LOCUS       BGC0001561             17578 bp    DNA     linear   BCT 13-JAN-2016
DEFINITION  Streptomyces curacoi strain DSM 40107 PRJNA299217_c028, whole genome
            shotgun sequence.
ACCESSION   BGC0001561
VERSION     BGC0001561
KEYWORDS    .
SOURCE      Streptomyces curacoi
  ORGANISM  Streptomyces curacoi
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:49:10
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17578
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..789)
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_010985010.1"
                     /locus_tag="AQI70_32520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KUM69037.1"
                     /transl_table=11
                     /translation="MTELLGFPALLRLIDERSVAFRATVASAPSLDVQVPTCPGWTLFD
                     LVRHLGGGHRRWADTVAAGPADARPAETAAQSAPAGLREREALLAWSAESTERLLSALR
                     EAGPDRGCWTWWGTSQSPQTSGAVARHQLQEVAVHTYDAQIALGAPQPLPDAAALDGVD
                     EFLSTCCATTSAWPHEAATADFHATEGPSWRLALSADGARATRLPTTTAAEDLDAATAL
                     ARGTASDLVLTLYGRVPVDSLKLDGNRKLFDLLQAWEPEE"
     protocluster    1..17578
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[13039:17578]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      13040..17578
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..17578
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..17578
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001561"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17578
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..789)
                     /locus_tag="AQI70_32520"
     misc_feature    complement(124..126)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1532..1885
                     /locus_tag="AQI70_32525"
     CDS             1532..1885
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_012936269.1"
                     /locus_tag="AQI70_32525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KUM69038.1"
                     /transl_table=11
                     /translation="MRCLAGQVRLTAGTLWRDPEAADAVLCRGALDERALAGPPRLFLV
                     DGAEPAHCALLRDAVDDGRAVAAVVTTEDVTAAAAADAVLFLHQGRVVDMVAGANPERI
                     RECLSWLGGEQES"
     gene            complement(1854..2633)
                     /locus_tag="AQI70_32530"
     CDS             complement(1854..2633)
                     /NRPS_PKS="Domain: Thioesterase (28-244). E-value: 1.1e-53.
                     Score: 174.8. Matches aSDomain:
                     nrpspksdomains_AQI70_32530_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 247; E-value: 2.4e-75)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_009628113.1"
                     /locus_tag="AQI70_32530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KUM69039.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.6e-10, bitscore:
                     31.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQQQSRSRARTAPRWTVARPARPDAAVRLFCFPYAGGGSSIFRN
                     WHTHLDDGIEVCPVLLPGREERYSEPAFTRADALVAALAEHLAPVFDKPFAFFGHSMGG
                     QIAFALARHLAAVGAPTPSRLFLAGCAPQHSRVLRHELPDEQLVAEIREMNGAPPEVLA
                     NEEVLQLLLPMIRADFALAEDSVPPAEAQVSTPVTAFAGSTDPEAGHDEVRLWARHTTG
                     SFESFELEGDHFFLHQPAALLDLVARRLTTPVPRPTS"
     aSDomain        complement(1902..2549)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_32530_Thioesterase.1"
                     /evalue="1.10E-53"
                     /label="AQI70_32530_Thioesterase.1"
                     /locus_tag="AQI70_32530"
                     /protein_end="244"
                     /protein_start="28"
                     /score="174.8"
                     /tool="antismash"
                     /translation="RLFCFPYAGGGSSIFRNWHTHLDDGIEVCPVLLPGREERYSEPAF
                     TRADALVAALAEHLAPVFDKPFAFFGHSMGGQIAFALARHLAAVGAPTPSRLFLAGCAP
                     QHSRVLRHELPDEQLVAEIREMNGAPPEVLANEEVLQLLLPMIRADFALAEDSVPPAEA
                     QVSTPVTAFAGSTDPEAGHDEVRLWARHTTGSFESFELEGDHFFLHQPAALLD"
     CDS_motif       complement(2292..2357)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32530_0001"
                     /evalue="7.00E-08"
                     /label="NRPS-te1"
                     /locus_tag="AQI70_32530"
                     /protein_end="114"
                     /protein_start="92"
                     /score="24.9"
                     /tool="antismash"
                     /translation="KPFAFFGHSMGGQIAFALARHL"
     gene            complement(2639..3817)
                     /locus_tag="AQI70_32535"
     CDS             complement(2639..3817)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 263.8; E-value: 4.2e-80)"
                     /gene_kind="transport"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_020636058.1"
                     /locus_tag="AQI70_32535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KUM69040.1"
                     /transl_table=11
                     /translation="MFALPLLVLALTGSAVQAGAASALSAVTRLVVLVPAGALTDRWDR
                     RRVMLWCELARLPVITALALALLRDSAGFGLVLLVAIVDGVAAALFAPAEEAVLPQVVD
                     KSQLSTAVAVTAARSYVATLAGPGIGGLLFSAHRALPFLANALTYALSGLLILCTRIKA
                     HRPPSERRSLVHEVGEGVRWIARNPVIRASLLVAVMASICFNALNLIVLAAAERAGVPT
                     GQIGLIGVLTGAGGLAGALLAPRFQRLMTPRTAILVLAWVSTALTPLLATTADALLFGA
                     VLGVIAFLAPTVQTAVVTYQMASTPDRLRGRVSAALGLTGGVAGAAGPLLGGTLVETVG
                     WRGAVLGCAGALLLAGVGAALSPALRSFTQVTGEAPAEPALTPTPATDTPER"
     gene            4192..4416
                     /locus_tag="AQI70_32540"
     CDS             4192..4416
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_004001170.1"
                     /locus_tag="AQI70_32540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KUM69041.1"
                     /transl_table=11
                     /translation="MARSTDYDEERASRKARGAWYVPPLLVFFVGAMLTSVVSHAVDGG
                     TYTAVMSAGFALDALAVIWAVVRWRRSAS"
     gene            4443..4871
                     /locus_tag="AQI70_32545"
     CDS             4443..4871
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_004001171.1"
                     /locus_tag="AQI70_32545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KUM69042.1"
                     /transl_table=11
                     /translation="MKSSLGMRTRLSERRRRFAGILAGGIIAVPATLGLTACDSAQDAL
                     DRGDMCLNILDIALFDPNPSSADEARKDVRERADKIDEIAEKASDDKLRDAAEQTAKEL
                     RDAADDDLDAGSVSEYVSQQNDRLKALRKTCSDLGDFG"
     misc_feature    4473..4475
