LOCUS       BGC0001556             21510 bp    DNA     linear   BCT 06-JUN-2018
DEFINITION  Streptomyces sp. strain S10 combamide biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0001556
VERSION     BGC0001556
KEYWORDS    .
SOURCE      Streptomyces sp
  ORGANISM  Streptomyces sp.
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:31:11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 21510
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..21510
                     /country="China: Nanjing Botanical Garden, Nanjing"
                     /db_xref="taxon:1931"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp."
                     /strain="S10"
     misc_feature    1..21510
                     /note="combamide biosynthetic gene cluster"
     protocluster    1..21510
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[3774:13779]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3775..13779
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     protocluster    1..21510
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[3774:13779]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      3775..13779
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     cand_cluster    1..21510
                     /SMILES="C([*])C(-O)NC(CCCN)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="chemical_hybrid"
                     /product="T1PKS"
                     /product="NRPS"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..21510
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001556"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21510
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             569..1234
                     /codon_start=1
                     /note="Orf-2"
                     /product="hypothetical protein"
                     /protein_id="AWO77085.1"
                     /transl_table=11
                     /translation="MFHTMKQRLAACAAAAAFAAAASLAAPSTAAGAAAVGELTYGSDI
                     LLQNQYGGDGGYLDTNGHSSQQGATYDVSTNQTPNSRGPATSVWKVVSATGKADGTRVT
                     SGDVIYLINQYGSGTYLDTNGHSTRQGAKYEVSTTVTKDRGPGTGKWHIFGRTSSPTDG
                     NIRTDDIVHLLNDYGSANGGFLDTNGHSSRQGAKYDVSTSHYTDRGTGTGSWKVLPAN"
     CDS             complement(1424..2302)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     289.4; E-value: 4.8e-88)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf-1"
                     /product="oxidoreductase"
                     /protein_id="AWO77086.1"
                     /transl_table=11
                     /translation="MTASAASRPAEASGTFSLGGDLPVRRIGYGAMQLTGPGVWGPPAD
                     PDEAVRVLRRAVELGVNLIDTADSYGPFVSEQLIHKALHPYPDDLVIATKAGLSRAGPD
                     DWRPLGRPEYLRQQCELSLRHLGLDRIDLFQLHRIDPKVPPADQLGELVLLQREGKIRH
                     IGVSEVTVEQIGQARRIADIVSVQNLYNLANRAAEDVLDHCEQENLAFIPWFPMATGEL
                     ARPGGPLDDAARKHHASPPQLALAWLLRRSPVMLPIPGTSSVAHLEQNVAAAEVTLTDE
                     EFSALADSVTA"
     gene            2824..3657
                     /gene="cbmE"
     CDS             2824..3657
                     /codon_start=1
                     /gene="cbmE"
                     /note="CbmE"
                     /product="sterol desaturase family protein"
                     /protein_id="AWO77087.1"
                     /transl_table=11
                     /translation="MWIRRTAYPVLLVLMVVVAVVVLRFHLNPGLATSAFQFGVIAYLM
                     IMERVIPYDRTWHPDRREWGWYGVYFVLTTSGSVIAQMLVAALVAVLSPAKPKLPLAAE
                     IPLALLVGSLASYLVHRLGHTNRWLWRLHGIHHVPEKVNVANNGVNHVLDVLLAQSSVQ
                     LSLSLFGFSQESVFATGLFVITQGYFIHANIDVRIGWLNYVFASPEQHRLHHSTDLSEA
                     GHYGSELAVWDRIFGSYTWYPDRKPLAVGLKDPASFPRTEAVFASQLRSWRRPVN"
     gene            3775..13779
                     /gene="cbmA"
     CDS             3775..13779
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (12-439). E-value:
                     9.2e-177. Score: 580.0. Matches aSDomain:
                     nrpspksdomains_cbmA_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (611-912). E-value: 4.9e-102.
                     Score: 333.1. Matches aSDomain:
                     nrpspksdomains_cbmA_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (974-1156). E-value: 2.4e-30.
                     Score: 97.9. Matches aSDomain:
                     nrpspksdomains_cbmA_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (1600-1793). E-value: 8.7e-55.
                     Score: 177.3. Matches aSDomain:
                     nrpspksdomains_cbmA_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (1882-1964). E-value: 5e-15.
                     Score: 47.5. Matches aSDomain:
                     nrpspksdomains_cbmA_PKS_PP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1989-2289). E-value:
                     1.7e-88. Score: 288.3. Matches aSDomain:
                     nrpspksdomains_cbmA_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (2458-2915). E-value:
                     6.7e-99. Score: 323.1. Matches aSDomain:
                     nrpspksdomains_cbmA_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (3023-3090). E-value: 5.8e-15.
                     Score: 47.1. Matches aSDomain: nrpspksdomains_cbmA_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (3112-3253). E-value:
                     1.3e-31. Score: 102.6. Matches aSDomain:
                     nrpspksdomains_cbmA_Thioesterase.1"
                     /codon_start=1
                     /gene="cbmA"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     364.1; E-value: 2e-110)"
                     /gene_kind="biosynthetic"
                     /note="CbmA"
                     /product="hybrid non-ribosomal peptide synthetase/type I
                     polyketide synthase"
                     /protein_id="AWO77084.1"
                     /sec_met_domain="Condensation (E-value: 4.8e-69, bitscore:
                     221.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-106, bitscore:
                     345.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.4e-14, bitscore:
                     42.5, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 1.5e-177, bitscore:
                     580.0, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 7.9e-103, bitscore:
                     333.1, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 8.2e-50, bitscore:
                     158.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLCKVATRDKIAIIGIGCRLPGGASDHRTFWQNLIDGRDCITA
                     TPGSRYDIATLASRDKTKPGRLVGGRGGYIDGFDEFDPAFFGISPREAAHMDPQQRKLL
                     EVAWEALEDGGQKPAELAGQDVGVFVGAFTLDYKILQFADLGFETLAAHTATGTMMTMV
                     SNRISYCFDFRGPSVSLDTACSSSLVAVHLACQSLSRGESSLALAGGTLLHMAPQYTIA
                     ETKGGFLSPEGRSRTFDASADGYVRAEGVGVVALKRLDDALRDGDPIHAVVIGSGVNQD
                     GRTTGITVPNADAQVALIERVCTEAGIAPGSLQYVEAHGTSTPVGDPIEAGALGRALSI
                     GREPGAACYVGSVKTNIGHTESAAGIAGLIKTALCLKHRKIPPHINLDQLNPAIDLDAL
                     PYRIPTSTVDWPEHDGPARAGVNSFGFGGTNAHVLLEAAPARAEAARNTAAATTSAAAG
                     TAAATEGAEGAAAASKGSSAEGATSTAGTSGSAAAAVVGAGAEVGVGAGGSAAAVPPSY
                     SILPLTTRDPALLPEAAAGIRKELAGSGHAPAASLTDIGYTLARRRQHLESRLSVVYDS
                     RTSLEAALDAYLRGDQHPHVLVDQRREGEQRRLVWVFTGMGPQWWAMGRQLFETEPVYR
                     AAVERCDREIRDLTGWSLVEELSADEADSKMSETWLAQPANFAVQVGLAALWRSRGVRP
                     DAVVGHSTGEVAAFYEAGVYTLRDAVTVVVHRSRLQQKLVDTGAMLAVSLSEEEAERRV
                     APYADRVSVAAVNSPTAITLAGDKDALAELALQLQAEDVFAKFLTVRVPYHSPRMDPIK
