BGC0001565: cyclosporin C biosynthetic gene cluster from Beauveria felina
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Location: 1 - 90,396 nt. (total: 90,396 nt).
This entry is originally from NCBI GenBank MF716954.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001565
Short description cyclosporin C biosynthetic gene cluster from Beauveria felina
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MF716954.1
via
Compounds
  • cyclosporin C
Species Beauveria felina [taxonomy]
References
Chemical products information
cyclosporin C Evidence:
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C62H111N11O13
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATQ39424.1
 172 - 2859 (-) hypothetical protein
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    • ATQ39425.1
    		 3732 - 5050 (-) bZIP transcription factor
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      • ATQ39426.1
      		 6927 - 8405 (+) F-box domain protein
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        • ATQ39428.1
        • cycC
        		 9189 - 55043 (-) cyclosporin C synthetase
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          • ATQ39427.1
          		 55629 - 56862 (+) alanine racemase
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            • ATQ39429.1
            		 61295 - 65554 (-) ABC transporter
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              • ATQ39430.1
              		 66945 - 68201 (+) esterase-like protein
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                • ATQ39431.1
                		 68327 - 70087 (-) cytochrome b2-like protein
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                  • ATQ39432.1
                  		 70770 - 79609 (-) PKS
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                    • ATQ39433.1
                    		 80999 - 82103 (+) hypothetical protein
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                      • ATQ39434.1
                      		 83899 - 85773 (+) cytochrome P450
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                        • ATQ39435.1
                        		 86278 - 87537 (-) aminotransferase
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                          • ATQ39436.1
                          		 89054 - 90079 (-) hypothetical protein
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            Unk01
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            D-alanine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk02
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            leucine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk03
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            leucine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk04
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            valine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk05
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            E-butenyl-4R-methylthreonine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk06
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            threonine, 2-aminobutyric acid (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk07
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            glycine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk08
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            leucine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk09
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            valine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk10
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            leucine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk11
                            Type
                            nrps-type1
                            Genes
                            cycC
                            Substrates
                            alanine (evidence: Structure-based inference, Homology)
                            Integrated Monomers
                            Domains
                            adenylation
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-08-02
                            MIBiG v4 annotathon
                            • (ID: JXNPUXPAL6VYCS4XEXVRJDGK)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Added NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2018-08-06
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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