LOCUS       BGC0001551              4553 bp    DNA     linear   CON 11-APR-2022
DEFINITION  Streptomyces glaucescens strain GLA.O chromosome, complete genome.
ACCESSION   BGC0001551
VERSION     BGC0001551
KEYWORDS    .
SOURCE      Streptomyces glaucescens
  ORGANISM  Streptomyces glaucescens
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CP009438.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:29:24
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..4553
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[143:2712]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      144..2712
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     cand_cluster    1..4553
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..4553
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001551"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..4553
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            7..117
                     /locus_tag="SGLAU_RS35025"
                     /old_locus_tag="SGLAU_31040"
     CDS             7..117
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lassopeptides)
                     predicted lassopeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638602.1"
                     /locus_tag="SGLAU_RS35025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGLAU_31040"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_107408983.1"
                     /transl_table=11
                     /translation="MKKAYEAPTLVRLGSFRQKTGLLQRHGNDRLILSKN"
     CDS_motif       7..69
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MKKAYEAPTLVRLGSFRQKTG"
                     /locus_tag="SGLAU_RS35025_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       70..117
                     /prepeptide="core"
                     /locus_tag="SGLAU_RS35025_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="3.30"
                     /molecular_weight="1759.0"
                     /monoisotopic_mass="1758.0"
                     /core_sequence="LLQRHGNDRLILSKN"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKKAYEAPTLVRLGSFRQKTG"
                     /leader_location="[6:69](+)"
     gene            144..2000
                     /locus_tag="SGLAU_RS30630"
                     /old_locus_tag="SGLAU_31045"
     CDS             144..2000
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 110.4; E-value: 1.6e-33)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656043.1"
                     /locus_tag="SGLAU_RS30630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGLAU_31045"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_043505821.1"
                     /sec_met_domain="Asn_synthase (E-value: 5.5e-48, bitscore:
                     152.8, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPELHESAEPGRGDAHFAVFPDCAEAAAAARFFRRPGTRVLTHAS
                     GRPWLIGRWSDAEIVTGRAPGTALAALGWCGAGPRHLERHAARMRDLAEVDALARSLPG
                     SFHLVAAHDGQLRVQGTASGLRLVFHARIHGVHVAATSADLLAAALGSRPDTGRLAVRL
                     LWPVPHPLYETSVWEGVDAVSPEDALIVSADGRRVRRSRWWRPPEPVRTLARGAPAVRE