                     DELLSSLAALEPRAARVPLYLTGGPQAAARGRAEGPELDADYWWRNVRDSVRFRDAVDR
                     LVEDGHGLFLEIGPHPVLGHSIAECLTAKGAEGRSLPSIRRQEDERARFTLSLAALHNA
                     GVDIAWEVLHPRGRPVPLPRYPWKRDRHWTEPKAVEQIRLGRREHPLLGRRLATAEPAW
                     EARLDVEALPYLLDHRIQGSALFPAAGYVEMATQAVRAMTGGGEAVIADIELRKALFLS
                     AGSDGGNAPEESGGDPAPAALGGDTATVQLSFSAENAAFTVATVHADDSRERTVHARGV
                     VRTGQRAAGTARLDAGPVKARSLRRLDGADCYAALRTLGYHYGPAFQGIEEVWIGRDEA
                     LARIRPTEPIGDDATRHHMHPVLLDACFQTLLTPQIVETGDDAGDTAGGIRLPLSIDEV
                     RMAAVGDRALWAHAVVTRRADGELVGDIAVHDDDGAPLGRISGFRAADIEKASAAVSLN
                     TVDSWLADVTWVHTPYAADVDTPYAADVDAPDTPGGDTASAARTDALHAADAGTSRTAD
                     PVAPYGAEAVAPYPGETVTPFPAEAVAAGGTAAPRWLVLADGRGVGDALAALIAGRGGH
                     CHLVRPGAAYRVADDLRESTVRPDSAADLDRLLADLRAAGGRPYDHVVHLWNLDLPTFD
                     ATAAADELRGLSGVGGYSLIALAQTLPSALPGGRLHIVTRGAQAVVPGDPVEPLSAPAW
                     GIGRVLWQQELTAHRGKLIDLDPASASCEADAEALLREVPAAGGTADDEIALRAGHRYT
                     SRLTPVAGRLTRPLPLRLRADGAYLVTGAFGALGRVLCRALVAWGARRLILVGRTRLPG
                     REHWRETDPGSAAGRAVRFVRELEALGAQPVLAPLDISDEASLTAWLAEYRRLASAPIR
                     GVFHLAGQVRDTLLPDMDRETFDAVHDPKVLGAYLLHRHLGAEPLDHFVLFSSIASVLT
                     TAGQTNYAAGNAFLDALAHHRRARGLPGLSLDWGPWATGMIEELGLIEHYRRNRGMSSL
                     SPEAGTAVLERVIGQDRAQLLVATVVDWPVFLAWYASPPPLVSELAAALGGPSAAQGEQ
                     SSFLDAFRGADDAARRTLVAERFTAVVAGVLRVATDQVELDHALGGLGLDSLLAMELRS
                     RVHAELGLALPVVTLLSSAPVGELIDRLHEGLAELVAAGADEAAGGAAVELFRDEGRHP
                     LTQNQKALWFLKQLNPDGFAYNIGGAVEVRVELEPELMFDAFRVLIERHPSLRANFTHE
                     QGQPVQKVAPAAEAALRRDVALFDVEGVAWDDVHAMIVREYRKPYDLERDPLIRLRLFR
                     RGPDRWVLMKAVHHIISDAISTFTFIEELLAVYEALRRGRAPELPPVSARYLDFLNWQN
                     QFLAGPEARRMLDHWKGRLPADVPVLGLPTDKPRPAVQTHNGASEFFVLDADLSARVHD
                     VAREHNVTVFMVLLSAYYLLLHHYSGQDDIIVGSPVTGRTQEEFSSVYGYFVNPLPLHV
                     DLGDGPSVEQLLARVRDVVLGGLDNQEYPFVLLVEELGLQHDPSRSAVFQAMFILLTHK
                     VATEKYGYRLEYIELPEEEGQFDLTLSVYEDEADRRFHCVFKYNTDLFLAETMRRLSGH
                     YVNVLDALTRAPAAQPAGRLELLGARERRQILGDWSGAGRRAAEPGVPVHELIARAAAE
                     HPGATAVCVPAEDGTTERMTYAALDRRSRDRARRLRELGVRDGAVVAVCMEKSAELVVT
                     LLAVLRAGGAYLPLDPGNPADRLAYMAEHAGAARVVVDGAGGARFAGHSGVLTLAELSD
                     AAGAPGTAAAPPKPAGQAEPAGPTDQIEPTGQARPVAAGTAAAAADAADPTDPTDPLVG
                     MDGPAYVIYTSGSTGRPKAVQVSHRNLASAYAAWRAEYRLDTDARVHLQMAGPAFDVFT
                     GDLVRALCSGGTLVLVGRELLFNTARLYATMRAERVDCAEFVPSVVRGLMAHCERDGAR
                     LDFMRLLIVGSDTWKVEEYDRLRGLTGPDTRVVNSYGLTEATVDSTYFEGPTDGLEPSQ
                     MVPIGRPFPGAEVYILDGHGAPVPPGVAGELWIGGAGVALGYLADPGHTAERFVSRTLD
                     HGSGAAPVRLYRTGDLARWDTGGGVHLLGRADSQVKVGGHRVEIGEIEFQLAEWPALAQ
                     AVVVVRPDRNGENTLCAYGVAAPGAKLDWRELRRHLGEHLPTYLVPAAFTELPALPLTP
                     NGKVDVNALPEPRFETGEDAHEPPVTLYETRMADHWAALLGLGEVGLQHDFFEVGGSSI
                     KLIELIHGLQDEFEISIPVSQLFKVTTLHGMARTVEHIITGRLPGAQPFLRFNRGAGPA
                     VFCFPPAGGHGLVYRRFAEQLPEYELVAFNYVAEDDKVARYADLIAAHQPEGPCALLGY
                     SLGGNLAFEVAKELERRGREVADVVIVDSYRIDAAFTPGAEHIEAFERELREHLHKHTG
                     SETLAQETLDQARDYIAFCGRTPNLGTVGAAVTVVSDEQKVAFYAAGERGTWHGTSTVR
                     TEVLRGAGVHADMLDPGCIEHNARLVRGVLTHTAVIEGAAPHAA"
     aSDomain        3811..5091
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cbmA_PKS_KS.1"
                     /domain_subtype="Hybrid-KS"
                     /evalue="9.20E-177"
                     /label="cbmA_PKS_KS.1"
                     /locus_tag="cbmA"
                     /protein_end="439"
                     /protein_start="12"
                     /score="580.0"
                     /tool="antismash"
                     /translation="IAIIGIGCRLPGGASDHRTFWQNLIDGRDCITATPGSRYDIATLA
                     SRDKTKPGRLVGGRGGYIDGFDEFDPAFFGISPREAAHMDPQQRKLLEVAWEALEDGGQ
                     KPAELAGQDVGVFVGAFTLDYKILQFADLGFETLAAHTATGTMMTMVSNRISYCFDFRG
                     PSVSLDTACSSSLVAVHLACQSLSRGESSLALAGGTLLHMAPQYTIAETKGGFLSPEGR
                     SRTFDASADGYVRAEGVGVVALKRLDDALRDGDPIHAVVIGSGVNQDGRTTGITVPNAD
                     AQVALIERVCTEAGIAPGSLQYVEAHGTSTPVGDPIEAGALGRALSIGREPGAACYVGS
                     VKTNIGHTESAAGIAGLIKTALCLKHRKIPPHINLDQLNPAIDLDALPYRIPTSTVDWP
                     EHDGPARAGVNSFGFGGTNAHVLLEAAP"
     aSModule        3811..9666
                     /complete
                     /domains="nrpspksdomains_cbmA_PKS_KS.1"
                     /domains="nrpspksdomains_cbmA_PKS_AT.1"
                     /domains="nrpspksdomains_cbmA_PKS_DH.1"
                     /domains="nrpspksdomains_cbmA_PKS_KR.1"
                     /domains="nrpspksdomains_cbmA_PKS_PP.1"
                     /locus_tags="cbmA"
                     /monomer_pairings="pk -> pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       4297..4344
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0001"
                     /evalue="7.30E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="cbmA"
                     /protein_end="190"
                     /protein_start="174"
                     /score="18.0"
                     /tool="antismash"
                     /translation="GPSVSLDTACSSSLVA"
     CDS_motif       4486..4524
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0002"
                     /evalue="2.80E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="cbmA"
                     /protein_end="250"
                     /protein_start="237"
                     /score="13.9"
                     /tool="antismash"
                     /translation="FDASADGYVRAEG"
     CDS_motif       4717..4764
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0003"
                     /evalue="1.30E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="cbmA"
                     /protein_end="330"
                     /protein_start="314"
                     /score="11.3"
                     /tool="antismash"
                     /translation="YVEAHGTSTPVGDPIE"
     misc_feature    4774..4776
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       4825..4869
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0004"
                     /evalue="9.90E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="cbmA"
                     /protein_end="365"
                     /protein_start="350"
                     /score="11.6"
                     /tool="antismash"
                     /translation="GSVKTNIGHTESAAG"
     CDS_motif       5602..5655
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0005"
                     /evalue="5.10E-03"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="cbmA"
                     /protein_end="627"
                     /protein_start="609"
                     /score="9.8"
                     /tool="antismash"
                     /translation="VWVFTGMGPQWWAMGRQL"
     aSDomain        5608..6510
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cbmA_PKS_AT.1"
                     /evalue="4.90E-102"
                     /label="cbmA_PKS_AT.1"
                     /locus_tag="cbmA"
                     /protein_end="912"
                     /protein_start="611"
                     /score="333.1"
                     /specificity="consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFTGMGPQWWAMGRQLFETEPVYRAAVERCDREIRDLTGWSLVEE
