BGC0001563 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001563 (Curvularia pallescens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	53,000	curvupallide-B	NRPS:Type I+PKS	100%

BGC0001563 - Region 1 - NRPS,T1PKS

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Location: 1 - 53,000 nt. (total: 53,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 53,001
Label		BGC0001563

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001563	1.87	NRP, Polyketide	curvupallide-B	Cochliobolus pallescens
BGC0002250	0.87	Polyketide, NRP	triticone D, triticone E, triticone A, triticone B, triticone F, triticone C	Pyrenophora tritici-repentis Pt-1C-BFP
BGC0001068	0.73	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000996	0.62	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000129	0.59	Polyketide	pyripyropene A	Aspergillus fumigatus Af293
BGC0002216	0.58	Terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0001268	0.55	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0000064	0.55	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0000170	0.54	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0002505	0.53	Polyketide, NRP	xenoacremone A	Xenoacremonium sp. BF-2018a

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001563	1.00	NRP, Polyketide	curvupallide-B	Cochliobolus pallescens
BGC0002250	0.81	Polyketide, NRP	triticone D, triticone E, triticone A, triticone B, triticone F, triticone C	Pyrenophora tritici-repentis Pt-1C-BFP
BGC0001068	0.69	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000996	0.64	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000129	0.63	Polyketide	pyripyropene A	Aspergillus fumigatus Af293
BGC0002216	0.63	Terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0001268	0.61	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0000064	0.61	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0000170	0.60	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0002505	0.60	Polyketide, NRP	xenoacremone A	Xenoacremonium sp. BF-2018a

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 42782:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BAZ95823.1

PKS_AT (556..877): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 77.0
Methoxymalonyl-CoA: 62.5
Isobutyryl-CoA: 52.3
Ethylmalonyl-CoA: 51.7
Malonyl-CoA: 42.1
Benzoyl-CoA: 29.2
trans-1,2-CPDA: 26.0
fatty_acid: 24.3
Propionyl-CoA: 22.9
Acetyl-CoA: 20.2
2-Methylbutyryl-CoA: 14.9
CHC-CoA: 11.6
3-Methylbutyryl-CoA: 10.2
inactive: 0.0

AMP-binding (2914..3328): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFDKFGSIAK
Nearest Stachelhaus code(s):: Phe NHDKFGSISK (76% 8Å match); MalAc NHDKFGSISK (74% 8Å match); Ser DFDTFGGILK (62% 8Å match); Tyr DFESFGNIAK (56% 8Å match)
Stachelhaus code match:: 70% (weak)