LOCUS       BGC0001579              8838 bp    DNA     linear   CON 15-JUL-2021
DEFINITION  Streptomyces cinnamoneus strain ATCC 12686 scaffold18, whole genome
            shotgun sequence.
ACCESSION   BGC0001579
VERSION     BGC0001579
KEYWORDS    .
SOURCE      Streptomyces cinnamoneus
  ORGANISM  Streptomyces cinnamoneus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces cinnamoneus group.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            MOEP01000024.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:40:01
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..360
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLK03_RS04550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="installing (2S,9S)-lysinoalanine"
                     /protein_id="WP_071962205.1"
                     /transl_table=11
                     /translation="MKSAKEPTIYQDVDIIRRIQELMVLCSLLPPDGKLREALELALAL
                     HEEPALARITPLTNLHPFATKAWLETLWLGEGVSSEEKELVAWQNKSENMGPAIRELKN
                     AEQQSGITLVARLTS"
     protocluster    1..8838
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[779:4031]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      780..4031
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..8838
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..8838
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001579"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8838
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..360
                     /locus_tag="BLK03_RS04550"
     gene            404..637
                     /locus_tag="BLK03_RS04555"
     CDS             404..637
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033431.1"
                     /locus_tag="BLK03_RS04555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="precursor peptide"
                     /protein_id="WP_071962206.1"
                     /transl_table=11
                     /translation="MTASILQSVVDADFRAALIENPAAFGASTAVLPTPVEQQDQASLD
                     FWTKDIAATEAFACKQSCSFGPFTFVCDGNTK"
     CDS_motif       404..577
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTASILQSVVDADFRAALIENPAAFGASTAVLPTPVEQQDQASLDFWTKDIAATEAFA"
                     /locus_tag="BLK03_RS04555_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       578..637
                     /prepeptide="core"
                     /locus_tag="BLK03_RS04555_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.60"
                     /molecular_weight="1997.3"
                     /monoisotopic_mass="1995.9"
                     /core_sequence="CKQSCSFGPFTFVCDGNTK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTASILQSVVDADFRAALIENPAAFGASTAVLPTPVEQQDQ
                     ASLDFWTKDIAATEAFA"
                     /leader_location="[403:577](+)"
                     /alternative_weights="2015.3"
     gene            780..4031
                     /locus_tag="BLK03_RS04560"