                     LSADEADSKMSETWLAQPANFAVQVGLAALWRSRGVRPDAVVGHSTGEVAAFYEAGVYT
                     LRDAVTVVVHRSRLQQKLVDTGAMLAVSLSEEEAERRVAPYADRVSVAAVNSPTAITLA
                     GDKDALAELALQLQAEDVFAKFLTVRVPYHSPRMDPIKDELLSSLAALEPRAARVPLYL
                     TGGPQAAARGRAEGPELDADYWWRNVRDSVRFRDAVDRLVEDGHGLFLEIGPHPVLGHS
                     IAECLTAKGAEGRSLPSIRR"
     CDS_motif       5788..5841
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0006"
                     /evalue="8.00E-05"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="cbmA"
                     /protein_end="689"
                     /protein_start="671"
                     /score="15.7"
                     /tool="antismash"
                     /translation="AQPANFAVQVGLAALWRS"
     CDS_motif       5845..5961
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0007"
                     /evalue="1.60E-14"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="cbmA"
                     /protein_end="729"
                     /protein_start="690"
                     /score="45.9"
                     /tool="antismash"
                     /translation="GVRPDAVVGHSTGEVAAFYEAGVYTLRDAVTVVVHRSRL"
     CDS_motif       6322..6369
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0008"
                     /evalue="1.80E-03"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="cbmA"
                     /protein_end="865"
                     /protein_start="849"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LDADYWWRNVRDSVRF"
     aSDomain        6697..7242
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cbmA_PKS_DH.1"
                     /evalue="2.40E-30"
                     /label="cbmA_PKS_DH.1"
                     /locus_tag="cbmA"
                     /protein_end="1156"
                     /protein_start="974"
                     /score="97.9"
                     /tool="antismash"
                     /translation="HPLLGRRLATAEPAWEARLDVEALPYLLDHRIQGSALFPAAGYVE
                     MATQAVRAMTGGGEAVIADIELRKALFLSAGSDGGNAPEESGGDPAPAALGGDTATVQL
                     SFSAENAAFTVATVHADDSRERTVHARGVVRTGQRAAGTARLDAGPVKARSLRRLDGAD
                     CYAALRTLGYHYGPAFQGI"
     CDS_motif       6772..6849
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0009"
                     /evalue="4.90E-11"
                     /label="PKSI-DH_m2"
                     /locus_tag="cbmA"
                     /protein_end="1025"
                     /protein_start="999"
                     /score="35.0"
                     /tool="antismash"
                     /translation="YLLDHRIQGSALFPAAGYVEMATQAV"
     CDS_motif       7210..7242
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0010"
                     /evalue="7.60E-03"
                     /label="PKSI-DH_m3"
                     /locus_tag="cbmA"
                     /protein_end="1156"
                     /protein_start="1145"
                     /score="9.3"
                     /tool="antismash"
                     /translation="GYHYGPAFQGI"
     aSDomain        8575..9153
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cbmA_PKS_KR.1"
                     /evalue="8.70E-55"
                     /label="cbmA_PKS_KR.1"
                     /locus_tag="cbmA"
                     /protein_end="1793"
                     /protein_start="1600"
                     /score="177.3"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="GAYLVTGAFGALGRVLCRALVAWGARRLILVGRTRLPGREHWRET
                     DPGSAAGRAVRFVRELEALGAQPVLAPLDISDEASLTAWLAEYRRLASAPIRGVFHLAG
                     QVRDTLLPDMDRETFDAVHDPKVLGAYLLHRHLGAEPLDHFVLFSSIASVLTTAGQTNY
                     AAGNAFLDALAHHRRARGLPGLSLDWGPWA"
     CDS_motif       8578..8676
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0011"
                     /evalue="1.40E-10"
                     /label="PKSI-KR_m1"
                     /locus_tag="cbmA"
                     /protein_end="1634"
                     /protein_start="1601"
                     /score="33.7"
                     /tool="antismash"
                     /translation="AYLVTGAFGALGRVLCRALVAWGARRLILVGRT"
     CDS_motif       8998..9108
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0012"
                     /evalue="1.50E-22"
                     /label="PKSI-KR_m4"
                     /locus_tag="cbmA"
                     /protein_end="1778"
                     /protein_start="1741"
                     /score="72.2"
                     /tool="antismash"
                     /translation="LDHFVLFSSIASVLTTAGQTNYAAGNAFLDALAHHRR"
     aSDomain        9421..9666
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cbmA_PKS_PP.1"
                     /evalue="5.00E-15"
                     /label="cbmA_PKS_PP.1"
                     /locus_tag="cbmA"
                     /protein_end="1964"
                     /protein_start="1882"
                     /score="47.5"
                     /tool="antismash"
                     /translation="GADDAARRTLVAERFTAVVAGVLRVATDQVELDHALGGLGLDSLL
                     AMELRSRVHAELGLALPVVTLLSSAPVGELIDRLHEG"
     aSDomain        9742..10641
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cbmA_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.70E-88"
                     /label="cbmA_Condensation_LCL.1"
                     /locus_tag="cbmA"
                     /protein_end="2289"
                     /protein_start="1989"
                     /score="288.3"
                     /tool="antismash"
                     /translation="RHPLTQNQKALWFLKQLNPDGFAYNIGGAVEVRVELEPELMFDAF
                     RVLIERHPSLRANFTHEQGQPVQKVAPAAEAALRRDVALFDVEGVAWDDVHAMIVREYR
                     KPYDLERDPLIRLRLFRRGPDRWVLMKAVHHIISDAISTFTFIEELLAVYEALRRGRAP
                     ELPPVSARYLDFLNWQNQFLAGPEARRMLDHWKGRLPADVPVLGLPTDKPRPAVQTHNG
                     ASEFFVLDADLSARVHDVAREHNVTVFMVLLSAYYLLLHHYSGQDDIIVGSPVTGRTQE
                     EFSSVYGYFVNPLPLHVDL"
     aSModule        9742..13533
                     /complete
                     /domains="nrpspksdomains_cbmA_Condensation_LCL.1"
                     /domains="nrpspksdomains_cbmA_AMP-binding.1"
                     /domains="nrpspksdomains_cbmA_PCP.1"
                     /domains="nrpspksdomains_cbmA_Thioesterase.1"
                     /final_module
                     /locus_tags="cbmA"
                     /monomer_pairings="orn -> orn"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       9808..9918
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0013"
                     /evalue="3.00E-08"
                     /label="C2_LCL_024-062"
                     /locus_tag="cbmA"
                     /protein_end="2048"
                     /protein_start="2011"
                     /score="26.1"
                     /tool="antismash"
                     /translation="AYNIGGAVEVRVELEPELMFDAFRVLIERHPSLRANF"
     CDS_motif       10138..10203
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0014"
                     /evalue="7.40E-06"
                     /label="C3_LCL_132-143"
                     /locus_tag="cbmA"
                     /protein_end="2143"
                     /protein_start="2121"
                     /score="18.6"
                     /tool="antismash"
                     /translation="VHHIISDAISTFTFIEELLAVY"
     CDS_motif       10543..10629
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0015"
                     /evalue="4.60E-10"
                     /label="C5_LCL_267-296"
