LOCUS       BGC0001549              4757 bp    DNA     linear   CON 03-SEP-2022
DEFINITION  Streptomyces aurantiacus JA 4570 Seq17, whole genome shotgun
            sequence.
ACCESSION   BGC0001549
VERSION     BGC0001549
KEYWORDS    .
SOURCE      Streptomyces aurantiacus JA 4570
  ORGANISM  Streptomyces aurantiacus JA 4570
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            AOPZ01000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:47:59
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..4757
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1838:4419]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1839..4419
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     cand_cluster    1..4757
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..4757
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001549"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..4757
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1779)
                     /locus_tag="STRAU_RS02290"
                     /old_locus_tag="STRAU_0465"
     CDS             complement(1..1779)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 335.1; E-value:
                     1.4e-101)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988508.1"
                     /locus_tag="STRAU_RS02290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_0465"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_078620925.1"
                     /transl_table=11
                     /translation="MFRLTAGHRSAMTIASVLTLGGSALGLAQPLLAKTIVDASSHGHI
                     VVPVLVLAALFVAEAATGAAGRFVLERMGEGIVRGLRSSLVSRLLRLEMREYDRHRTGD
                     LISRVTTDTSLLREVVSQALVDLMTGSLVAVGALALMLWIDPLLLLMVLLTVVAAAVVV
                     ASLLTGLRTAAEHMQGAIGAIAAELERALGALPMVRVHRAEEREAERMGACIDTAYSAG
                     VRTARLSSVLSPAVELAVHGSFLLVLVIGGLRVNGNANTLGDLVAFMLYATYLMVPLSS
                     VFQAVGLVQRGMGAFQRIDEALSLQAEPAEPEPAESESPKRPVPARCSPRPAPTTPEPA
                     LALDDVWFGYRPHCPVLQGVSLTVPPRRQVALVGRSGAGKSTIFALIARFYEPDSGTLR
                     FDGHPAAELGRPECRSRIAVVDQNTHVVHGSLWDNITYAAPTASPAEVRKAVELANLTD
                     VIDRLPGGLNGTVGERGSTLSAGERQRVALARALLTRPSLLLLDEPTSHLDAINEAALS
                     RVLQDVTRQCALLVIAHRLSTVQNADQIILLEAGRAIAAGRHEDLLTTSADYRELVAGQ
                     ALRTQSTNGRGTMRLR"
     gene            complement(1839..2273)
                     /locus_tag="STRAU_RS02295"
                     /old_locus_tag="STRAU_0466"
     CDS             complement(1839..2273)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602541.1"
                     /locus_tag="STRAU_RS02295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_0466"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_016638600.1"
                     /sec_met_domain="PF13471 (E-value: 3.8e-29, bitscore: 89.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALTRPTGIPLTRRLAARLVLIAAFLLSFLPPRRIRAVLNA
                     VRRGAAPASATQAKSARDAICAVSLRCAGPRGCLPRSLGTALLCRLGGTWPTWCTGVRM
                     VPPFTAHAWVEIDGRLVDEGVPDDYFSRLLTVPPVGRPTR"
     gene            complement(2270..2524)
                     /locus_tag="STRAU_RS02300"