                     ALAEAVDLRTRTGGVVSCDLSGGLDSTSVCFLAARSSASLVAATWPGRDPADTDLAWAR
                     QAADHLPKADHVVWDADASALVYSDLLGIDDLLDEPTIGVMDRSRVLQQLPWLAARGSR
                     VHLTGIGGDHVAWCSEAYYHRLLRTRPLFALGRLRGFRALWNWPLGATARALADAHSYP
                     DWLADSVRRLRAPMPETSVTGSLGWGMPPRLFPWMTAETERLARAALLASAARAEPLHR
                     DRGLHTDLELIRTCTRIIRQWERMATRAGLPMASPYLDDRVIEACLAVRPDERVTPWQY
                     KPLLTEAMRGVVPDECLRRTNKAEASMDASDGLRRHRGDLMTLWTDSRLERLGLVDGGE
                     LRRLAQRPSAPGLRDAILYSTIACEVWLRARDRAPRPGSAAA"
     gene            2027..2281
                     /locus_tag="SGLAU_RS30635"
                     /old_locus_tag="SGLAU_31050"
     CDS             2027..2281
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lasso_Fused_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004946593.1"
                     /locus_tag="SGLAU_RS30635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGLAU_31050"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_043505823.1"
                     /sec_met_domain="PF05402 (E-value: 7.1e-19, bitscore: 56.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5e-30,
                     bitscore: 92.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1.1e-10,
                     bitscore: 30.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRFHQDVSTAETGYGTVLLDQRTGEYWELNPTGALVVRTLMDD
                     GDETAAVTALVTRFDIDRDRAAQDVTALVRDLRDAGLVS"
     gene            2278..2712
                     /locus_tag="SGLAU_RS30640"
                     /old_locus_tag="SGLAU_31055"
     CDS             2278..2712
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987089.1"
                     /locus_tag="SGLAU_RS30640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGLAU_31055"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_043505824.1"
                     /sec_met_domain="PF13471 (E-value: 8.2e-29, bitscore: 88.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALDRPTGVPLARRLAARLVLLPALALSFLPPRHIRTVLER
                     VRRGARPATPAQAAAAREALCAVSLRCAGPRGCLPRSLGAALLCRVYGTWPTWCTGVRT
                     LPPFAAHAWIEAGGRPVGEGVPDDYFARLISVPPARRATT"
     gene            2826..4553
                     /locus_tag="SGLAU_RS30645"
                     /old_locus_tag="SGLAU_31060"
     CDS             2826..4553
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 358.2; E-value:
                     1.3e-108)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988508.1"
                     /locus_tag="SGLAU_RS30645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGLAU_31060"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_052414171.1"
                     /transl_table=11
                     /translation="MFRLTEGHRRGIAAATGLTLAASAVGLAQPLVAKHVVDAGSRGQV
                     LWPFLLLLSGLFVAEAAAGATGRFLLDRMGEGVVRTVRHGLVTRLLRLEMRELDRRRRG
                     DLVSRVTADTTLLRDVMSQALVDLLTGCLVSAGALVLMLWLDPLLLLLVVLTVALAAAV
                     VTTLLKGMRTASEQTQSSVGAIAAELERALAALPVVRVYRAEEREARRIGRRVDSAHGA
                     GVRAARLAAVMSSAVELAVQGSFLLVLVVGGVRAGSGGADSLGDLVAFLLYASYLVMPL