                     /locus_tag="cbmA"
                     /protein_end="2285"
                     /protein_start="2256"
                     /score="31.9"
                     /tool="antismash"
                     /translation="DIIVGSPVTGRTQEEFSSVYGYFVNPLPL"
     CDS_motif       10681..10800
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0016"
                     /evalue="8.50E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="cbmA"
                     /protein_end="2342"
                     /protein_start="2302"
                     /score="50.3"
                     /tool="antismash"
                     /translation="RDVVLGGLDNQEYPFVLLVEELGLQHDPSRSAVFQAMFIL"
     aSDomain        11149..12519
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cbmA_AMP-binding.1"
                     /evalue="6.70E-99"
                     /label="cbmA_AMP-binding.1"
                     /locus_tag="cbmA"
                     /protein_end="2915"
                     /protein_start="2458"
                     /score="323.1"
                     /specificity="consensus: orn"
                     /tool="antismash"
                     /translation="ARAAAEHPGATAVCVPAEDGTTERMTYAALDRRSRDRARRLRELG
                     VRDGAVVAVCMEKSAELVVTLLAVLRAGGAYLPLDPGNPADRLAYMAEHAGAARVVVDG
                     AGGARFAGHSGVLTLAELSDAAGAPGTAAAPPKPAGQAEPAGPTDQIEPTGQARPVAAG
                     TAAAAADAADPTDPTDPLVGMDGPAYVIYTSGSTGRPKAVQVSHRNLASAYAAWRAEYR
                     LDTDARVHLQMAGPAFDVFTGDLVRALCSGGTLVLVGRELLFNTARLYATMRAERVDCA
                     EFVPSVVRGLMAHCERDGARLDFMRLLIVGSDTWKVEEYDRLRGLTGPDTRVVNSYGLT
                     EATVDSTYFEGPTDGLEPSQMVPIGRPFPGAEVYILDGHGAPVPPGVAGELWIGGAGVA
                     LGYLADPGHTAERFVSRTLDHGSGAAPVRLYRTGDLARWDTGGGVHLLGRADSQVKVG"
     CDS_motif       11347..11388
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0017"
                     /evalue="9.10E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="cbmA"
                     /protein_end="2538"
                     /protein_start="2524"
                     /score="15.8"
                     /tool="antismash"
                     /translation="LAVLRAGGAYLPLD"
     CDS_motif       11710..11769
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0018"
                     /evalue="1.70E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="cbmA"
                     /protein_end="2665"
                     /protein_start="2645"
                     /score="29.7"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKAVQVSH"
     CDS_motif       12298..12387
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0019"
                     /evalue="6.60E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="cbmA"
                     /protein_end="2871"
                     /protein_start="2841"
                     /score="47.2"
                     /tool="antismash"
                     /translation="PPGVAGELWIGGAGVALGYLADPGHTAERF"
     CDS_motif       12487..12549
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0020"
                     /evalue="8.60E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="cbmA"
                     /protein_end="2925"
                     /protein_start="2904"
                     /score="27.7"
                     /tool="antismash"
                     /translation="LGRADSQVKVGGHRVEIGEIE"
     aSDomain        12844..13044
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cbmA_PCP.1"
                     /evalue="5.80E-15"
                     /label="cbmA_PCP.1"
                     /locus_tag="cbmA"
                     /protein_end="3090"
                     /protein_start="3023"
                     /score="47.1"
                     /tool="antismash"
                     /translation="ETRMADHWAALLGLGEVGLQHDFFEVGGSSIKLIELIHGLQDEFE
                     ISIPVSQLFKVTTLHGMARTVE"
     aSDomain        13111..13533
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cbmA_Thioesterase.1"
                     /evalue="1.30E-31"
                     /label="cbmA_Thioesterase.1"
                     /locus_tag="cbmA"
                     /protein_end="3253"
                     /protein_start="3112"
                     /score="102.6"
                     /tool="antismash"
                     /translation="AVFCFPPAGGHGLVYRRFAEQLPEYELVAFNYVAEDDKVARYADL
                     IAAHQPEGPCALLGYSLGGNLAFEVAKELERRGREVADVVIVDSYRIDAAFTPGAEHIE
                     AFERELREHLHKHTGSETLAQETLDQARDYIAFCGRT"
     CDS_motif       13258..13332
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cbmA_0021"
                     /evalue="6.60E-12"
                     /label="NRPS-te1"
                     /locus_tag="cbmA"
                     /protein_end="3186"
                     /protein_start="3161"
                     /score="37.8"
                     /tool="antismash"
                     /translation="QPEGPCALLGYSLGGNLAFEVAKEL"
     gene            13769..15433
                     /gene="cbmB"
     CDS             13769..15433
                     /codon_start=1
                     /gene="cbmB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 344.7; E-value: 1.8e-104)"
                     /gene_kind="biosynthetic-additional"
                     /note="CbmB"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="AWO77088.1"
                     /transl_table=11
                     /translation="MRRSNRVQWSERERAPGAKPRVIIVGAGLGGLSAGCYGQMSGMET
                     RVFEKHVLPGGCCTAWSRDGYVFDYCIEWLTGTAPGNEAHQVWRELGALDGKTIRNFEV
                     FNTVVDDDGRSVVFYNDPDRLERHLLRLSPADAPLIRSFCRDLRRFTDIDIFPFLKPAP
                     LLTLREKARALRKILPLLNLFRRTAGTSMESFAARFEDPLLRRALPFVFFQDHEVFPLL
                     PYLFNMAGAHQSNAGFPQGGSLGLARSIEERYTSLGGRIDYRARVEQILVEDGRAIGVE
                     LRGGERHYADHVVAACDGATTLDRLLKGRYSSPRTDRLFQSVLGTPKLVYPGVVSVFVG
                     FAGDVAPDAPHSATYLLSAADSARLPGVLQDSLVVQLRSRFSDGLAPPGKSVIHCSYFS
                     DYSSWKELRRTDRRAYRARKQEAGRFVREFLERHHPGIAARIEVVDVATPATTERYTGN
                     LHGSILAWKSYTEADGLIQHLIEKDRLRLPGLDGLSLAGQWFTGGGLIRVAAGGRFVAQ
                     YLCEELGLEFRAWESTAGETWHPGKLGHLPQLDKSMR"
     gene            15445..17178
                     /gene="cbmC"
     CDS             15445..17178
                     /codon_start=1
                     /gene="cbmC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 555.3; E-value: 2.5e-168)"
                     /gene_kind="biosynthetic-additional"
                     /note="CbmC"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="AWO77089.1"
                     /transl_table=11
                     /translation="MPRKPRERQTMIIIGAGLGGLSTGCYAQMNGYRTRIFEMHEIPGG
                     CCTAWDRGDFTFDCCVSWLLGNGPGNEMHQIWLELGALQGKQMRHFDVFNVVRGRDGRS
                     VYFYSDPDRLEAHLLEISPSDARLIRSFCSGLRKFRKCLAAYPFLKPVGLMGRAERWRM
                     LASFVPYFNVIRKSISVLMTDYSAKFRDPLLREAFNFILYEKHSAFPVLPFYFQLSAHA
                     NLSAGVPEGGSLGLATSIEQRYLRLGGEVSYNTKVEEILVEDDRAVGVRLSDGREFRAD
                     IVVSACDGHATTMKLLKGRYLPEEYRRLYTSVIDEPGMVFPGYVTLFLGLRRPFPEGAP
                     CTTYLLTEEEATRLVGIRHPSINVQFRSLHYPELSPERSTVVYATYFSDVGPWRALSDG
                     PEQRTRSRGGTELHTLPVRRGRPYYEAKHQVRDMLLGFLDRRFPGLTDSVAVRDVSTPL
                     TQVRYTGNYDGTVLGWQPFVESGETMEKVVKKYGPALPGLANFYLSGVWATTGGLIRAA
                     AAGRHVMQFVCRDDGRAFTAHIDASGPLPTHVVIPVGPDGKDGDPDERTTGAAAVSVHV
                     R"
     gene            17132..18328
                     /gene="cbmD"
