BGC0001574 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001574 (Streptomyces thioluteus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	24,094	SF2768	NRPS:Type I	100%

BGC0001574 - Region 1 - NRPS

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Location: 1 - 24,094 nt. (total: 24,094 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 24,095
Label		BGC0001574

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001574	1.00	NRP	diisonitrile antibiotic SF2768	Streptomyces thioluteus
BGC0002324	0.38	NRP, Polyketide	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0000343	0.35	NRP	enterobactin	Pseudomonas sp. J465
BGC0002476	0.34	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0002554	0.30	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0001627	0.29	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001903	0.27	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0002495	0.27	NRP	photobactin	Photorhabdus luminescens
BGC0002493	0.27	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0000294	0.25	NRP	acinetobactin	Acinetobacter baumannii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001574	1.00	NRP	diisonitrile antibiotic SF2768	Streptomyces thioluteus
BGC0002324	0.70	NRP, Polyketide	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0000343	0.68	NRP	enterobactin	Pseudomonas sp. J465
BGC0002476	0.67	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0002554	0.64	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0001627	0.62	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001903	0.61	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0002495	0.60	NRP	photobactin	Photorhabdus luminescens
BGC0002493	0.60	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0000294	0.58	NRP	acinetobactin	Acinetobacter baumannii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 24094:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gln)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ATY72527.1

AMP-binding (28..427): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GFGCVGINTK
Nearest Stachelhaus code(s):: Val DFFCVGIVHK (38% 8Å match)
Stachelhaus code match:: 60% (weak)

ATY72525.1

Search NORINE for peptide: strict or relaxed

AMP-binding (458..842): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAEDVGTVVK
Nearest Stachelhaus code(s):: Lys DAEDIGTVVK (91% 8Å match); Gln or Tyr DAESVGTVVK (68% 8Å match)
Stachelhaus code match:: 90% (moderate)