BGC0001573 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001573 (Claviceps africana)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	27,143	dihydrolysergic acid	other:other	100%

BGC0001573 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 27,143 nt. (total: 27,143 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 27,144
Label		BGC0001573

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001573	1.00	Alkaloid	dihydrolysergic acid	Claviceps africana
BGC0002157	0.34	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001249	0.33	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900	0.33	Other	ferrichrome	Aspergillus oryzae
BGC0002710	0.31	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0002199	0.29	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0001261	0.29	NRP	AM-toxin	Alternaria alternata
BGC0001545	0.28	NRP	chrysogine	Fusarium graminearum PH-1
BGC0000355	0.27	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0002606	0.27	NRP, Polyketide	ochratoxin A	Aspergillus niger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001573	1.00	Alkaloid	dihydrolysergic acid	Claviceps africana
BGC0002157	0.67	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001249	0.67	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0002710	0.64	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0002199	0.63	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0001261	0.62	NRP	AM-toxin	Alternaria alternata
BGC0001545	0.62	NRP	chrysogine	Fusarium graminearum PH-1
BGC0000355	0.61	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0002606	0.61	NRP, Polyketide	ochratoxin A	Aspergillus niger

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 27143:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Ala - Leu - Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

lpsB

AMP-binding (247..664): X

nrpys: D-Lya

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVGLVMK
Nearest Stachelhaus code(s):: D-Lya DVFSVGLVMK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

lpsA

Search NORINE for peptide: strict or relaxed

AMP-binding (282..685): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFFCGGPLK
Nearest Stachelhaus code(s):: Ala DLFFCGGPLK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1392..1788): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLLAMGAVAK
Nearest Stachelhaus code(s):: Leu DALFMGAVAK (47% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2513..2918): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVMLVAAAVK
Nearest Stachelhaus code(s):: Pro DVMLVGAVNK (53% 8Å match); Leu DAMLVGAACK (41% 8Å match)
Stachelhaus code match:: 70% (weak)