BGC0001576 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001576 (Prochloron didemni)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	16,772	divamide A	ribosomal:RiPP	100%

BGC0001576 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 16,772 nt. (total: 16,772 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 16,773
Label		BGC0001576

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001576	1.00	RiPP	divamide A	Prochloron didemni
BGC0001577	0.36	RiPP	divamide B	Prochloron didemni
BGC0001660	0.23	RiPP	mathermycin	Marinactinospora thermotolerans
BGC0001579	0.23	RiPP	duramycin	Streptomyces cinnamoneus
BGC0002346	0.20	RiPP	kyamicin	Saccharopolyspora sp.
BGC0000503	0.19	RiPP	cinnamycin	Streptomyces cinnamoneus
BGC0000516	0.19	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0001364	0.19	RiPP	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0001210	0.19	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002049	0.18	RiPP	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001576	1.00	RiPP	divamide A	Prochloron didemni
BGC0001577	0.69	RiPP	divamide B	Prochloron didemni
BGC0001660	0.56	RiPP	mathermycin	Marinactinospora thermotolerans
BGC0001579	0.56	RiPP	duramycin	Streptomyces cinnamoneus
BGC0002346	0.53	RiPP	kyamicin	Saccharopolyspora sp.
BGC0000503	0.52	RiPP	cinnamycin	Streptomyces cinnamoneus
BGC0000516	0.51	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0001364	0.51	RiPP	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0001210	0.51	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002049	0.49	RiPP	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102

Similar known gene clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for divM

allorf_02796_02897

Leader:

MREIACLPAA

Core:

CCIISQGKAIKLGSRISSLSRRG

Core with dehydrations:

CysCysIIDhaQGKAIKLGDhaRIDhaDhaLDhaRRG

allorf_04735_04938

Leader:

MECCLSSRMVATGA

Core:

ICPEIYLPTPQCFGTTNSGEPKESSRAFQCGGNGALSSCSCDGEFFSFVSQPA

Core with dehydrations:

ICysPEIYLPDhbPQCysFGDhbDhbNDhaGEPKEDhaDhaRAFQCysGGNGALDhaDhaCysDhaCysDGEFFDhaFVDhaQPA

antiSMASH-DB 4.0 matches for allorf_04735_04938

18.9% NZ_CP017965.1and 4 others:

NZ_CP022434.1 Lanthipeptides: CGQ36_RS27040_lanthipeptideNZ_JAMXJO010000001.1 Lanthipeptides: NGM33_RS17240_lanthipeptideNZ_KB906860.1 Lanthipeptides: G011_RS0113930_lanthipeptideNZ_LR134501.1 Lanthipeptides: EL646_RS16810_lanthipeptide

Lanthipeptides: A9R04_RS27085_lanthipeptide

PTPQCFGTTNSGEPKESSRAFQC

P P FGTT G P S+ C

PGPITFGTTCWGTPCPSANTISC

18.9% NZ_CP022753.1and 1 other:

NZ_CP022753.1 Lanthipeptides: CDO52_RS14300_lanthipeptide

Lanthipeptides: CDO52_RS14300_lanthipeptide

EPKESSR--AFQCGGNGALSSCSCD

+P + SR CGG LS+ CD

QPMQESRLSVITCGGLSQLSALLCD

18.9% NZ_CP074132.1and 3 others:

NZ_CP118614.1 Lanthipeptides: PV789_RS28830_lanthipeptideNZ_VWVV01000003.1 Lanthipeptides: FYW95_RS04825_lanthipeptideNZ_VWVW01000004.1 Lanthipeptides: FYW96_RS05650_lanthipeptide

