LOCUS       BGC0001575             29972 bp    DNA     linear   CON 12-APR-2023
DEFINITION  Ruminococcus sp. 5_1_39BFAA acpfZ-supercont2.3, whole genome shotgun
            sequence.
ACCESSION   BGC0001575
VERSION     BGC0001575
KEYWORDS    .
SOURCE      Ruminococcus sp. 5_1_39BFAA
  ORGANISM  Ruminococcus sp. 5_1_39BFAA
            Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
            Ruminococcus.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            ACII02000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:51:03
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..29972
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001575"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..29972
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    7..29972
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20006:28991]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20007..28991
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    7..29972
                     /SMILES="NC([*])C(=O)NC([*])C(=O)NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     gene            complement(1175..1384)
                     /locus_tag="RSAG_RS12235"
                     /old_locus_tag="RSAG_00963"
     CDS             complement(1175..1384)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019162864.1"
                     /locus_tag="RSAG_RS12235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00963"
                     /product="DUF6219 family protein"
                     /protein_id="WP_008704367.1"
                     /transl_table=11
                     /translation="MKAHKYWSLGALAAMIGTFYTGYKNMKTAHKYFACSSLLCMIMAI
                     YSGHKMISGKSRKKKNSVSKESAE"
     gene            complement(1450..1581)
                     /locus_tag="RSAG_RS19580"
     CDS             complement(1450..1581)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005350995.1"
                     /locus_tag="RSAG_RS19580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_008704366.1"
                     /transl_table=11
                     /translation="MQREDFSNRRNYEREFRTVSANIDMILGKSYEQEQQIEKEQNL"
     gene            2411..2803
                     /locus_tag="RSAG_RS12240"
                     /old_locus_tag="RSAG_00961"
     CDS             2411..2803
                     /EC_number="4.1.1.11"
                     /GO_function="GO:0004068 - aspartate 1-decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006523 - alanine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015526224.1"
                     /locus_tag="RSAG_RS12240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00961"
                     /product="aspartate 1-decarboxylase"
                     /protein_id="WP_008704365.1"
                     /transl_table=11
                     /translation="MTIEMLKGKIHRATVIQAELDYVGSITVDEELLEAAGILEYEKVQ
                     IVDVNNGSRFETYTICGKRGSGMICLNGAAARCVSTGDKIIIMAYAGYEPEEARTHKPA
                     VVFVDEENKISRVTNYEKHGLLKDMA"
     gene            2913..3752
                     /gene="panC"
                     /locus_tag="RSAG_RS12245"
                     /old_locus_tag="RSAG_00960"
     CDS             2913..3752
                     /GO_function="GO:0004592 - pantoate-beta-alanine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0015940 - pantothenate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="panC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015526223.1"
                     /locus_tag="RSAG_RS12245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00960"
                     /product="pantoate--beta-alanine ligase"
                     /protein_id="WP_008704364.1"
                     /transl_table=11
                     /translation="MQVTKTVEETRKQIKAWKKEGKTIGLVPTMGFLHEGHASLIKKCR
                     EQNDIVVVSDFVNPTQFGPTEDLEAYPRDFERDSKLCESLGTDLIFCPEPSEMYHDPHA
                     FVSIDTLSETLCGKTRPIHFKGVCTVVTKLFHIVAPDRAYFGQKDAQQLAIIRKMVQDL
                     NFDIEIVGCPIVREEDGLAKSSRNTYLSDEERKAALCLSRSVKLGQEIIHAGISAEELL
                     GKMRAVIEAEPLAKIDYVSMVDALTMQPVEKADHNVLVAMAVYIGKTRLIDNFSYEV"
     gene            3756..4739
                     /locus_tag="RSAG_RS12250"
                     /old_locus_tag="RSAG_00959"
     CDS             3756..4739
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015526222.1"
                     /locus_tag="RSAG_RS12250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00959"
                     /product="bile acid:sodium symporter family protein"
                     /protein_id="WP_008704363.1"
                     /transl_table=11
                     /translation="MENILKKIGKISSFASRYIGIIIIAFSCLAFFWRDGFAWMTNYTS
                     VFLGVIMFGMGLTIRLEDFRAIFSRPKEVIIGAVAQYTIMPVVAWVLCKVMNLPADLAL
                     GVILVGCCPGGTASNVITYIAGGDVALSVGMTIVSTLAAPVMTPFLVYILAGAWVEVSF
                     WAMVLSVVKVILVPVLLGILLRTLAGDHVDKVSDVMPLISVVAIVMIIGGIVAINAEKI
                     LSCGVLVLGVVAIHNFCGMMLGLLAAKIFHVEYTRATAIAIEVGMQNSGLAVSLAAANF
                     VANPLATLPGAIFSVWHNIAGSIFAGIRRSGVENRTRTGENGVSAA"
     gene            complement(4864..6258)
                     /locus_tag="RSAG_RS12255"
                     /old_locus_tag="RSAG_00958"
     CDS             complement(4864..6258)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037653.2"
                     /locus_tag="RSAG_RS12255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00958"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_020993838.1"
                     /transl_table=11
                     /translation="MQPSQCILVRGENYLFPYSCTDRATVQAKELFAVFNAAKQFLQTH
                     EQVSLYEELVRKGHSSHSLDEVINSASIKLGYSLVFCDKKFRILSYSTSIPVTDKLWKK
                     NIERGYCTYDFIKNVMSLEAVQGASASIEAVEVSCPESPYRKCSSKVFLNGVQVGFVLM
                     IENNIPFTAEHLAAMSDVSRAISSVVGHYHPELFQYTSADQQLLEALLIGTPADILADS
                     ISHLRVSDAMYALCIQPKTFLKENKLKQQLYPVIRHIFPEAYMTVHDNALVLLVPDQSS
                     VIFVDTQKIMLKTMAEYHLDVGISLVFSKMDEFYRAYQQARTVLEWNHRIPDNLKKEIS
                     WDQRYPMEHQIHRYSEIEFYEMMNKIKEPEKLADYIHPALYRLNKYDQRTGNELYHTLE
                     VYLQCFHNNKETANILCIHRNSLAYRMEKIIEIGKADLNDPMTEFLLRMSFKLVEYLKI
                     RDLDLP"
     gene            6615..9425
                     /locus_tag="RSAG_RS12260"
                     /old_locus_tag="RSAG_00957"
     CDS             6615..9425
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217:NADH:flavin oxidoreductase/NADH oxidase (Score:
                     381.8; E-value: 5e-116)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014357482.1"
                     /locus_tag="RSAG_RS12260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00957"
                     /product="acetoacetate decarboxylase family protein"
                     /protein_id="WP_020993839.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.2e-31, bitscore:
                     100.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYQEIFKQGKIGNITLKNRLVMSPMGTSLAEMDGSPSEDMIAFYE
                     ARAIGGAALIIPEIARVNDLHGAGMMRQLSVSKDRHIEGLAKLAETVHKYGTKIFIQLH
                     HPGRETVTALTGGPVVSASAIPCKYLQQETRALSTEEVKALIQQFISGAVRVKKAGCDG
                     VELHAAHGYLLQQFLSPYTNKREDEYGGSFENRLRMITEIINGIRVQCGPDFPIGVRLS
                     VEEFLDKTGVTEDYIHIQDGVKIAMALEKCGIDFIDVSVGLYETGSVCVEPISFPQGWR
                     KDLIKAVKDHVSIPVIGVSCIREPQVAESFLEGGIVDFVSMGRSWLADEQWGLKVLEGR
                     ENEICKCINCLRCFESLNAWMGAGIPAECAVNPRACRERLYGNAEYDTQEHKVVVVGGG
                     PCGMIAAKTLAERGMKVTLVDRQSELGGTINLAKKPPFKERMGWIADYYNVEFEKLGVE
                     LKLDMEATADKIAEMNPDAVLVATGSKSVIPGSIPGITGENVYTIEDILSGKAGLKNKK
                     VMIIGAGVTGLETAEYLCHEGNTVVLADMLDKVAPNANHTNVADVCGRLKEYNAQFMMA
                     HALKEIKKDGVVLERLNDKINVEVAADAVVLSLGFRPDNHLVEELKEKGIHAQAIGNAV
                     KDGTIAPASRSGFEAARKLFKTSVKTPSFITAPEEMPNFGKISLMKNQEGIYLAYLTDP
                     AAIAKVLPAPLKPFSVPVVTVSVCHVKEPTFADDYYEAILGVYCTYGTQLGLYPIGLVL
                     GGTGAEMAVQCGRDNGSIPKKLGSEFVIRRNNDHVTAQVCRRGTELVNIDLKIGEYNNA
                     MTGMLYQFPEAGKKTYGGGFYFHLDREPDKEGKSHFQNGALLQNLCEYNYHSWEPGFAA
                     IKLQSSIDDPWGELPIRTVIGGAYSSNDLMVHKLNLCEEIDADVLAPYLLTARYDRTAF
                     METGRR"
     gene            9439..10194
                     /locus_tag="RSAG_RS12265"
                     /old_locus_tag="RSAG_00956"
     CDS             9439..10194
                     /NRPS_PKS="Domain: PKS_KR (6-175). E-value: 7e-15. Score:
                     47.2. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12265_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     242.6; E-value: 7.1e-74)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014357483.1"
                     /locus_tag="RSAG_RS12265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00956"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_008704360.1"
                     /sec_met_domain="adh_short (E-value: 3.5e-39, bitscore:
                     124.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 8.8e-37, bitscore:
                     117.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFENKVAIITGSTRGIGRATAELFAKEGAKVIVVGTKEELGESC
                     VNAIKAAGGEAIFCKTDVTSDESLDNLVKTALDTYGKIDILVNNAGVGGTTANMDQITM
                     DEWNTVLATNLTAPFVLCKKIIPIMEKQGAGTIVNVASMAATAAGRGGLAYTSAKHGLL
                     GLTRQMSLDHGRTGVRINAVLPGPIATDMIARVLAIPQHPVTMKIGMSPAKRPGEPIEV
                     AQAIAFLASDEASFIHGAALAVDGGYTIF"
     aSDomain        9457..9963
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12265_PKS_KR.1"
                     /evalue="7.00E-15"
                     /label="RSAG_RS12265_PKS_KR.1"
                     /locus_tag="RSAG_RS12265"
                     /protein_end="175"
                     /protein_start="6"
                     /score="47.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAIITGSTRGIGRATAELFAKEGAKVIVVGTKEELGESCVNAIKA
                     AGGEAIFCKTDVTSDESLDNLVKTALDTYGKIDILVNNAGVGGTTANMDQITMDEWNTV
                     LATNLTAPFVLCKKIIPIMEKQGAGTIVNVASMAATAAGRGGLAYTSAKHGLLGLTRQM
                     SLDHGR"
     CDS_motif       9463..9543