     CDS             17132..18328
                     /codon_start=1
                     /gene="cbmD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 422.7; E-value:
                     2.3e-128)"
                     /gene_kind="biosynthetic-additional"
                     /note="CbmD"
                     /product="cytochrome P450"
                     /protein_id="AWO77090.1"
                     /sec_met_domain="p450 (E-value: 8.7e-20, bitscore: 60.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSERPAPLPYPFTSADPLELSPIYAELRNGPLRKVRLPYGEDTWL
                     VTRHADARFVLSDPRFSLAAGVERDQPRMRELSPGGDGLLSTDPPVHTRLRGVVARHFS
                     ARRVEQMRVVVREAAEGLLDRLEESGPPGDLVQDFAVPLSIAMICDLLGVPATDRHRVQ
                     KWLEVLLAQVVTNEDLAAESGAYFAYLTGLVEERRREPGDDLLTCLVRAHYEEGRLSYD
                     ELIKLSIELLTGGFVTTSKQIPNFCYLLLRRPEWLSRLREHPADLPVAIEEMLRYVPMP
                     NGLVFCRYATEDVEVGGDLVRAGEPVLVDTSAANRDPAVFRDPEALVLDRAPEAAHLTF
                     GHGAHFCVGARLGRLELQVALETLLTRLPALKLATPDGEVRWREETMLKGLHALPVDW"
     CDS             18984..19667
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071:GntR family
                     transcriptional regulator (Score: 174.8; E-value: 3.4e-53)"
                     /gene_kind="regulatory"
                     /note="Orf1"
                     /product="GntR family transcriptional regulator"
                     /protein_id="AWO77092.1"
                     /transl_table=11
                     /translation="MTSAALPTGTVPKLERPGPLRERVYEALLELIVTRSLKPGQHLVE
                     TELAGHLGVSRQPVREALQRLNTEGWVDLRPAQGAFVHDPTEDEADQLLVVRGLLEAEA
                     ARLAAANATPEATARLRELCEAGERALADDDVDAVVAANAAFHAYLMELAANSVLAELS
                     AQVDRRVRWFYTPVARTRGALSWQEHRAMIEAIEAGDEQHTRQLMRDHTEHTRVSYHKR
                     KKSEQ"
     CDS             complement(19869..21149)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1137:Major
                     facilitator superfamily MFS 1 (Score: 184.2; E-value:
                     5.4e-56)"
                     /gene_kind="transport"
                     /note="Orf2"
                     /product="MFS transporter"
                     /protein_id="AWO77091.1"
                     /transl_table=11
                     /translation="MVILPWVAMMAISVAEYAYGSAEEVLSDAHGWTSTNTFWVLGVWT
                     VFQAAVAFPTGRLRERGMLSARGATLIGAVLAGIGFFALSHAPNVPLAILGFGFFGGTG
                     AGMVYSTCVNIVGKWYPERRGGKTGFVNGGFAYGSVPMIFVFTYSFDAGNYHTVLDLVG
                     VYVLILVAICGWFFKDPPKNWWPQEVDPIEHSKNATSDRSLSKNPPAVRQYEPMEAIRT
                     GMLPLMWFCLVLCSGVSIFGISFQVPYAKDIGFGPLVAASSMGIMSIINGTGRGVTGWL
                     SDRLGRKQTLILVVAVEGLSQFGVLWAGDIRSEWLFLIFAFISGFGGGAFFPMFAALTP
                     DYFGENNNAQNYGLVYSSKLVGGLAGSGLGATVVAAWGYSGAYALAGCLGLASAALALL
                     LRQPGRPSAGRVRAGAGGALQVSGETV"
ORIGIN
        1 tcctggttcg cctgcgtcga tccctcagat gtgggcccgc ggctgtactt ccagcgggtc
       61 cccgagggga aggccgccaa gaaccgggtg catcttgatg tgcgggtcgg caccggactc
      121 gtgggtgaag agcgcctcgc cgcacttgag gccgaatgcg cacgactggt cccgctcggt
      181 gcggtgcacg tgcgcacgct gtatgacggc aatgattcgt gtatcccgat gctggacatc
      241 gagggcaacg agttctgtat cgactgagag gcccttctcg gctcctccgc cacgtgcgca
      301 ctccggcgtt gcccgtgagc cggaaccccg ctggtcgccg cgccaccagt caccgcgcca
      361 ccggtcaccg cgccgacggt cgccgcgcag ccgacctgcc cgtgttcgac gtcctccgcg
      421 acgacctgat cacacgagag ccggggaact tccccacata ggagggtttg gcgcgacaga
      481 aagcgcaagc cggacgcagc cgctccagcg ccgcgacaca ctcaccgctg tgcaaccgat
      541 cgcgtacaca gagcgacatg gagggtgcgt gttccacacc atgaagcagc gtctggcggc
      601 gtgcgccgcg gcagcggcct ttgccgcggc ggcctcgttg gccgctccgt cgacggccgc
      661 cggtgccgcc gccgtcggcg aactgaccta cggcagcgac atcctgctgc agaaccagta
      721 cggaggcgac ggcggctacc tggacaccaa cggacactcc agccagcagg gcgccaccta
      781 cgatgtgagc accaaccaga cccccaacag ccgcggcccc gcgacctcgg tctggaaggt
      841 cgtctccgcc accggcaagg ccgacggcac ccgcgtcacc agcggcgacg tcatctacct
      901 catcaaccag tacggcagcg gcacctacct ggacaccaac ggacactcca cccgtcaggg
      961 tgccaagtac gaggtgtcca cgaccgtcac caaggaccgc ggccccggca cggggaagtg
     1021 gcacatcttc ggcaggacgt cctcacccac ggacggcaac atccgcacgg acgacatcgt
     1081 gcacctgctg aacgactacg gatccgccaa cggcggcttc ctcgacacca acggccactc
     1141 cagccggcag ggcgccaagt acgacgtgtc caccagccac tacacggacc gcgggacggg
     1201 caccggctcc tggaaggtcc tgcccgccaa ctgacctgac cgagggtcgg ccgtctcacc
     1261 gtcgccgcgc gtcaccagtg cgaccacccc ttcttgtggt gtggtcccac ctgaggacgc
     1321 gcggcgttcg cgaccgtgac ccggtcctca acggggcgcg gccgggttcg cgttgggtgc
     1381 gaggcacggg tgcacgggtc gggcgagggc agctgcggac cggtcaggcg gtgacgctgt
     1441 cggccagcgc ggagaactcc tcgtcggtga gggtgacttc ggcggccgcg acgttctgtt
     1501 cgagatgggc gacgctcgac gtgccgggga tggggagcat caccggggaa cggcgcagca
     1561 accaggcgag cgcgagctgc ggcggactcg cgtggtgttt tctggccgcg tcgtccagcg
     1621 gaccgcccgg gcgggcgagt tcgcccgtgg ccatggggaa ccacgggatg aaggccaggt
     1681 tctcctgctc gcagtggtcc agtacgtcct cggcggcgcg gttggcgagg ttgtacaggt
     1741 tctgcacgga cacgatgtcc gcgatccgac gtgcctgacc gatctgctcg acggtgacct
     1801 cggacacgcc gatgtgccgg atcttgccct cccgctggag gaggaccagt tcgccgagtt
     1861 ggtcggccgg cggcaccttg gggtcgatgc ggtgcagttg gaagaggtca atgcggtcca
     1921 gaccgagatg gcgcaggctc agctcgcact gctggcgcag gtattcgggg cggccgagcg
     1981 ggcgccagtc gtccggaccg gcgcggctca ggccggcctt ggtggcgatg acgagatcgt
     2041 ccggatacgg atggagcgcc ttgtggatca actgctcgct gacgaagggg ccgtaggagt
     2101 ccgcggtgtc gatgaggttc acacccaact cgacggcacg ccgcaacacg cgcacggctt
     2161 cgtcgggatc cgcgggcggt ccccatacgc cggggccggt cagctgcatg gctccgtatc
     2221 cgatgcgacg gacgggcagg tcaccgccga gggagaaggt gccggaagcc tcggcggggc
     2281 gggaggcggc ggatgcggtc atggaatgtc cttcggtcag ggacggcgac agcggcgagg
     2341 ttccaccggg tacgcggccc ggtgcgcgtg ggcggcccac ggcccgcccg gcgcccaccg
     2401 cggccctgcc ggaggcacga cggtactgct gccgtacggc ttctctccca ccatcctgat
     2461 ccgtcggcac ccgcggcgca cccccgcggc ggtcctggcg gccgggccgg accggcgcct
     2521 ccgtcggccg ctgggcccgg acggccgttc cgtgccggtg gcggcgaggc gagcgtcacg
     2581 gtggtccgtg gggcccgccc gggccggtcg cccggacccg tcgcccaggc cggtcgcccg
     2641 agccggtcac tcagagcggc cacccatccg gagttcgatc ttccgttcaa cctttcaccc
     2701 ctgggtaacc ctggactctg caaatgtcat acaatcactc ttagttgtcg catgattaca
     2761 cactgccacg gggggcaggt acgaagcgag ggacacgggg tctcagggag gggaggggca
     2821 cccatgtgga ttcgtcgcac ggcctatccc gtgctgctgg tgctgatggt cgtcgtggcc
     2881 gtcgtggtac tgcgcttcca cctgaatccc ggactggcga cctccgcctt ccagttcgga
     2941 gtcatcgcct atctgatgat catggagcga gtgatcccct acgaccgcac ctggcacccg
     3001 gaccgccgcg aatggggctg gtacggcgtc tacttcgtgc tgaccacctc gggcagcgtc
     3061 atcgcgcaga tgctggtcgc cgcactcgtc gccgtcctgt ccccggccaa gccgaagctg
     3121 cccctggcag ccgagatccc actggcgctg ctggtggggt cgctggccag ctatctggtg
     3181 caccggttgg gtcacaccaa ccgctggctg tggcggctgc acggcatcca ccatgtgccg
     3241 gagaaggtca acgtcgccaa caacggcgtc aaccacgtcc tggacgtcct actggcgcag
     3301 agcagcgtgc agttgtcgct gagcctgttc gggttctccc aggaatccgt gttcgcgacc
     3361 ggcctcttcg tcatcaccca gggctatttc atccatgcga acatcgacgt ccgtatcggc
     3421 tggctcaact acgtgttcgc cagcccggaa cagcatcgtc tgcaccacag cacggatctc
     3481 tccgaggccg gtcactacgg ctcggaactg gctgtctggg accgaatatt cggcagttac
     3541 acctggtatc ccgaccggaa gccactcgcc gtgggtctca aggaccccgc gtccttcccg
     3601 aggaccgagg ccgtcttcgc cagccagctc cggtcgtggc gacgtcccgt gaactgacga