     CDS             780..4031
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     728.6; E-value: 1.9e-220)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="BLK03_RS04560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lantipeptide synthetase LanM"
                     /protein_id="WP_071962207.1"
                     /sec_met_domain="LANC_like (E-value: 2.4e-78, bitscore:
                     252.4, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 7.4e-78, bitscore:
                     251.3, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNAYPLDIAARAANLTERLRVVAAAGGAAETGQGTAVELDAFDR
                     WKIDTLAGKLADKFHQESLHRSRPPQHTKEELVGVLSAYRRIELGLDGADEETRELLSG
                     LHGAWLPTYRTALDAFDRERSDGAAAGKPSWRAFDVYYGRLAKACEPFLRELGRALTAV
                     RTAADDEGTLLSPELVEDMQRHLLDRFELSMAWAVEAAANVHCAQTGIDKSTAGREDYL
                     AYLDATFADGAAYHRFYLNFPVLGRWLAHTTALLTSFGRDVLESLAADAEAIGNEFFGQ
                     RITEFRSLRLGDSDPHAGARTVARVEAVLADGSTAEFFYKPRSVRSEAALQDLLARLAD
                     DGVVDFATRPVLPRDGYGYEALIPAGRNRVETPQEVERIYEELGGYLAVFYVLGGSDLH
                     FENILVADGHAFVCDAETVLGVHPQGRSQSEGTLLDSVFKTGLLEWPRSARPGEEAAAE
                     MRISGYAGGEGYEVPMPVARRNGEGLSFEASVVHRTGVHVETSASNRVFLGEELVRPED
                     HAESIMEGFNRVYAWFAKDPDAAVDFVMETFSWVTARFINWGTQIYAQLLSAARHPRCL
                     TEPLEVDLLANTVRTFPRTWDAEGILAAREVNAMWQLDVPLFTAGAHARQLVHAHGEPL
                     SSRLDLSPIDHAAARIRRLSEENREQQSQYIAASLSTDEISSPSFVATSLDYAVKIGNR
                     LCGELRVPEDPAPWTSYQLAGGRLEQVDIEADLYQGSAGVVLFLAYLDQLVPRPEYRQA
                     ARQGLDHVLAQWDRDRLGAFAGLGGVIYLLTHLHRLWGDKELLEKAVRLSDEIPGRIEE
                     DRHFDILHGAAGLIPVLIGLAEESGGHGLDHAHRCAGHLLRHAEDDGETLSWPPSAPDE
                     TYGNLTGFSHGSGGIGWALIQLGHHTGRSDYIEAGRKAFAYEDRYVDEAEKDWYDLRIN
                     NGSAVKGARHFSNAWCNGAAGIGLARITSWDALGRTDEQLLREAQQALSATMRNFPRLK
                     NHTLCHGTSGNAELFLRFARLNDEPAFQLEANVQVQALWRSFDEAGDSTADNSADFFPG
                     LMIGISGFGMHFLRLAAPDRVPSVLLLDPPSHHEQ"
     gene            4046..5029
                     /locus_tag="BLK03_RS04565"
     CDS             4046..5029
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLK03_RS04565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="Nif11-like leader peptide family natural product
                     precursor"
                     /protein_id="WP_071962208.1"
                     /transl_table=11
                     /translation="MALKTCEEFLRDALDPDRFGREMKAVTEIPEIVKLGHRHGYGFTA
                     EEFLTKAMSFGAPPAGAAAPGESASVPGQNGSSPGHAARAAMAGPEAGATSFAHYEYRL
                     DELPEFAPVVAELPKLKVMPPSVGPDRFAARYRDEDMRTISMSPADPAYQAWHQELAGR
                     GWRDAEDTAAAPDAPRRDFHLLNLDEHVDYPGYEEYFAAKTRVVAALENLFGGDVRCSG
                     SMWYPPSSYRLWHTNADQPGWRMYLVDVDRPFADPDRTSFFRYLHPRTREIVTLRESPR
                     IVRFFKVEQDPEKLFWHCIANPTDRHRWSFGYVVPENWMDALRHHG"