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12265_0001"
                     /evalue="2.70E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="RSAG_RS12265"
                     /protein_end="35"
                     /protein_start="8"
                     /score="20.0"
                     /tool="antismash"
                     /translation="IITGSTRGIGRATAELFAKEGAKVIVV"
     gene            10395..12086
                     /locus_tag="RSAG_RS12270"
                     /old_locus_tag="RSAG_00955"
     CDS             10395..12086
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /GO_process="GO:0006313 - transposition, DNA-mediated
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005421670.1"
                     /locus_tag="RSAG_RS12270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00955"
                     /product="transposase"
                     /protein_id="WP_008704359.1"
                     /transl_table=11
                     /translation="MYLKSRVKIPDVHGKLIRLRRGDITYIKYEYDRYYNPEKKYTYPQ
                     RATIGKVCADDDTMMIPNEAFLKYFPDAVLSDMEDRTERSSCLRVGTYAAIHKIVSNYS
                     LDKMLGQFFSKRDMALLLDLASYFIVEESNVAQHYPDYAYNHPLYSSGMKIYSDASVSD
                     FFKSITKDKSTGFLNEWNAKRNRRERIYISYDSTNKNCQAGEIELAEFGHAKADIGSAI
                     INYSVGYDLKNKEPLFYEAYPGSINDVSQLRAMLGRITGYGYKKIGFILDRGYFSRGNI
                     RYLDECGYSFVIMAKGTSSFISDLILENKGTFENKRSCDMNAYGVYGKTVQKTLFEGDE
                     KKRYIHIYHSISKDADERESFENALRERTTLLMSHQNETVEFGSAYEKYFYLHYDKDGV
                     FLYPEEKTTVTEREISLCGYFVIITSERMTAKEALHLYRSRDVSEKLFASDKSFLGNKS
                     MRSHTNEGVEGRIFTQFIALIIRNKIYTALQEENEKLEKKQNYMTVPAAIRELEKIEMT
                     RQTDNIYRLDHAVTANQKVILKAFGLDANSIKYFASELSKELKKSE"
     gene            12102..12233
                     /locus_tag="RSAG_RS19585"
                     /old_locus_tag="RSAG_00954"
     CDS             12102..12233
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RSAG_RS19585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RSAG_00954"
                     /product="hypothetical protein"
                     /protein_id="WP_008704358.1"
                     /transl_table=11
                     /translation="MARTRKTSKEALEEKIEKAEVDVIAAKKKYDQATANLKELLGK"
     gene            12346..13047
                     /locus_tag="RSAG_RS12275"
                     /old_locus_tag="RSAG_00953"
     CDS             12346..13047
                     /GO_function="GO:0003953 - NAD+ nucleosidase activity
                     [Evidence IEA]; GO:0005515 - protein binding [Evidence
                     IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015512635.1"
                     /locus_tag="RSAG_RS12275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00953"
                     /product="toll/interleukin-1 receptor domain-containing
                     protein"
                     /protein_id="WP_242832785.1"
                     /transl_table=11
                     /translation="MLAIFVNNNPYNFEFYIAVVYDIPKEEHVEKMIGLFENAGLVLRN
                     DLTFFMFMNSMKDRRFNSCAFLGEQDIDLKFENMFDFVEIEDLKKKGYYMQPFGKEKQV
                     FISHSSKDKKDVEMIIPYLNGQDLPVWFDKYSIPVGASITEQVQRGIEESDMVIFWVTD
                     NFLNSNWCQMEMKAYISRMIQENIRICIVMDDDIEIKKLPLFLRDIKHIRRDHRSVIEV
                     AEEIAGIIKHM"
     gene            13926..14369
                     /locus_tag="RSAG_RS12280"
                     /old_locus_tag="RSAG_00952"
     CDS             13926..14369
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]; GO:0046677 - response to antibiotic [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009245727.1"
                     /locus_tag="RSAG_RS12280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00952"
                     /product="VanZ family protein"
                     /protein_id="WP_044952088.1"
                     /transl_table=11
                     /translation="MFLLYFFSRKRGSLLTFLAIVFGSTVFTRTPGIRQYQLEIFWSWK
                     EILGIGTCGRLGSTTGDGLLQENLLNILLLFPAGILLPGLTGRKLKWWMGLLVGIAVSS
                     AIEISQLLLCRGLFEFDDIIHNSLGCMLGSLLGNRMLRLVHGK"
     gene            14759..15595
                     /locus_tag="RSAG_RS12285"
                     /old_locus_tag="RSAG_00951"
     CDS             14759..15595
                     /EC_number="3.1.21.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0016888 - endodeoxyribonuclease activity, producing
                     5'-phosphomonoesters [Evidence IEA]; GO:0008270 - zinc ion
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019161419.1"
                     /locus_tag="RSAG_RS12285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00951"
                     /product="deoxyribonuclease IV"
                     /protein_id="WP_008704353.1"
                     /transl_table=11
                     /translation="MLYIGNHTSSSRGYLAMGKQMLANGGNTFAFFTRNPRGGKAKDID
                     PQDVQAFGQLAEENHFGKLVAHAPYTMNCCAAKENLRDFAREIMADDLRRLEMTPGNYY
                     NFHPGSHVGQGAEVGISKIAEILNEVLTKDQSTIVLLETMSGKGTEVGRNFEELRQIID
                     RVELKDKLGVCLDTCHVWDGGYDIVNDLDSVFEEFDRIIGLDRLKAIHLNDSMNPLGSH
                     KDRHARIGEGEIGLEALVRVINHPATEGIPFILETPNDDEGWTHEIALLRNEYKQK"
     gene            15712..16092
                     /locus_tag="RSAG_RS12290"
                     /old_locus_tag="RSAG_00950"
     CDS             15712..16092
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019161727.1"
                     /locus_tag="RSAG_RS12290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00950"
                     /product="hypothetical protein"
                     /protein_id="WP_020993842.1"
                     /transl_table=11
                     /translation="MQQRQGYQAVEKLRKTLDEKYLWEVILLYAGESFKTYTGLPFTYE
                     VRKGRNGDYTRELWIDRRENSKSLALSSVLLALRNIKKVGAVVDRPKALGDIRGVSYIY
                     GMFYCFGLIDVPDTARQKMKCL"
     gene            16244..18115
                     /locus_tag="RSAG_RS12295"
                     /old_locus_tag="RSAG_00949"
     CDS             16244..18115
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015541171.1"
                     /locus_tag="RSAG_RS12295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00949"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_020993843.1"
                     /transl_table=11
                     /translation="MNKKKNVDSGRKSARPDYIQKTISQKSSGKRSGKVFFPKTLIKTG
                     GIIIFVLLLGFAGNKFFLSVSKTDSGKVKAVSASGADEEKEGRIIEKTKKTKEIKETKD
                     VVEMKKTKEINFQPHCVDSTKPENLISYTNIEVDGNVLENIGDYKADGDISFNIGQDYT
                     DVDGIVTFRGNSFRDTPSHGYADMTDFRLNKLWSADTGSLSSGSAVWTGSGWTGQPLMM
                     KWSKEVKAHMNMTEKAKADDELVEVIYACMDGYVYFLDLRTGEKTRDPLYLGYTFKGAG
                     ALDPRGYPIMYVGAGYNSNEGTAKVFVVNLLDCSVMYTFGDNDEFSLRGSLSFFDGSAL
                     VDAETDTLIYPGENGILYLIRLNTKYDLNSGTLSIDPGRTVKWRYYGTRSSTESFWLGM
                     EDSAAIYKGYIFMTDNGGNLMCLDLNTLQLVWVQDTLDDSNSTPVLEIEKGHLYLYVST
                     SFRLGWRSYDTATVPVWKIDAETGEIVWHTDYECTTDDGVSGGVQSTIACGKNSLADYI
                     YVTVAKTSDNASGVLACLRKSDGSKAWEDSSSYAWSSPVCVYNKDGSGKVLYCNSTGDI
                     RLLDGKTGKQEDVLSVSDGVIEASPAVYDNYAVVGTRDCKIWGIRLQ"
     gene            18248..19993
                     /locus_tag="RSAG_RS12300"
                     /old_locus_tag="RSAG_00948"
     CDS             18248..19993
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]; GO:0042910 - xenobiotic transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 265.3; E-value: 1.5e-80)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019161716.1"
                     /locus_tag="RSAG_RS12300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00948"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_008704346.1"
                     /transl_table=11
                     /translation="MEERNNRLLNAKLNKYIVPGIMMSLALQLGNIVDTIFVSNLIGVE
                     AMSAVTLSLPVETIVQLTGYCLGIGGSIAVGNMLGKRDKEGASKLFSATFIVTLVVGII
                     FSICALPAAEPVARLLVSGDGVLTGYTRDYIRVSMLGAPVIGIGLMMVNYLGVENHPEL
                     ASAYLIAANVINLVLDYIFLRYTPLGITGASLSTVLGFLFAMGIFVLYIRSDKRNLHLI
                     LLKPGELGITKEAIITGVPMLIFMAANFVKALGLNTIIMNQLGEEGMAVFTVCDNVLLI
                     VEMLTGGIIGVIPNVAGILFGEKDYVGIRVLCKKMLKYSYILLAVIFVFIMLFTEEITV
                     MFGSGGGELGSHMVQALRIFALCVAPYLWNKFIISYYESIEETAIASFATFLENAVVVL
                     PATLVGILVWKQIDGIGIDGIAAGFVATEIITAVAACIFRKIRHKNTSFYIVPDKNPGI
                     NLDFSIKSTMEEAQTVHKRIIEFCQEQGASKSKANLAAVCAEEMTVNIIRFGGKTSNWI
                     DINLCLEDDLCRLRIRDNGVNFNPLEYQYDSEDFDIHGIELVKKVSKSMDYIRAIDMNN
                     TIISF"
     gene            20007..28991
                     /locus_tag="RSAG_RS12305"
                     /old_locus_tag="RSAG_00947"
     CDS             20007..28991
                     /NRPS_PKS="Domain: AMP-binding (20-419). E-value: 1.8e-103.
                     Score: 338.1. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12305_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (521-585). E-value: 1.3e-11.
                     Score: 36.8. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12305_PP-binding.1"
                     /NRPS_PKS="Domain: Condensation_LCL (597-878). E-value:
                     3.3e-37. Score: 120.0. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12305_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1033-1421). E-value:
                     5.7e-91. Score: 297.0. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12305_AMP-binding.2"
                     /NRPS_PKS="Domain: PP-binding (1530-1591). E-value:
                     1.7e-10. Score: 33.2. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12305_PP-binding.2"
                     /NRPS_PKS="Domain: Condensation_LCL (1603-1879). E-value:
                     3.3e-38. Score: 123.2. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12305_Condensation_LCL.2"
                     /NRPS_PKS="Domain: AMP-binding (2027-2418). E-value: 3e-94.
                     Score: 307.8. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12305_AMP-binding.3"
                     /NRPS_PKS="Domain: PCP (2523-2590). E-value: 6.8e-21.
