BGC0001578 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001578 (Talaromyces stipitatus ATCC 10500)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	46,797	High	duclauxin	PKS

BGC0001578 - Region 1 - T1PKS

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Location: 1 - 46,797 nt. (total: 46,797 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,798
Label		BGC0001578

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

TSTA_083230: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

TSTA_083260: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

TSTA_083340: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: methyltransferase

TSTA_083330: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

TSTA_083310: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001578.3	0.98	PKS	duclauxin	Talaromyces stipitatus ATCC 10500
BGC0002175.3	0.78	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.78	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.77	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.77	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001578.3	0.98	PKS	duclauxin	Talaromyces stipitatus ATCC 10500
BGC0002175.3	0.78	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.78	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.77	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.77	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 46797:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

TSTA_083310: mal

PKS_AT (924..1227): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 95.0
Methoxymalonyl-CoA: 46.1
Methylmalonyl-CoA: 45.7
inactive: 38.8
Ethylmalonyl-CoA: 26.2
Isobutyryl-CoA: 25.8
Propionyl-CoA: 25.6
fatty_acid: 22.8
2-Methylbutyryl-CoA: 21.8
CHC-CoA: 17.3
Acetyl-CoA: 17.0
Benzoyl-CoA: 15.6
3-Methylbutyryl-CoA: 11.2
trans-1,2-CPDA: 0.0

Link to PARAS substrate predictor