                     /old_locus_tag="STRAU_0467"
     CDS             complement(2270..2524)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004946593.1"
                     /locus_tag="STRAU_RS02300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_0467"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_016638601.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 6.5e-29,
                     bitscore: 88.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.4e-18, bitscore: 55.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALRFAPDITTAETEYGTVLLDQRSGHYWELNPTGTLVVRTLLEG
                     GEEKDAVDAVIAEFDIDRAQAAQDVAALIHLLRTSGLTA"
     gene            complement(2569..4419)
                     /locus_tag="STRAU_RS02305"
                     /old_locus_tag="STRAU_0469"
     CDS             complement(2569..4419)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 104.5; E-value: 9.4e-32)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988505.1"
                     /locus_tag="STRAU_RS02305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_0469"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_037657108.1"
                     /sec_met_domain="Asn_synthase (E-value: 4.4e-48, bitscore:
                     153.1, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTSHETGGVGPGDAHFAVLPDCVDAIAAARSFLRPEARTLAHPS
                     GRPWLVGRWSDQEIVTAHAGRAAIAVVGCCSVGPDELKGYAERLRDLTELDALARRLSG
                     SFHLVAALDGRLRVQGTASGLRLVFHAIVDGVQVAATSAEVLAAATGAEPDEERLAVRL
                     LWPAPYPLSETSLWRTVTAVPPEDAVVVAPDGRTARHSRWWAPPDPVRSLAESAPLVRE
                     ALADAVDARTSAGGVVSCDLSGGLDSTSVCFLAARSPARVVASTWPGRDPADSDLYWAK
                     KAARFLPDIEHVIWDADESPLVYDDLLAIDDLIDEPTIGVMDRSRVLHHLPGLGQRGSR
                     VHLTGIGGDHVAWCSEAYYHRLVRTRPLIALRNLRGFRTLFHWPLGATARALADARPYG
                     QWLAHSSRDLREATAPPVSGTLGWGTPPRLFDWITPEAARVAGQALRDAAASAVPLHPD
                     RGMHTDLEQIRSCTRIVRQWDRMAARAGVPMASPFFDDRVIEACLAVNPIERVTPWAYK
                     PLLTTAMRQIVPDVCLERANKAQASMDASNGLRERRGDLMKLWEDSHLAQLGLVDGRAL
                     MELARRPSTPGLGEGTLYSTIACEVWLRSLSRHRREVFRG"
     gene            complement(4446..4556)
                     /locus_tag="STRAU_RS41245"
                     /old_locus_tag="STRAU_0468"
     CDS             complement(4446..4556)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lassopeptides)
                     predicted lassopeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656044.1"
                     /locus_tag="STRAU_RS41245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_0468"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_016638602.1"
                     /transl_table=11
                     /translation="MKKAYEAPTLVRLGTFRQRTGLLQRHGNDRLIFSKN"
     CDS_motif       complement(4494..4556)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKKAYEAPTLVRLGTFRQRTG"
                     /locus_tag="STRAU_RS41245_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(4446..4493)
                     /prepeptide="core"
                     /locus_tag="STRAU_RS41245_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="1.60"
