BGC0001579: duramycin biosynthetic gene cluster from Streptomyces cinnamoneus
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Location: 85,466 - 94,303 nt. (total: 8,838 nt).
This entry is originally from NCBI GenBank NZ_MOEP01000024.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001579
Short description duramycin biosynthetic gene cluster from Streptomyces cinnamoneus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "WP_071964624.1 may be hypothetical resistance gene based on its similarity to cinorf10.Streptoverticillium griseoverticillatum PA-48009 may also contain a duramycin-producing BGC based on reported isolation data (PMID: 2272918), however, no genomic data is avaliable mainly due to incomplete genome sequence."
Biosynthetic class(es)
  • RiPP (Lanthipeptide)
Loci NCBI GenBank: NZ_MOEP01000024.1
Compounds
  • duramycin
Species Streptomyces cinnamoneus [taxonomy]
References
Chemical products information
duramycin
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C89H125N23O25S3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BLK03_RS04550
  • WP_071962205.1
 85466 - 85825 (+) installing (2S,9S)-lysinoalanine
  • Scaffold biosynthesis
Activity assay
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  • BLK03_RS04555
  • WP_071962206.1
 85869 - 86102 (+) precursor peptide
  • Precursor biosynthesis
Other in vivo study
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  • BLK03_RS04560
  • WP_071962207.1
 86245 - 89496 (+) type 2 lantipeptide synthetase LanM
  • Scaffold biosynthesis
Other in vivo study
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  • BLK03_RS04565
  • WP_071962208.1
 89511 - 90494 (+) Nif11-like leader peptide family natural product precursor
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  • BLK03_RS04570
  • WP_079273648.1
 90541 - 91599 (+) ATP-binding cassette domain-containing protein
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  • BLK03_RS04575
  • WP_071962209.1
 91596 - 92468 (+) ABC transporter permease
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  • BLK03_RS04580
  • WP_071962210.1
 92568 - 93590 (+) CinY protein
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  • BLK03_RS04585
  • WP_071962211.1
 93677 - 94303 (-) YigZ family protein
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RiPP-specific information
Subclass Lanthipeptide
Cyclic? yes
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: ZMZXFLPDGFEHMQPX76IB4OQ3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Update compound, gene annotations, and biosynthetic class
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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