                     SSVFRAIGLIQRGTGAYLRIDEVLALPEEPARPPARAMPRPDPPGTPPALELTDVRFSY
                     VPGRPVLRGAALTVPRHGLVALVGRSGAGKSTLFSLITRLYDPDSGTIRYDGRPAAALS
                     RRESRAGIALVDQNTHVLEGTLRENLTYAAPDATEDDIVRVVRLARLGHVVRRLPGGLD
                     GRLGDHGGSLSAGERQRVALARALLARPRLLLLDEHTSHLDAVNETALTRTLGAVTRDC
                     AVLVITHRLATVRHADRIIVLQDGRTVASGRHDELLATSPAYRELAATHALHPEGRGS"
ORIGIN
        1 gatggcatga agaaggcgta cgaggccccg acgctcgtcc ggctcggatc gttccgccag
       61 aagaccggac tgctgcagcg ccacggcaac gaccgtctga tcctcagcaa gaactgaccg
      121 cggccggcgc gtaacgcgac cacatgcccg agctgcacga gagtgcggaa ccgggccgcg
      181 gcgacgccca cttcgcggtc ttccccgact gcgcggaggc ggccgccgcg gcccgcttct
      241 tccgccgacc cggtacccgt gtcctgaccc acgcctccgg ccggccctgg ctgatcggcc
      301 gttggtccga cgccgagatc gtcaccggcc gagcccccgg aacggccctc gccgccctcg
      361 gatggtgcgg cgccggcccc cgccacctcg aacggcacgc cgcccgcatg cgcgacctcg
      421 ccgaagtcga cgccctcgcc cggtccctgc cggggagttt ccacctggtc gccgcccacg
      481 acgggcagct cagggtgcag ggcaccgcct cagggctgcg gctggtgttc cacgcccgga
      541 tccacggtgt ccacgtggcc gcgaccagcg cggacctgct cgcggcggcc ctgggaagcc
      601 ggccggacac cggtcggctg gccgtcaggc tcctgtggcc cgtgccgcac ccgctgtacg
      661 agacctccgt gtgggaggga gtcgacgcgg tctcccccga ggacgccctg atcgtctccg
      721 ccgacggacg gcgggtccgc cgatcacgct ggtggcggcc cccggagccg gtccgcaccc
      781 tcgcgcgggg cgcgccggcc gtccgcgagg cgctggccga ggccgtcgac ctccgcaccc
      841 ggacgggcgg cgtggtcagc tgcgacctgt ccggcggact cgactccacc tcggtctgct
      901 tcctcgccgc ccgctcctcc gcctccctgg tggcggcgac ctggcccgga cgggatcccg
      961 cggacaccga cctggcctgg gcccggcagg ccgccgacca cctgccgaag gccgaccacg
     1021 tcgtctggga cgcggacgcg tcggccctcg tctactcgga cctgctcggc atcgacgacc
     1081 tgctcgacga gccgaccatc ggcgtgatgg accgctcacg cgtcctgcag cagctgccct
     1141 ggctggccgc acgcggcagc cgggtccacc tcaccggcat cggcggcgac cacgtcgcct
     1201 ggtgctcgga ggcctactac caccggctgc tgcgcacccg cccgctgttc gcgctgggcc
     1261 ggctgcgcgg cttccgcgcc ctgtggaact ggccgctcgg cgcgacggcg cgagccctcg
     1321 ccgacgccca ctcctacccc gactggctgg cggactccgt ccggcggctg cgcgcgccga
     1381 tgcccgagac ctcggtgacc gggagcctcg gctgggggat gccgccccgc ctgttcccct
     1441 ggatgaccgc cgagacggaa cggctggccc gcgccgccct gctggcctcg gccgcgcgcg
     1501 ccgagccgct gcaccgggac cgcggcctgc acaccgacct cgaactgatc cgcacctgta
     1561 cgcgcatcat ccgccagtgg gagcggatgg cgacccgggc cggccttccg atggcgtcac
     1621 cgtacctgga cgaccgggtg atcgaggcgt gcctggcggt ccggccggac gaacgcgtca
     1681 cgccctggca gtacaaaccg ctgctcaccg aggcgatgcg cggcgtcgtc ccggacgagt
     1741 gcctgcgccg taccaacaag gccgaggcct cgatggacgc gtcggacgga ctgcgtcgcc
     1801 accggggcga cctgatgacc ctgtggaccg actcccggct ggaacgcctc ggcctggtgg
     1861 acggcgggga actgcgccgg ctcgcccagc ggccctccgc ccccggcctg cgcgacgcga
     1921 tcctctactc gaccatcgcc tgcgaggtgt ggctgcgcgc ccgggaccga gcgccacgcc
     1981 cgggatccgc cgccgcatga cacgacagca gaaaggcgcc gaccctatga ccctccgctt
     2041 ccaccaggac gtctccaccg ccgagaccgg gtacggaacg gtactgctcg accagcgcac
