BGC0001561 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001561 (Streptomyces curacoi)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	17,578	curacomycin	NRPS:Type I	100%

BGC0001561 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 17,578 nt. (total: 17,578 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 17,579
Label		BGC0001561

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001561	1.00	NRP	curacomycin	Streptomyces curacoi
BGC0000900	0.32	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.31	NRP	dimethylcoprogen	Alternaria alternata
BGC0002710	0.28	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000979	0.27	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980	0.27	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000348	0.26	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001132	0.26	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128	0.25	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.25	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001561	1.00	NRP	curacomycin	Streptomyces curacoi
BGC0000900	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0002710	0.62	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000979	0.60	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980	0.60	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000348	0.60	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001132	0.60	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128	0.59	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.59	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 17578:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AQI70_32580

Search NORINE for peptide: strict or relaxed

AMP-binding (23..415): X

nrpys: 6-clTrp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVAMAGAVTK
Nearest Stachelhaus code(s):: 6-clTrp DVAMAGAVTK (97% 8Å match); 5-clTrp DVAMAGAVTK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1087..1485): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWLGGTFK
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)