                     Score: 66.2. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12305_PCP.1"
                     /NRPS_PKS="Domain: NAD_binding_4 (2634-2872). E-value:
                     5.5e-35. Score: 112.5. Matches aSDomain:
                     nrpspksdomains_RSAG_RS12305_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     143.5; E-value: 1.9e-43)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019161715.1"
                     /locus_tag="RSAG_RS12305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00947"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_020993844.1"
                     /sec_met_domain="AMP-binding (E-value: 2e-107, bitscore:
                     349.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.4e-12, bitscore:
                     36.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.5e-48, bitscore:
                     155.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.6e-08,
                     bitscore: 24.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 9.5e-14, bitscore:
                     41.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.9e-35, bitscore:
                     112.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNINERNNFVFEFRPVTELFEEQVKLHPEKCAVVSGKESFTYAQ
                     LNERANRIANALVEKGVRRETIVGVVLERCCDFYAVRQGILKAGGAFAVATPDYPDDRI
                     RYIFEDSRAPFIITTKEIAEERRELFAKLPCTVLLIEELLENENTENPQVKIGEHDLCY
                     CIYTSGSTGKPKGVLIEHINLANFVNPDPKNAETYGYVSRGSVSLSMAAMTFDVSVLEE
                     FLPLTNGMTAVIASDEEILNPLMLGELIVRNKVDIMTTTPTYLSNMIDLPQLEKAVSQI
                     KVFDVGAEAFPPALYDKIRRVNPDAYIMNGYGPTETTISCTMKVITDSRNITIGTPNGN
                     VKGYIVDKENKILPDGETGELVIAGLGVGRGYMNLPDKTEAVFIDLNGERAYKTGDLAR
                     ISPEGEIEFFGRIDNQIKLRGLRIELGEIEEVINSYEGIITSITLPVDNKFLCCYFMAD
                     RQINTEELSAYASESLAHYMVPEVFVQLEKMPVTQNGKIDKKALPKPVAQPKNLKEPQT
                     PMQKKIFEIVADVVENDFFGTDTSFYRAGLSSISAMKLCILISEEFGVTVKTSDIHENN
                     TVEKLEKYVMLAPKIRTYEKREVYPLTGSQKGIFAECMKNPESTVYNIPFLFELESSVD
                     VQKLSDAISQMIAAHPYLLTKVYLSDSGEMVQKPCEEAFVPEVVQTTNEQFEKMKDELV
                     RSFKLEKGRLFRAGIYVTEDRKYLFTDFHHILADGNSYDIIFEDIDRAYLGEKLEKESY
                     TGFDAALDEEQQMKEGKYKKAEKYYDSIFEGIETESLPLPDCSGKTPERGYLSMPVDTG
                     ESLVLSACEKLGVTPNILFTGVFGILMSRYSNSEESLFATIYNGRNDSRLENTVCMLVK
                     TLPVYCSCDPKVTIQAYMTELSEQILSSMANDIFPFSDICAKYGINSDLVFAYQAELGD
                     DFPIGDTVARGHDLSPDMSKMPLLIQVREYDHKYVLTAEYRSDMYSEAFVRGMLESYEA
                     AMDSLLKAKYISEVSVLSQNGADKISEFNNTACEYDRSKTIADMFEELVQTIPDHTAVV
                     FKDKKYTYRELDEISDRLGKYIASQGIGSEDVVSILIPRCEYMAIAPMGVIKAGAAYQP
                     LDPTYPRDRLMYMMEDSSAKLLIVDRELLPLVDGYKGPVLFTDQIWQLEDRDVVLKKPQ
                     LHDLFILLYTSGSTGVPKGCMLEYGNITAFCHWFKRYYGIDSECRIAAYASFGFDACMM
                     DIYGAITNGAQLHIIPEEIRLDFIGLQRYFEENGITHSFMTTQVGRQFALEMDCKSLRY
                     LSVGGEKLVPCEPPKDYKFINAYGPTEATIFTTVFEVDKYYPNVPIGKALDNVKLYITD
                     KLGHMLPPGACGELMITGWQVSRGYLNKPEKTAEVYTKNLYDDTPGYEVMYHSGDVARF
                     LPDGNIQIIGRKDSQVKIRGFRIELSEVEEVIRRYEGIRDATVVAFDDPNGGKYIAAYV
                     VSDSTVDINALNDFIKETKPAYMVPAVTMQIDKIPLNQNQKVNKKALPLPEKKAAEIIK
                     PENEVQQILFDCIAEVLGYTDFGITTDIYEAGLTSITAIKLNILISKAFDIVIKTSDIK
                     NHPTIRMMEEFVKTAGKESKREVQESYPLTNTQEGIFIECTANMGSTIYNIPYLLKLDN
                     KVDLDRLAEAIDSTVEAHPYLKTRLFMDDNGNVLQKRNDGLSYKTPILNGMNRDTLVRP
                     YMLFNEQLFRFEIYRTCDGNYLFLDLHHIVADGTSLAIIINDINRAYSGEKLEPEGYTS
                     YDLALDNRDALAGDIYKNAENYYKSVFEHAGGSISFYPDKNGAAPTAELYHRETRSISV
                     QDVKEFCKKHGITENVFFISAFGITLGKYNFKKDAVFTTIYHGRNDSRLSETVGMLVKT
                     LPVFCDFSGTAKDCLSGVQKQLIDSMNNDIYPFSQISHEFDIKADAMVIYQGDNFAFDT
                     IGGEYAQEEPVSLNMAKAPVSVSISIEKNRFVFEIEYRGDMYHEETIRYLADNLETTAE
                     GILRECDPADIRLMFEEKTQMEDIPEHAGKTFIDLFKEMAARYPDRPAVRDDSGDFTYR
                     ELDRMSDYIAQKLTENGFGPEQAAGILCGRTKEYTVAYVGVMKAGGAYVPLDPEYPQSR
                     IEYMLKDSGARNLLVIDQYQNLVEFYDGNVISLDSVPDEAEDFELSAELISPKPENLAY
                     MIYTSGSTGKPKGVMIEHRNLLNLIEYITLSRNTSPDDIVAEFASFCFDASVIDLFAPL
                     TAGAVLYILPESIRKDAIAISRYIKEKEITTVTFPTQMGELVTELLEDAPALKFVTLGG
                     EKFKHYRNRTYQMINGYGPTENTVSSTEFLVDRQYDNIPIGKSQRNVRSYIVDENLNRL
                     PVGASGELCHAGRQIARGYHNLPEKTASVFVENPFAVCEQESRLYRTGDMVRMKGDGNI
                     EYIGRIDSQVKIRGYRVELGEIEGALLKHELVKNAAVTVIEKGGNKYITAYYTGEAIPE
                     DELKTFLEPLIPDYMMPSFFVSIEEMPVTPGGKIDKKALPMPEVTTNTASYVEPVTAAQ
                     RALCEIFEKALGIERVGIEDNFFELGGSSLTASKVAVMCLSKNISLVYADIFKYPTVRE
                     LAALVDDDGVTEAAQSKNEFSDYNYNRIQNVISANTEENADRITKEKLGDIMVTGATGF
                     LGIHVLKAFIDNYDGKVYCLVRKGKYESSEKRMMNMLMYYFDDPYKELFESRIICVDGD
                     ITSKEQVTGFSEYKFSTIINCAACVKHFAADDVLERINVQGVENLIDFCKNNGRRLIQI
                     STVSVAGEGSDGVPPMSRVFCENDLYIGQNITNEYIRTKFLAERAVLEAVSEGLDGKVV
                     RVGNLMSRNSDGEFQINFITNGFLRSLRGYAAVGKFPMGGMHEVAEFSPIDSTALAVLR
                     LAQTDRRFTVFHACNSHHIYMADLIYAMRSYGFRIDIVRDEDFEAAVKEFAKTGQDSDA
                     VSGLIAYTSHNENEIYTIDYSNRFTAQVLYRLDYKWPVTDDRYLENAIAALDRLTFFD"
     aSDomain        20067..21263
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12305_AMP-binding.1"
                     /evalue="1.80E-103"
                     /label="RSAG_RS12305_AMP-binding.1"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="419"
                     /protein_start="20"
                     /score="338.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEEQVKLHPEKCAVVSGKESFTYAQLNERANRIANALVEKGVRRE
                     TIVGVVLERCCDFYAVRQGILKAGGAFAVATPDYPDDRIRYIFEDSRAPFIITTKEIAE
                     ERRELFAKLPCTVLLIEELLENENTENPQVKIGEHDLCYCIYTSGSTGKPKGVLIEHIN
                     LANFVNPDPKNAETYGYVSRGSVSLSMAAMTFDVSVLEEFLPLTNGMTAVIASDEEILN
                     PLMLGELIVRNKVDIMTTTPTYLSNMIDLPQLEKAVSQIKVFDVGAEAFPPALYDKIRR
                     VNPDAYIMNGYGPTETTISCTMKVITDSRNITIGTPNGNVKGYIVDKENKILPDGETGE
                     LVIAGLGVGRGYMNLPDKTEAVFIDLNGERAYKTGDLARISPEGEIEFFGRIDNQIKLR
                     "
     aSModule        20067..21761
                     /complete
                     /domains="nrpspksdomains_RSAG_RS12305_AMP-binding.1"
                     /domains="nrpspksdomains_RSAG_RS12305_PP-binding.1"
                     /locus_tags="RSAG_RS12305"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       20256..20282
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0001"
                     /evalue="8.30E-01"
                     /label="NRPS-A_a2"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="92"
                     /protein_start="83"
                     /score="3.9"
                     /tool="antismash"
                     /translation="GILKAGGAF"
     CDS_motif       20490..20549
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0002"
                     /evalue="1.70E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="181"
                     /protein_start="161"
                     /score="29.7"
                     /tool="antismash"
                     /translation="CYCIYTSGSTGKPKGVLIEH"
     CDS_motif       20940..20969
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0003"
                     /evalue="3.10E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="321"
                     /protein_start="311"
                     /score="7.4"
                     /tool="antismash"
                     /translation="YGPTETTISC"
     CDS_motif       21066..21155
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0004"
                     /evalue="2.90E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="383"
                     /protein_start="353"
                     /score="35.6"
                     /tool="antismash"
                     /translation="PDGETGELVIAGLGVGRGYMNLPDKTEAVF"
     CDS_motif       21228..21293
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0005"
                     /evalue="5.90E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="429"
                     /protein_start="407"
                     /score="31.3"
                     /tool="antismash"
                     /translation="FFGRIDNQIKLRGLRIELGEIE"
     aSDomain        21570..21761
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12305_PP-binding.1"
                     /evalue="1.30E-11"
                     /label="RSAG_RS12305_PP-binding.1"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="585"
                     /protein_start="521"
                     /score="36.8"
                     /tool="antismash"
                     /translation="KIFEIVADVVENDFFGTDTSFYRAGLSSISAMKLCILISEEFGVT
                     VKTSDIHENNTVEKLEKYV"
     aSDomain        21798..22640
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12305_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.30E-37"
                     /label="RSAG_RS12305_Condensation_LCL.1"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="878"
                     /protein_start="597"
                     /score="120.0"
                     /tool="antismash"
                     /translation="EVYPLTGSQKGIFAECMKNPESTVYNIPFLFELESSVDVQKLSDA
                     ISQMIAAHPYLLTKVYLSDSGEMVQKPCEEAFVPEVVQTTNEQFEKMKDELVRSFKLEK
                     GRLFRAGIYVTEDRKYLFTDFHHILADGNSYDIIFEDIDRAYLGEKLEKESYTGFDAAL
                     DEEQQMKEGKYKKAEKYYDSIFEGIETESLPLPDCSGKTPERGYLSMPVDTGESLVLSA
                     CEKLGVTPNILFTGVFGILMSRYSNSEESLFATIYNGRNDSRLENTVCMLVKTLPVYCS
                     "
     aSModule        21798..24779
                     /complete
                     /domains="nrpspksdomains_RSAG_RS12305_Condensation_LCL.1"
                     /domains="nrpspksdomains_RSAG_RS12305_AMP-binding.2"
                     /domains="nrpspksdomains_RSAG_RS12305_PP-binding.2"
                     /locus_tags="RSAG_RS12305"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       21864..21959
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0006"
