LOCUS       BGC0001552              4562 bp    DNA     linear   BCT 04-FEB-2015
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893 DNA, complete genome.
ACCESSION   BGC0001552
VERSION     BGC0001552
KEYWORDS    .
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     [WARNING] On Mar 24, 2016 this sequence was replaced by BA000030.4.
            On Jun 15, 2007 this sequence version replaced BA000030.2.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 02:29:32
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 6877532
            Orig. end    :: 6882094
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..1842)
                     /locus_tag="SAV_5686"
     CDS             complement(1..1842)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 319.2; E-value:
                     9.1e-97)"
                     /gene_kind="transport"
                     /locus_tag="SAV_5686"
                     /note="PF00005: ABC transporter"
                     /product="putative ABC transporter ATP-binding protein"
                     /protein_id="BAC73398.1"
                     /transl_table=11
                     /translation="MDQTQSAAEGDRSTRAAIATMYRLTTGHRASLTLATVLTLVGSAL
                     GLAQPLAAKQVVDASGRGQVLWPLLLLLAGLFVTEAATGAVGRFVLERMGEGIVRGLRH
                     SLVGRLLRLEMREYDRLRSGDLISRVTTDTTLLREVVSQALVDLLTGALVAAGAIVLMA
                     WIDPLLLLLIAATVATAAAIVASLLKGIRAASERMQTSVGAIAADLERALGALPMVRVH
                     RTEDREAGRIGECVESAYSAGVRTAKLASVMSPAVELAVQGSFLIVLVIGGLRVNGHAN
                     SLGDLVAFLLYASYLVLPLSSVFRAVGLIQRGMGAYQRIEQALSLPAEPSQETPTVRAR
                     TREPARQTVSYEKPALALRDIGFGYDPSRPVLRGLSFTAPHRCQTALVGLSGAGKSTIF
                     ALISRFYEPDSGTLLFDGLPATELSRAACRGRIAVVDQNTHVVHGTLWDNITYAAPDAT
                     EAEVRRAVELAQLEGVVRRLPGGLSGMLGERGSRLSAGERQRVALARALLARPSILLLD
                     EPTSHLDTLNETALTTVMKDVARECALLVIAHRLSTVQHADRIIVLDEGRAVACGRHEE
                     LLTSSPTYRELAAGQMLRPAATPPSPVTTARHPHSPL"
     subregion       1..4562
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..4562
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1854..2288)
                     /locus_tag="SAV_5687"
     CDS             complement(1854..2288)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /locus_tag="SAV_5687"
                     /product="hypothetical protein"
                     /protein_id="BAC73399.1"
                     /sec_met_domain="PF13471 (E-value: 1.3e-29, bitscore: 90.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALERPTGVPFARRMAARLVLSPALALSLLPPRRLRAVLHF
                     ACRGAMPATAAQAKNARDAMCAVSLRCAGPKGCLPRSLGAALLCRLGGSWPTWCTGVRV
                     VPPFTAHAWIEADGRPVDEGVPDDYFTRLITVAVASRSGR"
     gene            complement(2285..2572)
                     /locus_tag="SAV_5688"
     CDS             complement(2285..2572)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="SAV_5688"
                     /product="hypothetical protein"
                     /protein_id="BAC73400.1"
                     /sec_met_domain="PF05402 (E-value: 6.1e-18, bitscore: 53.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5e-29,
                     bitscore: 88.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVPQQKDTRMALKFGANVSTAETDYGTVLLDERAGEYWELNPT
                     GTLVVNTLMAGGDEAAAVVALADEFDIDLVQAKQDVDALVQQLRTSGLAE"
     gene            complement(2569..4341)
                     /gene="asnH2"
                     /locus_tag="SAV_5689"
     CDS             complement(2569..4341)
                     /codon_start=1