     gene            5076..6134
                     /locus_tag="BLK03_RS04570"
     CDS             5076..6134
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 221.9; E-value:
                     1.5e-67)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123204.1"
                     /locus_tag="BLK03_RS04570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_079273648.1"
                     /transl_table=11
                     /translation="MFGAGPRTARKPAADDGPAREPDGPAPADGTAAGPRSARPGPPAI
                     LARGLGKTYAGVEAVRGIDLTVAQGETFGFLGPNGAGKTTTISMLTTLATPTSGRIEIA
                     GHDTRTAPQQVRRNLGLVFQETTLDPELTAVENLRFHADLYALPRAGLSERITAMLELV
                     GLAARGGSLVRTFSGGMQRRLEIARGLLHRPRLLFLDEPTIGLDPQTRAQVWTHLAEIR
                     EREATTIFLTTHYLDEAEQCDRIAIIDDGRIVAQGSPAELKSVIGADRVDLRTGDDVAA
                     AALLRTRFGLDPVQGPAGLSVKVAEGARLVPALCAALDVAVYEVTVTRPSLDDVFLHHT
                     GRGIRDDSGAGA"
     gene            6131..7003
                     /locus_tag="BLK03_RS04575"
     CDS             6131..7003
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 152.5; E-value: 1.9e-46)"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024110.1"
                     /locus_tag="BLK03_RS04575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_071962209.1"
                     /transl_table=11
                     /translation="MTHATAALPAAAPRETGRIAAEWRAGTMVWRREMIHFLRSRAGIA
                     VSLLQPLLFLYVLGIGLSRMFSGAGSSDDYMVFLFPGVLVMAAQAPAISVGASIVWDRQ
                     SGFLREMLVAPVHRSTLLIGKCLGGATVAACQGAVVLASAGLVGVPYRIDLFAALLAEL
                     LLASLAMTVMGAVIAVRIQRIQTFHTALTVLTAPMVFLSGLMFPVSAMPAWMASLTLVN
                     PLTYAVDAMRQTITAFHPAPAAGASGAPFFDPVSWGGWDVPPGLSVALVAAFSAVALAV
                     AARRFARTD"
     gene            7103..8125
                     /locus_tag="BLK03_RS04580"
     CDS             7103..8125
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLK03_RS04580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="CinY protein"
                     /protein_id="WP_071962210.1"
                     /transl_table=11
                     /translation="MRTTRRLSLRRRTALLMGTASLAAPMLLTVQAGEAQAFGTINSLG
                     QRAEHERITRAALACEPGQASDGTCFEPRSIDQVAGHTGTFGAVGSPDSDEIFTPEAHC
                     DDADFLTASGYPRTRQQASDQLIACISKLQGRFGQGVSAGSATLNGDGTVSPGNSDLST
                     DCTFTGGVPGRGKCNAIEGFGRALHGVQDFYSHSNWADKADPNQAVGVANPPGLNMSGP
                     SPLLALKSGRPPAASSVPAQLSTGCFSLNPWGCSNRVTHTTLNKDTGLIDPATGATSDP
                     TTNRGRITGNFDRAVKGAIADTRRQWADFRTALTERYGQEKGARIGCVLTHDNPVRDCR
                     "
     gene            complement(8212..8838)
                     /locus_tag="BLK03_RS04585"
     CDS             complement(8212..8838)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970566.1"
                     /locus_tag="BLK03_RS04585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YigZ family protein"