                     /evalue="9.10E-06"
                     /label="C2_LCL_024-062"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="651"
                     /protein_start="619"
                     /score="18.1"
                     /tool="antismash"
                     /translation="TVYNIPFLFELESSVDVQKLSDAISQMIAAHP"
     CDS_motif       22170..22235
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0007"
                     /evalue="3.10E-04"
                     /label="C3_LCL_132-143"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="743"
                     /protein_start="721"
                     /score="13.5"
                     /tool="antismash"
                     /translation="FHHILADGNSYDIIFEDIDRAY"
     CDS_motif       22572..22631
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0008"
                     /evalue="5.10E-01"
                     /label="C5_starter_265-294"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="875"
                     /protein_start="855"
                     /score="3.1"
                     /tool="antismash"
                     /translation="GRNDSRLENTVCMLVKTLPV"
     aSDomain        23106..24269
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12305_AMP-binding.2"
                     /evalue="5.70E-91"
                     /label="RSAG_RS12305_AMP-binding.2"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1421"
                     /protein_start="1033"
                     /score="297.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEELVQTIPDHTAVVFKDKKYTYRELDEISDRLGKYIASQGIGSE
                     DVVSILIPRCEYMAIAPMGVIKAGAAYQPLDPTYPRDRLMYMMEDSSAKLLIVDRELLP
                     LVDGYKGPVLFTDQIWQLEDRDVVLKKPQLHDLFILLYTSGSTGVPKGCMLEYGNITAF
                     CHWFKRYYGIDSECRIAAYASFGFDACMMDIYGAITNGAQLHIIPEEIRLDFIGLQRYF
                     EENGITHSFMTTQVGRQFALEMDCKSLRYLSVGGEKLVPCEPPKDYKFINAYGPTEATI
                     FTTVFEVDKYYPNVPIGKALDNVKLYITDKLGHMLPPGACGELMITGWQVSRGYLNKPE
                     KTAEVYTKNLYDDTPGYEVMYHSGDVARFLPDGNIQIIGRKDSQVKIR"
     CDS_motif       23292..23333
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0009"
                     /evalue="5.90E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1109"
                     /protein_start="1095"
                     /score="13.3"
                     /tool="antismash"
                     /translation="MGVIKAGAAYQPLD"
     CDS_motif       23523..23573
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0010"
                     /evalue="1.40E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1189"
                     /protein_start="1172"
                     /score="20.8"
                     /tool="antismash"
                     /translation="LLYTSGSTGVPKGCMLE"
     CDS_motif       23925..23951
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0011"
                     /evalue="8.40E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1315"
                     /protein_start="1306"
                     /score="6.2"
                     /tool="antismash"
                     /translation="YGPTEATIF"
     CDS_motif       24054..24140
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0012"
                     /evalue="2.10E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1378"
                     /protein_start="1349"
                     /score="39.2"
                     /tool="antismash"
                     /translation="PPGACGELMITGWQVSRGYLNKPEKTAEV"
     CDS_motif       24237..24299
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0013"
                     /evalue="1.60E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1431"
                     /protein_start="1410"
                     /score="33.1"
                     /tool="antismash"
                     /translation="IGRKDSQVKIRGFRIELSEVE"
     aSDomain        24597..24779
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12305_PP-binding.2"
                     /evalue="1.70E-10"
                     /label="RSAG_RS12305_PP-binding.2"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1591"
                     /protein_start="1530"
                     /score="33.2"
                     /tool="antismash"
                     /translation="DCIAEVLGYTDFGITTDIYEAGLTSITAIKLNILISKAFDIVIKT
                     SDIKNHPTIRMMEEFV"
     aSDomain        24816..25643
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12305_Condensation_LCL.2"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.30E-38"
                     /label="RSAG_RS12305_Condensation_LCL.2"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1879"
                     /protein_start="1603"
                     /score="123.2"
                     /tool="antismash"
                     /translation="ESYPLTNTQEGIFIECTANMGSTIYNIPYLLKLDNKVDLDRLAEA
                     IDSTVEAHPYLKTRLFMDDNGNVLQKRNDGLSYKTPILNGMNRDTLVRPYMLFNEQLFR
                     FEIYRTCDGNYLFLDLHHIVADGTSLAIIINDINRAYSGEKLEPEGYTSYDLALDNRDA
                     LAGDIYKNAENYYKSVFEHAGGSISFYPDKNGAAPTAELYHRETRSISVQDVKEFCKKH
                     GITENVFFISAFGITLGKYNFKKDAVFTTIYHGRNDSRLSETVGMLVKTLPVFC"
     aSModule        24816..28622
                     /complete
                     /domains="nrpspksdomains_RSAG_RS12305_Condensation_LCL.2"
                     /domains="nrpspksdomains_RSAG_RS12305_AMP-binding.3"
                     /domains="nrpspksdomains_RSAG_RS12305_PCP.1"
                     /domains="nrpspksdomains_RSAG_RS12305_NAD_binding_4.1"
                     /locus_tags="RSAG_RS12305"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       24882..24992
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0014"
                     /evalue="2.50E-07"
                     /label="C2_LCL_024-062"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1662"
                     /protein_start="1625"
                     /score="23.1"
                     /tool="antismash"
                     /translation="TIYNIPYLLKLDNKVDLDRLAEAIDSTVEAHPYLKTR"
     CDS_motif       25173..25238
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0015"
                     /evalue="1.60E-07"
                     /label="C3_LCL_132-143"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1744"
                     /protein_start="1722"
                     /score="23.9"
                     /tool="antismash"
                     /translation="LHHIVADGTSLAIIINDINRAY"
     CDS_motif       25557..25637
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0016"
                     /evalue="3.60E-02"
                     /label="C5_starter_265-294"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="1877"
                     /protein_start="1850"
                     /score="6.8"
                     /tool="antismash"
                     /translation="VFTTIYHGRNDSRLSETVGMLVKTLPV"
     aSDomain        26088..27260
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12305_AMP-binding.3"
                     /evalue="3.00E-94"
                     /label="RSAG_RS12305_AMP-binding.3"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="2418"
                     /protein_start="2027"
                     /score="307.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FKEMAARYPDRPAVRDDSGDFTYRELDRMSDYIAQKLTENGFGPE
                     QAAGILCGRTKEYTVAYVGVMKAGGAYVPLDPEYPQSRIEYMLKDSGARNLLVIDQYQN
                     LVEFYDGNVISLDSVPDEAEDFELSAELISPKPENLAYMIYTSGSTGKPKGVMIEHRNL
                     LNLIEYITLSRNTSPDDIVAEFASFCFDASVIDLFAPLTAGAVLYILPESIRKDAIAIS
                     RYIKEKEITTVTFPTQMGELVTELLEDAPALKFVTLGGEKFKHYRNRTYQMINGYGPTE
                     NTVSSTEFLVDRQYDNIPIGKSQRNVRSYIVDENLNRLPVGASGELCHAGRQIARGYHN
                     LPEKTASVFVENPFAVCEQESRLYRTGDMVRMKGDGNIEYIGRIDSQVKIR"
     CDS_motif       26277..26315
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0017"
                     /evalue="3.30E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="2103"
                     /protein_start="2090"
                     /score="17.1"
                     /tool="antismash"
                     /translation="GVMKAGGAYVPLD"
     CDS_motif       26508..26567
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0018"
                     /evalue="8.00E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="2187"
                     /protein_start="2167"
                     /score="33.7"
                     /tool="antismash"
                     /translation="AYMIYTSGSTGKPKGVMIEH"
     CDS_motif       26916..26945
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0019"
                     /evalue="9.60E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="2313"
                     /protein_start="2303"
                     /score="6.0"
                     /tool="antismash"
                     /translation="YGPTENTVSS"
     CDS_motif       27045..27134
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0020"
                     /evalue="1.90E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="2376"
                     /protein_start="2346"
                     /score="39.3"
                     /tool="antismash"
                     /translation="PVGASGELCHAGRQIARGYHNLPEKTASVF"
     CDS_motif       27225..27290
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_RSAG_RS12305_0021"
                     /evalue="1.00E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="2428"
                     /protein_start="2406"
                     /score="36.7"
                     /tool="antismash"
                     /translation="YIGRIDSQVKIRGYRVELGEIE"
     aSDomain        27576..27776
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12305_PCP.1"
                     /evalue="6.80E-21"
                     /label="RSAG_RS12305_PCP.1"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="2590"
                     /protein_start="2523"
                     /score="66.2"
                     /tool="antismash"
                     /translation="RALCEIFEKALGIERVGIEDNFFELGGSSLTASKVAVMCLSKNIS
                     LVYADIFKYPTVRELAALVDDD"
     aSDomain        27909..28622
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12305_NAD_binding_4.1"