                     /gene="asnH2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 103; E-value: 2.6e-31)"
                     /gene_kind="biosynthetic"
                     /locus_tag="SAV_5689"
                     /note="PF00733: Asparagine synthase"
                     /product="putative asparagine synthetase"
                     /protein_id="BAC73401.1"
                     /sec_met_domain="Asn_synthase (E-value: 5.2e-52, bitscore:
                     165.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARSFARPGTRILQHASGRPWLVGQWHDQEIVTARAGHTALAVIG
                     CCPIDAVELERQAGRLRDLAELDALARSLPGSFHLVAALDGRLRVQGTASGLRLVFHAP
                     VDGTQVAATRADVLAAALGTDPDEEQLAIRLLWPVPHTLAEAPMWRGITAVSPQDALII
                     SPDGRTVRRSRWWTPPEPVRTLADGAPLVREALAAAVDARTRQGGVVSCDLSGGLDSTS
                     ICFLADRSPARVVASTWPGRDPADTDLYWAEQAARSLPEIDHVVWDADTSPLVYTGLLD
                     IDDLLDEPTIGVMDRSRVLHHLPGLAERGSRLHLTGIGGDHVAWCSEAYYHRLLRTRPL
                     FALRQLRGFRALWQWPLGGTARALADSRPYGKWLADSSGRLRDPLPATVSTSLGWGMPP
                     RLFDWVTADAERMAQRALREAAMTAVPLHPDRGLHTDLEQILSCTRIIRQWDRMAARAG
                     VPMASPFLDDRVIEACLAVRPSERVTPWQYKPLLTAAMSGIVPDACLRRTNKAAASMDA
                     SNGLREHRADLLALWEGSRLEQLGLVDGTALRRLAQRPATPELRDAILYSTIAAEVWLR
                     GLHRTSEPKAPASS"
ORIGIN
        1 tcacagtggg ctgtgcggat ggcgcgcggt cgtcacgggg gagggcgggg tggcggccgg
       61 ccgaagcatt tggccggcgg ccagttcgcg gtaagtgggg ctgctggtga gtagttcctc
      121 gtgacgcccg caggcgacgg ctctgccctc gtccaacacg atgatccggt ccgcgtgctg
      181 gaccgtggag agccggtgtg cgatgaccag cagggcgcat tcccgggcga cgtccttcat
      241 cacggtggtg agcgcggttt cattgagggt gtcgaggtgg gaggtgggct cgtcgagcag
      301 aaggatcgag gggcgggcga gcagggcgcg ggccagggcc acgcgctggc gctctcccgc
      361 ggacagcctg ctgccgcgct caccgagcat tcccgacaag ccgcccggca gtcgccgtac
      421 gaccccttcc agctgggcga gctcgacggc gcgtcgcact tcggcctcgg tggcgtcggg
      481 cgcggcgtag gtgatgttgt cccacagggt gccgtggacg acgtgggtgt tctggtcgac
      541 gacggcgatg cgcccgcggc atgcggcgcg gctcagttcg gtggcgggca ggccgtcgaa
      601 gagcagggtc ccggagtccg gttcgtaaaa tctggagatg agggcgaaga tcgtgctctt
      661 tccggcaccc gacaggccga ccagggctgt ctggcaccgg tgaggggcgg tgaaggagag
      721 gccgcgcagc accggccggc tcgggtcgta gccgaagccg atgtcccgca gggcgagggc
      781 gggtttctcg tacgagacgg tctgccgggc cggttcgcgt gtacgtgccc ggacggtcgg
      841 cgtctcctgg gagggctccg ccggcaggga cagcgcctgc tcgatgcgct ggtaggcccc
      901 catgccacgc tggatcaggc cgaccgcccg gaagaccgag gacagcggaa ggaccaggta
      961 ggaggcgtac agcaggaagg cgaccaggtc gccgagggag ttggcgtggc cgttgacccg
     1021 caggccgccg atgaccagga cgatcaggaa ggagccctgt accgcgagtt cgaccgccgg
     1081 gctcatcacg gaggcaagtt tcgcggtgcg tacgccggcg ctgtacgccg attcgacaca
     1141 ttctccgatg cggcccgctt cacggtcctc ggttcggtga acccggacca tcggcagggc
     1201 gccgagcgcg cgttcgaggt cggcggcgat cgcgccgacg gaggtctgca tgcgttcgga
     1261 ggcagcccgg attcccttga gaagcgaggc gacgatcgcg gcggcggtag ccacggtcgc
     1321 cgcgatcagg agcagcagca gcgggtcgat ccacgccatg aggacgatcg cccccgccgc
     1381 gacgagggca cccgtcaaca gatcgaccag tgcttgggag acgacttctc tgagcagggt
     1441 ggtgtcggtg gtgacccggg agatcaggtc gccgctgcgg agccggtcgt actcccgcat
     1501 ctccagccgg agcagccgcc ccaccaggct gtggcgcagc cctcgtacga tgccttcgcc
     1561 catgcgctcc agaacgaagc ggcctacagc gccggtcgcc gcttcggtga cgaagagccc
     1621 ggcgaggaga agcaacagtg gccacaacac ctgtccgcgc ccgctcgcgt ccacgacctg
     1681 cttggcagcg agcggctggg cgagcccgag cgcggagccg acgagggtga gtacggtggc