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5194..5865)
                     /locus_tag="AQI70_32550"
     CDS             complement(5194..5865)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 149.1; E-value:
                     1.8e-45)"
                     /gene_kind="regulatory"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_004001172.1"
                     /locus_tag="AQI70_32550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LuxR family transcriptional regulator"
                     /protein_id="KUM69043.1"
                     /transl_table=11
                     /translation="MRILIAEDNALLREGMTLLLTRNGHEVVATCASGPEIMPTLRRTE
                     PDAAVLDVRLPPSFRDEGLRAAVAARQEFPELPILVLSQYVEQAYAAELLALGARGVGY
                     LLKDRVGRVEQFLEALERISEGGTALDPEVVNEIIQQRASTRSLEGLTAREHEVLELMA
                     QGLANAAIAERLFVTERAVSKHIRGIFDKLNLPAEGTSVHRRVLAVLAYLGNDISGEAS
                     R"
     misc_feature    complement(5833..5835)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5853..7064)
                     /locus_tag="AQI70_32555"
     CDS             complement(5853..7064)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 215; E-value: 3.1e-65)"
                     /gene_kind="regulatory"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_004001173.1"
                     /locus_tag="AQI70_32555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine kinase"
                     /protein_id="KUM69047.1"
                     /transl_table=11
                     /translation="MAYFSSQLRRSWQASCHLFFGVPVAMAAFLGCFAVPIGVFFTLFV
                     IGAPAWPEIVRILRRFAGYERVRAGGWLGKPIPELYLPLDGSPSDRVRLALTDPGTWRD
                     ALWLPFATVSILGFSAVVLVLWPLTLLVDGTAAAVRRSLERRDTAPFDPAPEPPRALLL
                     PVFEILADAQARWTAALLKPSASTKLGQRVAELSESRAGAMEAHSAELRRIERDLHDGV
                     QAQLVALSMRIGLARQQVRNDPDAATEWLDEAQEEIDATLAALRGIVRTVHPPVLTDRG
                     LAGAVRTLAVSADIPVEMNLAAVENGHRLPAAVEAAVYFVIAECLTNIRKHSGATQASV
                     RFTRADGSLQVVVTDNGRGGAEEHGGSGLLGIRRRVAALDGTTEITSPPGGPTRMKVEL
                     PCGS"
     misc_feature    complement(6741..6743)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7288..8100
                     /locus_tag="AQI70_32560"
     CDS             7288..8100
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 209.2; E-value:
                     1.2e-63)"
                     /gene_kind="transport"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_004001174.1"
                     /locus_tag="AQI70_32560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="KUM69048.1"
                     /transl_table=11
                     /translation="MSLRMGRRTPTPAGPTRAAGRDTAGAHALTLDSVTRRYWRGGKDF
                     HALEDVSMEVPQGHFLAVMGRSGSGKTTFLQCAAGLDQPTSGTVWIGDTDLSRLSEAAL
                     TRLRRDRIGFVFQSLNLVPSLTVGENTALPLLLRGMNPQDPAVRERSLKVLDAVGLADR
                     ADDSPLRLSGGQQQRVAIARALVTDPAVIFADEPTGALDPVTAREVLQLLRQAVDVSGH
                     TVVMVTHDPQAAAWTDEAIFIEAGRIVAREERPGPETVARRLAQLGER"
     misc_feature    7792..7794
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8097..10850
                     /locus_tag="AQI70_32565"
     CDS             8097..10850
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_004001175.1"
                     /locus_tag="AQI70_32565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="KUM69044.1"
                     /transl_table=11
                     /translation="MTVAVDTRQPAGRTPARERHGESVGRVQRTAHFLARRSMRLHRKA
                     WAAVFAALVLTALLLGSFALATLSAFVGHAHVERYAATTAVVAADQSTRYRAKPWGDPP
                     TTVTQSLTERVRVPADVVDRLAKVPGVRAAIPDSSFPVALAGPDGRGVPGPDSDSGTAP
                     VYGHGWPTAALAPFTLRAGKAPSAARQVAIDGDLAARAGVGTGDRIRLQTLGAPAEYVV
                     SGIVAPDGEADDTGLAHQGAVFFTEDQAVRLSGHPGTVDAIGVLAADGVSVHQLYPELR
                     KALDGAEPARDAVADSRDRQDSSRLRVLTGNGRGQAEFLEAAPSRASLLNLLAMLCATV
                     IMIAVLVVAGTVSQAVHQRARELALLRAVGATPWQLRVTVGREVTGVATTAAVLGAVGS
                     LPVFLMLLWMLRDRGAVPVGLDLPVLPWMFATPVLTAVLTLVVARVSAALACGRIAKIR
                     PAQALGEAASEPGQPGRGRTVTGLVVLFAGLSSAGTAALQSGELAAMAAGSAALALVIA
                     CALLGPWIARGAMRLLAPLTRRLGGAGGYLAAASTTANSRRLGAAITPVVLVVAFVGVQ
                     LAAGATMDHEGSAQARQAMRADLVVTTEEAGLPAEAARDVAAVPGVEAATGALHSTVVL
                     ARREAGDPVLERLPVVGVTPGALPATLDPDVTSGSLRDLREGTVAVGAARADSLDVKVG
                     SKVRLRYGDGVVASLRVVAVYERNLALGDFLFARDALAPHVSAPLDTRVLARVAPDADR
                     DAVQRAVREALSGAALDVQVAANPSPEHLRSEDRGVSQVLTTVAVGVVGGFTVIAVLST
                     LVLILIGRRQELVLLRLVGAGRRQVRRMLRVEAAIVIVTGLVVGALAALIPLTAFSLSV
                     TGSLPYLPPVQAGAIVLVVVVTVAAGILLPARPALRRRRPAALQRP"
     gene            10958..11365
                     /locus_tag="AQI70_32570"
     CDS             10958..11365
                     /codon_start=1
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_010060984.1"
                     /locus_tag="AQI70_32570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KUM69045.1"
                     /transl_table=11
                     /translation="MARIAAVLLTLVGAAALVLSAFQPWYEGREPREVALTDLFTGLEP
                     AAAGGAATSMLLPLVAVAAVAVLGLLVRSRAVLAVACVAGLATGILWTVQQIRAVAPVA
                     FEVTEVQRGLWNAGGGVLALVIAAIVLPPRT"
     gene            11675..12955
                     /locus_tag="AQI70_32575"
     CDS             11675..12955
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 190.5; E-value: 6.7e-58)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_017611258.1"
                     /locus_tag="AQI70_32575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="KUM69046.1"
                     /transl_table=11
                     /translation="MAVLHRGALTTWAFGTEEYETGRPVGDHSLFAYGSVTKAFTAALL
                     LQLVSDGDLDLDRPIGSRMPARRPAAQGVSAATPRMLLSHTAGLPSDHDDERARSLRDW
                     YEGFLDRAGTHPAGWPARGAFSYSNVGYGIAGRLIETVTELSWWEALRSYLLEPLGTGV
                     RLLGGTPLDPGPNPAPCGHRTRTGADGNPVVHAVPARTDAGSMAAGGLAGSATDLVRFA
                     RLHLARPADRDHADLVDPDVLREMGRPVPGPGPYGLAHSWGAGLGLFGRPGSLWLGHDG
                     ALDGTTCHLRIRPDDGTVVALTTNSATGVRLWDALVQRLRDGGIDVGVHEPEVPPAVSA
                     ARFAECAGTYRNGDLTVDVVVASDGMTLRLPGGLSEHLVPRAGGVFSSVGTEFPATLGR
                     FVKDRTTGRIQALQYSGRTLLRELRPT"
     gene            13040..17578
                     /locus_tag="AQI70_32580"
                     /pseudo=""
     CDS             13040..17578
                     /NRPS_PKS="Domain: AMP-binding (23-415). E-value: 3.8e-108.