                     /evalue="5.50E-35"
                     /label="RSAG_RS12305_NAD_binding_4.1"
                     /locus_tag="RSAG_RS12305"
                     /protein_end="2872"
                     /protein_start="2634"
                     /score="112.5"
                     /tool="antismash"
                     /translation="VTGATGFLGIHVLKAFIDNYDGKVYCLVRKGKYESSEKRMMNMLM
                     YYFDDPYKELFESRIICVDGDITSKEQVTGFSEYKFSTIINCAACVKHFAADDVLERIN
                     VQGVENLIDFCKNNGRRLIQISTVSVAGEGSDGVPPMSRVFCENDLYIGQNITNEYIRT
                     KFLAERAVLEAVSEGLDGKVVRVGNLMSRNSDGEFQINFITNGFLRSLRGYAAVGKFPM
                     GGMHEVAEFSPIDSTA"
     gene            29011..29313
                     /locus_tag="RSAG_RS12310"
                     /old_locus_tag="RSAG_00946"
     CDS             29011..29313
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008704342.1"
                     /locus_tag="RSAG_RS12310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00946"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_008704342.1"
                     /transl_table=11
                     /translation="MEIITKTEGNKATMEISGWLDTQTAPQLGEALSGLEDSITSLVFD
                     FTNLEYISSAGLRQVIVAYKKMAQKDGFKIINVSDEVYDVFSLTGFDSKIDIQKK"
     gene            29325..29972
                     /locus_tag="RSAG_RS12315"
                     /old_locus_tag="RSAG_00945"
     CDS             29325..29972
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]; GO:0000287 - magnesium
                     ion binding [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (98-159). E-value: 2.8e-13. Score:
                     41.7. Matches aSDomain: nrpspksdomains_RSAG_RS12315_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 128.1;
                     E-value: 5.1e-39)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019161712.1"
                     /locus_tag="RSAG_RS12315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RSAG_00945"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_008704340.1"
                     /transl_table=11
                     /translation="MQKLYRININHFEDPLKNERILDLVGIRRREKVIRYRMPDDRKRS
                     LGAGIIIRKILDENGLTESCLRYSDNEKPVVDGLFFNVSHAGDYVVGVLSDCEVGCDIE
                     KNANAPLEVAEHYFYHSELAYIKAAKNKDKAFFTLWTLKESYMKMTGRGMSLPLDSFEV
                     VPTAEGFVLGKSSERPCFFETMEFDGYIFSVSSERAFSLHNPLEIVFDDIYV"
     aSDomain        29619..29801
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RSAG_RS12315_ACPS.1"
                     /evalue="2.80E-13"
                     /label="RSAG_RS12315_ACPS.1"
                     /locus_tag="RSAG_RS12315"
                     /protein_end="159"
                     /protein_start="98"
                     /score="41.7"
                     /tool="antismash"
                     /translation="VGCDIEKNANAPLEVAEHYFYHSELAYIKAAKNKDKAFFTLWTLK
                     ESYMKMTGRGMSLPLD"
ORIGIN
        1 agaatataac tatcctgtaa ttcaacaaat ggatattgta tgggaaaaat atcaaaatat
       61 ttcgttatat ttaaggaata tggattacag tacaatttat gatgaaatag aaaaaaatca
      121 taattataat gttaaattgc cagatggcgg tatcatacag ttgatgtatc gctttaatag
      181 aacgggaaaa gaattgattt cgcacagatt ggggtattat ccatcaccgt cgtatgaact
      241 ttatcagaat gatccggaat tatacgatgt tgactatatt tacggagata ttttaaataa
      301 atctgtattg cctgtgatta ttcgagctga ttacaatcga gatccggagg agagcgaact
      361 gcatcatcca tattcacata ttactttagg gggatataaa aattgtagaa ttcctgtaga
      421 tcgtccaata tcaccgatga aatttgtgaa atttattatg gaacattttt attatgttcc
      481 gagttcacag ttggaattca attttgaaat tgagggtata gtagctttcg aagaacatat
      541 tgcagaaaaa gacataaata agagcagaat aatagtatga aaatggagaa tgaaatatgg
      601 aaattgttag agaatctata ttcatacaaa cagctataaa attatagtgt aaattatagt
      661 agaaaagtaa ttgacatatt catggtggca agttaatata atattaacaa caggcaacag
      721 gagtgtctgt caagcgttga agtaaggtgt tgtgccagga ggcagtgcct taccagcttt
      781 ataagggttt agcatttacc acaatctggc tagggagcaa aagctctcaa aagaaaatgc
      841 tgggaggctc tgccaagtgc agggcctttc ttaattttat tatgaaaata aagggagttg
      901 cggaaaatat agatgagaac agttgttgat tgtgtatcat catttattcc tctcttatca
      961 acaatcaaca gagtatgaaa ttgttctggg aagaaaaaat gttgcggtta aacttataat
     1021 aacgtttgat aagaaggact gttttcattt gatgggatta caggattaca tatattatac
     1081 gacagattga aaaaagatgt aaaatagcaa gattgcctga tggaaaatat ttattccatc
     1141 aggcaatcct atgtaaacat ttctttagtt ttgattattc tgcagattct ttagaaacag
     1201 aatttttctt ttttctggat ttaccagaaa tcattttatg accggagtag atagccataa
     1261 tcatgcagag aagagagctg caagcaaaat atttgtgagc agttttcatg tttttatagc
     1321 cggtataaaa ggttccaatc atggctgcca atgcaccaag tgaccaatat ttatgtgctt
     1381 tcatttgaat atacctcctg cgttttttta ttataatacc tctttttaga aagcatgaaa
     1441 acaggaaatt tataaattct gttctttctc aatctgctgt tcctgttcgt agctcttccc
     1501 aaggatcata tcaatattgg cagacacggt acgaaactcc cgttcataat tccggcggtt
     1561 agaaaaatct tcccgttgca tatttcgcaa ttcaataagt cggtcttttt cagcatagag
     1621 ggatttcgtg gaaggcagct tatttccgac agatttttct ttcagtgttc ggagagctgt
     1681 atcataaaga gaaacttttt atttttatgg taatagctgt ttagtttctg acattcagat
     1741 tacaaacctg tttgcggcag agttattgat gccgtatgaa gtctttcgga aaaatttctt
     1801 tgcacatatg aacgaattgg aaataactcc cgggaaggta cggttggatg aggctatccg
     1861 tctgattgtt tgtcagatga gtgatttttt ggttccttat gtgattagca taaattaagt
     1921 ctgcgaagca aacgatactc cttgggcttt gcacaaggag attcatattt attgtatttc
     1981 gcagtgtatt actgggcgcg gagtgaacag taaccagtaa ataaacaatt tattgacaaa
     2041 taactgacca gatgtaataa taccactcag agatagtatt tggactcaaa actatactct
     2101 ggctgaaatc actggaatct tatataaaag cagccagccg gaatccggaa acgggaacgg
     2161 agggatgtat gtaattttaa aagatacgag ccggtattta tgatacaaaa aatcagattt
     2221 ccaataatct atggaatagt aaaacatatt ttatgtatca gaaacaggac tcaatataca
     2281 gggaatcaat cagaagcgtt tcagggtcaa agtgtatcct gatgcgcttt ttttgcagat
     2341 cataaaggta tatttccttt ttatggtgct gcttgactct gatttttccc gcaggaaagg
     2401 actatataag atgacaatag aaatgttaaa aggaaaaatc cacagagcaa ctgttatcca
     2461 ggctgaactg gattatgtgg gaagcattac tgtggatgaa gaactgctgg aagctgccgg
     2521 aatactggaa tatgagaaag ttcagattgt agatgtgaac aatggcagtc gattcgagac
     2581 atacacaatc tgcggaaaac gcggaagcgg tatgatctgt ctgaacggag cagcagcaag
     2641 atgtgtaagc acaggtgaca agattatcat catggcttac gcaggatatg agcctgaaga
     2701 ggcacgcact cataagcctg cagttgtatt tgtagatgaa gagaataaga tcagcagagt
     2761 gaccaattat gagaaacatg gtctgctgaa agacatggcc tgaaaacgtt gatatcagat
     2821 tagaggctat cataagatga aagtgaattc agaaaagagg ctatctcaaa atctatgata
     2881 ccggtccatt gaccgagaaa gaggagataa caatgcaggt aacaaaaaca gtagaagaaa
     2941 caagaaaaca gatcaaagca tggaaaaaag aaggtaaaac tataggtctt gttccaacaa
     3001 tgggatttct tcatgaggga catgcaagtc tgatcaaaaa atgcagagaa cagaacgaca
     3061 ttgtagttgt gtctgacttt gtcaatccaa cacagtttgg tccgacagag gatcttgagg
     3121 catatccaag agatttcgaa cgcgacagca aactctgtga aagtcttggc acagacctga
     3181 tcttctgccc tgaaccttct gaaatgtatc atgatcccca tgcatttgta agtatcgata
     3241 cattatctga gacactttgt ggaaaaacac gtcctatcca tttcaaaggt gtgtgcacag
     3301 ttgtaaccaa gctgttccat attgtagccc cggacagagc atatttcgga cagaaggatg
     3361 ctcagcagct ggccatcatc cgcaaaatgg tccaggatct gaattttgat atagaaatcg
     3421 taggctgccc gattgtccgt gaagaggacg gactggcaaa atcctccaga aatacatatt
     3481 taagcgatga agagagaaag gctgctctct gtctgtccag atccgtaaaa ctcggacagg
     3541 aaatcattca cgcaggcatt tccgcagaag aacttctcgg caaaatgcgt gcagtgatcg
     3601 aggcagagcc tctggcaaaa atcgattacg tttccatggt agatgcactt accatgcagc
     3661 ctgtggaaaa agctgatcat aatgttctcg tagcaatggc tgtctatatt ggcaaaacaa
     3721 gactgatcga taacttcagc tacgaggtat aatatatgga aaatatttta aagaaaatag
     3781 gaaaaatcag cagttttgca tccagatata ttggaatcat catcattgcc ttttcatgcc
     3841 ttgccttttt ctggagggat ggatttgcat ggatgacaaa ttatacatct gtttttctgg
     3901 gcgtgatcat gtttggtatg ggactgacca tacgtctgga agacttccgg gcaatttttt
     3961 ccagaccaaa ggaagtgatc attggcgcag ttgcacagta tacgatcatg ccagtcgtag
     4021 cctgggtatt gtgtaaagtt atgaatcttc ccgcagatct ggctctgggt gtgattcttg
     4081 tgggatgctg tcctggtgga acagccagca atgtgatcac ctatattgca ggcggtgatg
     4141 ttgcactttc agtaggaatg accatcgttt ccactctggc tgctcctgtt atgactccat
     4201 ttcttgtgta cattctggca ggtgcctggg tggaagtatc cttctgggca atggtacttt
     4261 ctgttgtaaa agtaattctg gttcctgtac ttcttggaat ccttctccgt acacttgcag
     4321 gagatcatgt agataaagtt tcagatgtta tgccattgat ctctgttgta gccattgtta
     4381 tgatcattgg cggaatcgtg gcaattaatg cagagaaaat cttaagctgc ggagttctgg
     4441 tccttggcgt tgttgcgatc cacaatttct gtggtatgat gcttgggctc cttgcagcaa
     4501 aaattttcca tgtagaatat acacgggcaa cagctatagc tattgaagtg ggcatgcaaa
     4561 acagcggact ggcagtttct ctggcagcag ctaactttgt agccaatcca ctggcaactc
     4621 ttccaggtgc tattttcagt gtatggcata atattgcagg ctccatcttt gcaggaatcc
     4681 gccgttccgg cgtagaaaac cggacacgca caggtgaaaa tggtgtgtca gcagcataaa
     4741 taacaaggga acgtagaaaa caaaatcagg aagttcacgt ttacactacg ccatgttttg
     4801 agacatttac ggtttgtaat atataaactg aaggaagcct ataccgggct tcctttttaa
     4861 atatcagggg agatcgaggt ctcttatctt caaatattcc acaagcttaa aagacattct
     4921 caacagaaac tctgtcatgg gatcgtttaa atcggcttta cctatttcaa tgattttttc
     4981 cattcgataa gccagcgaat tcctgtgaat acacaaaatg ttagctgttt ccttattgtt
     5041 atggaaacac tgtagatata cctcaagtgt atggtaaagt tcatttcccg ttctctggtc
     5101 atatttattc agtctgtaaa gggcagggtg gatataatct gcaagttttt ctggttcttt
     5161 gatcttgttc atcatttcgt agaactcaat ttcagaatac cgatgaattt gatgctccat
     5221 cggatacctt tgatcccatg atatttcctt cttaaggtta tcagggattc tgtgattcca
     5281 ttcaagaact gtccgcgcct gctgataagc tctgtaaaat tcatccattt ttgaaaaaac
     5341 cagggagatt cctacatcca gatgatactc tgccatcgtt ttaagcatta ttttttgagt
     5401 atctacaaat ataacagaac tctgatctgg tacaagcagg actagtgcat tgtcgtggac
     5461 agtcatatat gcttccggaa agatatgtcg gatcacagga taaagctgct gctttaattt
     5521 attttccttc aaaaatgtct tcggttggat acaaagtgca tacattgcat cagatactcg
     5581 aagatgagaa atggaatctg ccaatatatc agccggagtt ccaatcagca aggcttcaag
     5641 aagctgctgg tccgcactgg tgtactgaaa cagttcagga tgataatgtc caactacgga
     5701 gctgattgcc cggcttacat cactcatagc tgctaagtgt tctgcggtaa aagggatatt