                     /molecular_weight="1793.0"
                     /monoisotopic_mass="1792.0"
                     /core_sequence="LLQRHGNDRLIFSKN"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAYEAPTLVRLGTFRQRTG"
                     /leader_location="[4493:4556](-)"
ORIGIN
        1 tcagcgaagc cgcatcgtcc cccgcccgtt cgtgctctga gtccgcagcg cctgccccgc
       61 caccagttcc cggtagtcgg cactggtcgt caggaggtcc tcgtggcgcc ccgcggcgat
      121 ggcgcggcct gcttccagca ggatgatttg gtcggcgttc tggaccgtgg agaggcggtg
      181 ggcgatgacc agaagggcgc attgacgtgt gacgtcctgg agcacgcggc tgagcgccgc
      241 ttcgttgatg gcgtccaggt gggaggtggg ttcgtccagg aggagcagag aggggcgggt
      301 gaggagggcc cgggcgaggg ccacgcgttg gcgttctccc gccgagagag tgctgccccg
      361 ttcgcccacg gtgccgttca gaccgccggg caagcggtcg atcacatcgg tgaggttggc
      421 gagttcgaca gccttccgga cctcggccgg gctcgccgtg ggcgccgcgt aggtgatgtt
      481 gtcccagagc gagccgtgga cgacgtgggt gttctggtcg acgacggcga tgcgcgagcg
      541 gcactccggg cggcccagtt cggccgccgg atgcccgtcg aaccggagcg tgccggagtc
      601 cggctcgtag aagcgtgcga tcagggcgaa gatcgtgctc tttcccgcgc ccgacctgcc
      661 gaccagggcg acctgccggc ggggtggcac ggtcagggag acgccttgga ggaccgggca
      721 gtgggggcgg tagccgaacc acacgtcgtc gagggcgagg gcgggctccg gcgtggtcgg
      781 ggcgggccgt ggggagcagc gggcgggcac cggccgcttc ggcgactccg attccgcggg
      841 ctccggttcc gcgggctccg cctgcaggga gagcgcctcg tcgatgcgct ggaaggctcc
      901 catcccccgc tgcaccaagc cgaccgcctg gaacaccgac gacagcggca ccatcaggta
      961 cgtggcgtag agcatgaagg cgacgaggtc accgagtgtg ttggcgttcc cgttcacccg
     1021 caggccgccg atgaccagga cgagcaggaa cgaaccgtgc acggcgagtt cgaccgcggg
     1081 gctcagcacg gatgacagcc gcgcggtgcg tacgcctgcg ctgtacgccg tgtcgatgca
     1141 cgcccccatg cgctcggctt cccgctcctc ggcccggtgc acccgcacca tcggcagcgc
     1201 gcccagcgcc cgttccagtt cggcggcgat cgccccgatg gccccttgca tgtgctccgc
     1261 ggccgtgcgc agcccggtca gcagcgaggc caccaccacg gccgccgcga cgacggtcag
     1321 cagcaccatg agcagcagca gcgggtcgat ccacaacatc agcgccaggg ctcccacggc
     1381 gacgagggag ccggtcatca ggtccaccag cgcttgtgag acgacctcgc gcaggaggga
     1441 ggtgtcggtg gtgacccggg agatcagatc gccggtgcga tgcctgtcgt actcccgcat
     1501 ctccaggcgc agcagccggc tgaccagact gctgcgcagg ccgcggacga ttccctcacc
     1561 catgcgttcc aggacgaagc ggccggccgc gcccgtcgcc gcttcggcga cgaagagggc
     1621 cgcgaggacc agcaccggca ccacgatgtg tccgtgggaa ctcgcgtcga cgatggtctt
     1681 ggcgagcagt ggctgggcca gaccgagggc ggagcccccc aaggtgagca ccgaggcgat
     1741 cgtcatcgcc gaccggtgcc cggcggtgag ccggaacatg gcggcgatcg cgcccggcac
     1801 cgacgggccg tccgcgcccg tggccgcggc cttctcgctc accgagtcgg ccgccctacc
     1861 ggggggacag tcaggaggcg gctgaagtag tcgtccggta ctccttcgtc caccagtcgg
     1921 ccatcgatct ccacccaggc gtgcgccgtg aacgggggaa ccatacgcac ccccgtgcac
     1981 caggtcggcc aggttccccc gagccggcac agcagtgcgg tgcccaggga gcgcggaagg
     2041 cagccgcggg ggcctgcgca ccggaggctg acggcgcata tcgcgtcccg tgcggacttg
     2101 gcctgcgtgg cggaggcggg cgccgcacca cggcgtacgg cgttgagtac cgcccggatc
     2161 cggcgcggtg gcaggaagga cagaaggaag gcggcgatga ggacgagccg tgcggccagc
     2221 cgtcgggtga gcgggatgcc cgtcggccgc gtcagtgcgc tcggtgtcgt catgcggtca