     2101 cggtgagtac tgggaactca accccacggg cgcgctggtg gtgcggaccc tcatggacga
     2161 cggcgacgag acggccgcgg tcacggcgct cgtcacccgg ttcgacatcg accgcgaccg
     2221 cgcggcacag gacgtgacgg cactggtgcg cgacctccgg gacgcggggc tggtctcatg
     2281 accacaccca gcgccctgga ccgccccacc ggagtgcccc tcgcccggcg gctcgccgcc
     2341 cgtctcgtcc tgctgcccgc cctggccctg tcgttcctgc cgcctcgcca catccggacc
     2401 gtgctggagc gcgtacgccg gggcgcgcgg cccgccaccc ccgcacaggc cgcggcggcc
     2461 cgcgaggcac tgtgcgcggt gagcctgcgc tgcgcgggcc cgcgcggctg cctgccgcgt
     2521 tcgctgggcg ccgccctgct gtgccgggtg tacgggacct ggcccacctg gtgcaccgga
     2581 gtgcgcaccc tgccgccgtt cgccgcccac gcctggatcg aggccggcgg ccgccccgtg
     2641 ggggagggcg taccggacga ctacttcgcg cggctcatca gcgtgccccc ggcacggcgg
     2701 gcgacgacgt gagcgacacg gccgtcgcgg acgggacccc gtccggaccc ggaccgggcg
     2761 aggacgcggc gggacggcca ccgcgcaccg cggacacaag gacgacggcg ggttcggtcg
     2821 ccgccctgtt ccggctgacg gagggtcacc ggcgcggcat cgccgcggcg accgggctca
     2881 ccctggccgc gtcggccgtg ggactcgccc agccgctcgt cgccaagcac gtcgtggacg
     2941 ccggatcccg cggacaggtg ctgtggccgt tcctgctgct gctgtccggg ctgttcgtcg
     3001 ccgaggccgc cgcgggcgcg accggccggt tcctgctgga ccgcatgggc gagggcgtgg
     3061 tccgtacggt gcgccacgga ctcgtgacgc ggctgctgcg gctggagatg cgggagctgg
     3121 accggcgccg ccgcggcgac ctggtctccc gtgtcaccgc cgacaccacg ctgctgcggg
     3181 acgtgatgtc gcaggccctg gtcgacctgc tcaccggctg cctggtctcc gccggggcgc
     3241 tcgtgctgat gctgtggctg gacccgctgc tgctgctcct cgtcgtgctg acggtcgccc
     3301 tcgccgcggc cgtcgtcacc accctgctga agggcatgcg tacggcctcg gagcagacgc
     3361 agtcctccgt gggcgcgatc gccgcggaac tggagcgggc cctggccgcg ctgcccgtgg
     3421 tgcgggtgta ccgggccgag gagcgcgagg cgcgccgcat cggccggcgg gtggactcgg
     3481 cccacggggc gggtgtacgg gcggcgaggc tggccgcggt catgagcagc gccgtcgaac
     3541 tcgcggtcca gggctccttc ctgctggtcc tggtcgtcgg cggcgtgcgg gccggcagcg
     3601 ggggagcgga ctccctcgga gacctggtcg ccttcctgct gtacgcctcc tacctggtca
     3661 tgcccctgtc gtcggtgttc cgcgccatcg gactgatcca gcgcggcacc ggtgcgtacc
     3721 tgaggatcga cgaggtcctc gccctccccg aggaacccgc acgcccgccc gcccgcgcga
     3781 tgccccgccc ggacccgccc ggcacgccgc ccgcgctgga gctcacggac gtccgcttct
     3841 cctacgtccc tggccggccg gtcctgcgcg gagcggccct caccgtgccg cggcacggac
     3901 tggtggccct cgtcggccgc tcgggcgccg gcaagagcac cctgttctcg ctgatcaccc
     3961 gactgtacga cccggactcc gggaccatcc ggtacgacgg gcgcccggcg gcggccctga
     4021 gccgccggga gagccgggcc ggcatcgccc tcgtcgacca gaacacccat gtgctggagg
     4081 gaacactccg cgagaacctc acctacgccg cccccgacgc caccgaggac gacatcgtcc
     4141 gcgtcgtccg gctggcccgg ctcggccacg tggtgcgccg attgcccggg ggcctggacg
     4201 gcagactggg cgaccacggt ggcagcctct ccgcgggaga acgccagcgc gtcgccctgg
     4261 cccgcgcgct gctcgcccgt ccgcggctgc tcctgctcga cgagcacacc tcacacctgg
     4321 acgccgtcaa cgagacggcg ctcacccgga cgctgggcgc ggtcacccgc gactgcgcgg
     4381 tcctcgtcat cacccaccgt ctcgccacgg tgcggcacgc cgaccggatt atcgtcctcc
     4441 aggacggccg cacggtggcc tcgggccggc acgacgaact cctcgccacc agtccggcgt
     4501 accgggaact ggccgccacg cacgccctgc acccggaggg ccgcgggagc tga
//
