BGC0001556 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001556 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	21,510	combamide	NRPS:Type I+PKS	100%

BGC0001556 - Region 1 - NRPS,T1PKS

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Location: 1 - 21,510 nt. (total: 21,510 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 21,511
Label		BGC0001556

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001556	2.00	NRP, Polyketide	combamide	Streptomyces sp.
BGC0001043	0.78	NRP, Polyketide	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365	0.77	Other, Polyketide	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001726	0.65	NRP, Polyketide	pactamides	Streptomyces pactum
BGC0000996	0.63	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000844	0.60	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000170	0.60	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001068	0.60	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001954	0.59	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001556	1.00	NRP, Polyketide	combamide	Streptomyces sp.
BGC0001043	0.71	NRP, Polyketide	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365	0.71	Other, Polyketide	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001726	0.66	NRP, Polyketide	pactamides	Streptomyces pactum
BGC0000996	0.65	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000844	0.64	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000170	0.63	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001068	0.63	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001954	0.63	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 21510:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cbmA

Search NORINE for peptide: strict or relaxed

PKS_AT (611..912): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; CE-Malonyl-CoA: 58.3%; Acetyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 123.8
Malonyl-CoA: 119.1
Methoxymalonyl-CoA: 118.7
Ethylmalonyl-CoA: 106.5
Isobutyryl-CoA: 101.4
Acetyl-CoA: 81.2
Propionyl-CoA: 68.4
2-Methylbutyryl-CoA: 63.9
trans-1,2-CPDA: 60.9
Benzoyl-CoA: 57.4
CHC-CoA: 48.4
fatty_acid: 44.8
3-Methylbutyryl-CoA: 40.3
inactive: 29.5

AMP-binding (2458..2915): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEIGSVDK
Nearest Stachelhaus code(s):: Orn DVGEIGSVDK (76% 8Å match)
Stachelhaus code match:: 100% (strong)