     2281 gccccgaggt ccgcagcagg tggatgagcg ccgcgacgtc ttgcgcggcc tgggcgcggt
     2341 cgatgtcgaa ttcggcgatg accgcgtcga ccgcgtcctt ttcctcgccg ccttcgagca
     2401 gtgtccggac cacgagtgtg ccggtggggt tgagctccca gtagtgaccg ctgcgctggt
     2461 cgagcaggac ggtgccgtat tccgtctccg cggtggtgat atcaggggcg aaacgcagtg
     2521 ccatatgccg agtccttttc tgccgaaaac cggcgaaccc ttgagccttc agcctctgaa
     2581 aacctctcgc ctatgacgag aaaggcttcg cagccacact tcacaggcga tcgtcgaata
     2641 caaagttcct tcgcccagcc cgggtgtgga cggccgtcgg gccagctcca tcagcgctcg
     2701 gccgtccacc aggccgagct gggccaagtg cgagtcctcc cacaacttca tgaggtcgcc
     2761 gcggcgttcg cgcaatccgt tggaggcgtc catggatgcc tgtgctttgt tggcacgctc
     2821 caggcacacg tccggcacga tctgccgcat ggcggtggtc agcaggggct tgtaggccca
     2881 gggcgtgacg cgctcgatgg ggttgacggc caggcatgcc tcgatcaccc ggtcgtcgaa
     2941 gaacggtgag gccatgggca cgcccgcgcg ggcggccatc cggtcccact gccggacgat
     3001 cctcgtgcag ctgcggatct gttcgaggtc ggtgtgcatg ccccggtcgg ggtggagcgg
     3061 tacggcgctc gcggccgcgt cgcgcagtgc ctgcccggcg acgcgtgccg cctcgggggt
     3121 gatccagtcg aacaggcgcg gtggtgtccc ccagccgagg gttccgctga cgggcggcgc
     3181 cgttgcctcg cgcaggtctc ggctggagtg cgcgagccac tgtccgtagg gccgggcgtc
     3241 ggccagggcg cgcgcggtgg cgcccagcgg ccagtggaac agggttcgga agccgcgtag
     3301 gttccgaagg gcgatcagcg ggcgggtacg gacgaggcgg tggtaatagg cttcggagca
     3361 ccaggcgacg tggtcgcctc cgatgccggt caggtgcact cggctgcctc gctgccccag
     3421 cccgggcagg tggtgcagga cgcgtgaccg gtccatgacg ccgatggtgg gctcgtcgat
     3481 gaggtcgtcg atcgccagca agtcgtcgta caccagcggg gattcgtcgg cgtcccagat
     3541 cacatgctcg atgtccggga ggaagcgggc ggccttcttg gcccagtaca ggtcggagtc
     3601 ggcggggtcg cggccgggcc aggtgctggc caccacacgg gccggtgacc gcgcggccag
     3661 aaagcagacc gaggtggagt ccaggccgcc ggacaggtca cagctgacca ctccgcccgc
     3721 gctcgtacgg gcgtcgacgg cgtccgccag cgcctcccgc accaagggcg cgctctcagc
     3781 cagggagcgc accgggtcgg gcggcgccca ccagcgcgag tgccgggccg tccgcccgtc
     3841 gggcgcgacg accaccgcgt cctcgggggg aacggccgtc acggtccgcc agagcgaggt
     3901 ctccgacagc gggtagggag ccggccacaa cagccgtacg gccagccgtt cttcgtccgg
     3961 ttcagcgccg gtcgcggcgg cgagcacctc ggcactggtg gcggccacct gcacgccgtc
     4021 gacgatcgcg tggaagacga ggcgcaggcc ggatgcggtc ccctgcacgc gcagccgtcc
     4081 gtcgagcgcg gcgacgaggt ggaagctgcc ggagagcctt cgggccagcg cgtcgagttc
     4141 ggtgaggtcc cgcaaccgct ctgcgtaccc cttgagttcg tccggtccga ccgagcagca
     4201 gcccaccacg gcgatggcgg cccgcccggc gtgcgcggtg acgatttcct ggtcgctcca
     4261 ccggccgacc agccacggcc gacccgaggg atgcgccagg gtcctggctt ctgggcggag
     4321 aaaggagcgg gccgcggcga tcgcgtccac gcagtccgga aggaccgcga agtgtgcgtc
     4381 accggggccc actccccccg tctcatgcga cgtaggcatg gcgtcgattc tgcgagccgg
     4441 ctgccttagt tcttgctgaa gatcagacgg tcgttgccgt ggcgctgcaa gagaccggtc
     4501 cgctgacgga acgtcccgag ccggacgagg gtcggggctt cgtacgcctt cttcatgacg
     4561 tctcctcagt gatctctgat gtacctggca ccctggccga accgagaaac cggcgcgcat
     4621 cggccccggc gcattcgtga tcggcataat tgcctgtcac gtaccagggg cctggtcgta
     4681 tagaaatact agcgccgttc ccgacatacg aagccagccc gcgcaggaaa aaatacagtc
     4741 gcaccgcctt cgatatc
//