                     Score: 353.5. Matches aSDomain:
                     nrpspksdomains_AQI70_32580_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (525-592). E-value: 7e-24. Score:
                     75.7. Matches aSDomain: nrpspksdomains_AQI70_32580_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (611-923). E-value:
                     2.1e-100. Score: 327.4. Matches aSDomain:
                     nrpspksdomains_AQI70_32580_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1087-1485). E-value:
                     2.4e-105. Score: 344.3. Matches aSDomain:
                     nrpspksdomains_AQI70_32580_AMP-binding.2"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     413.5; E-value: 2.1e-125)"
                     /gene_kind="biosynthetic"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_003951361.1"
                     /locus_tag="AQI70_32580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /pseudo=""
                     /sec_met_domain="AMP-binding (E-value: 1e-117, bitscore:
                     382.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-16, bitscore:
                     50.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 4.1e-72, bitscore:
                     232.5, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSDSSTHQQVRQPSGGVTLHGLFEAQAARRPAHPAVECGTTVLT
                     YGEVDRRANRLAHRLAELGVGPETRVGVCLERGPDLLVVLLAILKAGGAYLPLDPGYPS
                     DRLEFMVADADVRLVVSSREAANRPAGDPAVLLLDGPAGLDTSHPDTPPRVTVLPDNTA
                     YVLFTSGSTGRPKGVAVTHRGIPHLGAAHASALAIDGDSRVLQFASPNFDVSIADIVQT
                     WYAGATLVLPSRATQTVGDALAELLADAAITHAMIPPSVLATVPPTPLPGLRALATGGE
                     PCPPEVVARWAAGRRMFNAYGPTEATVTATMNGPLATDLGQAPGIGRPVDGVRVLVLGE
                     QLRPVPDGEVGELCIAGEGVGRGYVNRAALTAERFVADPYGEAGSRMYRTGDLARRLPD
                     GTFEFVGRADDQVKIRGLRVELGEIETALTEHEAVLQAVVVLRKDQGPGRLVAYYVPAD
                     TARPPGHQTLRHHLTGRLPAHMVPAALVPLDRFPLTPNGKVDRAALPAPEAPAGPGTHA
                     HTEPRDETERALAAIWAELLPVERIGVHDDFFAAGGDSISALRTAFQVERRLGVPLEAA
                     ALFDHPTVERLAAQLRTLARQQTPQRPAITPVPRGQRLPLSAAQQRLWFLDRHEPGSAA
                     YNCATGLRLHGSVDPEALGAALTALVARHEPLRTSFPEEDGTPAQMIAEPGTVRVPVPV
                     EDLTARTPAERDRALDRLLRAEVGAPFDLATAPLLRARLVRTAPEEHLLVLTAHHIAAD
                     AWSMEVLTRELGALYAATLRDPNARPDALATAAGLAELPLQYADFAAWQRALQDTPEVE
                     EQLAHWKRVLDGAVPLELPADRPRPPVRTSAGDRVLFTVPAGTARRLTELGRTAGGTLF
                     TALTAGVQLFLARLTGQRDIVLGTVDSGRLRAELADLVGFFVDTLALRADVDESLTFAE
                     FVARGRRTAADAVAHSLVPFDRVVDAVLPGRDPSIPPLVQVMLVLQNVPGGVPELPGIR
                     VEEAVLPREAALFDLTLEFWPGDDGSLTASAEYNTDLFDRGTVERFAGHLRTLLAALAE
                     TPDRPMADAALLTDRQRRRVLQEWNTAERGVAPATLTDLFARQVARTPDAVAVHQADTR
                     LTYADLDARANRLAHHLRERGVRTGDRVGLSLPRGTSLIVALLGILKAGAAYVPVDPAY
                     PVARQEFMLDDSEAVLLVTDAAGGRRLGTDRRPLVLVDTDRQAVEAAPAGPVDAGLTPD
                     HGAYVIYTSGSTGTPKGTLTPHRAIDRVVRHTPYIELTPQDVVAQAASVSFDAATFEIW
                     GALLNGATLALAPAGVLDPPELREFLTTHGVTTLWLTAGLFHEVVDADIEALAGLRHLL
                     AGGDALSPRHCRAVLEQLPGTTLINGYGPTETTTFAAAGALRPADLARETVPLGGPIGD
                     TRLYVLDDRLRPVAPGVGGELHIAGEGLAHGYVNRAALTAERFVADPFGEPGGRMYRTG
                     DRVRWTADGSLEFLGRGDGQVKIRGFRVEVGEIESALADHPKVAQAVVTAVA"
     aSDomain        13109..14284
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_32580_AMP-binding.1"
                     /evalue="3.80E-108"
                     /label="AQI70_32580_AMP-binding.1"
                     /locus_tag="AQI70_32580"
                     /protein_end="415"
                     /protein_start="23"
                     /score="353.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEAQAARRPAHPAVECGTTVLTYGEVDRRANRLAHRLAELGVGPE
                     TRVGVCLERGPDLLVVLLAILKAGGAYLPLDPGYPSDRLEFMVADADVRLVVSSREAAN
                     RPAGDPAVLLLDGPAGLDTSHPDTPPRVTVLPDNTAYVLFTSGSTGRPKGVAVTHRGIP
                     HLGAAHASALAIDGDSRVLQFASPNFDVSIADIVQTWYAGATLVLPSRATQTVGDALAE
                     LLADAAITHAMIPPSVLATVPPTPLPGLRALATGGEPCPPEVVARWAAGRRMFNAYGPT
                     EATVTATMNGPLATDLGQAPGIGRPVDGVRVLVLGEQLRPVPDGEVGELCIAGEGVGRG
                     YVNRAALTAERFVADPYGEAGSRMYRTGDLARRLPDGTFEFVGRADDQVKIR"
     aSModule        13109..14815
                     /complete
                     /domains="nrpspksdomains_AQI70_32580_AMP-binding.1"
                     /domains="nrpspksdomains_AQI70_32580_PCP.1"
                     /locus_tags="AQI70_32580"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       13295..13336
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0001"
                     /evalue="9.20E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="AQI70_32580"
                     /protein_end="99"
                     /protein_start="85"
                     /score="18.7"
                     /tool="antismash"
                     /translation="LAILKAGGAYLPLD"
     CDS_motif       13526..13585
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0002"
                     /evalue="2.10E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="AQI70_32580"
                     /protein_end="182"
                     /protein_start="162"
                     /score="32.4"
                     /tool="antismash"
                     /translation="AYVLFTSGSTGRPKGVAVTH"
     CDS_motif       13940..13966
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0003"
                     /evalue="2.00E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="AQI70_32580"
                     /protein_end="309"
                     /protein_start="300"
                     /score="7.9"
                     /tool="antismash"
                     /translation="YGPTEATVT"
     CDS_motif       14075..14164
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0004"
                     /evalue="1.90E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="AQI70_32580"
