BGC0001562 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001562 (Streptomyces curacoi)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,betalactone	1	19,443	curacomycin	NRPS:Type I	100%

BGC0001562 - Region 1 - NRPS,betalactone

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Location: 1 - 19,443 nt. (total: 19,443 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,444
Label		BGC0001562

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001562	2.00	NRP	curacomycin	Streptomyces curacoi
BGC0001569	0.79	NRP	dechlorocuracomycin	Streptomyces noursei ATCC 11455
BGC0001133	0.78	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001050	0.78	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000426	0.76	NRP	sevadicin	Paenibacillus larvae
BGC0001814	0.75	NRP	ulleungmycin	Streptomyces sp. KCB13F003
BGC0002071	0.71	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002017	0.69	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0002437	0.68	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0000465	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001562	1.00	NRP	curacomycin	Streptomyces curacoi
BGC0001569	0.72	NRP	dechlorocuracomycin	Streptomyces noursei ATCC 11455
BGC0001133	0.71	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001050	0.71	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000426	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0001814	0.70	NRP	ulleungmycin	Streptomyces sp. KCB13F003
BGC0002071	0.68	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002017	0.67	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0002437	0.67	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0000465	0.66	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19443:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val) + (Orn - D-Asn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AQI70_05495

Search NORINE for peptide: strict or relaxed

AMP-binding (517..929): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DTEDMGFVDK
Nearest Stachelhaus code(s):: Orn DTEDMGFVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1598..2000): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGEVGK
Nearest Stachelhaus code(s):: Asn DLTKVGEVGK (100% 8Å match); Trp DLTKVGEVGK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AQI70_05500

Search NORINE for peptide: strict or relaxed

AMP-binding (423..822): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DALWMGGVFK
Nearest Stachelhaus code(s):: Val DALWMGGVFK (97% 8Å match)
Stachelhaus code match:: 100% (strong)