BGC0001569: dechlorocuracomycin biosynthetic gene cluster from Streptomyces noursei ATCC 11455
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Location: 2,863,457 - 2,909,713 nt. (total: 46,257 nt).
This entry is originally from NCBI GenBank CP011533.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001569
Short description dechlorocuracomycin biosynthetic gene cluster from Streptomyces noursei ATCC 11455
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP011533.1
2863457 - 2909713
via
Compounds
  • dechlorocuracomycin
Species Streptomyces noursei ATCC 11455 [taxonomy]
References
Chemical products information
dechlorocuracomycin Evidence:
Copy SMILES
C37H57N9O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SNOUR_12590
  • ANZ15829.1
 2863457 - 2865154 (-) 2-isopropylmalate synthase
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    • SNOUR_12595
    • ANZ15830.1
    		 2865244 - 2866125 (-) amidinotransferase
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      • SNOUR_12600
      • ANZ15831.1
      		 2866175 - 2866720 (-) oxidase
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        • SNOUR_12605
        • ANZ15832.1
        		 2866717 - 2867973 (-) sodium/hydrogen exchanger
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          • SNOUR_12610
          • ANZ15833.1
          		 2868013 - 2869563 (-) tryptophan halogenase
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            • SNOUR_12615
            • ANZ15834.1
            		 2869733 - 2870248 (-) hypothetical protein
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              • SNOUR_12620
              • ANZ15835.1
              		 2870245 - 2871357 (-) putative branched-chain-amino-acid aminotransferase
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                • SNOUR_12625
                • ANZ15836.1
                		 2871402 - 2871788 (-) ketosteroid isomerase-like protein
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                  • SNOUR_12630
                  • ANZ15837.1
                  		 2871778 - 2872794 (-) SyrP protein
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                    • SNOUR_12635
                    • ANZ15838.1
                    		 2872817 - 2873029 (-) hypothetical protein
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                      • SNOUR_12640
                      • ANZ15839.1
                      		 2873066 - 2880967 (-) peptide synthetase ScpsB
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                        • SNOUR_12645
                        • ANZ15840.1
                        		 2881027 - 2895225 (-) non-ribosomal peptide synthase/amino acid adenylation enzyme
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                          • SNOUR_12650
                          • ANZ15841.1
                          		 2895283 - 2896602 (-) penicillin-binding protein, beta-lactamase class C
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                            • SNOUR_12655
                            • ANZ15842.1
                            		 2896793 - 2897209 (-) hypothetical protein
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                              • SNOUR_12660
                              • ANZ15843.1
                              		 2897242 - 2899989 (-) ABC transporter permease
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                                • SNOUR_12665
                                • ANZ15844.1
                                		 2899995 - 2900795 (-) putative ABC transporter ATP-binding protein
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                                  • SNOUR_12670
                                  • ANZ15845.1
                                  		 2901037 - 2902248 (+) integral membrane sensor signal transduction histidine kinase
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                                    • SNOUR_12675
                                    • ANZ15846.1
                                    		 2902236 - 2902907 (+) LuxR family two component transcriptional regulator
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                                      • SNOUR_12680
                                      • ANZ15847.1
                                      		 2903082 - 2903513 (-) hypothetical protein
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                                        • SNOUR_12685
                                        • ANZ15848.1
                                        		 2903554 - 2903763 (-) membrane protein
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                                          • SNOUR_12690
                                          • ANZ15849.1
                                          		 2904001 - 2905344 (+) arabinose efflux permease family protein
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                                            • SNOUR_12695
                                            • ANZ15850.1
                                            		 2905348 - 2906085 (+) Oleoyl-(acyl-carrier-protein) hydrolase
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                                              • SNOUR_12700
                                              • ANZ15851.1
                                              		 2906161 - 2906721 (-) ABC transporter
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                                                • SNOUR_12705
                                                • ANZ15852.1
                                                		 2907554 - 2909713 (-) RecQ family ATP-dependent DNA helicase
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                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  Unk01
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  SNOUR_12640
                                                  Substrates
                                                  ornithine (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk02
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  SNOUR_12640
                                                  Substrates
                                                  asparagine (evidence: Structure-based inference, Sequence-based prediction, Homology)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk03
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  SNOUR_12645
                                                  Substrates
                                                  tryptophan, 5-chlorotryptophan (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk04
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  SNOUR_12645
                                                  Substrates
                                                  valine (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk05
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  SNOUR_12645
                                                  Substrates
                                                  leucine (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk06
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  SNOUR_12645
                                                  Substrates
                                                  isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Annotation changelog

                                                  Entry version: 3

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Corrected publication
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Added NRP substrate specificities
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2019-10-16
                                                  Migrated from v1.4
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2018-08-06
                                                  Submitted
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Detailed domain annotation
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