                     /protein_id="WP_071962211.1"
                     /transl_table=11
                     /translation="MQDEYRTVALEGEHEIEISRSRFICALAPAATEEEAQAFVARIRK
                     EHPTARHHCWAYVIGADGSVQKASDDGEPGGTAGVPMLQMLVRRDMRYVVAVVTRYFGG
                     VKLGAGGLIRAYGGVVGEALDTLGTVTRRRFRLATVTVDHQRAGKLENELRATGRDVRE
                     VSYGAGVRIGIGLPEADVEGFRAWLADTTAGSAVLELGGEAYGDA"
ORIGIN
        1 atgaaaagcg ccaaggaacc gacgatctac caggacgtgg atatcatccg ccgcatccag
       61 gagctcatgg ttctgtgctc cctgctgccg cccgacggca agctgcgtga agcgctggag
      121 ctcgctctcg cgctccacga ggagccggca ctggcccgga tcactcccct caccaatctc
      181 catcccttcg cgacgaaggc ctggctcgag accctgtggc tcggggaggg cgtttccagc
      241 gaggagaagg aactggtcgc ctggcagaac aagagcgaga acatgggccc ggccattcgt
      301 gaactcaaga acgccgaaca gcaatccggc atcacgttgg tcgcccggct gacgtcctga
      361 catcgccagg tgtcgggatt cacctcaaca tcggaggtaa gtcatgaccg cttcgattct
      421 tcagtccgtc gtggacgccg acttccgcgc cgcgctgatc gagaacccgg ccgcgttcgg
      481 tgcctcgacc gcggtcctgc ccacgcccgt ggagcagcag gaccaggcgt ccctcgactt
      541 ctggaccaag gacatcgccg ctacggaagc cttcgcctgc aagcagagct gcagcttcgg
      601 cccgttcacc ttcgtgtgtg acggcaacac caagtaagcg gccgttgccc tcgggcggta
      661 acgcccgccc ggtgcgatga cgcggtgggt cggcactcgc cggcccaccg cgttgcgccg
      721 cgcggcggac ccccggccac gagcgctccc tcgacttcga ccgcaggaga gtttcgcaca
      781 tgggtaacgc ttatccgctg gacatcgcgg cgcgggcggc caatctgacc gagcgattgc
      841 gggtcgtcgc cgcggcgggc ggcgccgcgg agaccggtca gggcacggcg gtcgagctcg
      901 acgcgttcga ccgctggaag atcgacacac tggccgggaa gctggccgac aagttccacc
      961 aggagtccct ccaccgctcc aggccgcccc agcacaccaa ggaagagctc gtcggcgtgc
     1021 tgtccgcgta ccgccggatc gaactgggcc tggacggggc ggacgaggag acgcgcgagc
     1081 tcctgagcgg gctgcacggc gcctggctgc ccacctaccg caccgccctg gacgccttcg
     1141 accgcgagcg gtcggacggg gcggccgccg ggaagccctc ctggcgcgcg ttcgacgtgt
     1201 attacgggcg gctggccaag gcctgcgagc cgttcctgcg cgaattgggg cgcgccctga
     1261 ccgccgtacg gacggcggcg gacgacgaag gcaccctgct gagccccgag ctggtcgagg
     1321 acatgcagcg ccacctgctc gaccgcttcg agttgagcat ggcctgggcc gtggaagccg
     1381 ccgccaacgt gcactgcgcg cagaccggaa tcgacaagtc caccgcaggc cgcgaggact
     1441 atctcgccta tctcgacgcc acgttcgccg acggcgcggc ctatcaccgc ttctatctga
     1501 atttccccgt gctcggccgc tggctcgcgc acaccaccgc cctgctcacc tccttcggcc
     1561 gggacgtcct cgaaagcctg gcggccgacg cggaggccat cggaaacgaa ttcttcgggc
     1621 agcggatcac cgaattccgc tcccttcggc tgggcgactc cgacccgcac gcgggggcgc
     1681 gtaccgtcgc ccgcgtcgaa gccgtgctcg ccgacgggag cacggccgaa ttcttctaca
     1741 agccgcgcag cgtccgctcc gaggcggcgc tccaggacct gctcgcacga ctggcggacg
     1801 acggggtcgt cgacttcgcg acccggcccg tcctgcccag ggacggctac ggctacgaag
     1861 ccctgatacc tgccgggcgc aaccgcgtgg aaacgccgca ggaagtcgag cggatctacg
