDAYWMMQQA
                     VQSDDPVIFFEPKRRYWDKGEVDTESIPGPLHKAVTAREGSDLTLVAYGPMVKVCLEAA
                     AAAQEEGKSIEVLDLRSMAPIDFDAIQRSAEKTGRVVVVHEAPVFYGSGAEIAARITER
                     CFYHLEAPVLRVGGYHVPYPPARLEDEYLPGLDRVLDAVDRSLAF"
     gene            complement(2778..3938)
                     /gene="bkdA1"
     CDS             complement(2778..3938)
                     /codon_start=1
                     /gene="bkdA1"
                     /note="branched-chain alpha-keto acid dehydrogenase, E1
                     component, alpha subunit"
                     /product="BkdA1"
                     /protein_id="AVE17170.1"
                     /transl_table=11
                     /translation="MTVESTAAARKPRRASKRTSAAKKPQSAEPQLVQLLTPEGERVEH
                     PDYSIDLSAEELRGLYRDMVLTRRFDAEATALQRQGELGLWASLLGQEAAQIGSGRALR
                     DDDYVFPTYREHGVAWCRGVDPTNLLGMFRGVNHGGWDPNSNNFHLYTIVIGSQTLHAT
                     GYAMGVAKDGADSAVIAYFGDGASSQGDVAESFTFSAVYNAPVVFFCQNNQWAISEPTE
                     RQTRVPLYQRAQGYGFPGVRVDGNDVLACLAVTRSALERARRGEGPTLVEAFTYRMGAH
                     TTSDDPTKYRADEERAAWEAKDPILRLRTYLEKAGHADEAFFTALDEESETLGKRVREA
                     VRAMPDPEPMALFEHAYADGNSLVDEERAQFAAYQASFADSAEEGK"
ORIGIN
        1 gtcgacgaag cagaaggtga ccaccaagag cggtggctac cgctacatgt cgtggaccaa
       61 caccaacaag ctgctcggca gttacagcgg cgcgaccggc gtcaagaccg gctcaggacc
      121 gaccgccaag tactgcctgg tcttcgcggc gacccgcaag ggcaagacgg tcatcggcac
      181 ggtgctcacg tcgacctccg aggcgaaccg caccgccgac gcgaagaaga tgatggacta
      241 cgggttcaag atctagcccg caggcgttgt acgtcgaagg ggcccggccc gcacagtctg
      301 tgcgggccgg gccccttcgg ctgtcgcgga agcgtcaggc ccaggtgatc agccgcttcg
      361 gctgctccag gatcgccgcc acatcggcca gcaccttgga gcccagctcg ccgtcgacca
      421 ggcggtggtc gaacgagagc gccagcgtgg tgacctgacg aggcttcacc ttgcccttgt
      481 gcacccacgg ctggagcttg atcgcaccga ccgccaggat cgcggactcg cccgggttga
      541 ggatcggcgt accggtgtcg acgccgaaga cgccgacgtt ggtgatggtc accgtaccgc
      601 ccgccatcgc cgccggggac gtcttgccgt cccgggccgt ggcgaccagc tcacccagcg
      661 cctccgcgag ctgcggcagc gtcttgtcgt gcgcgtcctt gatgttcggc acgatcagac
      721 cgcgcggggt ggccgccgcg atgcccaggt tgacgtagtg cttctgcacg atctcctgat
      781 tggcctcgtc ccaggcggcg ttgacctcgg ggttccgctt gatcgcgacg aggagggcct
      841 tggcgatgat gagcagcggg ttgacccgca cccccgccat gtccttgtcc tccttgagct
      901 cggccacgag cttcatcgtg cgcgtcacgt cgaccgtgac gaactcggtg acgtgcggcg
      961 cggtgaaggc cgaaccgacc atcgcctgcg cgatcgcctt gcggactccc ctgaccggga
     1021 tgcgcgtctc gcgggcggag tcggatacca ccgcaggggc ctcggcgacc gccggcgcgg
     1081 aggtcaccgg gggcgcgacc gccgcgggag cctcgggagc ggccggggcc gccgcagcgt
     1141 ggacgtcctc gcgggtgatg atgccgtcct tgccggtcgg caccaccgtc gccaggtcga
     1201 tgcccaggtc cttggccagc ttgcggaccg ggggcttggc gagcgggcgg ccgccctgga
     1261 ccggaacagc cggggccgga gccgacgcgg ccggcgcccc gtgcccgttc agctcggcct
     1321 gcaccgccgc agcgacggcg gcggcctcgg gcgcggtggc cgcgcccttg cgcgggcggc
     1381 gcttggtgga ggactcggcg accccgtagc ccaccaggac cggcgtacgg cccttcggct
     1441 cggcttccgc ctcgggctcc gcggccggct cctggaccgg agcggcggcg gccgggacgg
     1501 gcgcgtcgcc gctgcccggg gccacgtcga tcgcgatgat cacctggccg acgtcgacgg
     1561 tcgtgccctc ggggaagcgc agctcgtgca ccaccccgtc gaacgggatc ggcagctcga
     1621 cggccgcctt cgcggtctcg acctcgcaca cgacctggcc gtcggtgacg gtgtcgccgg