     5761 gttttctatc atcagaacaa aaccaacctg aacaccgttt aaaaacactt tcgaactaca
     5821 tttacgatat ggtgattccg ggcaagatac ttcaacagcc tcaatgctgg ctgaagcccc
     5881 ctggacagct tccaatgaca ttacattttt aatgaaatcg tatgtacaat atccacgttc
     5941 aatattcttt ttccataatt tatccgtaac cggaattgat gtagaatatg acaggatacg
     6001 gaatttcttg tcgcaaaata ccaaagaata tcctaatttg atggatgcag agttaatcac
     6061 ttcatccagg ctatgggaag agtggccttt tcgaaccagt tcttcatata aactaacctg
     6121 ttcatgtgtc tgaagaaact gttttgctgc attaaaaacc gcaaaaagct cttttgcctg
     6181 tactgttgca cgatccgtgc aggaataagg aaaaagatag ttttctccac gaacaaggat
     6241 acattgagaa ggctgcatat caggagacaa gacatctgga taaccaaaat agacaatatc
     6301 tgtggcgtat cctgtttgag tgccatccag cagctctaca tctcgtattt catgaagatc
     6361 agtagaacaa tttagtatta tgttaaaagt ttttcatttt taaataatca ataagatcgg
     6421 aaaacagcat cttcatactc ctctttacaa ttatttgtga aaaatgcaca gtgttttgca
     6481 gattattatt aattatagtg cattgtgcat aaatacacaa tgtctttttt atatttatgc
     6541 cgttgttttt ttaacaatga aaatgttatt tttaagccat aataatcaag agacacaagt
     6601 aaaggagggt gtacatgtat caggaaatat ttaaacaggg aaaaattgga aatattacac
     6661 ttaaaaaccg gcttgtaatg tcaccgatgg gtacaagcct ggcggagatg gatgggtctc
     6721 catcggaaga catgattgca ttctatgagg cacgtgcaat tggtggcgca gcgcttatta
     6781 ttccggagat tgcaagggta aacgatctgc atggtgcagg gatgatgcgt cagctgtctg
     6841 tttcaaaaga cagacatatc gaaggtcttg caaagcttgc agaaacagta cataaatatg
     6901 ggacaaagat attcatccag ctgcatcacc ctggacgtga aacagtaact gctcttacag
     6961 gcggcccggt agtatctgct tcagcaatac cgtgcaaata tcttcagcag gaaacaaggg
     7021 ctctttcaac agaagaagta aaagctttga tccaacagtt tatctcaggt gctgtacgag
     7081 taaaaaaagc gggttgcgat ggagtagagc ttcatgcggc tcatgggtat ctattacaac
     7141 agtttctttc cccttacaca aataaacgcg aagatgagta tggtggttcc tttgaaaaca
     7201 ggcttcgtat gatcactgag atcataaatg gaatccgcgt acagtgtgga ccggactttc
     7261 caatcggtgt ccgtttaagc gtggaagaat ttctggataa gacaggagta acagaggatt
     7321 atatccatat ccaggatgga gttaagattg caatggcgct tgagaaatgc gggattgatt
     7381 ttattgatgt gtctgttggt ttatacgaaa caggaagtgt atgtgtagag ccgatctcct
     7441 tcccccaggg ttggagaaaa gatctgatca aggccgtaaa agatcacgtt tctattccag
     7501 tgataggagt ttcctgcata cgtgaaccac aggtagctga gagttttctg gaaggaggta
     7561 ttgttgattt tgtctccatg ggaagaagct ggctcgcaga cgaacagtgg ggactcaagg
     7621 tacttgaagg aagagagaat gaaatttgta aatgtatcaa ttgtctgcgc tgctttgaga
     7681 gcctgaatgc atggatgggc gcgggtattc cggcggaatg tgcagttaat ccacgtgcat
     7741 gccgcgaacg tctttatgga aatgcagaat atgacactca ggaacataag gtagtagttg
     7801 ttggtggcgg tccatgtggt atgatcgctg ctaaaacact tgctgaacgc ggcatgaagg
     7861 taacactggt tgaccgccag agtgagcttg gaggtacgat aaaccttgca aagaagcctc
     7921 ctttcaaaga acgtatgggc tggattgccg attattataa tgttgaattt gagaaacttg
     7981 gagttgaatt aaaacttgat atggaagcga ctgcggataa aattgcagaa atgaatccgg
     8041 acgcggtgct tgtagcaaca ggttctaaat ctgtcattcc aggatctatt cccggaataa
     8101 ccggagaaaa tgtatatacg atcgaagata ttctttccgg aaaagccgga ctgaagaata
     8161 aaaaagtaat gatcatcgga gcaggtgtta cgggacttga aacagcagaa tatctctgtc
     8221 acgaaggaaa tactgttgta cttgcggata tgcttgacaa agttgctcct aatgcaaatc
     8281 atacaaatgt tgcagatgta tgtggaagat tgaaagaata caatgcccag ttcatgatgg
     8341 cacatgccct taaagagatc aaaaaagatg gagttgttct tgaaagattg aacgataaga
     8401 taaatgtgga agtcgctgca gatgctgttg ttctttcact tggtttccgt ccggacaacc
     8461 atcttgttga agaattaaaa gaaaaaggaa tccatgctca ggctatcgga aatgctgtga
     8521 aagacggtac gattgctcct gcatccagaa gtggttttga agcagcaagg aaattgttta
     8581 agacatctgt caaaactcca agctttatca ccgctccgga ggaaatgcct aatttcggta
     8641 agatctctct tatgaaaaat caggagggaa tatatcttgc atacctcacc gatcctgcgg
     8701 cgattgcaaa ggttctgcct gcaccgttaa aaccattttc cgtgcctgta gttacggtat
     8761 ctgtgtgcca tgttaaggag cctacctttg ctgatgatta ttatgaagca atccttggtg
     8821 tttactgtac atatggaaca cagcttggat tatatccaat agggcttgta cttgggggaa
     8881 ccggtgcaga aatggcagtt cagtgtggac gtgacaatgg atcaattcca aagaaactgg
     8941 gatctgaatt tgtaatccgt cgaaacaatg atcatgtgac cgctcaagtc tgccgtcgtg
     9001 gtactgaact tgtaaatatt gatctcaaga ttggtgaata taataacgca atgaccggaa
     9061 tgctgtatca gttcccagaa gccggtaaaa agacatatgg cggtggtttc tacttccacc
     9121 ttgaccgcga accggataaa gaaggaaaat cacatttcca gaatggtgct ctgcttcaga
     9181 atctctgtga atacaattac cattcatggg agcctggttt tgcagcgatt aaattacaat
     9241 cgtccattga tgatccttgg ggagaacttc caatcagaac agtcattgga ggtgcgtatt
     9301 cctcaaatga tctgatggtt cataaactga atttatgtga agagattgac gcagatgttc
     9361 tggcaccgta tctgcttacc gcacggtatg acagaacagc attcatggaa acaggaagaa
     9421 gataaggagg gcattgccat gaagtttgaa aacaaagtag caatcattac cggttcaaca
     9481 agaggaatcg gaagagcaac cgcagaactc tttgcaaaag aaggagcaaa agtcatagtt
     9541 gttggaacaa aggaagaact gggagaaagc tgtgtgaatg caatcaaggc agccggagga
     9601 gaagcaattt tctgtaaaac agacgtgaca tctgatgaaa gtcttgataa cctggttaaa
     9661 acagctctgg acacctacgg aaaaattgac attctcgtaa ataatgcagg agtaggcgga
     9721 acaactgcca atatggatca gattacaatg gatgaatgga acaccgttct tgcaacaaat
     9781 ctcacagcac catttgttct ttgcaagaaa ataatcccta ttatggaaaa acaaggggct
     9841 ggaaccatcg tcaatgtagc ttccatggca gcaaccgcag caggccgcgg agggcttgct
     9901 tacacttctg ccaaacatgg ccttcttgga ctcacccgtc agatgtcatt ggatcatgga
     9961 cgtacaggag tgcgtataaa tgctgttctt ccaggaccga ttgcaacaga tatgattgca
    10021 cgtgtgcttg caattccaca gcatccggta acaatgaaga ttggaatgag tccggcaaaa
    10081 cgtcctggag aacctatcga agtagcacag gctattgcat tccttgcatc agacgaagct
    10141 agtttcatcc atggagcggc tttggctgta gatggcggat atacgatatt ttaaaaataa
    10201 ttgatatgca ttggaaaaag gagtcatttg gactcctttt ttcagtacgt aggatcctta
    10261 acttccaaaa atgagtagcc ctaacgaaaa taaaattaaa aaaagcccgt atttctgcgg
    10321 aaattattgc aaaaatacgg gttttgctgc ataataaatt tagggctata tgagcctaaa
    10381 taaaggaggc gaatatgtac ctgaaatcaa gagtaaaaat accagatgta catggaaaat
    10441 tgatccgatt aagaagaggg gatatcacat atattaagta tgagtatgat cgctattata
    10501 atccggagaa aaaatatacc tatccacaga gagcaactat aggcaaggtg tgtgcggatg
    10561 atgacactat gatgattcct aacgaagcct ttctgaaata ctttccagat gcagttttat
    10621 cagatatgga agaccgaaca gagcgtagca gctgtctgcg ggttggtaca tatgctgcaa
    10681 tacataagat agtatcgaat tattcgttag ataagatgct tggacagttc ttctctaagc
    10741 gggatatggc actactgctc gaccttgcat cttactttat tgtagaagaa agcaatgtag
    10801 cacagcatta tccggattac gcatacaatc atccactgta tagttctggt atgaagatct
    10861 atagtgatgc gtcagtaagt gatttcttta agagcatcac taaggataag agcacaggct
    10921 ttctgaatga atggaatgca aagaggaatc gaagggagcg tatttatatt tcctatgatt
    10981 ctacgaataa gaactgccag gccggagaga ttgaactggc tgaattcggt catgccaagg
    11041 cagatatcgg ttcagctatc atcaactatt cggttggata tgatcttaag aataaagaac
    11101 cactctttta cgaagcttat cctggaagta ttaacgacgt atcacagctt agggccatgc
    11161 ttggcaggat cactgggtat ggctataaaa aaatcggttt cattttggac aggggatatt
    11221 tcagccgtgg aaatatacgc tatttagacg aatgtggtta tagttttgtg atcatggcta
    11281 aaggaacgtc ttctttcata agtgatttga tcttagagaa caaaggaacg ttcgaaaata
    11341 agcgctcctg tgatatgaac gcttatggtg tgtatggaaa aacagtacaa aagactttat
    11401 ttgaaggtga tgaaaaaaag agatacattc atatttatca cagtatttca aaagatgctg
    11461 atgaacggga gagttttgaa aacgcactga gagagcggac aactttgctg atgtcgcatc
    11521 agaatgaaac agtagagttc ggttcagctt acgaaaaata cttttatctt cactacgata
    11581 aagatggcgt gtttttatat ccggaagaaa aaacaactgt gacagaacgg gaaatatcat
    11641 tatgcggata ctttgttatt atcacatccg aaaggatgac agcaaaggaa gcactgcatc
    11701 tttataggag ccgtgatgta tctgagaaac tttttgcctc tgataaatca ttccttggaa
    11761 acaagagcat gcgttcgcat acaaacgaag gcgttgaagg acggattttc acacaattta
    11821 tcgcactgat aatccgaaac aaaatttata ctgcattaca ggaagagaac gaaaagcttg
    11881 agaagaaaca gaattatatg acagttccgg cagcaatcag ggaacttgag aagattgaaa
    11941 tgacacgcca gacggataat atataccgtc tggatcatgc agtaacagcg aaccagaaag
    12001 taatattgaa agcctttgga ttggatgcga atagtataaa atactttgca tcggagctga
    12061 gcaaggaact gaaaaaatca gaataaggaa ggaaaataaa gatggcaaga acaagaaaaa
    12121 caagtaagga agcattagaa gaaaagattg aaaaagcaga ggttgatgtg atcgcagcaa
    12181 agaaaaagta tgatcaggca acagcaaatc tgaaagaact gttaggaaag tgagaatcag
    12241 ttatatggaa aaaattatat ctggcaggga gagtatggaa aaagatcaca cctgaaagta
    12301 tcatttaaag aattactaaa agaacaggat tcatcttcgt tggaaatgct ggcaattttt
    12361 gtgaataata atccatataa ttttgaattt tatatcgcgg tagtttatga tatccccaaa
    12421 gaagaacacg tagaaaagat gataggatta tttgaaaatg ccgggttggt tctgagaaat
    12481 gatcttactt ttttcatgtt tatgaattcg atgaaagata gaagatttaa ttcatgtgct
    12541 tttctgggag aacaggatat tgacttaaaa tttgaaaata tgtttgattt tgtggagatt
    12601 gaagatttga agaaaaaggg atattatatg cagccatttg gaaaagaaaa acaggtcttt
    12661 atcagccatt cttcgaagga taaaaaggat gtggaaatga taattcccta tttaaatgga
    12721 caagatctac cagtttggtt tgacaaatat agtattcctg tcggtgcatc aattacagag
    12781 caggtacaaa ggggaattga agagtctgat atggtgattt tctgggtgac agacaatttc
    12841 ttgaattcaa attggtgtca gatggagatg aaagcatata ttagcagaat gatacaggaa
    12901 aatattcgaa tatgtattgt aatggacgat gatatagaaa ttaagaaact tcctttattt
    12961 ttacgagata taaaacatat tcgaagagat caccgatcgg tcatagaagt agcggaagag
    13021 attgcaggaa ttatcaaaca tatgtaaaga tatatacata aataatgctg gcattcatca
    13081 acgatttgtt tgctgttttt ctcgataatg tcgtgaatca atgttgcgaa gctgtttccc
    13141 tccgtgcggt aacgaacaag atactgtttt gtaacgggaa acatttttat gtaatgtagt
    13201 ccgtgacgat tttttggtct tgtctgcgga cgaggaggca gagcaaagta ctgatctttg
    13261 ggtgccgatg cgggaatgtt tgaacgaatg ggaacagcaa agtcatagca ggcatccttg
    13321 tattttaaac ggacaactag aacataaggt ctggttgatt tctgtagtac ctctgaatcg
    13381 ccggtgtatt tgagcaacag cgcattattt attgtaacga gtttcatgac tggttttcct
    13441 tcctaaaaaa gaagagcctg cctttcggca agcccttcct acacgtaagc gatattctac
    13501 gctttgcagc accccgtcgc ttgcggaagc taaacataca cgttcatcat attctagccg
    13561 tgatgaccga caagccatta actcacttat agtatactca ataatcgccg caaatgcaac
    13621 gggttcaaaa gataattttt aggataataa gcgggaaggt tactgttcag aggtatgcat
    13681 aagtcattgt aaaaaatgac gaaatttatt tttttatttt gtggataacc attcgcggca
    13741 ggaaaaactg tgtttatagt ttttcctgct gttctttttg tcaaaagtta tacactagat
    13801 tctggttttg ggaacccatt cttgaagctt caaggtctgc atgaatactt tttttattat