     1741 gagggtgagg gacgcccggt ggccggtggt gagccggtac atggtggcga tcgcggcccg
     1801 ggtggagcgg tcgccctcgg ccgccgactg tgtctgatcc acgacggtgt cggtcatcgg
     1861 cctgatcggc tcgcgacggc gaccgtgatg agccgggtga agtagtcgtc gggtacgccc
     1921 tcgtccacag ggcggccgtc cgcctcgatc caggcgtgcg ccgtgaacgg cggcaccacg
     1981 cgtaccccgg tgcaccaggt cggccagctc cctcccaggc ggcacagcag cgcggctccc
     2041 agagaacggg gcaggcagcc tttcgggcct gcgcagcgca ggctcaccgc gcacatcgcg
     2101 tcccgtgcgt tctttgcctg ggcggcggtg gccggcatgg ctccgcgaca tgcgaagtgg
     2161 agcacggcgc ggagccggcg gggcggcagg agcgagagcg cgagggcggg ggaaaggacg
     2221 agacgggcgg ccatgcgccg ggcgaagggc acgccggtgg gccgctccag ggcgctgggg
     2281 gtcgtcattc ggccagcccc gaggtccgca gttgctgtac gagggcgtcg acgtcctgct
     2341 tcgcctggac gaggtcgatg tcgaactcgt cggcgagcgc gacgaccgcg gcggcttcgt
     2401 caccgcccgc catcagggtg ttgaccacca aggtgccggt gggattcaac tcccaatatt
     2461 ccccggcgcg ttcgtccagc aggaccgtgc cgtagtccgt ctcggcagtg gagacattgg
     2521 cgccgaactt caatgccatg cgggtgtctt tctgctgggg aacggtggtc atgaggaggc
     2581 gggggccttg ggctcgctag ttcggtggag gccgcgcagc cacacttcgg cggcgatggt
     2641 cgagtagagg atcgcgtcgc gcagttcggg tgtggccgga cgctgggcga gccggcgcag
     2701 ggccgtgccg tcgacgaggc cgagctgttc cagccgggag ccctcccaga gcgccagcag
     2761 atcggcgcgg tgttcgcgca gtccgttgga tgcgtccatg gaagcggcgg ccttgttggt
     2821 gcgccgcagg cacgcatcgg gcacgatccc gctcatggcg gcggtcagga ggggtttgta
     2881 ctgccagggc gtgacgcgct cgctcgggcg gacggcgagg catgcctcga tgacgcggtc
     2941 gtcgaggaac ggcgatgcca tcggaactcc ggcccgggcg gccatccggt cccactggcg
     3001 gatgatgcgg gtgcaggaaa ggatctgttc gaggtcggtg tgcaggccgc ggtccgggtg
     3061 cagcggtacg gcggtcatgg cggcctcgcg cagcgcccgt tgggccatcc gttcggcgtc
     3121 ggcggtgacc cagtcgaaca ggcgaggggg catgccccag ccgaggctgg tgctgacggt
     3181 ggcggggagc gggtctcgca ggcggccgct ggagtcggcc agccacttcc cgtacggccg
     3241 cgagtcggcc agcgcgcgtg ccgtgccgcc aagtggccac tgccacaggg ccctgaagcc
     3301 gcgcagttgg cgcagcgcga acagcgggcg ggtgcggagc agccggtggt agtacgcctc
     3361 cgagcaccag gccacgtggt cgccgccgat gccggtcagg tgcaaccggc tgccccgctc
     3421 cgccaggccg ggcagatggt gcaggaccct tgatcggtcc atgacgccga tggtcggctc
     3481 gtccagcagg tcatcgatgt cgagcaggcc ggtgtagacg agcggcgagg tatcggcgtc
     3541 ccagaccaca tggtcgattt ccggcaacga gcgggcggcc tgttcagccc agtacagatc
     3601 ggtgtcggcg gggtcgcgac ccggccaggt gctggccacc acccgggccg gtgagcggtc
     3661 cgccaggaaa cagatggagg tggaatccag gccgcccgac aggtcgcagc tgaccacgcc
     3721 accctgccgg gtacgggcgt cgaccgccgc cgccagggct tcgcggacga gcggggcgcc
     3781 atcggcgagc gtgcgtaccg gttccggcgg agtccaccag cgcgagcggc gtacggtccg
     3841 gccgtccggc gagatgatca gcgcgtcctg gggggacacg gcggtgatcc ctcgccacat
     3901 gggtgcctcg gcgagtgtat ggggaaccgg ccacagcagc cggatggcca gttgctcctc
     3961 gtccgggtcg gtgcccagcg cggcggcgag tacgtcggcg cgggtggcag ccacctgcgt
     4021 tccgtcaacg ggggcatgga ataccagccg gagcccggag gcggtgccct gcaccctgag
     4081 ccgcccatcg agcgcggcga cgagatggaa actccctgga agggagcggg ccagtgcgtc
     4141 gagttcggcg agatcacgta gccgcccggc ttggcgctcg agctctacgg cgtcgatcgg
     4201 acagcagccg atgacggcga gggccgtgtg gccggcgcgc gcggtgacga tctcctggtc
     4261 gtgccactgc cccaccagcc agggccggcc cgaagcgtgc tgcaggattc gcgttccggg
     4321 gcgggcgaag gagcgggcca cggcggtcgc gtcctcccgg tcggtgaaga ccgtgaagtg
     4381 cgcgtcgccg gggcccgtcc ccgcactttc gtgcagttca gtcatgacgt cgggtcagga
     4441 accgtcgctc gtcagttctt gctcaggatg agacggtcgt tgccggagcg ccccaagagc
     4501 ccggtcttct tccggaacgt tccgagccgg accagcgtcg gagcctcgta agccttcttc
     4561 at
//