     1681 gctggacgaa ccacttgagg atctcggcct cggtcagtcc ttcgcccacg tcgggcatct
     1741 tgaactcacg gaagcgagca gacgtttcgg tcatcgtcgt cacgaaccct ctcctcagaa
     1801 cgccagcgag cggtcgacgg cgtcgagcac ccggtccagg ccgggcaggt actcgtcctc
     1861 cagccgggcc ggcgggtagg ggacgtggta gccgccgacc cgcagtacgg gggcttcgag
     1921 gtggtagaag cagcgctcgg tgatccgggc ggcgatctcc gcgccggagc cgtagaagac
     1981 gggcgcctcg tggacgacca cgacccggcc ggtcttctcc gccgacctct ggatggcgtc
     2041 gaagtcgatg ggggccatcg agcgcaggtc gaggacctcg atcgacttgc cctcctcctg
     2101 ggcggccgcg gccgcctcca ggcagacctt gaccatcggc ccgtacgcga cgagcgtgag
     2161 gtcgctgccc tcgcgggcgg tgacggcctt gtgcagcggg ccggggatgg actcggtgtc
     2221 gacctcgccc ttgtcccagt agcgccgctt gggctcgaag aagatcaccg ggtcgtcgct
     2281 ctggacggcc tgctgcatca tccagtacgc gtcgctcgcg ttggacggcg agaccacctt
     2341 caggcccgcg acgtgcgcga agagcgcctc gggggactcg ctgtggtgct cgaccgcgcc
     2401 gatgccaccg ccgtacggaa tgcgtacgac gaccggcagc ttgaccttgc cgagcgcgcg
     2461 ggcgtgcatc ttggcgagct gcgtgacgat ctggtcgtac gcggggaaga cgaagccgtc
     2521 gaactggatc tcgacgatcg ggcggtagcc gcgcagggcc aggccgatcg ccgtgccgac
     2581 gatgccggac tcggcgagcg gggtgtcgat cacccggtcc tcgccgaagt ccttctggag
     2641 cccgtcggtg atccggaaga caccgccgag cttgcccacg tcctcaccca tgatgaggac
     2701 cttggggtcg gtgtcgaggg cgaggcggag cgactcgttg agcgctttcg cgatggacat
     2761 cttttccacg gccatggcta cttgccctcc tcggcagagt cggcgaacga tgcctggtag
     2821 gcggcgaact gggcccgctc ctcgtccacg agggagttcc cgtcggcgta ggcgtgctcg
     2881 aacagggcca tcggctccgg gtcgggcatc gcgcgtaccg cttcccgtac ccgcttgccg
     2941 agggtctcgc tctcctcgtc cagggcggtg aagaacgcct cgtcggcgtg gccggccttc
     3001 tccaggtacg tccgcagccg caggatcggg tccttggcct cccaggcggc ccgctcctcg
     3061 tcggcccggt acttcgtcgg gtcgtcggag gtggtgtggg cgcccatgcg gtacgtgaac
     3121 gcctcgacca gcgtcgggcc ctcgccgcga cgggcccgct ccagcgcgga gcgggtgacg
     3181 gcgaggcagg cgaggacgtc gttgccgtcg acgcggacgc cggggaagcc gtagccctgg
     3241 gctcgctggt agagcggcac gcgggtctgg cgctcggtgg gctcggagat ggcccactgg
     3301 ttgttctggc agaagaagac gaccggggcg ttgtagaccg cggagaaggt gaacgactcg
     3361 gcgacgtcgc cctggctgga ggcgccgtca ccgaagtacg cgatcacggc ggagtccgca
     3421 ccgtccttgg cgacgcccat ggcgtagccg gtggcgtgca gcgtctgcga gccgatgacg
     3481 atcgtgtaca ggtggaagtt gttgctgttc gggtcccagc cgccgtggtt cacgccgcgg
     3541 aacatgccga gcaagttggt cgggtcgacg ccgcggcacc aggcgacgcc gtgctcccgg
     3601 taggtcggga agacgtagtc gtcgtcgcgc agggcgcggc cactgccgat ctgggcggcc
     3661 tcctggccga gcagcgaggc ccacaggccc agctcgccct gacgctggag ggcggtcgcc
     3721 tcggcgtcga agcggcgcgt gagcaccatg tcccggtaca ggccgcgcag ctcttccgcg
     3781 ctcaggtcga tgctgtagtc cgggtgctcg acgcgctcgc cctcgggcgt cagcagctgt
     3841 acgagctggg gctcggcgct ctgcggcttc ttcgcggcgc tggtccgctt gctggcgcgt
     3901 cgcggtttac gcgcggcggc agtgctctcc acggtcacgt gcgtgctcct ccgtcggtcc
     3961 ggcccccggg gtccgccggg aaccagtgcg gctcgcctga gtccggagcc gtgcacgggg
     4021 tgggtgccgg tcgggccggg atcaggcgtg acaggtgccc cggcgagcgc cctgtcatag
     4081 gcacgttacc cagtgcatcg cataactgcg aaaccctctc tgacctgcga ttttgcttgg
     4141 atttccaagt aaatcgaaaa aaacgcgaag cgctgctggt cagggcactg gaaacagcct
     4201 tgcaggccgc cggaacaacg gcacgttatc ccgcggatca gcgccaggga agagcggagg
     4261 ggaagcgagt atgtgagact gcgatcgtgc gcgaagatgg aaaaatcacg gtatttctgc
     4321 tcgacgatca cgaggtcgtc cggcgcggcg tccatgagct gctcgcctcg gaaccggata
     4381 tcgaggtggt c
//