     3661 cgcacctccc tgtacgaacc tctgcctgac cgcggccgga gccggccgcg gtcgggccat
     3721 cgtcctgcct ttgccacacg cgccgccgtg ccacgacaac tcaaggattc ggccatgtcg
     3781 gacctatgca aggtcgccac ccgcgacaag atcgcgatca tcggaatcgg ctgccgcctg
     3841 cccggcggcg cctcggacca ccggacgttc tggcagaacc tgatcgacgg cagggactgc
     3901 atcaccgcga cgcccggaag ccggtatgac atcgcgaccc tcgccagccg ggacaagacc
     3961 aagcccggcc gactggtcgg cgggcgcggg ggttacatcg acggttttga cgaattcgac
     4021 ccggcgttct tcggcatcag cccccgcgag gccgcgcaca tggacccgca gcagcgcaag
     4081 ttgctggagg tggcctggga ggcgctggag gacggcgggc agaagccggc cgagctggcc
     4141 gggcaggacg tcggcgtctt cgtcggcgcg ttcacgctgg actacaagat cctgcaattc
     4201 gccgacctgg ggttcgagac gctggccgcc cacaccgcga ccggcacgat gatgacgatg
     4261 gtgtcgaacc gcatctcgta ctgcttcgac ttccgcggcc ccagcgtctc cctcgacacg
     4321 gcgtgcagtt cctcgctggt ggcggtccac ctggcctgcc agagcctgag ccgtggcgag
     4381 agcagcctcg cgctcgccgg cggcacgctg ctgcacatgg cgccgcagta caccatcgcc
     4441 gagaccaagg gcggcttcct ctcccccgag ggccgctccc gcaccttcga cgcgtcggcc
     4501 gacggttacg tgcgtgccga aggcgtcggc gtggtcgccc tcaagcgcct ggacgacgcc
     4561 ctgcgcgacg gcgatccgat ccacgcggtg gtcatcggca gcggcgtcaa ccaggacggc
     4621 cgtaccaccg gcatcaccgt gccgaacgcc gacgcccagg tcgccctgat cgaacgggtc
     4681 tgcaccgagg cgggcatcgc gcccggcagc ctgcagtacg tcgaggccca cggcacgtcg
     4741 accccggtcg gcgacccgat cgaggcgggc gcgttaggcc gggcgctgtc gatcgggaga
     4801 gaacccggcg ccgcctgcta cgtgggctcg gtcaagacca acatcgggca caccgaatcg
     4861 gccgccggca tcgccgggtt gatcaagaca gcgctctgcc tgaagcaccg gaagatccca
     4921 ccccacatca atctcgacca gctcaatccc gcgatcgacc tggacgcgct gccctaccgg
     4981 atcccgacca gcacggtcga ctggccggag cacgacggac ccgcccgcgc cggggtcaac
     5041 tccttcggtt tcggcggcac caacgcccac gtgctgctcg aagcggcacc ggcccgtgcg
     5101 gaggccgcga ggaacacggc agcggccacg acgagcgcgg cagcgggtac ggcagcggcc
     5161 acggagggcg ctgaaggcgc ggcagcggct tcaaagggca gttcggcaga gggcgcgacg
     5221 agcacggcag ggacttcggg cagtgcggcg gcggccgttg tgggcgcggg ggccgaggtg
     5281 ggcgtggggg ccgggggctc ggcggcagcg gttccgcctt cgtactccat ccttccgctg
     5341 accacgcgtg acccggcgct gctccccgag gcggcggccg gcatccgcaa ggagctggcc
     5401 gggtccggcc acgctccggc cgcctcgctg accgacatcg gctacaccct ggcccgccgt
     5461 cggcagcacc tcgaatcgcg gctgtcggtc gtctacgact cgcgtacgtc gctcgaagcg
     5521 gccctcgacg cctatctgcg cggcgaccag cacccccatg tgctggtcga ccagcggcgc
     5581 gagggcgagc agcggcggct ggtctgggtc ttcaccggga tggggccgca gtggtgggcc
     5641 atgggccggc agttgttcga gaccgagccg gtctaccgcg ctgcggtcga acgctgcgac
     5701 cgcgagatcc gtgacctcac cggctggtcg ctggtggagg agttgtccgc cgacgaggcg
     5761 gactcgaaga tgagcgagac ctggctggcc cagcccgcca acttcgccgt ccaggtcggg
     5821 ctcgcggccc tgtggcgcag ccgcggcgtc cgtccggacg ccgtcgtcgg ccacagcacc
     5881 ggcgaggtcg cggcgttcta cgaagcgggc gtctacaccc tgcgggacgc ggtcacggtc
     5941 gtcgtgcacc gcagccgcct ccagcagaag ctcgtggaca ccggcgcgat gctggccgtg
     6001 agtctgtccg aggaggaggc cgagcggcgg gtggcgccgt acgcggaccg cgtgtcggtg
     6061 gccgccgtca acagcccgac ggcgatcacc ctcgccgggg acaaggacgc gctcgcggag
     6121 ctggccctgc aactccaggc ggaggacgtc ttcgccaagt tcctcaccgt acgagtgcct
     6181 taccacagcc cccgtatgga tccgatcaag gacgagttgc tgtcctcgct cgccgcgctg
     6241 gagccgcgcg ccgcgcgggt gccgctgtat ctgacgggag ggccgcaggc cgcggcccgc
     6301 ggccgggcgg aagggcccga gctggacgcg gactactggt ggcgcaacgt ccgcgacagc
     6361 gtgcgcttcc gggacgccgt cgaccgcctc gtcgaggacg gccatggcct cttcctggag
     6421 atcggcccgc atcccgtgct gggtcactcg atcgccgaat gcctgaccgc caagggcgcc
     6481 gaggggcgca gcctgccctc gatccggcgc caggaggacg agcgcgcgcg gttcaccctc
     6541 tccctcgcgg ctctccacaa cgcgggcgtc gacatcgcct gggaggtact gcacccgcgg
     6601 ggcaggccgg tgccgctgcc ccgctacccc tggaagcggg accggcactg gacggagccg
     6661 aaggcggtcg agcagatccg gctcggcagg cgcgaacacc cgctgctggg ccgtcggctg
     6721 gccacggcgg aaccggcctg ggaggcccga ctcgacgtcg aggccctgcc ctatctgctc
     6781 gaccaccgca tccagggcag tgcgctgttc ccggcggcgg gctacgtgga gatggcgacg
     6841 caggcggtgc gcgcgatgac cggcggcggg gaggccgtga tcgccgacat cgagctgcgc
     6901 aaggcgctgt tcctgtcggc cggttcggac ggcgggaacg ccccggagga gtccggcggt
     6961 gacccggccc cggccgcctt gggcggcgac accgccaccg tgcagctctc cttctccgcg
     7021 gagaacgccg cgttcaccgt cgccacggtg cacgccgacg actcccggga gcggaccgtg
     7081 cacgcacgcg gagtcgtccg taccgggcaa cgcgccgccg gtacggcccg gctcgacgcc
     7141 ggcccggtta aggcgcgcag cctgcgccgc ctcgacggcg ccgactgcta tgccgccctc
     7201 aggacgctgg gctaccacta cggcccggcg ttccagggca tcgaggaggt gtggatcggc
     7261 cgggacgagg cgctggcccg gatccgtccg acggagccga tcggtgacga cgccacccgc
     7321 caccacatgc acccggtcct cctcgacgcc tgcttccaga ccctgctgac cccgcagatc
     7381 gtcgagaccg gtgacgacgc cggggacacc gcgggcggca tccggctgcc gttgtcgatc
     7441 gacgaggtgc gcatggccgc cgtgggcgac cgtgcgctgt gggcgcacgc cgtcgtcacc
     7501 cgccgggcgg acggtgaact cgtcggtgac atcgccgtcc acgacgacga cggtgcgccg
     7561 ctcggccgga tcagcggctt ccgcgccgcc gacatcgaga aagcctccgc cgccgtcagc
     7621 ctgaacaccg tggactcctg gctggccgac gtcacctggg tccacacgcc gtacgcggcg
     7681 gacgtcgaca ccccgtacgc ggcagacgtc gacgccccgg acacaccggg cggcgacacc
     7741 gcgtccgcgg cacgcaccga cgccctccac gcagcggacg ccggcacatc gcgtacggcg
     7801 gacccggtcg ctccgtacgg ggcggaagcc gtcgcgccgt acccgggaga gaccgtcacc
     7861 ccgttcccgg cagaggccgt agccgcgggc gggacggccg cgccccgctg gctcgtcctc
     7921 gccgacggcc gcggcgtcgg cgacgcgctc gcggcgctga tcgccgggcg cggcgggcac
     7981 tgccacctgg tacgcccagg agccgcctac cgcgtcgccg acgacctgcg ggagtcgacg
     8041 gtccggccgg actccgccgc cgacctggac cgtctcctcg ccgacctgcg cgccgcgggc
     8101 ggccggccgt acgaccacgt cgtgcacctg tggaacctcg acctgcccac gttcgacgcg
     8161 acggccgccg ccgacgagct gcgtggactc tccggtgtcg gcggctactc gctgatcgcg
     8221 ctcgcccaga cgctgccgtc cgcgctgccg ggcggcaggc tgcacatcgt cacccgcggc
     8281 gcccaggccg tcgtaccggg tgatccggtc gagccgctgt ccgctccggc ctggggcatc
     8341 gggcgcgtgc tgtggcagca ggaactcacc gcccaccgcg ggaagctgat cgatctcgat
     8401 cccgcgtccg cctcgtgcga ggccgacgcc gaggcactgc tgcgggaggt gccggccgcc
     8461 ggtgggaccg ccgacgacga gatcgcgctg cgcgccggcc accgctacac cagccgcctc
     8521 accccggtcg ccggccggct gacccgtccg ctgccgctgc ggctgcgcgc cgacggcgcc
     8581 tacctggtga ccggtgcctt cggcgcgctg ggccgggtgc tctgccgcgc cctggtcgcc
     8641 tggggcgcac ggcggctgat cctggtgggc cggacccggc tgcccggccg ggagcactgg
     8701 cgcgagaccg accccggctc cgcggccggc cgcgccgtcc ggttcgtgcg ggagctggag
     8761 gcgctgggcg cccagcccgt cctcgcgccc ctcgacatca gcgacgaggc gagcctgacg
     8821 gcctggctgg cggagtaccg gcggctcgcg tccgcgccga tccgcggtgt cttccacctc
     8881 gcgggccagg tccgcgacac cctgctgccc gacatggacc gggagacctt cgacgcggtc
     8941 cacgatccca aggtcctcgg cgcgtacctc ctgcaccggc atctcggcgc ggaaccgctc
     9001 gaccacttcg tgctcttctc ctcgatcgcc tccgtgctga cgaccgccgg gcagaccaac
     9061 tacgcggcgg gcaacgcgtt cctcgacgcg ctggcgcacc accgccgggc ccgcggcctg
     9121 cccggtctca gcctggactg gggtccctgg gcgaccggca tgatcgagga gctggggctc
     9181 atcgagcact accgcaggaa ccgcggcatg agttccctgt cgcccgaggc ggggacggcc
     9241 gtgctggaac gcgtcatcgg gcaggaccgg gcccagctgc tcgtcgccac cgtcgtcgac
     9301 tggccggtct tcctcgcctg gtacgcctcc ccgccgccgc tggtgagcga gctggccgcg
     9361 gccctgggcg gtccgtccgc cgcacagggg gaacagagca gcttcctcga cgcgttccgg
     9421 ggcgccgatg acgcggcccg tcggaccctg gtggccgagc gcttcacggc ggtggtcgcg
     9481 ggtgtgctgc gggtggcgac cgaccaggtc gagctcgacc acgcactggg cggactgggc
     9541 ctggactcgc tgctcgcgat ggagctgcgc tcccgcgtgc acgcggaact cggcctcgcg