     1921 aggagctcgg cggctatctg gcggtcttct acgtgctggg cggcagcgac ctgcacttcg
     1981 agaacatcct cgtcgccgac gggcacgcct tcgtctgcga cgcggagacg gtcctcggcg
     2041 tccacccgca gggccgctcg caatccgaag gcaccctcct cgactccgtg ttcaagaccg
     2101 ggctgctcga gtggccgcgc tccgcccggc cgggcgagga ggccgccgcc gagatgcgga
     2161 tcagcggcta cgcgggcggc gagggatacg aggtccccat gccggtggcg cgcaggaacg
     2221 gcgaggggct cagcttcgag gcgtccgtgg tgcaccgcac cggcgtccac gtggagacca
     2281 gcgcctccaa ccgcgtcttc ctcggcgagg agctcgtccg ccccgaggac cacgccgagt
     2341 cgatcatgga gggcttcaac cgggtctacg cctggttcgc caaggacccc gacgcagccg
     2401 tcgacttcgt gatggagacg ttcagctggg tcactgcccg cttcatcaac tggggcaccc
     2461 agatctacgc ccagctgctg agcgccgccc gccacccgag gtgcctgacc gagcccctcg
     2521 aggtggacct gctcgccaac accgtgcgca ccttcccccg cacctgggac gccgagggca
     2581 tcctcgccgc acgcgaagtg aacgccatgt ggcagctgga cgtgccgctg ttcaccgcgg
     2641 gcgcccatgc caggcagctg gtgcacgcgc acggcgagcc gctgtcctcg cgcctggacc
     2701 tctcgcccat cgaccacgcc gccgcccgca tcaggcggct gtcggaggag aaccgcgagc
     2761 agcagagcca gtacatcgcc gccagtctct ccacggacga gatcagcagc ccctccttcg
     2821 tcgccacttc cctggactat gcggtcaaga tcggcaaccg gctgtgcggc gagctcaggg
     2881 tgcccgagga ccccgcaccc tggacctcgt accagctggc gggcggccgg ctcgagcagg
     2941 tggacatcga ggccgacctc taccagggct ccgcgggcgt cgtgctcttc ctcgcctacc
     3001 tcgatcagct cgtgccccgg ccggagtacc ggcaggccgc ccggcagggc ctcgaccacg
     3061 tcctcgccca atgggaccgc gaccggctgg gcgcgttcgc ggggctcggc ggcgtcatct
     3121 acctcctcac ccacctgcac cggctgtggg gcgacaagga gctgctcgag aaggccgtcc
     3181 ggctgagcga cgagatcccc ggacgcatcg aggaggaccg gcacttcgac atcctgcacg
     3241 gagcggcggg cctcatcccc gtcctgatcg gcctcgccga ggagagcggc gggcacggcc
     3301 tcgaccacgc ccaccggtgc gccggccacc tgctgcggca cgccgaggac gacggcgaga
     3361 ccctcagctg gccgccgtcc gcgcccgacg agacctacgg caacctcacc ggcttctccc
     3421 acggctccgg cggcatcggc tgggccctga tccagctcgg ccaccacacc ggccggagcg
     3481 actacatcga ggccgggcgc aaggccttcg cctacgagga ccggtacgtc gacgaggcgg
     3541 agaaggactg gtacgacctg cggatcaaca acggctccgc ggtcaagggc gcccggcact
     3601 tctccaacgc ctggtgcaac ggggcggccg gcatcgggct cgcccggatc accagctggg
     3661 acgcgctcgg ccgcaccgac gaacaactgc tgcgcgaggc ccagcaggcg ctgtcggcga
     3721 ccatgcgcaa cttcccccgg ctgaagaacc acaccctgtg ccacggcacg tccggcaacg
     3781 ccgagctctt cctgcgcttc gcccggctca acgacgaacc ggccttccag ctggaggcca
     3841 acgtccaggt ccaggcgctg tggcggagct tcgacgaggc gggcgacagc acggcggaca
     3901 acagtgccga cttcttcccg ggactgatga tcggcatctc cggattcggc atgcacttcc
     3961 tgcggctggc ggccccggac cgcgtcccgt ccgtgctgct cctcgacccg ccgtcgcacc
     4021 acgaacagta aggagtcgct ccaccatggc cctgaagacc tgcgaggaat tcctgcgcga
     4081 cgccctcgac cccgaccgct tcggccggga gatgaaggcg gtcacggaga taccggagat
     4141 cgtcaagctc ggccaccgcc acggatacgg cttcaccgcc gaggagttcc tgacgaaggc
     4201 catgtccttc ggcgccccgc cggccggtgc cgcggcgcca ggggagagcg cgagcgtgcc
