BGC0001579 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001579 (Streptomyces cinnamoneus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	23,252	High	duramycin	ribosomal:RiPP:Lanthipeptide

BGC0001579 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 23,252 nt. (total: 23,252 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,253
Label		BGC0001579

Tailoring functions

Lyases: cyclase

BLK03_RS04560: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001579.4	1.00	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000503.5	0.80	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.61	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001660.3	0.60	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000563.4	0.60	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.59	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001576.3	0.52	ribosomal	divamide A	Prochloron didemni
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001364.3	0.45	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000626.3	0.43	ribosomal	thuricin	Bacillus thuringiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001579.4	1.00	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000503.5	0.80	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.61	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001660.3	0.60	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000563.4	0.60	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.59	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001576.3	0.52	ribosomal	divamide A	Prochloron didemni
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001364.3	0.45	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000626.3	0.43	ribosomal	thuricin	Bacillus thuringiensis

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for BLK03_RS04560

BLK03_RS04555

Leader:

MTASILQSVVDADFRAALIENPAAFGASTAVLPTPVEQQDQASLDFWTKDIAATEAFA

Core:

CKQSCSFGPFTFVCDGNTK

Core with dehydrations:

CysKQDhaCysDhaFGPFDhbFVCysDGNDhbK

antiSMASH-DB 4.0 matches for BLK03_RS04555

84.2%

NZ_CP073318.1:

Lanthipeptides: JJ691_RS07165_lanthipeptide

CKQSCSFGPFTFVCDGNTK

C QSCS+GPFT VCDGNTK

CVQSCSWGPFTAVCDGNTK

78.9%

NZ_CP059557.1:

Lanthipeptides: H2Q94_RS19875_lanthipeptide

CKQSCSFGPFTFVCDGNTK

C QSCS+GP T VCDGNTK

CVQSCSWGPVTAVCDGNTK

63.2%

NZ_JAPFGB010000043.1:

Lanthipeptides: OOZ19_RS28825_lanthipeptide

CKQSCSFGPFTFVCDGNTK

C +CS GPFT +CDG+TK

CASTCSSGPFTILCDGSTK

with 6 more sequence matches

35.0%

NZ_JH792121.1and 2 others:

NZ_JH792158.1 Lanthipeptides: allorf_244385_244483_lanthipeptideNZ_NVFD01000061.1 Lanthipeptides: allorf_20050_20148_lanthipeptide

Lanthipeptides: allorf_130702_130800_lanthipeptide

KQSCSFGPFTFVCDGN

K CS G F+F+ G

KVPCSRGTFSFIFSGK

31.8%

NZ_JADG01000011.1:

Lanthipeptides: P696_RS0120030_lanthipeptide

CKQSCSFGPFTFVCDGNTK

C +CSFGPFT VCDG TK

CSSTCSFGPFTIVCDGTTK

31.0%

NZ_FUWS01000010.1:

Lanthipeptides: B5D66_RS17810_lanthipeptide

CKQSCSFGPFTFVCDGNTK

C +CSFGPFT CDG TK

CASTCSFGPFTIACDGTTK

24.0%

NZ_JAFCGV010000005.1:

Lanthipeptides: JQI09_RS04275_lanthipeptide

QSCSFGPFTFVC

C G F FVC

SECYLGTFAFVC

23.6%

NZ_BMRD01000003.1and 1 other:

NZ_JANBBD010000039.1 Lanthipeptides: BS35_RS35910_lanthipeptide

Lanthipeptides: IEZ14_RS08160_lanthipeptide

CKQSCSFGPFTFVCDGNTK

C +CS GPFTF CDG+TK

CASTCSSGPFTFACDGSTK

20.5%

NZ_CP016795.1and 1 other:

NZ_CP016795.1 Lanthipeptides: allorf_4197591_4197734_lanthipeptide

Lanthipeptides: allorf_4197591_4197734_lanthipeptide

CKQSCSFGPFTFVCDGNT

C S GP TF+ G T

CWSSVGMGPRTFLPKGRT

MIBiG 4.0 matches for BLK03_RS04555

94.7%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

CKQSCSFGPFTFVCDGNTK

C+QSCSFGPFTFVCDGNTK

CRQSCSFGPFTFVCDGNTK

allorf_01019_01192

Leader:

MSRYGSPFRRTTTGS

Core:

PGRPRRPPRTTPSPPRRTPRSTASACSSRTRPTSRSPRGRYR

Core with dehydrations:

PGRPRRPPRDhbDhbPDhaPPRRDhbPRDhaDhbADhaACysDhaDhaRDhbRPDhbDhaRDhaPRGRYR

antiSMASH-DB 4.0 matches for allorf_01019_01192

22.4%

NZ_BNBI01000017.1:

Lanthipeptides: allorf_038334_038561_lanthipeptide

RRTPRSTASACSSRTRPTSRSPRGRY

R+ R TA AC SRT P +R P G

RQMVRVTA-ACGSRT-PLARVPLGEL

19.0%

NZ_AZXF01000022.1and 1 other:

NZ_AZXF01000022.1 Lanthipeptides: B042_RS0111455_lanthipeptide

Lanthipeptides: B042_RS0111455_lanthipeptide

TPSPPRRTPRSTASACSS

T T + TASAC+S

TGDGCGNTCQGTASACNS

allorf_02275_02343

Leader:

MPGTPSTISQLGRRVGG

Core:

SVCCP

Core with dehydrations:

DhaVCysCysP

allorf_03486_03629

Leader:

MWSPTSGHPRRRSDTSLPAG

Core:

RCRRPSPPATPWTSTPCPTGPGRRPRR

Core with dehydrations:

RCysRRPDhaPPADhbPWDhbDhaDhbPCysPDhbGPGRRPRR

antiSMASH-DB 4.0 matches for allorf_03486_03629

29.6%

NZ_SIMU01000019.1:

Lanthipeptides: allorf_19974_20192_lanthipeptide

ATPWTSTPCPTGPGRRPRR

+P +TPCP G RP+

GSPHGTTPCPPGSAVRPQE

12.2%

NZ_MOWR01000001.1:

Lanthipeptides: BMI76_RS01735_lanthipeptide

PPATPWTSTPCPTGPG

ATP+ + C G G

AAATPYVTLACAAGAG

allorf_04363_04602

Leader:

MGRIPSEFSPGVTVPRRPESWASFRLLGPDPAVRLRRADSARA

Core:

IVRPCRRPSSRSAARKREKAGLLKSDGTACRSIGFR

Core with dehydrations:

IVRPCysRRPDhaDhaRDhaAARKREKAGLLKDhaDGDhbACysRDhaIGFR

antiSMASH-DB 4.0 matches for allorf_04363_04602

26.7%

NZ_BIFH01000022.1and 1 other:

NZ_BIFH01000022.1 Lanthipeptides: allorf_299950_300183_lanthipeptide

Lanthipeptides: allorf_299950_300183_lanthipeptide

PCRRPSSRSAARKREKAGLLKSDG

PCRR SAAR G +SDG

PCRR----SAARPTVGVGGPESDG

MIBiG 4.0 matches for allorf_04363_04602

19.4%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

EKAGLLKSDGTACRSI

E GLL T C I

ECVGLLTLLNTVCIGI

allorf_05617_05850

Leader:

MSCSLRAARGG

Core:

PRVPHSAVATASVSRCSAAGAAACAAPAFLALIRMTMKEPRPNSRAATRPSQENFFSHSSATLPTE

Core with dehydrations:

PRVPHDhaAVADhbADhaVDhaRCysDhaAAGAAACysAAPAFLALIRMDhbMKEPRPNDhaRAADhbRPDhaQENFFDhaHDhaDhaADhbLPDhbE

antiSMASH-DB 4.0 matches for allorf_05617_05850

15.2%

NZ_CP033923.1:

Lanthipeptides: EG343_RS10035_lanthipeptide

CSAAGAA-ACAAPAFLALIRMTMKEPRPNS

C A G++ C A A + T++ PRP

CGATGSSSGCDATAVCGCVTQTIRIPRPKG

13.6%

NZ_CP033932.1and 1 other:

NZ_CP084347.1 Lanthipeptides: KB553_RS11820_lanthipeptide

Lanthipeptides: EG339_RS01270_lanthipeptide

CSAAGAA-ACAAPAFLALIRMTMKEPR

C A G++ C A A + T+K+P+

CGATGSSSGCDATAVCGCVTQTIKKPK

12.1%

NC_019673.1:

Lanthipeptides: allorf_4537799_4537888_lanthipeptide

RVPHSAVATASVSRC

R+ HS T S SRC

RLTHSGDCTRSNSRC

allorf_19455_19631

Leader:

MGRRAGAVPFLLPEAVADDVFQPLVHLVDQFGG

Core:

HESSTDKPDELSIPFHGCFVHAVGE

Core with dehydrations:

HEDhaDhaDhbDKPDELDhaIPFHGCysFVHAVGE

allorf_19874_19972

Leader:

MECLRRGSRPRRASREVHPGA

Core:

ARAAGQTACRL

Core with dehydrations:

ARAAGQDhbACysRL

allorf_21360_21512

Leader:

MCGGRRNAGQGA

Core:

GRDGDYPPALGVGPSAVCVGAAGCVRHPSPCLVAPRQP

Core with dehydrations:

GRDGDYPPALGVGPDhaAVCysVGAAGCysVRHPDhaPCysLVAPRQP

antiSMASH-DB 4.0 matches for allorf_21360_21512

28.9%

NZ_CP048887.1:

Lanthipeptides: BMG_RS29400_lanthipeptide

GDYPPA---LGVGPSAVCVGAAGCVRHPSPC

GD P + V SAVC+G G + C

GDVQPETTPVAVTSSAVCIGVTGAIISIKYC

25.6%

NZ_AZVD01000036.1and 1 other:

NZ_KB913036.1 Lanthipeptides: allorf_1248238_1248429_lanthipeptide

Lanthipeptides: allorf_03594_03785_lanthipeptide

VGAAGCVRHPSPCL

VG A C RHP PCL

VGGAQCHRHP-PCL

18.4%

NZ_CM000951.1:

Lassopeptides: SSEG_RS44950_lassopeptide

GDYPPALGVGPSAVCV

GD LG G + +CV

GDCTDFLGCGTAWICV

with 1 more sequence matches

18.4%

NZ_CP017708.2and 1 other:

NZ_CP017708.2 Lanthipeptides: BJP36_RS08560_lanthipeptide

Lanthipeptides: BJP36_RS08560_lanthipeptide

GAAGCVRHPSPCL

GAA VR PC+

GAAAAVRSSQPCV

allorf_22575_22688

Leader:

MDDSGRARDLQGA

Core:

RCAEPVDGSGGLEGSGPSRCSHAA

Core with dehydrations:

RCysAEPVDGDhaGGLEGDhaGPDhaRCysDhaHAA

antiSMASH-DB 4.0 matches for allorf_22575_22688

22.9%

NZ_JAPTYM010000001.1:

Lanthipeptides: allorf_00301141_00301338_lanthipeptide

RCAEPVDGSGGLEGSGPSRCS

RC EPV+ SG G+G R S

RCREPVNLSG--HGTGRHRTS

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

BLK03_RS04555 - Class II

Cleavage pHMM score: -2.60

RODEO score: 0

Monoisotopic mass: 1995.9 Da

Molecular weight: 1997.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2015.3 Da N = 1

allorf_01019_01192 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 4521.6 Da

Molecular weight: 4524.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4542.1 Da N = 1; 4560.1 Da N = 2; 4578.1 Da N = 3; 4596.1 Da N = 4; 4614.2 Da N = 5; 4632.2 Da N = 6; 4650.2 Da N = 7; 4668.2 Da N = 8; 4686.2 Da N = 9; 4704.3 Da N = 10; 4722.3 Da N = 11; 4740.3 Da N = 12

allorf_02275_02343 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 489.2 Da

Molecular weight: 489.6 Da

Number of bridges: 1

allorf_03486_03629 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 2934.6 Da

Molecular weight: 2936.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2954.4 Da N = 1; 2972.4 Da N = 2; 2990.4 Da N = 3; 3008.4 Da N = 4

allorf_04363_04602 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 3877.2 Da

Molecular weight: 3879.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3897.5 Da N = 1; 3915.5 Da N = 2; 3933.6 Da N = 3; 3951.6 Da N = 4

allorf_05617_05850 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 6597.4 Da

Molecular weight: 6601.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 6619.5 Da N = 1; 6637.5 Da N = 2; 6655.5 Da N = 3; 6673.5 Da N = 4; 6691.5 Da N = 5; 6709.6 Da N = 6; 6727.6 Da N = 7; 6745.6 Da N = 8; 6763.6 Da N = 9; 6781.6 Da N = 10; 6799.7 Da N = 11; 6817.7 Da N = 12

allorf_19455_19631 - Class II

Cleavage pHMM score: -4.30

RODEO score: 0

Monoisotopic mass: 2665.2 Da

Molecular weight: 2666.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2684.9 Da N = 1; 2702.9 Da N = 2; 2720.9 Da N = 3

allorf_19874_19972 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 1098.6 Da

Molecular weight: 1099.3 Da

Number of bridges: 1

allorf_21360_21512 - Class II

Cleavage pHMM score: -4.90

RODEO score: 0

Monoisotopic mass: 3689.8 Da

Molecular weight: 3692.2 Da

Number of bridges: 2

allorf_22575_22688 - Class II

Cleavage pHMM score: 0.10

RODEO score: 0

Monoisotopic mass: 2227.0 Da

Molecular weight: 2228.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2246.4 Da N = 1; 2264.4 Da N = 2