     9601 ctcccggtcg tcaccctgct cagcagcgcc ccggtgggcg aactgatcga ccggctccac
     9661 gagggcctgg ccgagctggt ggcggccggt gcggacgagg ccgccggcgg tgccgcggtc
     9721 gagctgttcc gcgacgaggg acggcacccg ctgacccaga accagaaggc gctgtggttc
     9781 ctcaagcagc tcaaccccga cggtttcgcc tacaacatcg gcggcgcggt cgaggtgcgc
     9841 gtggaactcg aaccggagct gatgttcgac gcgttccggg tgctgatcga gcgccatccc
     9901 agcctgcgcg ccaacttcac gcacgagcag gggcagccgg tgcagaaggt cgcccccgcc
     9961 gccgaggccg cgctgcgccg ggacgtcgcc ctcttcgacg tggagggcgt ggcgtgggac
    10021 gacgtccacg cgatgatcgt gcgcgagtac cgcaagccgt acgacctcga acgcgacccg
    10081 ctgatccggt tgcgcctgtt ccggcgcggt cccgaccgct gggtgctgat gaaggccgtc
    10141 caccacatca tctccgacgc gatctctacc ttcaccttca tcgaggagct gctcgcggtc
    10201 tacgaggcgc tgcgccgggg ccgcgccccc gagctgccgc cggtctcggc ccgctacctc
    10261 gacttcctga actggcagaa ccagttcctc gccggacccg aggcgcgccg gatgctcgac
    10321 cactggaagg gccggctgcc ggccgacgtc ccggtgctcg gcctgcccac cgacaagccc
    10381 cgtcccgcgg tgcagaccca caacggcgcg tccgagttct tcgtgctcga cgccgacctc
    10441 agcgcccgcg tccacgacgt ggcccgcgag cacaacgtca ccgtgttcat ggtgctgctc
    10501 agcgcctact acctgctgct ccaccactac tccgggcagg acgacatcat cgtcggcagc
    10561 ccggtgacgg gccgtaccca ggaggagttc tcctcggtct acggctactt cgtcaatccg
    10621 ctgccgctgc acgtcgatct gggggacggc ccgtcggtgg agcagttgct cgcccgggtc
    10681 cgggatgtcg tgctcggcgg cctggacaac caggagtacc cgttcgtgct gctggtggag
    10741 gagctgggcc tccagcacga cccgagccgg tccgcggtct tccaagccat gttcatcctg
    10801 ctcacccaca aggtggccac cgagaagtac ggctaccgcc tggagtacat cgaactgccc
    10861 gaggaggagg gccagttcga cctgacgctg tcggtgtacg aggacgaggc ggaccggcgt
    10921 ttccactgcg tcttcaagta caacaccgac ctgttcctgg ccgagacgat gcggcggctg
    10981 tccgggcact acgtcaacgt cctcgacgcc ctgacccgcg cccccgccgc gcagccggcc
    11041 ggccggctgg aactgctggg cgcccgtgag cgccggcaga tcctcggcga ctggagcggg
    11101 gccggacgcc gggccgccga gcccggtgtg ccggtgcacg agctgatcgc ccgggccgcc
    11161 gccgagcacc ccggggcgac cgccgtctgc gtgcccgccg aggacggcac gaccgagcgc
    11221 atgacctacg ccgcactcga ccgccgcagc cgcgaccgcg cgcgacggct gcgcgaactg
    11281 ggcgtccgcg acggcgcggt ggtcgccgtc tgcatggaga agtcggccga gctggtggtc
    11341 accctgctgg cggtcctccg ggcgggcggc gcctatctgc cgctcgaccc cggcaacccg
    11401 gccgaccggc tggcctacat ggccgagcac gccggggccg cgcgcgtcgt cgtggacggg
    11461 gcgggcggtg cgcgcttcgc cgggcattcc ggcgtgctca ccctggcgga gctgtccgac
    11521 gcggcgggcg cgcccggcac ggcggccgcc ccgccaaaac cggcggggca ggcggaaccg
    11581 gccgggccga cggaccagat cgagcccacc gggcaggcca ggccggtcgc ggccggtact
    11641 gcggctgccg cggccgacgc agccgatccg accgacccga ccgacccact cgtcggcatg
    11701 gacggcccgg cctacgtcat ctacacctcc ggctccacgg gccgtcccaa ggcggtgcag
    11761 gtcagccatc gcaacctggc gtccgcctac gccgcctggc gagcggagta ccgcctcgac
    11821 acggacgccc gggtccatct ccagatggcc ggcccggcgt tcgacgtgtt caccggtgac
    11881 ctggtccgcg ccctgtgctc cggcgggacc ctggtgctgg tcggccgtga gctgctgttc
    11941 aacacggccc ggctgtacgc gaccatgcgc gccgagcggg tcgactgcgc cgagttcgtg
    12001 ccctccgtcg tgcgcggcct gatggcccac tgcgaacgcg acggcgcccg gctggacttc
    12061 atgcgcctgc tgatcgtcgg ctcggacacc tggaaggtgg aggagtacga ccggctgcgc
    12121 ggcctgaccg gaccggacac ccgcgtggtc aactcctacg gcctcaccga ggccaccgtg
    12181 gacagcacct acttcgaggg cccgaccgac ggcctggaac cgagccagat ggtgccgatc
    12241 ggccggccgt tccccggtgc cgaggtgtac atcctggacg ggcacggcgc accggtgccg
    12301 ccgggcgtcg cgggcgagct gtggatcggc ggcgccgggg tcgccctcgg ttatctcgcc
    12361 gatcccgggc acaccgccga gcgtttcgtc agccgcaccc tggaccacgg cagcggcgcg
    12421 gcaccggtac ggctgtaccg gaccggcgac ctggcccgct gggacaccgg cggcggagtc
    12481 cacctgctcg gccgggccga ctcacaggtc aaggtcggcg gccaccgggt ggagatcggc
    12541 gagatcgagt tccagctcgc ggaatggccc gcgctggccc aggcggtcgt cgtcgtccgg
    12601 ccggaccgca acggcgagaa cacgctgtgc gcgtacggcg tcgccgcacc cggcgcgaag
    12661 ctcgactggc gggagctgcg ccggcacctc ggcgagcacc tgccgacgta tctggtcccg
    12721 gcggctttca ccgagctgcc cgcgctgccg ctcaccccga acggcaaggt cgacgtcaac
    12781 gcgctgcccg agccccggtt cgagaccggc gaggacgccc acgagccgcc cgtgacgctc
    12841 tacgagacgc ggatggccga ccactgggcg gcgctgctcg gtctcgggga ggtcggtctc
    12901 cagcacgact tcttcgaggt cggcggcagc tccatcaagc tgatcgagct gatccacggg
    12961 ttgcaggacg agttcgagat cagcatcccg gtcagccagc tgttcaaggt cacgacgctg
    13021 cacgggatgg cccggaccgt cgagcacatc atcaccggcc ggctgccggg cgcccagccg
    13081 ttcctccgct tcaaccgggg ggcgggtccc gccgtgttct gcttcccgcc cgcgggcggg
    13141 cacggcctgg tctaccggcg gttcgccgag cagctgccgg agtacgaact cgtggcgttc
    13201 aactacgtcg ccgaggacga caaggtcgcc cggtacgccg atctgatcgc cgcgcaccag
    13261 cccgaggggc cctgcgcgct gctcggctac tccctcggcg ggaacctcgc cttcgaggtg
    13321 gccaaggaac tcgaacggcg cggccgtgag gtcgccgacg tcgtcatcgt cgactcgtac
    13381 cgcatcgatg ccgccttcac cccgggcgcc gagcacatcg aggcgttcga gcgggagctg
    13441 cgcgagcacc tgcacaagca caccggctcc gagaccctcg cgcaggagac cctcgaccag
    13501 gccagggact acatcgcctt ctgcggccgt actcccaacc tcggcacggt cggcgcggcc
    13561 gtcaccgtcg tctccgacga gcagaaggtg gccttctacg ccgcgggcga gcgcgggacc
    13621 tggcacggca cctcgaccgt gcgcaccgag gtgctgcgcg gcgccggcgt ccacgcggac
    13681 atgctcgacc cggggtgcat cgagcacaac gcccggctgg tgcgcggcgt cctcacgcac
    13741 accgccgtga tcgaaggggc ggccccgcat gcggcgtagt aacagggtgc agtggagcga
    13801 acgcgagcgt gcccccgggg ccaagccgcg cgtcatcatc gtcggagcgg gcctgggcgg
    13861 gctctccgcc ggctgctacg ggcagatgag cggcatggag acccgtgtct tcgagaagca
    13921 cgtgctgccg ggcggctgct gcacggcctg gtcccgggac ggctacgtct tcgactactg
    13981 catcgaatgg ctgaccggca ccgccccggg caacgaggcc catcaggtct ggcgcgagct
    14041 gggggccctg gacgggaaga ccatccgcaa cttcgaggtg ttcaacacgg tcgtcgacga
    14101 cgacggccgg tcggtggtct tctacaacga ccccgaccgg ctggagcggc acctgctgcg
    14161 gctctcgccg gcggacgcgc cgctgatccg gtcgttctgc cgtgacctgc ggcggttcac
    14221 cgacatcgac atcttcccgt tcctgaagcc ggccccgctg ctgacgctgc gggagaaggc
    14281 cagggcgctg cggaagatcc tgccgctgct gaacctgttc cggcgcaccg ccgggacctc
    14341 catggagtcc ttcgccgcgc gcttcgagga tccgctgctg cgccgggcgc tgccgttcgt
    14401 cttcttccag gaccacgagg tcttcccact gctgccgtac ctgttcaaca tggcgggggc
    14461 ccaccagtcc aacgcgggct tcccgcaggg cggttcgctg gggctggccc ggtcgatcga
    14521 ggagcgctac acctcgctcg gcggccggat cgactaccgc gcccgggtgg agcagatcct
    14581 ggtcgaggac ggccgggcga tcggcgtgga actgcgcggc ggcgagcggc actacgcgga
    14641 ccacgtggtg gcggcctgcg acggcgccac caccctggac cggttgctga agggacgcta
    14701 ctccagcccg cggaccgacc ggctgttcca gtcggtcctc ggcaccccga agctggtcta
    14761 cccgggggtg gtgtcggtgt tcgtcgggtt cgccggggac gtggcgccgg acgccccgca
    14821 cagcgcgacc tatctgctct ccgccgccga cagcgcccgg ctgcccggcg tgctccagga
    14881 cagtctggtg gtgcagttgc gctcccggtt ctcggacggg ctggcaccgc ccggcaagtc
    14941 ggtgatccac tgctcctact tcagcgacta cagctcctgg aaggaactgc gccgcaccga
    15001 ccgccgcgcc taccgggcgc gcaagcagga ggccggccgg ttcgtgcggg agttcctgga
    15061 gcgccaccat ccggggatcg ccgcgcgcat cgaggtggtc gacgtcgcca cgcccgcgac
    15121 caccgagcgc tacaccggca atctgcacgg ctccatcctc gcctggaagt cctacaccga
    15181 agccgacggc ctgatccagc acctgatcga gaaggaccgg ctgcggctgc cggggctcga
    15241 cgggctctcg ctggcgggtc agtggttcac cggcggcggg ctgatccggg tggcggccgg
    15301 cggccggttc gtggcccagt acctctgcga ggagctgggc ctcgagttcc gggcgtggga
    15361 gagcacggcc ggtgagacgt ggcatcccgg gaagctgggc cacctgcccc agctcgacaa
    15421 gagcatgagg tgaggggcgt gacgatgcct cgcaagcccc gcgagcgcca gacaatgatc
    15481 atcatcgggg ccggtctcgg cgggctgtcc accggctgct acgcgcagat gaacggctac
    15541 cggacccgga tcttcgagat gcacgagatc ccgggcggct gctgcacggc ctgggaccgt