Lanthipeptides: KGD83_RS01675_lanthipeptide

PTPQCFGTTNSGEPKESSRAFQC

P P FGTT G P S+ C

PGPITFGTTCWGTPCPSANTVSC

with 2 more sequence matches

18.9% NZ_ML703349.1: Lanthipeptides: FYW99_RS06090_lanthipeptide

LPTPQCFGTTNSGEPKESSRAFQC

+P P FGTT G P S+ C

VPGPITFGTTCWGTPCPSANTISC

15.1% NZ_FOET01000004.1: Lanthipeptides: allorf_078361_078546_lanthipeptide

CGGNGALSSCSCD

CGG+ AL SCD

CGGSEALGRWSCD

MIBiG 3.1 matches for allorf_04735_04938

7.5% BGC0000503 (cinA): Lanthipeptide: cinnamycin

AFQCGGN

F C GN

TFVCDGN

5.7% BGC0000563 (AEA03263.1): Lanthipeptide: venezuelin

SSCSCDGEF

++C C G

ATCECVGLL

allorf_08466_08552

Leader:

MFIKHRLGVILGD

Core:

DIMSENIIPIICLAP

Core with dehydrations:

DIMDhaENIIPIICysLAP

allorf_08491_08682

Leader:

MIFSDMISSPKITPSLCFINIFLYKKFDKSAFCVYWAEMTIFGS

Core:

ERQQHCGIFTNTWFCPFVK

Core with dehydrations:

ERQQHCysGIFDhbNDhbWFCysPFVK

antiSMASH-DB 4.0 matches for allorf_08491_08682

26.3% NZ_CP069396.1: Lanthipeptides: allorf_07965209_07965286_lanthipeptide

HCGIFTNTWFCP

CG + +W CP

SCGGCSGSWVCP

22.6% NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide

Lanthipeptides: C8268_RS00150_lanthipeptide

GIFTNTWFCPFV

GI T++W C FV

GITTSSWICGFV

21.9% NZ_CP006058.1and 25 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide

Lanthipeptides: BAMY6639_RS19790_lanthipeptide

CGIFTNTWFCPFVK

CG+F FCP K

CGVFVTAAFCPSTK

with 3 more sequence matches

21.9% NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

CGIFTNTWFCPFVK

CGI + FCP K

CGIAVSALFCPTTK

20.0% NZ_CP029639.1: Lanthipeptides: DMB88_RS07755_lanthipeptide

QQHCGIF---TNTWFC

CG+ TNTW C

SSECGLTRQCTNTWLC

20.0% NZ_CP075910.1and 3 others:

NZ_CP075971.1 Lanthipeptides: KLF29_RS14850_lanthipeptideNZ_CP075982.1 Lanthipeptides: KLF51_RS14900_lanthipeptideNZ_CP075994.1 Lanthipeptides: KLF26_RS16110_lanthipeptide

Lanthipeptides: KLF45_RS14835_lanthipeptide

QQHCGIF---TNTWFC

CG+ TNTW C

SSECGLTRSCTNTWLC

allorf_15599_15754

Leader:

MRDRRNLPLQDLLQMRVIAAQIFCFLFRRSRRVAIAFS

Core:

PIPKVSAKSALCQ

Core with dehydrations:

PIPKVDhaAKDhaALCysQ

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

allorf_02796_02897 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 2342.3 Da

Molecular weight: 2343.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2361.8 Da N = 1; 2379.8 Da N = 2; 2397.9 Da N = 3

allorf_04735_04938 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 5352.4 Da

Molecular weight: 5355.9 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 5373.9 Da N = 1; 5391.9 Da N = 2; 5409.9 Da N = 3; 5427.9 Da N = 4; 5446.0 Da N = 5; 5464.0 Da N = 6

allorf_08466_08552 - Class II

Cleavage pHMM score: -5.90

RODEO score: 0

Monoisotopic mass: 1622.9 Da

Molecular weight: 1624.0 Da

Number of bridges: 1

allorf_08491_08682 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 2304.1 Da

Molecular weight: 2305.6 Da

Number of bridges: 2

allorf_15599_15754 - Class II

Cleavage pHMM score: -3.00

RODEO score: 0

Monoisotopic mass: 1304.7 Da

Molecular weight: 1305.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1323.6 Da N = 1