                     /protein_end="375"
                     /protein_start="345"
                     /score="48.9"
                     /tool="antismash"
                     /translation="PDGEVGELCIAGEGVGRGYVNRAALTAERF"
     CDS_motif       14249..14314
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0005"
                     /evalue="5.00E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="AQI70_32580"
                     /protein_end="425"
                     /protein_start="403"
                     /score="37.7"
                     /tool="antismash"
                     /translation="FVGRADDQVKIRGLRVELGEIE"
     aSDomain        14615..14815
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_32580_PCP.1"
                     /evalue="7.00E-24"
                     /label="AQI70_32580_PCP.1"
                     /locus_tag="AQI70_32580"
                     /protein_end="592"
                     /protein_start="525"
                     /score="75.7"
                     /tool="antismash"
                     /translation="ERALAAIWAELLPVERIGVHDDFFAAGGDSISALRTAFQVERRLG
                     VPLEAAALFDHPTVERLAAQLR"
     aSDomain        14873..15808
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_32580_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.10E-100"
                     /label="AQI70_32580_Condensation_LCL.1"
                     /locus_tag="AQI70_32580"
                     /protein_end="923"
                     /protein_start="611"
                     /score="327.4"
                     /tool="antismash"
                     /translation="QRLPLSAAQQRLWFLDRHEPGSAAYNCATGLRLHGSVDPEALGAA
                     LTALVARHEPLRTSFPEEDGTPAQMIAEPGTVRVPVPVEDLTARTPAERDRALDRLLRA
                     EVGAPFDLATAPLLRARLVRTAPEEHLLVLTAHHIAADAWSMEVLTRELGALYAATLRD
                     PNARPDALATAAGLAELPLQYADFAAWQRALQDTPEVEEQLAHWKRVLDGAVPLELPAD
                     RPRPPVRTSAGDRVLFTVPAGTARRLTELGRTAGGTLFTALTAGVQLFLARLTGQRDIV
                     LGTVDSGRLRAELADLVGFFVDTLALRADVD"
     aSModule        14873..17494
                     /domains="nrpspksdomains_AQI70_32580_Condensation_LCL.1"
                     /domains="nrpspksdomains_AQI70_32580_AMP-binding.2"
                     /incomplete
                     /locus_tags="AQI70_32580"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       14939..15055
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0006"
                     /evalue="1.60E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="AQI70_32580"
                     /protein_end="672"
                     /protein_start="633"
                     /score="55.9"
                     /tool="antismash"
                     /translation="AAYNCATGLRLHGSVDPEALGAALTALVARHEPLRTSFP"
     CDS_motif       15281..15343
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0007"
                     /evalue="6.10E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="AQI70_32580"
                     /protein_end="768"
                     /protein_start="747"
                     /score="34.7"
                     /tool="antismash"
                     /translation="HHIAADAWSMEVLTRELGALY"
     CDS_motif       15419..15451
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0008"
                     /evalue="5.10E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="AQI70_32580"
                     /protein_end="804"
                     /protein_start="793"
                     /score="15.8"
                     /tool="antismash"
                     /translation="QYADFAAWQRA"
     CDS_motif       15707..15796
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0009"
                     /evalue="3.00E-11"
                     /label="C5_LCL_267-296"
                     /locus_tag="AQI70_32580"
                     /protein_end="919"
                     /protein_start="889"
                     /score="35.7"
                     /tool="antismash"
                     /translation="DIVLGTVDSGRLRAELADLVGFFVDTLALR"
     CDS_motif       15845..15964
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0010"
                     /evalue="1.40E-14"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="AQI70_32580"
                     /protein_end="975"
                     /protein_start="935"
                     /score="46.4"
                     /tool="antismash"
                     /translation="RRTAADAVAHSLVPFDRVVDAVLPGRDPSIPPLVQVMLVL"
     aSDomain        16301..17494
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AQI70_32580_AMP-binding.2"
                     /evalue="2.40E-105"
                     /label="AQI70_32580_AMP-binding.2"
                     /locus_tag="AQI70_32580"
                     /protein_end="1485"
                     /protein_start="1087"
                     /score="344.3"
                     /specificity="substrate consensus: Val"
                     /tool="antismash"
                     /translation="FARQVARTPDAVAVHQADTRLTYADLDARANRLAHHLRERGVRTG
                     DRVGLSLPRGTSLIVALLGILKAGAAYVPVDPAYPVARQEFMLDDSEAVLLVTDAAGGR
                     RLGTDRRPLVLVDTDRQAVEAAPAGPVDAGLTPDHGAYVIYTSGSTGTPKGTLTPHRAI
                     DRVVRHTPYIELTPQDVVAQAASVSFDAATFEIWGALLNGATLALAPAGVLDPPELREF
                     LTTHGVTTLWLTAGLFHEVVDADIEALAGLRHLLAGGDALSPRHCRAVLEQLPGTTLIN
                     GYGPTETTTFAAAGALRPADLARETVPLGGPIGDTRLYVLDDRLRPVAPGVGGELHIAG
                     EGLAHGYVNRAALTAERFVADPFGEPGGRMYRTGDRVRWTADGSLEFLGRGDGQVKIR"
     CDS_motif       16487..16528
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0011"
                     /evalue="8.70E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="AQI70_32580"
                     /protein_end="1163"
                     /protein_start="1149"
                     /score="18.8"
                     /tool="antismash"
                     /translation="LGILKAGAAYVPVD"
     CDS_motif       16721..16780