     4261 ggggcagaac ggctcctcgc ccggccacgc cgcccgggcc gccatggccg gcccggaggc
     4321 cggcgccacc agcttcgccc actacgagta ccgcctggac gagctccccg agttcgcacc
     4381 cgtcgtcgcg gagctcccca agctgaaggt catgccgccc tccgtcggac cggaccgctt
     4441 cgccgcccgc taccgcgacg aggacatgcg gacgatctcg atgtcccccg ccgaccccgc
     4501 ctaccaggcc tggcaccagg agctcgccgg gcggggctgg cgggacgccg aggacacagc
     4561 tgccgcaccg gacgcacccc ggcgggactt ccacctcctc aacctcgacg aacacgtcga
     4621 ctaccccggc tacgaggagt acttcgcggc gaagaccagg gtcgtggcgg ccctggaaaa
     4681 cctcttcggc ggcgacgtgc gctgctcggg ctccatgtgg tacccgccgt ccagctaccg
     4741 gctgtggcac accaacgccg accagccggg atggcgcatg tacctcgtgg acgtcgaccg
     4801 gcccttcgcc gaccccgacc ggacctcgtt cttccgctac ctccacccgc gcacccggga
     4861 gatcgtcacg ctgcgcgaga gcccgcgcat cgtgcggttc ttcaaggtcg agcaggaccc
     4921 ggagaagctg ttctggcact gcatcgccaa ccccacggac cggcaccgct ggagcttcgg
     4981 ctatgtcgtg ccggagaact ggatggacgc cctccgccac cacggctgac cccgcacccg
     5041 tcgccgcgcg caccgcgggg caccaaggag gagcgatgtt cggagcagga ccgcggaccg
     5101 cgcgcaagcc ggcggcggac gacgggcccg cgcgcgagcc cgacgggccg gcgccggccg
     5161 acgggaccgc ggccgggccc cggtccgcgc ggcccggccc gccggccatc ctggccagag
     5221 ggctgggcaa gacgtacgcg ggcgtggaag cggtgcgcgg catcgacctg accgtcgccc
     5281 agggtgagac cttcggcttc ctcggcccca acggggcggg caagaccacg acgatctcca
     5341 tgctgaccac cctggccacg cccacctcgg gccggatcga gatcgccggc cacgacaccc
     5401 gcaccgcccc ccagcaggtg cgccgcaacc tcgggctggt cttccaggag accacgctcg
     5461 acccggagct gacggccgtg gagaacctgc gcttccacgc cgacctctac gccctgccgc
     5521 gcgccgggct gagcgagcgc atcaccgcca tgctcgaact cgtcgggctc gcggcccgcg
     5581 gcggcagcct cgtgcgcacc ttctccggcg gcatgcagcg ccggctggag atcgcacgcg
     5641 ggctgctgca ccggccgcgg ctgctcttcc tcgacgagcc gaccatcggc ctcgacccgc
     5701 agacccgggc ccaggtgtgg acgcacctgg ccgagatccg cgaacgcgag gccacgacca
     5761 tcttcctgac cacgcactac ctcgacgagg ccgagcagtg cgaccgcatc gccatcatcg
     5821 acgacggccg gatcgtcgcc cagggcagcc cggccgagct gaagtcggtc atcggggccg
     5881 accgcgtgga cctgcgcacg ggtgacgacg tcgcggcggc cgcgctgctg cggacacgct
     5941 tcggcctcga cccggtccag ggcccggccg gcctcagcgt caaggtcgcg gagggcgcca
     6001 ggctcgtccc ggcgctgtgc gccgccctcg acgtggccgt ctacgaggtg accgtcaccc
     6061 gccccagcct cgacgacgtc ttcctccacc acacggggcg cggaatccgc gacgactcag
     6121 gagccggcgc atgacgcacg ccacggccgc actgccggcc gccgcccccc gcgaaaccgg
     6181 ccgcatcgcc gccgaatggc gcgccggcac catggtgtgg cgacgcgaaa tgatccactt
     6241 cctgcgctcg cgcgccggga tcgccgtgtc cctgctgcag ccgctgctgt tcctgtacgt
     6301 gttgggcatc ggcctgtccc ggatgttcag cggcgccggc tcctccgacg actacatggt
     6361 gttccttttc ccaggcgtgc tggtgatggc ggctcaggcc ccggccatct cggtgggcgc
     6421 gtccatcgtc tgggaccggc agagcgggtt cctgcgcgag atgctggtgg cgcccgtcca
     6481 ccgcagcacc ctgctgatcg gcaagtgcct cggcggcgcc accgtcgcgg cgtgccaggg
