BGC0001553 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001553 (Streptomyces sp. JV178)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	20,863	clifednamide A	NRPS:Type I+PKS	100%

BGC0001553 - Region 1 - NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 20,863 nt. (total: 20,863 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 20,864
Label		BGC0001553

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001553	2.00	NRP, Polyketide	clifednamide A	Streptomyces sp. JV178
BGC0002434	0.68	Polyketide, NRP	clifednamide D, clifednamide E, clifednamide F, clifednamide G, clifednamide H, clifednamide I, clifednamide J	Kitasatospora sp.
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002365	0.63	Other, Polyketide	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001043	0.63	NRP, Polyketide	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001954	0.63	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001068	0.61	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001553	1.00	NRP, Polyketide	clifednamide A	Streptomyces sp. JV178
BGC0002434	0.67	Polyketide, NRP	clifednamide D, clifednamide E, clifednamide F, clifednamide G, clifednamide H, clifednamide I, clifednamide J	Kitasatospora sp.
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002365	0.65	Other, Polyketide	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001043	0.65	NRP, Polyketide	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001954	0.65	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001068	0.64	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 20863:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AUD08663.1

Search NORINE for peptide: strict or relaxed

PKS_AT (649..945): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; CE-Malonyl-CoA: 54.2%; Acetyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 111.7
Malonyl-CoA: 111.1
Methoxymalonyl-CoA: 106.5
Ethylmalonyl-CoA: 90.3
Isobutyryl-CoA: 72.0
Acetyl-CoA: 61.0
2-Methylbutyryl-CoA: 55.9
Propionyl-CoA: 55.8
Benzoyl-CoA: 48.3
3-Methylbutyryl-CoA: 41.6
fatty_acid: 36.2
trans-1,2-CPDA: 34.1
CHC-CoA: 33.1
inactive: 25.1

AMP-binding (2448..2871): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEVGSVDK
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)