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0012"
                     /evalue="8.80E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="AQI70_32580"
                     /protein_end="1247"
                     /protein_start="1227"
                     /score="27.5"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGTPKGTLTPH"
     CDS_motif       17147..17170
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0013"
                     /evalue="1.50E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="AQI70_32580"
                     /protein_end="1377"
                     /protein_start="1369"
                     /score="5.4"
                     /tool="antismash"
                     /translation="YGPTETTT"
     CDS_motif       17288..17374
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0014"
                     /evalue="2.10E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="AQI70_32580"
                     /protein_end="1445"
                     /protein_start="1416"
                     /score="42.4"
                     /tool="antismash"
                     /translation="PGVGGELHIAGEGLAHGYVNRAALTAERF"
     CDS_motif       17459..17524
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AQI70_32580_0015"
                     /evalue="1.70E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="AQI70_32580"
                     /protein_end="1495"
                     /protein_start="1473"
                     /score="32.9"
                     /tool="antismash"
                     /translation="FLGRGDGQVKIRGFRVEVGEIE"
ORIGIN
        1 ttactcctcc ggctcccagg cctggagcag gtcgaagagc tttcggttgc cgtcgagctt
       61 cagggagtcc accggaacac ggccgtacag ggtgaggacc aggtcactgg ccgtgccccg
      121 ggctaaggcg gtggccgcgt ccaggtcctc ggcggcggtg gtggtgggga gacgggtggc
      181 ccgggcgccg tcggcggaga gtgcgaggcg ccaggagggg ccctcggtgg cgtggaagtc
      241 ggcggtggcg gcctcgtgcg gccaggcgct ggtcgtcgcg cagcaggtgg acaggaactc
      301 gtcgacaccg tcgagtgccg ctgcgtccgg cagcggctgc ggggcgccca gggcgatctg
      361 ggcgtcgtag gtgtgtaccg cgacttcctg gagctggtgc cgggcgacgg caccggaggt
      421 ctgcggcgac tgcgacgtac cccaccacgt ccagcagccg cgatccgggc cggcctcgcg
      481 cagtgcgctc agcagccgct ccgtcgactc ggccgaccag gccagcaggg cctcgcgctc
      541 ccgaagtccg gccggggcgc tctgcgcggc ggtctcggcc gggcgagcgt cggcaggccc
      601 cgcggcgacg gtgtcggccc agcgccggtg tcccccgccc agatgccgca ccaggtcgaa
      661 cagcgtccag ccggggcagg tcggcacctg cacgtcgagg ctgggcgcgg aggcgacggt
      721 ggcgcggaac gcgaccgacc gttcgtcgat cagccgcagg agcgcgggga acccgagtag
      781 ctctgtcacc ccggatgtct accagcacgc ccggacgacc gcagtcgatt ttcccggccg
      841 gcccggcccg gtcggcccag cgggcccagg gggcggcgcg tgccatgagc cgcatgctct
      901 cgggtgacgg ggtgccctcc cccccgaccc cgctgcgatg ttcaccggac ttccaccctt
      961 ccgcccggga aatggaggtc cgccgaagcg cgaagtgcgc gccacctctg cagcgtgaaa
     1021 tcggttgtcc ggcggcttgg ttgaacgttc attccggcca gatagcggag caatgggccg
     1081 gatttctctg cgttcgcggt tcacccgcat tccaagcccg tgctgatccc cgcgagtcag
     1141 aaaacgatta ctgcgcctgg ctctgcccga ggtacagctg tctccacgct tgatgggtag
     1201 ttggctgaac ccggcattct cctgtgaacc ttctgttgac ggccctgcgc gggcggtacg
     1261 ttatgggcgt cgaatgccgt tccggcattc cgtgcttccc tccgtatcgg agggggcaca
     1321 cgtcaatcca cgctgaggtg cgagcatggg gcggggctgc atggaagagt catccgagga
     1381 aggcgacgag atcgttattc ttgaggacgc ggtcaagacg tacgaaaatt tgatcgattc
     1441 cgcgtcgggc attcgcggtg tgaacctcgt gttacggaaa gggagatttc tggcggtgat
     1501 ggggcccgag gaatcgggca aggcaacttt gttgcgatgc ctcgccggac aggtccggct
     1561 gaccgccggc accctgtggc gcgaccccga ggccgccgac gccgtgctgt gccggggcgc
     1621 actggacgag cgggctctcg ccgggccgcc ccggctcttc ctcgtcgacg gcgccgagcc
     1681 ggcgcactgc gcgctgctgc gggacgccgt cgacgacggc cgcgcggtgg ccgccgtggt
     1741 gaccaccgag gacgtgacgg cagccgccgc cgcggacgcc gtgctgttcc tgcaccaggg
     1801 tcgcgtcgtc gacatggtgg ccggcgcgaa ccccgagcgg atccgggagt gcctcagctg
     1861 gttgggcggg gaacaggagt cgtgagcctg cgggcgacca gatcgagcag cgcggcaggc
     1921 tggtgcagga agaaatggtc gccctcgagc tcgaacgact cgaaggaacc cgtcgtgtgc
     1981 cgcgcccaca gccgcacctc gtcgtgcccg gcctcgggat cggtcgagcc ggcgaacgcg
     2041 gtgaccggcg tggacacttg ggcctcggca ggcggcacgg agtcctcggc cagggcgaag
     2101 tcggcccgga tcatgggcag gaggagctgt agcacctcct cgttggcgag cacttcgggc
     2161 ggagcaccgt tcatctcccg tatctccgcg accagttgct cgtcgggaag ttcgtgccgc
     2221 agcaccctgc tgtgctgcgg cgcgcacccc gccaggaaca gacggctcgg cgtcggcgcc
     2281 cccacggcgg ccagatggcg ggcgagagcg aacgcgatct ggccgcccat gctgtggccg
     2341 aagaacgcga acggcttgtc gaagacgggc gccaagtgct cggcgagcgc cgccaccaga
     2401 gcgtcggcgc gggtgaacgc gggctcgctg tagcgttcct cgcggcccgg cagcagcacc
     2461 gggcacacct cgatcccgtc gtccaggtgg gtgtgccagt tgcggaagat gctggaaccg
     2521 ccgcccgcgt acgggaagca gaagagccgg accgcggcgt cgggccgggc cggcctggct
     2581 accgtccacc gtggggcggt ccgggcgcgc gagcgggact gttgctgggt catgcctgtc
     2641 acctttccgg ggtgtccgtg gcgggagtgg gagtgagcgc gggctcggcc ggtgcctcgc
     2701 ccgtcacctg ggtgaaggag cgcagggccg ggctgagtgc cgcgccgacg ccggccagca
     2761 gcagggcgcc ggcgcagccg agcacggcgc cgcgccagcc gacggtctcg acgagcgtgc
     2821 cgcccagcag cggccccgcc gcgcccgcga ccccgccggt gagtccgagc gcggcactga
     2881 cccgcccgcg cagccggtcg ggcgtcgacg ccatctggta ggtcaccacg gccgtctgca
     2941 cggtcggggc gaggaaggcg atcacgccga gcacggcgcc gaacagcagg gcgtcggccg
     3001 tcgtggccag cagcggggtg agggcggtgc tcacccaggc cagcaccagg atcgcggtcc
     3061 tcggcgtcat caggcgctgg aaccgagggg cgagcagcgc tccggcgagc ccgcccgccc
     3121 cggtcagcac gccgatcagg ccgatctgcc cggtgggcac cccggcacgc tcggcggcgg
     3181 ccagcacgat caggttcagg gcgttgaagc agatgctcgc catgaccgcg accagcaggc
     3241 tcgcgcggat gactgggttg cgggcgatcc agcggacccc ctcaccgacc tcgtgcacca
     3301 gggagcgccg ttcggacggc ggacggtgcg ccttgatacg ggtgcacagg atgagcagac
     3361 ccgacagcgc gtacgtcagc gcgttcgcca ggaacggcag tgcgcggtgg gcgctgaaga
     3421 gcagaccgcc gatgccggga ccggccagcg tggcgacgta actgcgggcg gcggtcaccg