    15601 ggcgacttca ccttcgactg ctgcgtcagc tggctgctcg gcaacgggcc cggcaacgag
    15661 atgcaccaga tctggctgga gctgggcgcg ctccagggca agcagatgcg gcacttcgac
    15721 gtcttcaacg tggtgcgcgg gcgggacggc cggtcggtct acttctattc cgacccggac
    15781 cggctcgaag cccatctgct ggagatctcc ccgtccgacg ccaggctgat ccgaagtttc
    15841 tgctcggggc tgcggaagtt ccgcaagtgc cttgccgcgt atcccttcct caaaccggtg
    15901 ggactgatgg gccgcgccga acgctggcgc atgctcgcgt cgttcgtccc ctatttcaat
    15961 gtcatccgca agtcgatcag cgtcctgatg acggactatt ccgcgaagtt cagggatccg
    16021 ctgctgcgcg aggcgttcaa tttcatcctc tacgagaagc attccgcttt tccggtgctg
    16081 ccgttctatt tccagctgtc cgcgcacgcc aatctctcgg ccggggtgcc ggagggcggc
    16141 tcactggggc tcgcgacctc gatcgagcag cgctatctgc ggctcggcgg cgaggtcagc
    16201 tacaacacga aggtcgagga gatcctcgtc gaggacgacc gggcggtggg ggtacggctc
    16261 agcgacgggc gggagttccg cgcggacatc gtggtctcgg cctgcgacgg gcacgccacc
    16321 acgatgaagc tcctgaaggg ccgttacctc cccgaggagt accggcggct gtacacctcg
    16381 gtcatcgacg agccgggcat ggtcttcccc ggatacgtca ccctcttcct cgggctgcgg
    16441 cgccccttcc ccgagggcgc cccctgcacc acgtacctgc tgaccgagga ggaggccacc
    16501 cggctggtcg gcatccgcca tccgagcatc aacgtccagt tccgcagcct gcactacccg
    16561 gagctgtcgc ccgagcggtc gaccgtcgtc tacgccacct acttcagcga cgtcggtccc
    16621 tggcgcgcgc tgagcgacgg cccggagcag cgcacccgca gccggggcgg aacggagctg
    16681 cacaccctgc cggtgcgccg cgggcgcccg tactacgagg ctaagcacca ggtgcgcgac
    16741 atgctgctgg gcttcctcga ccggcggttc cccggcctga cggacagcgt cgcggtgcgg
    16801 gacgtgtcga ccccgctcac ccaggtccgt tacaccggga actacgacgg gaccgtcctc
    16861 ggctggcagc cgttcgtgga aagcggcgag acgatggaga aggtcgtcaa gaagtacggg
    16921 ccggccctgc ccggcctcgc gaacttctac ctctccgggg tctgggccac caccggcggc
    16981 ctcatccgcg ccgcggccgc cggccggcac gtcatgcagt tcgtctgccg cgacgacggc
    17041 agggcgttca ccgcacacat cgacgcgtcg gggccgctcc cgacccatgt cgtcatcccc
    17101 gtaggacccg atgggaagga tggagacccc gatgagcgaa cgaccggcgc cgctgccgta
    17161 tccgttcacg tccgctgacc ccctggagct ttcgccgatc tacgccgaac tgcgcaacgg
    17221 gccgctgcgc aaggtccggc tgccctacgg cgaggacacc tggctggtca cccggcacgc
    17281 cgacgcgcgg ttcgtgctgt ccgacccgcg gttcagtctg gcggccggag tggaacggga
    17341 ccagccccgg atgagggagc tgtcccccgg cggtgacggg ctgctctcca ccgacccgcc
    17401 cgtacacacc cggctgcgcg gtgtggtggc ccggcacttc agcgcgcgcc gtgtcgagca
    17461 gatgcgggtc gtggtgcgcg aggccgccga ggggctgttg gaccggctcg aggagtcggg
    17521 accaccgggc gacctcgtgc aggacttcgc cgtcccgctg tcgatcgcca tgatctgcga
    17581 tctgctcggc gtgccggcga cggaccgcca ccgtgtccag aagtggctcg aagtcctgct
    17641 ggcccaggtc gtgaccaacg aggacctcgc cgccgaatcg ggggcgtatt tcgcctacct
    17701 gaccggcctg gtggaggagc gccggcggga gccgggcgac gacctgctca cctgcctcgt
    17761 acgggcgcac tacgaggagg gacgcctctc ctacgacgaa ctgatcaagc tgtccatcga
    17821 gttgctcacc ggcgggttcg tcaccacctc caagcagatc cccaacttct gctatctgct
    17881 gctgcgtcgc cccgagtggc tgtcgcgact gcgcgagcac ccggcggacc tcccggtcgc
    17941 catcgaggag atgctgcgct acgtgccgat gcccaacggc ctcgtcttct gccggtacgc
    18001 gaccgaggac gtcgaagtgg gcggggatct cgtccgcgcg ggggaaccgg tcctggtcga
    18061 cacgtcggcg gccaaccggg atcccgcggt cttccgcgac cccgaggcgc tcgtcctcga
    18121 ccgggcgccg gaggccgcgc atctgacctt cggacacggc gcgcacttct gtgtcggggc
    18181 acggctgggc cggctggaac tccaggtggc gctggaaacc ctgctgaccc gcctgcccgc
    18241 gctgaagctg gccacgcccg acggcgaggt gcgctggagg gaggagacga tgctcaaggg
    18301 cctccacgcg ctgccggtcg actggtgagg ccgccggcgg cacttcggcg gtccgggtgc
    18361 cgttcggggc cgcggcaccg ccggccgccg tgatgtttcc tggccgcccg cgcgcatggc
    18421 gtggttcctc aggcgcgcgg gcggagcggt gcgtaggggg tgctgacgcg gggaccggcc
    18481 ggcccagggg gcgcacccgc cggccggtcc cgcgtccgtg tcacgtgccg catcgccgtc
    18541 agctcacggt ggccgccgta cgctgagtcg ggcgttgctc gcgcgtgtac acgatcatgg
    18601 aatgccgcgc aggccggtgt cgacggccgg gcggccctcg gccagggaca ggaccgggtc
    18661 ctgtcgggac acgtcgctgc tcctgcggca ccactcggtg atccggcccg tgtcgaccag
    18721 ccctggctca gtgactcgct gcagcaatcc ctgtccttat gaatggcgcg cgtgcaccac
    18781 gcttcctgcc gtgttcgaga tcggcagggc tctcctgatg gtcgacaaca ttctgtctac
    18841 agtatgctgc gcgcgcaata aaggtgcaga acaatggcct gatctctccc aacccgcgcg
    18901 aggtcatgcc cacgtgcaat cgagcgcgta gactgtagac gaaaaccaat ttcagccagg
    18961 aaccgctgcc gagaggtgga gccatgacgt ccgcggcatt gccgaccggt accgtaccca
    19021 agctggagcg ccccggcccg ctgcgcgagc gcgtctacga ggccctgctg gagctgatcg
    19081 tcaccaggtc gctcaaaccc ggacagcatc tggtcgagac cgaactcgcc ggccatctgg
    19141 gcgtctcccg ccagccggtc cgcgaggccc tgcaacggct caacaccgag ggctgggtgg
    19201 atctgcgccc ggcccagggg gcgttcgtcc acgaccccac ggaggacgag gccgaccaac
    19261 tgctggtcgt ccggggtctg ctggaggccg aggcggcgcg gctggcggcg gccaacgcca
    19321 ccccggaggc cacggcgcgg ctgcgcgagc tgtgcgaggc gggcgagcgg gccctggcgg
    19381 acgacgacgt cgacgccgtg gtcgccgcga acgccgcctt ccacgcgtat ctgatggagc
    19441 tggcggcgaa ttcggtcctg gcggagctgt ccgcgcaggt ggatcgccgc gtccggtggt
    19501 tctacacgcc cgtggcccgt acccgcggcg cgttgtcgtg gcaggagcac cgggcgatga
    19561 tcgaggccat cgaggcgggc gacgagcagc acacccggca gctgatgcgg gaccacaccg
    19621 agcacacccg cgtcagctac cacaagcgca agaaatccga gcagtaggca cggaccagtg
    19681 ggcacagggc aataggcacg gaagcagtga gcacaggtag gcacgggcag tgggcgcgga
    19741 cgtacgcgcg taccggagcg gtgcggcgcc ggacgccgca cgggagagcc gcccgccgcg
    19801 gtccgtccgc cgatgacggg ggacggatcg cgacgagcgg ctgtgtcagc cgggtgcgcg
    19861 ggtgcgggtc agaccgtttc gccgctcacc tgcaacgcac caccggcccc ggcccggacc
    19921 cggcccgccg agggacggcc cggttgccgc agcagcagcg cgagcgccgc cgaggccagc
    19981 ccgaggcatc cggcgagggc gtacgccccg gagtagcccc acgccgcgac gaccgtcgca
    20041 ccgaggccgc tgccggccag cccgccgacc agcttggagc tgtagaccag tccgtagttc
    20101 tgggcgttgt tgttctcgcc gaagtagtcc ggggtcagtg ccgcgaacat cgggaagaac
    20161 gcgccgccgc cgaagccgga gatgaaggcg aagatgagga acaaccattc actgcggatg
    20221 tcaccggccc acaggacacc gaactgcgac agtccctcga ccgccaccac caggatcagg
    20281 gtctgcttgc ggccgagccg gtcggacagc cagccggtca caccgcggcc ggtgccgttg
    20341 atgatggaca tgatgcccat cgacgaggcg gccaccagcg gaccgaaccc gatgtccttc
    20401 gcgtacggga cctggaagga gatgccgaag atggacaccc cggagcacag caccaggcag
    20461 aaccacatca gcgggagcat cccggtgcgg atggcctcca tcggctcgta ctgccgcacg
    20521 gcaggcgggt tcttggacag cgacctgtcg ctggtggcgt tcttgctgtg ttcgatcggg
    20581 tcgacctcct gcggccacca gttcttcggc gggtccttga agaaccagcc gcagatcgcc
    20641 acgaggatca gtacgtagac accgaccagg tcgagcaccg tgtggtagtt gccggcgtcg
    20701 aaggagtagg tgaagacgaa gatcatcggt acggatccgt aggcgaagcc gccgttgacg
    20761 aagccggtct tgccgcctcg ccgttccgga taccacttgc cgacgatgtt gacacaggtc
    20821 gagtagacca tgccggcgcc cgtgccaccg aagaacccga agcccaggat cgccagcggc
    20881 acgttcggcg cgtggctgag ggcgaagaaa ccgatcccgg ccaggacggc tcctatgagg
    20941 gtggcaccgc gggcactgag catcccgcgt tcccgcagcc ttcccgtcgg gaaggcgact
    21001 gcggcctgga agaccgtcca cacgcccaga acccagaacg tgttggtgga cgtccagcca
    21061 tgcgcgtcgg acaggacttc ctcggccgag ccgtaggcgt attccgcgac gctgatggcc
    21121 atcatggcca cccacggaag tatcaccatc agcaggcgcg ggccgcccag aatgtctctg
    21181 gcgctctcgc cgacccggta cacacgtccg ttcgcatctg tgacctctcg gtatgcgggt
    21241 cgtacggttg atgccgttgt catttccaat ccccttgctc aagagactcg ccagcgcccc
    21301 ctggtcggta ctccatggca gtacggggag gtctggccgc gggcgacggt gcccgagccg
    21361 gacctgtcac gcgggccggt cgtgccggtc cgcgggtctg ggggtgggtg acggcgccgc
    21421 gggggtccgc gtcgccgtgc cggcagcggc ggatgccggg ccgctccggt cgagtggcgg
    21481 cggtttcgct gcatgctcag atcactccgt
//
