BGC0001568: cytorhodin biosynthetic gene cluster from Streptomyces sp. SCSIO 1666
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Location: 1 - 58,217 nt. (total: 58,217 nt).
This entry is originally from NCBI GenBank MF773975.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001568
Short description cytorhodin biosynthetic gene cluster from Streptomyces sp. SCSIO 1666
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
MF773975.1
via
Compounds
  • cytorhodin
Species Streptomyces sp. SCSIO 1666 [taxonomy]
References
Chemical products information
cytorhodin Evidence: NMR [1]
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C48H68N2O15
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATJ00741.1
 1 - 1428 (-) ribonuclease BN
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    • ATJ00742.1
    		 1617 - 1892 (-) hypothetical protein
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      • ATJ00743.1
      		 2116 - 2718 (-) CytR4
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        • ATJ00744.1
        		 2743 - 3291 (-) DinB family protein
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          • ATJ00745.1
          		 3458 - 5743 (-) ABC transporter
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            • ATJ00746.1
            		 5797 - 6321 (-) glutathione peroxidase
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              • ATJ00747.1
              		 6529 - 7359 (-) ABC-2 type transporter
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                • ATJ00748.1
                		 7359 - 8345 (-) ABC transporter
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                  • ATJ00749.1
                  		 8421 - 9404 (-) dTDP-glucose 4,6-dehydratase
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                    • ATJ00750.1
                    		 9426 - 10706 (-) glycosyl transferase family 28
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                      • ATJ00751.1
                      		 10741 - 11991 (-) cytochrome P450 like protein
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                        • ATJ00752.1
                        		 12121 - 13173 (-) polyketide synthase
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                          • ATJ00753.1
                          		 13170 - 14204 (-) 3-oxoacyl-ACP synthase
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                            • ATJ00754.1
                            		 14201 - 15445 (-) beta-ketoacyl synthase
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                              • ATJ00755.1
                              		 15442 - 16710 (-) beta-ACP synthase
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                                • ATJ00756.1
                                		 16707 - 17042 (-) antibiotic biosynthesis monooxygenase
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                                  • ATJ00757.1
                                  		 17158 - 18138 (-) ornithine cyclodeaminase
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                                    • ATJ00758.1
                                    		 18428 - 18991 (-) PadR-like family transcriptional regulator
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                                      • ATJ00759.1
                                      		 19287 - 20579 (+) glycosyl transferase family 28
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                                        • ATJ00760.1
                                        		 20648 - 21274 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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                                          • ATJ00761.1
                                          		 21241 - 22278 (+) NAD-dependent epimerase
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                                            • ATJ00762.1
                                            		 22275 - 23732 (+) NDP-hexose 2,3-dehydratase
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                                              • ATJ00763.1
                                              		 23897 - 24043 (-) toxin-antitoxin system antitoxin
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                                                • ATJ00764.1
                                                		 24443 - 25282 (+) transposase
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                                                  • ATJ00765.1
                                                  		 25340 - 26449 (-) NDP-hexose aminotransferase
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                                                    • ATJ00766.1
                                                    		 26446 - 27174 (-) SAM-dependent methyltransferase
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                                                      • ATJ00767.1
                                                      		 27230 - 28009 (-) cyclase
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                                                        • ATJ00768.1
                                                        		 28156 - 28563 (+) hydroxylacyl-CoA dehydrogenase/cyclase
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                                                          • ATJ00769.1
                                                          		 28604 - 29350 (+) C-7 ketoreductase
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                                                            • ATJ00770.1
                                                            		 29592 - 30950 (-) aromatase
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                                                              • ATJ00771.1
                                                              		 30959 - 31744 (-) ketoacyl reductase
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                                                                • ATJ00772.1
                                                                		 31752 - 33053 (-) RfbH/ NDP-hexose 3,4-dehydratase
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                                                                  • ATJ00773.1
                                                                  		 33064 - 34383 (-) glycosyl transferase
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                                                                    • ATJ00774.1
                                                                    		 34380 - 35510 (-) cytochrome P450 like protein
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                                                                      • ATJ00775.1
                                                                      		 35673 - 36713 (+) NDP-hexose-3-ketoreductase
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                                                                        • ATJ00776.1
                                                                        		 36804 - 38399 (-) FAD-dependent oxidoreductase
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                                                                          • ATJ00777.1
                                                                          		 38396 - 39193 (-) SAM-dependent methyltransferase
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                                                                            • ATJ00778.1
                                                                            		 39190 - 40086 (-) alpha/beta hydrolase esterase
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                                                                              • ATJ00779.1
                                                                              		 40091 - 41194 (-) O-methyltransferase
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                                                                                • ATJ00780.1
                                                                                		 41234 - 41671 (-) aklanonic acid methyl ester cyclase
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                                                                                  • ATJ00781.1
                                                                                  		 41859 - 42716 (+) methyltransferase
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                                                                                    • ATJ00782.1
                                                                                    		 42828 - 43715 (-) transcriptional regulator
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                                                                                      • ATJ00783.1
                                                                                      		 43869 - 44123 (-) acyl carrier protein
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                                                                                        • ATJ00784.1
                                                                                        		 44410 - 45285 (+) glucose-1-phosphate thythymidylyltransferase
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                                                                                          • ATJ00785.1
                                                                                          		 45346 - 46200 (-) aldo/keto reductase
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                                                                                            • ATJ00786.1
                                                                                            		 46227 - 47837 (-) FAD-linked oxidase
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                                                                                              • ATJ00787.1
                                                                                              		 48020 - 48469 (-) anthracycline 7-deglycosylase
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                                                                                                • ATJ00788.1
                                                                                                		 48551 - 49441 (-) MarR family transcriptional regulator
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                                                                                                  • ATJ00789.1
                                                                                                  		 49507 - 50247 (+) hypothetical protein
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                                                                                                    • ATJ00790.1
                                                                                                    		 50244 - 51023 (+) hypothetical protein
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                                                                                                      • ATJ00791.1
                                                                                                      		 51501 - 58217 (-) hypothetical protein
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                                                                                                        Biosynthesis information

                                                                                                        Biosynthetic paths

                                                                                                        cytorhodin
                                                                                                        Pathway: cytG1/L/cytG3/W > cytG2 > cytG2/cytG3/W [1]
                                                                                                        Annotation changelog

                                                                                                        Entry version: next

                                                                                                        Date
                                                                                                        Changes
                                                                                                        Submitters
                                                                                                        Reviewers
                                                                                                        2024-03-19
                                                                                                        MIBiG v4 annotathon
                                                                                                        • (ID: HSOJFFPY5IUT4HBQLSN7DGJX)
                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                        Entry version: 4

                                                                                                        Date
                                                                                                        Changes
                                                                                                        Submitters
                                                                                                        Reviewers
                                                                                                        2022-10-07
                                                                                                        Update chemical activity to schema version 2.11
                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                        Entry version: 3

                                                                                                        Date
                                                                                                        Changes
                                                                                                        Submitters
                                                                                                        Reviewers
                                                                                                        2022-09-15
                                                                                                        Updated bioactivity data
                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                        Entry version: 2

                                                                                                        Date
                                                                                                        Changes
                                                                                                        Submitters
                                                                                                        Reviewers
                                                                                                        2019-10-16
                                                                                                        Migrated from v1.4
                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                        Entry version: 1

                                                                                                        Date
                                                                                                        Changes
                                                                                                        Submitters
                                                                                                        Reviewers
                                                                                                        2018-08-06
                                                                                                        Submitted
                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                        Detailed domain annotation
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