     3481 ccaccgccgt cgacagctgg ctcttgtcca ccacttgggg gagtacggcc tcctcggccg
     3541 gcgcgaacag cgcggcggcc accccgtcga cgatggcgac cagcagcacc aggccgaacc
     3601 cggccgagtc ccgcagcagg gccagcgcga gggcggtgat caccggcagc cgggccaact
     3661 cgcaccagag catgacccgt cggcggtccc agcggtccgt cagggccccg gccgggacca
     3721 ggacgacgag ccgggtgacg gcgctcaggg cgctggccgc accggcctgg accgcggaac
     3781 cggtcagggc cagcaccagc agcggcaggg cgaacaccga gatctgggcg ccgagttcgg
     3841 acagaacctg acttgaccac aacaggttgt agtttctgtt gcggaacagc ggcgtgggtg
     3901 cttgaggagt ttccagcgtc gctgtccttc ctgtgcgcgg gcccgtacgg ccaggtgcat
     3961 gctggcatcg ccgcccgcgg ccggacaggg ctttaaacca cgcgtcaaac gcgctggtgg
     4021 cagcggttcg ggcaggccgt cggccggtgc ggaaccagca atggtggtgc aggcttcacc
     4081 ccggttcggg tgcgcggtgt actgcccgca accccgcggc cgggcagcat ggaggagacg
     4141 gcgcggcggg gccgcgtgac gcgacgagca cggagtggag tgggagttct catggcacgt
     4201 tcgaccgact acgacgagga gcgcgcctcc cggaaggcca ggggagcgtg gtacgtgccg
     4261 ccactgctgg tgttcttcgt gggcgccatg ctcacgtccg tggtctcgca cgccgtggac
     4321 ggcggtacct acaccgccgt catgagcgcg ggattcgccc tcgacgcact cgcggtgatc
     4381 tgggcggtcg tccgctggcg gcgatccgcg agctgagaaa gcactcaggg agagaatgca
     4441 gaatgaagtc gtcactgggc atgcggacgc gcttatcgga aaggcgccgg aggttcgccg
     4501 ggatcctggc cggcggaatc atcgccgtcc cggccaccct cggcctgacc gcctgtgatt
     4561 ccgcgcagga cgcgctggat cggggcgaca tgtgcctcaa cattctggac atcgcgcttt
     4621 tcgaccccaa cccgtcgagc gcggacgagg cccgtaagga cgtccgtgaa cgcgccgaca
     4681 agattgacga gatcgccgaa aaggcctccg acgacaaact gcgggacgcc gcggagcaga
     4741 ccgcgaagga actgcgggac gccgccgacg acgatctgga tgcgggatcg gtctcggagt
     4801 acgtgtcaca gcagaacgac cggctgaagg cactgcgcaa gacgtgctcc gatctcggtg
     4861 acttcggctg acacgcacca ccgcagagcc gggagtccgg ggtcccggaa gacatccccc
     4921 gcaccgtgga gttcggattc ccccaagggc gtccggggcc ggcgccccgg acgccctttc
     4981 tgcttcccgg ccgctgcccg gcggcgccta ggccctgtcg tttggatcag cccggcgtcg
     5041 cggggtctgg tgcgcacatc tgccgcgttg tcgtcagtcg ccatggctcc gccatgactc
     5101 cctcctccgc cttgcagctg cacgcaccag accccgctcg ggtcgcccgg aaggcaccgc
     5161 acctcacagc cgacctgatc caaacgacag gacctaccgg gacgcctcgc cggagatgtc
     5221 gttgcccagg tacgcgagga ccgccagaac ccggcggtgg acgctggtgc cctccgcggg
     5281 caggttcagc ttgtcgaaga tgccccggat gtgcttgctg acggcccgct ccgtgacgaa
     5341 gagccgttcc gcgatggccg cgttggccag cccctgggcc atcagctcca gcacctcgtg
     5401 ctcgcgcgcc gtcagcccct ccagcgaccg ggtcgacgcc ctctgctgga tgatctcgtt
     5461 gaccacctcg ggatcgaggg cggtgccgcc ctcgctgatg cgctccaggg cctccaggaa
     5521 ctgctccacc cggccgaccc ggtccttgag cagatagccg accccgcggg cgcccagggc
     5581 cagcagctcc gcggcgtagg cctgttcgac gtactgcgac agcaccagga tgggcagctc
     5641 ggggaactcc tgccgggccg cgacggccgc gcgcaggccc tcgtcgcgga agctcggcgg
     5701 cagtcgcacg tccaggaccg ccgcgtccgg ctcggtgcgg cgcagggtcg gcatgatctc
     5761 gggtcccgat gcgcacgtgg ccaccacctc gtggccgttg cgggtcagca gcagcgtcat
     5821 gccctcccgg agtaatgcgt tgtcctccgc gatcaagatc cgcatggcag ctccaccttc
     5881 atcctcgtcg gccccccggg agggctcgtg atctcggtcg tgccgtcgag cgccgcgacc
     5941 cgtcggcgta tgccgagcag cccgcttccg ccgtgttcct cagccccgcc gcgcccgttg
     6001 tcggtcacga cgacctgcag cgacccgtcg gcccgggtga agcgtactga ggcctgggtc
     6061 gccccactgt gcttgcggat gttcgtcaga cactccgcga tcacgaagta caccgcggcc
     6121 tccacggccg ccggcagccg gtgaccgttc tccacggccg ccaggttcat ctcgaccggg
     6181 atgtcagcgg acaccgcgag cgtgcgcacc gctccggcca gaccgcggtc ggtgaggacc
     6241 gggggatgca ccgtacggac gatgccccgc agcgccgcga gcgtggcgtc gatctcctcc
     6301 tgggcctcgt cgagccactc cgtcgcggca tccgggtcgt tccgcacctg ctggcgcgcg
     6361 agcccgatgc gcatggacag cgccaccagc tgggcctgca ccccgtcgtg cagatcgcgc
     6421 tcgatgcggc gcagttcggc gctgtgggcc tccatggcgc cggcccggga ctcggacagc
     6481 tccgcgacac gttggccgag tttcgtcgag gccgacggct tgagcagcgc cgccgtccac
     6541 cgggcctggg cgtccgccag gatctcgaac acgggcagca gcagcgcccg agggggttcg
     6601 ggagcggggt cgaagggcgc ggtgtccctg cgctccagcg accggcggac cgcggccgcg
     6661 gtgccgtcga cgagcagcgt caggggccac aggaccagca cgaccgcgct gaagccgagg
     6721 atgctgacgg tcgcgaaggg taaccagagc gcgtcgcgcc aggtaccggg gtcggtgagc
     6781 gccagccgca cccggtcgct gggcgagccg tccagcggca ggtacagctc cgggatcggc
     6841 ttgcccagcc agccgccggc ccggacgcgt tcgtatccgg cgaaccggcg cagtatgcgc
     6901 acgatctccg gccaggccgg cgcgccgatg acgaacagcg tgaagaacac cccgatcggg
     6961 accgcgaagc agcccaggaa cgcggccatg gccaccggaa cgccgaagaa caggtggcag
     7021 gacgcctgcc aggaccgccg cagctgggag gagaagtacg ccatgaaagc acggtagttg
     7081 gcggtgcggc ccgcgggcgg tgtgcccatc tccccagacc ccggtggtgc tggctgaacc
     7141 cgggaatggg tgggcgctcc atcgtgccgc cccggggccc ggacctacag tcgccacagg
     7201 tggaggatcc ctccctcgca tcccccgaag gacgaggcga ggcaggtgaa cgacacggtc
     7261 ggtgaccgcg acctggaagg cgaatcaatg tcacttcgca tggggagaag gacccctacg
     7321 cccgccggcc cgacgcgggc ggcaggccgc gacacggcgg gcgcccacgc gctcaccctc
     7381 gactccgtca cccggcgcta ctggcgcggt gggaaggact tccacgcgct ggaggacgtg
     7441 agcatggaag tgccgcaggg tcatttcctg gcggtcatgg gccgctccgg ctccggcaag
     7501 accacgttcc tgcagtgcgc cgccgggctc gaccagccca cctcgggcac ggtgtggatc
     7561 ggcgacaccg acctgtcccg gctgtccgag gcggcgttga cccggctgcg cagggaccgg
     7621 atcggcttcg tcttccagtc cctgaacctc gtaccgtcgc tcaccgtcgg cgagaacacc
     7681 gccctgccgc tgctgctgcg cggcatgaac ccccaggacc ccgcggtgcg ggagcgctcc
     7741 ctgaaggtgc tggacgccgt cggactggcc gaccgcgcgg acgactcgcc gttacggctg
     7801 tcgggcggcc agcagcagcg cgtggccatc gcccgggccc tggtcaccga ccccgccgtg
     7861 atcttcgccg acgagccgac cggggcactc gacccggtca ccgcccgcga ggtcctgcaa
     7921 ctgctgcgcc aggccgtgga cgtgtcgggg cacaccgtgg tgatggtgac ccacgacccg
     7981 caggccgccg cctggaccga cgaagcgatc ttcatcgagg cgggacgcat cgtcgcccga
     8041 gaggagcgcc ccggtccgga gaccgtggcc cggcggctcg cccagctcgg ggagcgatga
     8101 ccgtggccgt cgacacccgg cagcccgcag gccgcacccc ggcccgggaa cggcacggag