    13861 aaaacagcta tttatccaca gtcagattga cgaaaaggta ctttctggtg attcgctttt
    13921 tttctatgtt tctgttatac tttttctcaa gaaagagagg ttcacttctg acgtttcttg
    13981 caattgtatt tggttctact gtttttacga ggactccggg gatcaggcag tatcagctag
    14041 agatattctg gtcatggaag gaaatcctgg ggattggtac atgtggcaga ctgggaagta
    14101 ctacgggaga tggtttactg caggagaatc tgttgaatat tctgctactt tttccggcag
    14161 ggattttatt gccggggttg acaggcagaa aactgaaatg gtggatggga ttgcttgtgg
    14221 gaattgcagt atcatctgct atcgagatta gtcagctgct gctttgcaga gggttgtttg
    14281 agtttgatga tattattcat aatagtttgg gatgtatgct ggggagtttg ttggggaata
    14341 ggatgttaag gttggtgcat ggaaagtaaa gggcaggacc agatgaaaaa ctgacaagtc
    14401 atcttgaatt gcgatttcag gaaggtcacg ttcaaaactt aacagttttt gtgaagcatt
    14461 ttgaaaaccg tccctgctat cagcaggggc ggctttcatt tgtgcgccta tttattgttt
    14521 tcgctgacat gaagatagtt cataagcgca acctgaaaaa ttttggaaca attgactccg
    14581 ttcacagcaa tgtctttttg acgtaaaatt gtttataaca gtaaaaatgt ttaacaaaat
    14641 ctgttaaaat gctataatgc agatatgaaa ctgataatct tgagaaaatc cataatgtat
    14701 gataaaagga ttgctataaa ctggtactgt gaaaatacga cagaagagga gtaaaaaaat
    14761 gttatatata ggaaatcaca caagctcatc ccggggatat cttgcaatgg ggaagcagat
    14821 gctggcaaat ggcggtaaca catttgcatt ttttaccaga aatccaagag gagggaaagc
    14881 caaagacatt gatccgcagg atgtgcaggc atttgggcag ctggcagaag agaatcattt
    14941 tggaaagctg gtggctcatg cgccttacac tatgaactgc tgcgctgcca aagaaaacct
    15001 cagggatttt gccagagaaa tcatggcaga tgatctgaga cgtctggaaa tgacaccggg
    15061 aaattattac aattttcatc cgggcagtca cgtaggacag ggtgcagaag taggaatcag
    15121 taaaattgca gaaattctca atgaagtgct gacaaaagat cagagtacga ttgtacttct
    15181 ggaaactatg tcaggaaagg gcacagaagt aggaagaaat ttcgaagaac ttcgtcagat
    15241 cattgacagg gtggagttaa aagataaatt aggtgtttgt ctggatacct gtcatgtctg
    15301 ggatggtgga tatgatattg taaacgatct tgacagcgta tttgaagaat ttgaccggat
    15361 aataggtctg gacagactaa aagccatcca tttaaatgac agcatgaatc cccttggcag
    15421 ccataaggac cgccatgcca gaatcggaga aggtgaaata ggactggagg cacttgtccg
    15481 cgtgatcaat catcctgcca cagagggaat tccgtttatt ctggagacac caaatgatga
    15541 tgagggatgg actcatgaga ttgcgttgct cagaaatgag tataaacaga aatgagtata
    15601 aatatatctg tccgagtcag gaagataaat tggggcgtgc tgacaagttg taagtgcaaa
    15661 tcaaaagagt aggagtgaga tcaaaaggaa ggaatgcagg aaagatcaga gatgcagcaa
    15721 agacaaggat atcaggcagt agagaagctg agaaaaacac tggacgagaa gtatctgtgg
    15781 gaggttattt tactctatgc aggtgagagt ttcaaaacct atacagggct tccgttcact
    15841 tatgaagtaa gaaaggggcg gaatggagac tacacaaggg aattgtggat cgaccgtagg
    15901 gagaacagta agagtctggc gttaagttca gtgctgctgg cattgagaaa cataaagaag
    15961 gtgggagctg tggttgacag acccaaagct ctgggcgaca tccgcggagt gagttatatc
    16021 tatggaatgt tctactgctt tgggctgatc gatgtgccgg atacagccag gcagaagatg
    16081 aagtgtctgt gaaagcagta tgcgagagtg ctgtcagata gtatgttgtc agattgtagc
    16141 ttttggggtt actttatctg tgcttgtatg ataaatttta ttatgtatta tgcatgatta
    16201 ttatatgtga atttcacatg atatgttttt taggaggaaa ggtatgaata agaagaaaaa
    16261 cgtggattcc gggagaaagt ctgcaagacc ggattacatt cagaaaacaa tatcacagaa
    16321 aagttcagga aaacgcagtg gaaaagtttt cttccccaaa accctcataa agactggggg
    16381 gattataatt tttgtacttc tgcttgggtt tgcaggaaac aagtttttcc tgtctgtcag
    16441 caaaacagac agcgggaagg tgaaggccgt atcagcttca ggtgcagatg aggaaaaaga
    16501 aggcaggata atcgaaaaaa ctaaaaaaac taaagaaatt aaagaaacca aagatgtggt
    16561 tgaaatgaaa aagactaaag agattaattt tcagcctcat tgtgtggatt ctacaaaacc
    16621 ggaaaatctg atcagctata ctaatattga ggtggatgga aacgtacttg aaaatattgg
    16681 agattataag gctgatggtg atatttcctt taatatagga caggattata cagatgtgga
    16741 tgggatcgtc acatttcgcg gaaacagttt tcgcgatacc ccttcccatg gttatgcaga
    16801 tatgactgat ttcaggctga acaaactatg gtctgcagat acaggttctc tttcttcggg
    16861 cagtgcagtc tggacaggaa gtggctggac aggacagccg cttatgatga aatggtcaaa
    16921 agaagttaaa gcacatatga atatgacaga gaaagcaaag gcagatgatg aactggttga
    16981 ggtgatttat gcctgtatgg atggatatgt gtattttctg gatctgagaa cgggagaaaa
    17041 gacacgtgac ccattatatc tgggatatac ttttaagggt gcgggtgccc ttgatccgag
    17101 aggatatccg attatgtatg ttggcgccgg atataacagc aacgaaggaa ctgcaaaggt
    17161 atttgtagta aacttgctgg attgtagtgt tatgtatact tttggagaca atgatgagtt
    17221 ttcactcaga ggaagtctga gcttttttga cggatcagca cttgtggatg cagagacaga
    17281 taccctgatc tatccgggag agaacggaat cctgtatctg atcaggctga atacaaaata
    17341 tgatctgaac agtgggactt tatccattga tccgggcaga actgtaaaat ggcgctacta
    17401 tggaacaaga agcagtacag agtctttctg gcttggaatg gaagacagtg cggcaatcta
    17461 taaaggctat atatttatga ccgataatgg gggaaatctt atgtgtctgg atctgaacac
    17521 tcttcagctg gtatgggttc aggatacatt ggatgattct aattcaacgc ctgttctgga
    17581 aatcgaaaaa ggacatctgt atctgtatgt aagtacttcc ttccgccttg gatggagaag
    17641 ttatgacaca gccactgtcc ctgtctggaa gattgatgca gaaaccggcg agatcgtgtg
    17701 gcatacagat tatgaatgta ctactgatga cggtgtctcc ggtggagtcc agtctacgat
    17761 tgcctgtgga aagaacagcc ttgctgatta tatatatgtg acagtggcaa agacctctga
    17821 caatgcatcg ggagttcttg cctgtctgag aaaatctgac ggatctaaag catgggagga
    17881 ttcttcctca tatgcctggt cttctccggt gtgcgtttat aacaaagacg gatcaggaaa
    17941 ggttctttat tgcaacagta caggcgatat ccgccttctt gatggtaaaa caggtaaaca
    18001 ggaagatgta ttatctgtca gcgatggcgt gatagaggct tccccggctg tctacgataa
    18061 ctatgcggtt gtaggcacca gagactgtaa aatatgggga atcaggttac agtaaatagc
    18121 aatatttatt tgctttctcc cattctttat taacttgcca tttatcgcac taaatggtaa
    18181 aatttaaata tcttacagtt ttacggcaca atattttgaa aaaactgaaa acaaaggaga
    18241 ggaagcgatg gaagagagaa ataacagact gctgaatgcg aagctgaaca agtatattgt
    18301 tccggggatt atgatgtctc tggcgcttca gctgggaaat atcgtagata cgatatttgt
    18361 aagtaacctg atcggggtgg aggcaatgtc tgcagttacc ctgagcctgc ctgtggagac
    18421 aatcgttcag ctgacaggat actgccttgg tatcggcggt tccatagcag tgggaaacat
    18481 gcttggcaaa cgagacaaag aaggggcatc gaaattgttt tctgccacat ttatagtaac
    18541 acttgtggtg ggaatcattt tttcaatctg cgcccttcct gcagcagaac ctgttgccag
    18601 acttctggta tcaggtgacg gtgtcctgac cggttatacc agagattaca tacgtgtaag
    18661 tatgctgggg gcaccggtga tcggaattgg actgatgatg gtcaattacc ttggtgtgga
    18721 gaatcatccg gagctggcat cagcctacct tatcgcagcc aatgtgatca atcttgtgct
    18781 ggactatata ttcctcagat atactccgct gggaattaca ggtgcatcct tatcaactgt
    18841 tcttggtttc ctgtttgcaa tgggaatttt tgtgctttat atccgctctg ataagcgaaa
    18901 cctccacctg atcctgctaa agccgggcga acttggaatc acaaaggaag caatcatcac
    18961 aggcgtgcca atgctgatct ttatggcagc taattttgta aaggcgcttg gactgaatac
    19021 cattatcatg aaccagctgg gcgaggaagg tatggcagta tttactgtct gtgacaatgt
    19081 gctgctgatc gtcgagatgc ttacaggcgg aatcatcggt gtgatcccca atgtggcagg
    19141 aatccttttt ggagagaagg actacgtggg aatccgggtt ctctgtaaaa agatgctgaa
    19201 atacagttac atcctgctgg ctgtgatctt tgtctttatt atgctgttta ccgaggaaat
    19261 cactgtcatg ttcggaagcg gcggtggcga gctgggcagt catatggtcc aggcgctgcg
    19321 catctttgct ttgtgtgtgg caccttatct gtggaataag tttattatca gctattacga
    19381 gtccattgag gagacagcca ttgcaagttt tgccacattt ctggagaatg cggtggtagt
    19441 tctgcctgca accctggtgg gaatccttgt atggaaacag attgacggga ttggtatcga
    19501 cggaattgca gcaggatttg ttgccactga gatcataact gcagttgcag cctgtatttt
    19561 cagaaaaatc aggcataaga atacaagctt ttatattgtt cctgacaaaa atccggggat
    19621 taatctggat ttttccatta agagtaccat ggaggaagca caaacggttc ataagaggat
    19681 catagagttc tgccaggaac agggagcttc taaaagcaag gcaaatcttg ccgcagtgtg
    19741 tgcggaggaa atgactgtaa atattatacg attcggtgga aaaacctcca actggatcga
    19801 cattaacctc tgtctggagg atgatctctg cagactgagg atcagagata acggtgtaaa
    19861 tttcaaccct ctggaatatc agtatgacag tgaagacttt gatatacatg ggattgaact
    19921 tgtcaagaag gtatcaaaat ccatggatta tattcgtgcg attgatatga ataataccat
    19981 aatatctttt taggaggtac atgaaaatga aaaatattaa tgaaaggaac aattttgttt
    20041 ttgagtttcg gccggtaaca gaattgttcg aggaacaggt gaagcttcat cctgagaaat
    20101 gtgcagttgt ctccggcaaa gagagcttca cctatgcaca gctcaacgaa cgggccaaca
    20161 ggattgccaa tgcacttgtg gaaaaaggtg tcagacggga gaccatcgta ggtgtggttc
    20221 ttgagagatg ctgtgatttc tatgcagtgc gacagggtat cctgaaggca ggaggcgcat
    20281 ttgcagttgc cacaccggat tatcctgatg acaggatccg gtatattttt gaggattcac
    20341 gagctccttt tattatcaca acaaaggaga tcgcagagga acgaagggaa ctgtttgcta
    20401 agcttccctg tacagtactt ctgatcgagg aacttctgga gaatgagaat acagagaatc
    20461 ctcaggtaaa gatcggggag catgatcttt gttattgtat ctatacttcc ggttccacag
    20521 gcaagcccaa gggtgtgctg atcgaacata tcaaccttgc caattttgta aatccggatc
    20581 cgaaaaatgc ggaaacttat ggttatgtca gcaggggatc ggtttctctt tccatggcag
    20641 ccatgacctt tgatgtgtct gttctggagg aatttctgcc acttaccaac gggatgactg
    20701 cggtgatcgc ctctgatgag gagattctga atcctcttat gctgggtgag ctgatcgtca
    20761 gaaataaagt ggatattatg accacaactc ctacttacct gtccaatatg atcgatctgc
    20821 cccagcttga aaaagcagtt tctcagatta aggtgtttga tgtaggtgca gaggcttttc
    20881 ctccggctct gtatgacaag attcgcagag taaacccgga tgcttacatt atgaatggtt
    20941 atggacctac ggaaactacc atcagctgta ccatgaaggt aattacggac agcagaaaca
    21001 ttaccattgg tacgcctaac ggtaatgtga agggatatat tgtagataaa gagaataaga
    21061 tccttccgga cggagagacc ggagagcttg tgattgcagg actgggcgtt ggcagaggtt
    21121 atatgaatct gccggataaa acagaggctg tattcattga tcttaacgga gagagagctt
    21181 ataagaccgg tgaccttgca aggatcagcc ctgagggtga gattgaattt ttcggaagaa
    21241 tagacaatca gatcaagctt cgcggtctga ggattgagct tggtgagatc gaggaggtga
    21301 ttaattccta tgagggaatc attaccagca ttactctgcc tgtagataac aaattcctct
    21361 gctgctattt tatggctgac cgccagatca atacagagga gctttctgcc tatgcatcag
    21421 agtccctggc tcattatatg gttcctgagg tttttgtcca actggaaaag atgcctgtga
    21481 cacagaatgg taaaattgat aagaaagcac tgccaaagcc ggttgcacag ccaaagaatc
    21541 tgaaagaacc ccagactcct atgcagaaga agatttttga aatcgttgca gacgttgtgg
    21601 agaatgattt ttttggaact gacacaagtt tttacagggc ggggctgtct tctatcagtg
    21661 ccatgaagct ttgtattctg atctcagagg aattcggagt gactgtgaaa accagtgata
    21721 tccacgaaaa caatacggtg gagaaactgg aaaaatatgt gatgcttgca ccgaagatca
    21781 gaacctatga aaagagagaa gtttaccctc ttaccggctc ccagaagggt atttttgcag
    21841 agtgcatgaa gaatcctgag agtacggtat acaatattcc gttcctgttt gaactggaaa