     6541 cgcggtcgtc ctggccagcg ccgggctcgt gggtgtgccg taccggatcg acctcttcgc
     6601 cgccctgctg gccgaactgc tcctcgcctc cctcgcgatg acggtcatgg gcgcggtgat
     6661 cgcggtcagg atccagcgga tccagacgtt ccataccgcg ctgacggtcc tgacggcccc
     6721 catggtcttc ctgtcggggc tgatgttccc cgtcagcgcc atgccggcct ggatggcctc
     6781 gctcaccctc gtcaaccccc tgacgtacgc ggtcgatgcc atgcggcaga cgatcaccgc
     6841 gttccacccc gccccggcgg ccggggcgtc gggggcaccg ttcttcgacc cggtctcctg
     6901 gggaggctgg gacgtcccgc cggggctgtc ggtggccctg gtggccgcgt tctccgcggt
     6961 ggctctggcg gtggccgccc gccgcttcgc acggaccgac tgaagtccca cgaagcgact
     7021 gaaaacgccg tcgtcccggg cgacccaacc gtggatcatc gctcacgacc gtagcgccga
     7081 accgatcaga ggagaccgca ccatgcgcac caccagacgc ctttcgctgc gccgccgtac
     7141 cgctctgctc atgggcaccg cttcgctcgc ggccccgatg ctgctcacgg tccaggccgg
     7201 cgaggcgcag gcgttcggca cgatcaactc gctcgggcag cgtgccgagc acgagcgcat
     7261 cacccgggcg gcgctcgcct gcgagcctgg ccaggcatcc gacgggacgt gtttcgagcc
     7321 gcgctcgatc gaccaagtgg cgggccacac cggcacgttc ggggccgtgg gctcgcccga
     7381 ctcggacgag atcttcaccc ccgaggcgca ctgcgacgac gccgacttcc tcacggcctc
     7441 cggctacccc cgcacccggc agcaggccag cgaccagctc atcgcctgca tatccaagct
     7501 gcagggacgt ttcggccagg gggtctccgc gggttccgcc accctgaacg gcgacggcac
     7561 cgtctcaccg ggcaacagcg acctgtccac ggactgcacc ttcacgggcg gcgtccccgg
     7621 gcgcggcaag tgcaacgcca tcgagggctt cggccgcgcg ctgcacggcg tgcaggactt
     7681 ctactcgcac agcaactggg ccgacaaggc ggaccccaac caggccgtcg gcgtcgccaa
     7741 cccgcccggc ctgaacatga gcggcccgtc cccgctgctc gccctcaaga gcggccggcc
     7801 gccggccgcc tcctcggtgc cggcgcagct gtccacgggc tgcttctcgc tcaacccctg
     7861 gggctgctcg aaccgggtca cgcacaccac cctcaacaag gacaccggcc tgatcgatcc
     7921 ggccaccggc gccaccagtg acccgaccac caaccgcggc cggatcaccg gcaacttcga
     7981 ccgcgccgtc aagggcgcga tcgccgacac ccgtcgtcag tgggccgact tccgcaccgc
     8041 gctgaccgag cgctacggcc aggagaaggg tgcccgcatc ggctgcgtcc tgacgcacga
     8101 caaccccgtg cgcgactgcc gctgacccct ggctccaccc cgatccgcct gccggcccgg
     8161 ccgccccggg ccggcaggtg cgtgtggggc gccgtagccg taccgccgcg ctcaggcgtc
     8221 gccgtacgcc tcgccgccga gctccagcac cgccgagccg gccgtggtgt ccgccagcca
     8281 ggccctgaac ccctccacgt ccgcctcggg cagcccgatc ccgatccgca cgcccgcccc
     8341 gtaggacacc tcgcgcacgt cccgcccggt ggcccgcagt tcgttctcca gcttgccggc
     8401 ccgctggtgg tcgaccgtga ccgtcgccag ccggaagcgc cgccgggtca cggtgcccag
     8461 ggtgtcgagc gcctcgccga ccaccccgcc gtaggcccgg atcaggccgc cggcgccgag
     8521 cttgacgccg ccgaagtagc gggtgaccac ggcgacgacg tagcgcatgt cgcgccgcac
     8581 gagcatctgc agcatgggca cgcccgccgt gcccccgggc tcgccgtcgt cgctcgcctt
     8641 ctgcaccgag ccgtcggcgc cgatgacgta cgcccagcag tggtgccggg cggtggggtg
     8701 ctccttgcgg atacgcgcga cgaacgcctg cgcctcctcc tcggtggcgg cgggcgcgag
     8761 cgcgcagatg aagcgcgacc tgctgatctc gatctcgtgc tcgccctcga gcgcgaccgt
     8821 ccggtactcg tcctgcat
//