     8161 agtcggtggg gcgcgtccag cgcaccgccc acttcctcgc ccgccgctcc atgcgtctgc
     8221 accgcaaggc ctgggccgcc gtgttcgcgg ccctcgtgct caccgcactg ctcctgggca
     8281 gcttcgccct cgccaccctc tcggcgttcg tggggcacgc ccacgtcgag cggtacgccg
     8341 ccaccacggc ggtggtcgcc gccgaccaga gcacccggta ccgggccaag ccgtggggcg
     8401 acccgccgac caccgtgacc cagtcgctca ccgaacgcgt ccgcgtcccg gccgacgtcg
     8461 tggaccggct cgccaaggta cccggcgtcc gcgccgccat cccggacagc agcttcccgg
     8521 tcgcgctcgc cggccccgac ggccggggcg taccgggacc ggacagcgac tccggcaccg
     8581 cgcccgtgta cggccacggc tggcctacgg cggcactcgc cccgttcacc ctgcgggcgg
     8641 gcaaggctcc ctccgcggcg cggcaggtgg cgatcgacgg cgacctggcc gcgcgcgcgg
     8701 gggtcggcac cggcgaccgg atccggctgc agacgctcgg cgcaccggcc gagtacgtcg
     8761 tctccggcat cgtcgccccc gacggcgagg ccgacgacac cggcctcgcc caccagggcg
     8821 ccgtcttctt caccgaggac caggccgtcc ggctgtccgg ccaccccggc accgtggacg
     8881 ccatcggcgt gctcgccgcg gacggcgtga gcgtgcacca gctctacccc gagctgcgca
     8941 aggccctcga cggcgcggag ccggcgcggg acgccgtcgc cgacagccgg gaccggcagg
     9001 actcctcccg gctgcgggtg ctgaccggca acgggcgcgg ccaggccgag ttcctggagg
     9061 cggcgccgag ccgggccagc ctgctcaacc tgctggccat gctgtgcgcg accgtcatca
     9121 tgatcgccgt gctcgtggtg gccggcaccg tcagccaggc ggtgcaccag cgggcccgtg
     9181 aactggcgct gctgcgcgcc gtcggggcga cgccctggca gctgcgggtg acggtgggcc
     9241 gggaggtgac cggagtcgcc accacggccg ccgtgctcgg cgcggtgggc tccctcccgg
     9301 tcttcctgat gctgctgtgg atgctgcgcg accggggcgc cgtccccgtc gggctcgacc
     9361 tcccggtcct gccgtggatg ttcgccaccc ccgtgctgac ggccgtcctc accctggtcg
     9421 tcgcccgggt ctcggccgcc ctggcgtgcg gacgcatcgc caagatccgt cccgcgcagg
     9481 ccctcggcga ggccgcgagc gaacccgggc agcccggccg cggccgtacc gtcaccggcc
     9541 tcgtcgtcct cttcgccggc ctcagctccg cgggcaccgc ggcgctgcag tcgggcgaac
     9601 tggccgccat ggccgcgggc agcgcggccc tcgccctggt gatcgcctgc gcgctgctcg
     9661 gcccgtggat cgcccgcgga gccatgcgcc tgctcgcacc gctcacccgg cggctgggcg
     9721 gcgccggcgg ctacctcgcc gccgcgtcga ccacggcgaa ctcgcgccgg ctgggcgcgg
     9781 ccatcacccc ggtcgtcctg gtggtcgcct tcgtgggcgt ccagctcgcg gcgggcgcca
     9841 ccatggacca cgagggcagc gcccaggccc ggcaggcgat gcgcgccgac ctcgtggtga
     9901 ccaccgagga ggccggactg cccgccgagg ccgcgcggga cgtggccgcc gtgccgggtg
     9961 tcgaggccgc cacgggcgcc ctccacagca cggtcgtgct cgcccggcga gaggccggtg
    10021 accccgtgct ggagcggctc ccggtggtgg gcgtcacgcc cggcgccctg cccgcgacgc
    10081 tcgatcccga cgtcacctcc ggatccctgc gggacctgcg cgagggcacc gtggcggtgg
    10141 gcgccgcccg ggccgactcg ctggacgtga aggtcggctc caaggtccgg ctgcgctatg
    10201 gcgacggcgt cgtcgcctcg ctgcgggtgg tggcggtcta cgaacgcaac ctcgcgctcg
    10261 gtgacttcct gttcgcgcgg gacgcgctgg ccccccatgt gtccgccccc ctggacaccc
    10321 gcgtcctggc ccgggtcgcc ccggacgccg accgggacgc cgtacagcgg gcggtgcgcg
    10381 aggcactgtc cggtgccgcg ctcgacgtac aggtggccgc gaacccgagc ccggagcacc
    10441 tgcggtccga ggaccggggc gtgagccagg tgctcaccac cgtggccgtc ggcgtcgtcg
    10501 gcgggttcac cgtcatcgcc gtcctcagca ccctggtgct gatcctgatc ggacgccggc
    10561 aggagctggt gctgctccgg ctggtgggcg cggggcgacg ccaggtcagg cggatgctgc
    10621 gggtcgaggc ggcgatagtg atcgtcaccg gactggtggt cggcgcgctg gccgcgctga
    10681 tccccctcac ggcgttcagc ctgtccgtca ccggatccct gccctacctg ccgccggtcc
    10741 aggcgggggc catcgtcctg gtcgtcgtcg tgaccgtggc cgcgggcatc ctcctgcccg
    10801 cccgcccggc gctgcgccga cggcgcccgg cggcgctgca gcggccctga ccgcagatcc
    10861 gccgccccgt caacaaaggc cgtgcgaggg ccggttgggc ggggcaggat cgaacgcgac
    10921 gcgacagaaa cgcaacagag atcgaggagc cgcacccatg gcccgtatcg ccgcagtcct
    10981 gctcaccctg gtcggagcgg cggcgctggt gctcagcgcc ttccagccct ggtacgaggg
    11041 gcgggagccg cgcgaggtgg cgctgacgga cctgttcacc ggcctggagc ccgccgcggc
    11101 cggcggcgcc gccacctcca tgctgctgcc gctggtcgcc gtggccgccg tcgccgtgct
    11161 cggcctgctc gtccggtccc gggccgtgct ggccgtggcc tgcgtggcgg gcctggcgac
    11221 ggggatcctg tggaccgtgc agcagatccg tgcggtggct cccgtcgcct tcgaggtgac
    11281 cgaggtgcag cgcgggctgt ggaacgccgg tggcggggtt ctggcgctgg tgatcgccgc
    11341 catcgtgctg ccgccgcgga cctgacggcc cgcgcgtgac gtgggcgcct cccgccgggc
    11401 cgccgtcggc gtccgaccgg cgcggcgccc acggactgcg tgtttgcgac agagctaaat
    11461 ctcctgttcg atttggcccc gctcgccgag gatttccccc gggcggtgcg ccgcgagacg
    11521 gcatccgaac accgccttcc atggaatacc catgcgactg gggaggcggg gttcgtccgt
    11581 gtctggcaca ccgacgagaa catggcccga aacgtgccct gaccgggaca cggtgaaaga
    11641 actcgcggaa agctgcgatg tggtcggcgg ccaattggcc gtcctccatc ggggcgccct
    11701 gaccacctgg gcattcggca ccgaggaata cgaaaccggg cggccggtcg gcgaccattc
    11761 ccttttcgcc tacgggtcgg tgaccaaggc gttcacggcg gccctgctgc tgcaactcgt
    11821 ctccgacggt gacctggacc tggaccgtcc gatcggcagc cggatgccgg cccgccggcc
    11881 cgccgcccag ggcgtgtccg ccgccacccc acgcatgctc ctcagccaca ccgcgggcct
    11941 gccctccgac cacgacgacg agcgggcgcg cagcctgcgg gactggtacg agggcttcct
    12001 ggaccgcgcc ggcacccacc cggcggggtg gccggcgcgc ggggcgttct cgtactccaa
    12061 cgtcggctac ggcatcgccg gccgcctcat cgagaccgtg accgagctgt cgtggtggga
    12121 ggccctgcgg agctacctgc tcgaaccgct cggcaccggg gtccggctgc tcggcggcac
    12181 ccccctcgat cccggcccca accccgcgcc ctgcgggcac cgcacccgca ccggcgccga
    12241 cggcaacccg gtcgtgcacg ccgtcccggc acggaccgac gccggatcca tggccgccgg
    12301 cggtctcgcc ggcagtgcca cggacctggt gcgcttcgcc cggctgcacc tggcccggcc
    12361 ggcggaccgg gaccacgcgg acctcgtcga cccggacgta ctgcgcgaga tgggccgccc
    12421 ggtgcccgga ccgggtccct acgggctggc ccactcctgg ggcgcgggac tgggcctgtt
    12481 cggccgtccc ggcagcctct ggctcggcca cgacggggcc ctggacggca ccacctgcca
    12541 tctgcgcatc cgccccgacg acggcacggt ggtcgccctg accaccaact ccgcgacggg
    12601 agtgcggctg tgggacgcgc tggtgcaacg gctgcgcgac ggcgggatcg acgtgggcgt
    12661 acacgaaccg gaggtcccgc cggcggtgtc cgcggcgcgg ttcgcggaat gcgcggggac
    12721 gtaccgcaac ggcgacctca ccgtcgatgt cgtcgtcgcg tccgacggaa tgacgctacg
    12781 gctgccgggc ggtctgtccg agcacctcgt gccccgcgcc ggcggcgtat tcagctcggt
    12841 gggaaccgaa ttccccgcca cgctcggacg attcgtcaag gaccgcacga cgggccgtat
