BGC0001560 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001560 (Moorena producens JHB)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	28,792	cryptomaldamide	NRPS:Type I+PKS	100%

BGC0001560 - Region 1 - NRPS,T1PKS

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Location: 1 - 28,792 nt. (total: 28,792 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,793
Label		BGC0001560

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001560	2.00	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0000342	0.63	NRP	enniatin	Fusarium equiseti
BGC0000313	0.52	NRP	beauvericin	Beauveria bassiana
BGC0001873	0.51	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002135	0.50	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.50	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001132	0.50	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002518	0.49	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001833	0.48	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128	0.48	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001560	1.00	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0000342	0.65	NRP	enniatin	Fusarium equiseti
BGC0000313	0.60	NRP	beauvericin	Beauveria bassiana
BGC0001873	0.59	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002135	0.58	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.58	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001132	0.58	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002518	0.58	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001833	0.57	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128	0.57	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 28792:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys - Val - NMe-Val - Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cpmB

Search NORINE for peptide: strict or relaxed

AMP-binding (494..893): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNIGIVWK
Nearest Stachelhaus code(s):: Cys DLYNIGIVWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1580..1978): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMFTGGVFK
Nearest Stachelhaus code(s):: Val DAMFTGGVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2633..3035): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DALWLGGTFK
Nearest Stachelhaus code(s):: Val DALWLGGTFK (100% 8Å match); bOH-Val DALWLGGTFK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

PKS_AT (4165..4471): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 173.8
inactive: 103.5
Methoxymalonyl-CoA: 63.7
Methylmalonyl-CoA: 59.9
Isobutyryl-CoA: 53.7
Propionyl-CoA: 42.9
Ethylmalonyl-CoA: 21.2
Benzoyl-CoA: 16.3
2-Methylbutyryl-CoA: 15.1
CHC-CoA: 14.9
Acetyl-CoA: 13.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0