BGC0001567 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001567 (Streptomyces lincolnensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	30,866	cysteoamide	NRPS:Type I	100%

BGC0001567 - Region 1 - NRPS

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Location: 1 - 30,866 nt. (total: 30,866 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 30,867
Label		BGC0001567

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001567	1.00	NRP	cysteoamide	Streptomyces lincolnensis
BGC0001628	0.47	NRP	JBIR-78, JBIR-95	Kibdelosporangium sp. AK-AA56
BGC0000426	0.42	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.41	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002017	0.36	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0001185	0.34	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401	0.33	NRP	paenibactin	Paenibacillus elgii B69
BGC0002075	0.33	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002437	0.33	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001567	1.00	NRP	cysteoamide	Streptomyces lincolnensis
BGC0001628	0.77	NRP	JBIR-78, JBIR-95	Kibdelosporangium sp. AK-AA56
BGC0000426	0.73	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.73	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002017	0.68	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0001185	0.67	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401	0.66	NRP	paenibactin	Paenibacillus elgii B69
BGC0002075	0.66	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002437	0.66	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 30866:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - D-Asp) + (Val - D-Lys) + (Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SLINC_0742

Search NORINE for peptide: strict or relaxed

AMP-binding (483..877): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSAGFIYK
Nearest Stachelhaus code(s):: Thr DVFSAGFIYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

SLINC_0743

Search NORINE for peptide: strict or relaxed

AMP-binding (483..881): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code(s):: Val DFWNVGMVHK (100% 8Å match); Thr DFWNVGMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1542..1907): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMLIGAVCK
Nearest Stachelhaus code(s):: Lys DAMLIGAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

SLINC_0744

Search NORINE for peptide: strict or relaxed

AMP-binding (453..841): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYWWGGTFK
Nearest Stachelhaus code(s):: Val DAYWWGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1499..1882): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DATKMGHVGK
Nearest Stachelhaus code(s):: Asp DATKMGHVGK (100% 8Å match); CysA DATKMGHVGK (85% 8Å match)
Stachelhaus code match:: 100% (strong)