    12901 tcaggccctc caatacagcg ggcgcaccct gctgagggaa cttcgcccga cgtgagcacc
    12961 gacgaaccgg cgcagcggaa ccgggcagtt ggatattcct tttccattcg gcgttttctg
    13021 ggttttctgg ggtctcgcaa tgaagtctga cagcagcact caccagcagg tccggcagcc
    13081 gtccggcggc gtcaccctgc acggcctgtt cgaggcgcag gcggcacgac gccccgccca
    13141 cccggccgtg gagtgcggca cgacggtgct gacatacggc gaggtggacc gccgcgccaa
    13201 ccggctggcc caccggctgg ccgagctggg cgtcggcccg gagacccggg tcggcgtgtg
    13261 cctggagcgg ggcccggacc tcctggtcgt cctgctggcc atcctcaagg ccggcggcgc
    13321 ctacctcccc ctcgaccccg gctacccctc ggaccggctg gagttcatgg tcgccgacgc
    13381 ggacgtccgg ctcgtcgtca gcagccgcga ggccgccaac cgcccggccg gcgaccccgc
    13441 cgtcctgctg ctcgacggcc ccgccggcct ggacacctcc caccccgaca ccccgccccg
    13501 ggtgacggtc ctgcccgaca acaccgccta cgtcctgttc acctcgggct ccaccggccg
    13561 ccccaagggc gtcgccgtca cccaccgggg catcccgcac ctcggcgccg cgcacgcctc
    13621 ggctctcgcc atcgacggcg acagccgcgt gcttcagttc gcctcgccca acttcgacgt
    13681 ctccatcgcc gacatcgtgc agacctggta cgcgggcgcg accctggtgc tgccctcccg
    13741 ggccacccag accgtcggcg acgccctggc cgagctgctg gccgacgcgg cgatcaccca
    13801 cgccatgatc ccgccctcgg tgctggccac cgtcccgccc accccgctgc ccggcctgcg
    13861 cgccctggcc accggcggcg agccctgccc gcccgaggtg gtggcccggt gggccgccgg
    13921 ccggcgcatg ttcaacgcct acggccccac cgaggcgacc gtgacggcga ccatgaacgg
    13981 gccgctggcc accgacctcg gccaggcgcc cggcatcggg cggcccgtgg acggcgtacg
    14041 ggtcctcgtc ctcggcgagc agctgcgccc cgtgcccgac ggcgaggtcg gcgaactgtg
    14101 catcgcgggc gaaggagtgg gccgcggcta cgtcaaccgg gccgccctga ccgccgagcg
    14161 gttcgtggcc gacccgtacg gcgaggcggg ctcgcggatg taccgcaccg gcgacctcgc
    14221 ccgccgactg cccgacggca ccttcgagtt cgtgggccgg gccgacgacc aggtcaagat
    14281 ccgcgggctg cgcgtcgagc tcggcgagat cgagaccgcc ctcaccgaac acgaggccgt
    14341 gctccaggcc gtggtcgtcc tccgcaagga ccaggggccc ggccggctcg tcgcctacta
    14401 cgtgcccgcc gacaccgccc gcccgcccgg ccaccagacc ctgcggcacc acctgaccgg
    14461 ccggctgccc gcccacatgg tgcccgcggc cctcgtcccg ctggaccgct tccccctcac
    14521 ccccaacggc aaggtcgacc gcgcggccct gcccgccccc gaggcgcccg ccgggcccgg
    14581 cacccacgcg cacaccgagc cgcgcgacga gaccgagcgt gccctcgccg ccatctgggc
    14641 ggagctgctc ccggtggagc ggatcggcgt gcacgacgac ttcttcgccg ccggcggcga
    14701 ctccatatcc gctctgcgca ccgccttcca ggtggagcga cgcctcggcg tccccctcga
    14761 agccgccgcc ctcttcgacc accccaccgt cgaacggctc gccgcccaac tgcgcaccct
    14821 cgcccggcag cagactccgc agcggcccgc catcaccccc gtcccccgcg ggcagcggct
    14881 gccgctgtcc gccgcccagc agcgcctgtg gttcctcgac cgccacgaac cgggctcggc
    14941 cgcctacaac tgcgccaccg ggctgcggct gcacggcagc gtcgaccccg aggcgctcgg
    15001 cgccgcgctg accgccctgg tcgcccggca cgagccgctg cgcacctcct tccccgagga
    15061 ggacggcacc ccggcccaga tgatcgccga acccggtacc gtgcgcgtcc ccgtgcccgt
    15121 cgaggacctc accgcccgga ccccggccga acgcgaccgg gcactggacc ggctgctgcg
    15181 cgccgaggtc ggcgccccct tcgacctcgc caccgcgccg ctgctgcggg cacgcctggt
    15241 gcgcacggcg cccgaggagc acctgctggt cctgacggcc caccacatcg ccgccgacgc
    15301 ctggtcgatg gaggtgctca cccgcgagct gggcgcgctc tacgccgcca cgctgcggga
    15361 cccgaacgcc cggcccgacg ccctcgccac ggccgccggg ctcgccgaac tccccctcca
    15421 gtacgccgac ttcgccgcct ggcagcgcgc cctgcaggac accccggagg tggaggagca
    15481 gctcgcccac tggaagcggg tcctggacgg cgcggtcccc ctggagctgc ccgccgaccg
    15541 gccgcgcccg ccggtgcgca cctcggccgg cgaccgtgtc ctgttcaccg tgcccgccgg
    15601 caccgcacgc cggctgaccg agctgggccg taccgcgggc ggcacgctgt tcaccgcgct
    15661 caccgccggt gtgcagctct tcctcgcccg gctcaccgga cagcgcgaca tcgtcctcgg
    15721 caccgtcgac tccggccgcc tgcgggccga actcgccgac ctggtcggct tcttcgtcga
    15781 caccctcgcc ctgcgcgccg acgtcgacga gtcgctgacc ttcgccgagt tcgtcgcccg
    15841 cggccgacgg accgcggccg acgccgtcgc ccacagcctg gtccccttcg accgggtcgt
    15901 ggacgccgtc ctgcccgggc gcgacccgag catcccgccg ctcgtgcagg tcatgctcgt
    15961 gctccagaac gtgcccggtg gcgttcccga gctgcccggg atccgcgtcg aggaggccgt
    16021 cctgccccgg gaggccgccc tgttcgacct caccctggag ttctggccgg gcgacgacgg
    16081 ctcgctcacc gcctccgccg agtacaacac cgacctcttc gaccgcggca ccgtcgagcg
    16141 cttcgcgggc catctgcgca ccctgctcgc cgcactcgcc gagaccccgg accgccccat
    16201 ggccgacgcc gccctcctga ccgaccggca gcgccgccgg gtgctccagg agtggaacac
    16261 cgccgagcgg ggcgtggcgc cggccaccct caccgacctg ttcgcccgcc aggtcgcgcg
    16321 cacccccgac gccgtcgccg tccaccaggc cgacacccgg ctcacctacg ccgacctgga
    16381 cgcccgtgcc aaccggctgg cccaccatct gcgcgagcgg ggcgtgcgca ccggcgaccg
    16441 cgtcggcctc tccctgcccc gcggcacctc cctgatcgtc gccctgctcg gcatcctcaa
    16501 ggcgggggcc gcctatgtgc ccgtggaccc cgcgtacccc gtcgcccgcc aggagttcat
    16561 gctcgacgac tccgaggccg tactcctggt caccgacgcg gccggcggcc ggcggctcgg
    16621 caccgaccgg cgccccctcg tcctcgtcga caccgaccgc caggccgtcg aggccgcccc
    16681 ggcgggaccg gtcgacgccg gcctcacccc cgaccacggc gcctacgtca tctacacctc
    16741 cggctccacg ggcacgccca agggcaccct caccccgcac cgggccatcg accgcgtggt
    16801 gcgccacacc ccgtacatcg agctcacgcc gcaggacgtc gtcgcgcagg ccgcgtccgt
    16861 ctccttcgac gccgccacct tcgagatctg gggagccctg ctcaacgggg cgacgctggc
    16921 cctggccccg gccggcgtcc tggacccgcc cgagctgcgg gagttcctca ccacccacgg
    16981 cgtcaccacg ctctggctga ccgccgggct cttccacgag gtggtggacg ccgacatcga
    17041 ggccctcgcc ggactgcgcc acctgctggc cggcggcgac gccctctccc cgcggcactg
    17101 ccgcgccgtc ctcgaacagc ttcccggcac caccctcatc aacggctacg gccccaccga
    17161 gaccaccacc ttcgccgcgg ccggagccct gcgcccggcc gacctggccc gcgagaccgt
    17221 gcccctcggc ggcccgatcg gcgacacccg gctctacgtc ctggacgacc gcctgcgccc
    17281 ggtcgccccc ggagtcggcg gcgagctcca catcgcgggc gagggcctcg cccacggcta
    17341 cgtcaaccgg gccgccctga ccgccgagcg gttcgtggcc gacccgttcg gcgagcccgg
    17401 cggccgtatg taccgcaccg gcgaccgcgt gcgctggacc gccgacggaa gcctggagtt
    17461 cctcggccgg ggcgacggac aggtcaagat ccgcggcttc cgcgtggagg tcggtgagat
    17521 cgagtccgcc ctcgccgacc acccgaaggt cgcgcaggcc gtggtgacgg ccgtggcc
//