    21901 gctctgttga cgttcagaag ctgtcagatg ccatttctca gatgatcgct gcacatccgt
    21961 atctgctgac aaaggtttat ttaagtgaca gcggagagat ggtgcagaag ccttgtgagg
    22021 aagcctttgt accagaggtg gtacagacca caaatgagca gtttgaaaag atgaaagatg
    22081 agctggtgcg ttcctttaag ctggaaaagg gacggctgtt ccgggcgggg atttatgtga
    22141 cagaagacag gaaatatctt tttacagatt tccaccatat cctggcagat ggtaattcct
    22201 atgatattat ttttgaggat atcgatcggg cctatctggg tgagaaattg gagaaagaat
    22261 cctacacagg ctttgatgct gcccttgatg aagaacagca gatgaaagag ggaaaatata
    22321 agaaggccga gaaatattat gacagtattt tcgagggaat tgagacagaa tccctgcctc
    22381 ttcctgactg ctcaggaaag actcctgaga gaggatatct gtcgatgcct gtggataccg
    22441 gagagtctct ggtactttct gcctgcgaga agctgggggt tactccaaac attctgttta
    22501 caggtgtatt cggcattctc atgagcagat attccaattc cgaggagagt ctttttgcaa
    22561 ctatttataa tggaagaaat gattccagac tggagaatac agtctgcatg cttgtaaaga
    22621 ctctgccggt ttactgttcc tgtgatccga aagtcaccat acaggcctat atgacagagc
    22681 tctctgagca gattctgtct tccatggcaa atgatatttt tccgttctct gatatttgtg
    22741 caaagtacgg gattaattct gatctggtat ttgcatatca ggcagagctt ggggatgatt
    22801 tcccgatcgg tgatactgtt gccaggggcc atgacctttc tccggatatg tcaaagatgc
    22861 ctctgctgat ccaggtaaga gaatacgatc ataaatatgt gcttactgca gaataccgca
    22921 gtgacatgta cagtgaagcc tttgtacgtg gaatgctgga atcctatgag gcagctatgg
    22981 attccctgct gaaagcaaaa tatatttcgg aagtttctgt tctttcccaa aatggagcgg
    23041 acaaaatttc ggaatttaat aatactgcct gcgaatatga cagaagtaag accatcgctg
    23101 atatgtttga ggagctggta cagaccattc ctgaccatac ggctgtggta tttaaggata
    23161 aaaaatatac ttacagagaa ctggatgaga tcagtgacag acttggaaaa tatatcgcat
    23221 cccagggaat tggcagtgaa gatgttgttt ccattctgat cccccgctgt gaatatatgg
    23281 cgatcgcacc gatgggcgtg ataaaggcag gtgcagctta ccagcctctg gatccaacct
    23341 atcccaggga ccgcctgatg tacatgatgg aggattcctc tgcaaagctt ctcattgttg
    23401 acagagagct tcttcctctg gtagacggat ataaaggacc ggtgctgttt acagatcaga
    23461 tctggcagct ggaggatagg gatgttgtgc ttaagaagcc gcagctgcat gatctgttta
    23521 tccttttgta tacttccggt tccacaggtg tgccaaaggg ctgtatgctg gaatatggaa
    23581 atattactgc tttctgtcac tggttcaaga gatattatgg catagattcg gagtgcagga
    23641 tagctgcata tgcttccttt ggttttgatg cctgcatgat ggatatttac ggtgccatca
    23701 caaacggtgc acagcttcac attattccgg aggaaatccg tctggatttc attggactgc
    23761 agcgctattt tgaggaaaat ggtatcacgc attcctttat gactactcag gtgggaaggc
    23821 agtttgcgct ggagatggat tgtaagagcc tgagatatct ttctgtagga ggagagaagc
    23881 tggttccatg tgagccgcca aaagattata agtttatcaa tgcttatgga cctacagagg
    23941 cgactatttt tacgactgta tttgaagtgg acaaatatta tccaaatgtc ccgatcggaa
    24001 aagcacttga caatgtgaag ctttatatta cggacaagct ggggcatatg cttcctcccg
    24061 gtgcatgcgg agagctgatg atcaccggct ggcaggtttc cagaggatat cttaacaagc
    24121 cggaaaaaac tgccgaggtc tatacaaaga atctttatga tgatacaccg ggatacgaag
    24181 tgatgtatca ttcaggtgat gtggcaagat ttcttccgga tggaaatatc cagatcattg
    24241 gcagaaagga ttcccaggtg aagatcagag gtttcaggat tgagctttct gaggttgagg
    24301 aagtgatccg cagatatgag ggcatcaggg atgccactgt agttgccttt gatgatccaa
    24361 atggtggaaa atatattgct gcctatgtgg tatcggacag cactgttgat atcaatgccc
    24421 tgaatgattt tattaaagag acaaagcctg cctatatggt acctgcagtt accatgcaga
    24481 ttgacaaaat tcctctgaac cagaaccaga aggtaaataa aaaggctctt cctctgcctg
    24541 agaaaaaagc agcggagatc attaagcctg agaatgaggt tcagcagata ttatttgact
    24601 gtatcgcaga ggttctgggg tatacggatt ttgggattac cacagatatt tatgaggcag
    24661 gtctgacatc tatcactgcc attaagctga atatcctgat ctccaaagcc tttgacattg
    24721 tgatcaaaac ttcagatatt aagaatcatc ctactatccg aatgatggag gaatttgtaa
    24781 aaactgcggg aaaagaaagc aaaagggaag tacaggaaag ttatcctctt accaacactc
    24841 aggaggggat tttcattgag tgtactgcaa atatgggttc taccatttac aatatcccgt
    24901 atctgttaaa gcttgataac aaggtggatc tggacagact ggcagaagcc attgacagta
    24961 ctgttgaggc acatccttat ctgaaaaccc gtctgtttat ggatgacaac ggaaatgtac
    25021 ttcagaaacg aaacgatggg ctcagttata aaacaccgat tttaaacgga atgaacagag
    25081 acactctggt acgtccatat atgttgttta atgaacagct tttccggttt gaaatctaca
    25141 gaacctgtga tggcaattat ctgttcctgg accttcacca cattgttgcc gatggtacat
    25201 ctctggctat tataattaat gatattaaca gagcttacag cggtgagaag ctggaaccgg
    25261 aaggttatac ttcctatgat ctggcactgg ataacagaga tgccctggca ggtgatatct
    25321 ataaaaatgc agagaattat tataagtcag tatttgaaca tgcaggtgga agcatcagct
    25381 tctatccgga caaaaacggt gcggctccaa cagcagaact ttaccacaga gagaccagat
    25441 ccatttctgt gcaggatgtg aaggaattct gtaaaaagca tggaattacg gagaatgtat
    25501 tcttcatttc cgcttttggt atcacacttg gaaaatataa tttcaaaaag gatgctgtat
    25561 ttaccactat ttaccatgga agaaacgatt ccagactttc ggaaacagtg ggtatgctgg
    25621 taaaaacact ccctgttttc tgcgatttct caggaacagc caaagattgc ttaagcggtg
    25681 tacagaaaca gctgatcgat tccatgaaca acgatattta tcctttctca cagatcagcc
    25741 atgagtttga tattaaggca gatgccatgg ttatttacca gggcgacaat tttgcttttg
    25801 acaccattgg cggggaatat gcacaggagg agcctgtcag cctgaacatg gcaaaggcac
    25861 cggtttctgt cagcatttcc attgaaaaga acagatttgt ctttgagatt gagtacagag
    25921 gagatatgta ccatgaggaa actatccggt atctggctga caatctggaa accactgcag
    25981 agggaatctt aagggaatgc gatccggctg atatccggct gatgtttgag gaaaaaactc
    26041 agatggagga tattccggaa catgcaggaa agaccttcat agatctgttt aaggagatgg
    26101 ctgccagata tccggacaga ccggcagtgc gggatgactc cggagatttt acttacagag
    26161 agttggacag aatgtctgat tatattgctc agaagcttac ggaaaacgga tttggcccgg
    26221 aacaggcagc aggtatcctg tgcggcagga caaaagaata tacagtagcc tatgtgggtg
    26281 ttatgaaggc cggcggagcc tatgttcctc tggatccgga gtatccacag agcagaattg
    26341 aatatatgct gaaggattca ggagcaagaa atctccttgt gatcgatcag tatcagaatc
    26401 ttgtggaatt ttatgacgga aatgtgatca gtctggacag tgtgccagat gaggctgagg
    26461 attttgaact ttctgcagag cttatttctc cgaaaccgga gaaccttgcc tatatgatct
    26521 atacctcagg ctccacagga aagccaaagg gtgttatgat cgagcacaga aatctgttga
    26581 acctgatcga atatatcaca ctgagcagaa atacttcacc ggatgacatt gtggcagagt
    26641 ttgcgagctt ctgtttcgat gcgtcagtga tcgatctgtt tgcacctctt accgcaggag
    26701 cagtcctgta tattttaccg gagagtatcc gtaaggacgc cattgccata agcagatata
    26761 taaaggaaaa agagatcacc accgtaacct tccctaccca gatgggagaa ctggttacag
    26821 aacttctgga ggatgcacct gctcttaaat ttgttacact tggcggcgag aaattcaagc
    26881 attaccgtaa ccgtacctat cagatgatca atggctacgg tcctacagag aatacggttt
    26941 cttccacaga gtttttggta gacagacagt atgacaacat cccgatcgga aaatcacagc
    27001 ggaatgtgcg cagctacatt gtggatgaga atctgaaccg gcttccggtg ggtgcgtccg
    27061 gcgaactttg tcacgcagga aggcagattg ccagaggata tcataatctt ccggaaaaaa
    27121 cagcatctgt gtttgtagaa aatccatttg ctgtatgtga gcaggaaagc cgtctttaca
    27181 ggaccggtga tatggtccgc atgaaaggtg acggaaatat tgagtacata ggccggatcg
    27241 attcacaggt gaagatcaga ggatatcgtg tggagcttgg tgagatcgaa ggtgcccttc
    27301 tgaaacatga gctggtgaaa aatgcagccg ttacagtaat tgaaaagggt ggaaataaat
    27361 atatcacagc ttattataca ggagaagcca tcccggagga tgaactgaag accttcctgg
    27421 agccgctgat cccggattat atgatgccgt ctttctttgt cagcattgag gaaatgcctg
    27481 tgacaccggg cggtaagatt gataaaaaag cactgccaat gccggaggta accacgaaca
    27541 ctgccagcta tgtagagccg gttactgcag ctcagagagc actctgtgag atttttgaga
    27601 aagcactggg aattgaaaga gtagggattg aggacaactt ctttgagctg ggcggatctt
    27661 cccttactgc atccaaggtt gctgttatgt gtctgtcaaa gaatatttca ctggtatatg
    27721 cggatatttt caaatatcct actgtacggg aacttgcagc tttggttgat gatgacggag
    27781 ttacagaggc tgcacagagc aagaatgaat tttcggatta taactataac aggatccaga
    27841 atgtgatcag cgcaaataca gaagaaaatg cagaccggat cacaaaggaa aagctgggag
    27901 atattatggt cacaggtgcc acaggtttcc tggggatcca tgtccttaaa gcattcattg
    27961 acaattatga cggtaaggtt tactgtcttg tacgtaaggg caaatatgaa tcgtctgaaa
    28021 agcgaatgat gaacatgctg atgtactatt ttgatgatcc atacaaagag ctgtttgaaa
    28081 gccgtattat ctgtgtggat ggggatatta cctcaaagga acaggtaaca ggattttcag
    28141 aatacaaatt cagcaccatc attaactgcg ctgcctgcgt aaagcatttt gcggctgatg
    28201 atgtactgga aagaattaat gtgcagggtg tggaaaatct gatcgatttc tgtaagaata
    28261 acggccgcag actgatccag atttctacgg tttccgttgc gggagaaggt tctgacggtg
    28321 ttccgccaat gtccagagtt ttctgtgaga atgatctgta catcggacag aatattacca
    28381 acgaatatat ccgtaccaaa ttcctggcag agagggcggt tctggaagca gtttccgagg
    28441 gactggacgg caaggtagtc cgggtaggta atctgatgag ccgaaactct gacggtgagt
    28501 tccagattaa tttcattacc aatggattcc ttcgcagcct gagaggttat gcggctgtag
    28561 gtaaattccc tatgggcggt atgcatgagg tggcagaatt ctcaccgatt gattctactg
    28621 cgctggcagt tctgagactg gctcagaccg accggagatt tactgtattc catgcatgca
    28681 acagccatca tatttatatg gcagacctga tctacgcaat gcgcagttat ggattcagga
    28741 ttgatattgt aagagatgag gattttgagg cagcagtgaa ggaatttgca aagaccggtc
    28801 aggattctga tgcggtttcc ggactgatcg cctatacctc acataatgaa aatgaaatct
    28861 ataccattga ttacagcaat cgttttacag cacaggttct gtacaggctg gattataaat
    28921 ggccggttac agatgacaga tatctggaaa atgcaattgc agcacttgac agacttacat
    28981 tttttgattg attcaggagg gaaaatcaca atggaaatta tcacaaaaac agaaggtaac
    29041 aaagcaacta tggaaatcag cggatggctt gatacacaga cagctcccca gttaggggag
    29101 gctctgtccg gacttgaaga cagcatcaca agtctggtat ttgattttac aaatctggaa
    29161 tatatttcat ctgcaggctt acgtcaggtg atcgtggcct acaaaaaaat ggctcaaaag
    29221 gatggattta agatcatcaa tgtttctgat gaggtttacg atgtattcag ccttacaggg
    29281 tttgacagca agatcgatat tcagaagaag taactgttga tcagatgcag aaattataca
    29341 ggatcaatat taatcatttt gaggatccgc ttaagaatga aaggattctg gatctggttg
    29401 ggatcagaag aagagaaaag gtcatcaggt atcgtatgcc tgatgaccgc aaaagaagtc
    29461 tgggtgcagg gatcatcatc agaaaaatcc tcgatgaaaa cgggcttacg gaaagctgcc
    29521 tgagatattc tgacaatgaa aagccggttg tggatggcct tttttttaat gtatctcatg
    29581 cgggggacta tgttgtgggt gtgctgtcag actgcgaagt cgggtgcgat attgagaaaa
    29641 atgccaatgc gcctcttgag gtggcagaac attatttcta ccattcagag cttgcttaca
    29701 tcaaggctgc gaagaacaaa gataaggcgt tttttacgct ctggacatta aaagaaagtt
    29761 atatgaaaat gacaggcaga ggaatgagcc tccctttgga ttcttttgaa gtggttccca
    29821 cagcagaggg gtttgtcctc ggaaaatcct cagaaaggcc atgctttttt gagacaatgg
    29881 aatttgacgg ttatattttc tcggtcagca gtgagagggc tttttctctt cacaatccat
    29941 tggaaattgt tttcgacgat atttatgtat ga
//
