BGC0001566 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001566 (Cylindrospermum licheniforme UTEX B 2014 (Cylindrospermum licheniforme ATCC 29412))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS,T3PKS,PKS-like	1	30,207	High	Cylindrocyclophane D/Cylindrocyclophane E/Cylindrocyclophane F	PKS

BGC0001566 - Region 1 - PKS-like,T1PKS,T3PKS

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Location: 1 - 30,207 nt. (total: 30,207 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 30,208
Label		BGC0001566

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

cylH: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

cylM: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acylase glycosyltransferase methyltransferase

cylD: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

cylJ: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

cylN: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Lyases: hydratase

cylG: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

cylA: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

cylE: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

cylF: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

cylI: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001064.5	3.00	PKS	cylindrocyclophane D, cylindrocyclophane E, cylindrocyclophane F	Cylindrospermum licheniforme UTEX B 2014
BGC0001566.3	3.00	PKS	Cylindrocyclophane D, Cylindrocyclophane E, Cylindrocyclophane F	Cylindrospermum licheniforme UTEX B 2014
BGC0001357.3	1.36	PKS	carbamidocyclophane A, carbamidocyclophane B, carbamidocyclophane C, carbamidocyclophane D, carbamidocyclophane E, carbamidocyclophane F, carbamidocyclophane H, carbamidocyclophane M, carbamidocyclophane N, carbamidocyclophane O, carbamidocyclophane P, carbamidocyclophane Q, carbamidocyclophane R, carbamidocyclophane S, carbamidocyclophane T, carbamidocyclophane U	Nostoc sp. CAVN2
BGC0000282.3	1.02	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001257.3	1.00	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	1.00	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.99	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001164.3	0.99	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002154.2	0.99	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001160.5	0.97	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001064.5	1.00	PKS	cylindrocyclophane D, cylindrocyclophane E, cylindrocyclophane F	Cylindrospermum licheniforme UTEX B 2014
BGC0001566.3	1.00	PKS	Cylindrocyclophane D, Cylindrocyclophane E, Cylindrocyclophane F	Cylindrospermum licheniforme UTEX B 2014
BGC0001357.3	0.75	PKS	carbamidocyclophane A, carbamidocyclophane B, carbamidocyclophane C, carbamidocyclophane D, carbamidocyclophane E, carbamidocyclophane F, carbamidocyclophane H, carbamidocyclophane M, carbamidocyclophane N, carbamidocyclophane O, carbamidocyclophane P, carbamidocyclophane Q, carbamidocyclophane R, carbamidocyclophane S, carbamidocyclophane T, carbamidocyclophane U	Nostoc sp. CAVN2
BGC0000282.3	0.67	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 30207:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (mal)
Non-colinear ordering:: cylD + cylH

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cylA: NH2

CAL_domain (41..477): NH2

minowa: NH2

Prediction, score:

NH2: 183.9
fatty_acid: 25.4
AHBA: 18.4
shikimic_acid: 0.0
Acetyl-CoA: -2.5

cylD: mal

PKS_AT (534..831): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 100.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.4
inactive: 186.7
Methoxymalonyl-CoA: 68.1
Methylmalonyl-CoA: 62.0
Propionyl-CoA: 50.0
Acetyl-CoA: 34.2
2-Methylbutyryl-CoA: 32.7
Isobutyryl-CoA: 32.4
Benzoyl-CoA: 25.0
trans-1,2-CPDA: 23.6
Ethylmalonyl-CoA: 21.7
CHC-CoA: 17.0
fatty_acid: 11.7
3-Methylbutyryl-CoA: 4.2

cylH: mal

PKS_AT (1415..1710): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 167.4
inactive: 165.1
Methoxymalonyl-CoA: 52.0
Methylmalonyl-CoA: 47.8
Propionyl-CoA: 25.9
Benzoyl-CoA: 25.0
Acetyl-CoA: 22.0
Isobutyryl-CoA: 20.9
trans-1,2-CPDA: 13.7
CHC-CoA: 13.1
2-Methylbutyryl-CoA: 10.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor