BGC0001579: duramycin biosynthetic gene cluster from Streptomyces cinnamoneus
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Location: 85,466 - 94,303 nt. (total: 8,838 nt).
This entry is originally from NCBI GenBank NZ_MOEP01000024.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001579
Short description duramycin biosynthetic gene cluster from Streptomyces cinnamoneus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "WP_071964624.1 may be hypothetical resistance gene based on its similarity to cinorf10.Streptoverticillium griseoverticillatum PA-48009 may also contain a duramycin-producing BGC based on reported isolation data (PMID: 2272918), however, no genomic data is avaliable mainly due to incomplete genome sequence."
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
NZ_MOEP01000024.1
85466 - 94303
via Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • duramycin
Species Streptomyces cinnamoneus [taxonomy]
References
Chemical products information
duramycin Evidence:
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C89H125N23O25S3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BLK03_RS04550
  • WP_071962205.1
 85466 - 85825 (+) installing (2S,9S)-lysinoalanine
  • Scaffold biosynthesis
  • Activity assay
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  • BLK03_RS04555
  • WP_071962206.1
 85869 - 86102 (+) precursor peptide
  • Precursor biosynthesis
  • Other in vivo study
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  • BLK03_RS04560
  • WP_071962207.1
 86245 - 89496 (+) type 2 lantipeptide synthetase LanM
  • Scaffold biosynthesis
  • Other in vivo study
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  • BLK03_RS04565
  • WP_071962208.1
 89511 - 90494 (+) Nif11-like leader peptide family natural product precursor
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    • BLK03_RS04570
    • WP_079273648.1
    		 90541 - 91599 (+) ATP-binding cassette domain-containing protein
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      • BLK03_RS04575
      • WP_071962209.1
      		 91596 - 92468 (+) ABC transporter permease
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        • BLK03_RS04580
        • WP_071962210.1
        		 92568 - 93590 (+) CinY protein
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          • BLK03_RS04585
          • WP_071962211.1
          		 93677 - 94303 (-) YigZ family protein
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            Biosynthesis information
            Annotation changelog

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2019-10-16
            Update compound, gene annotations, and biosynthetic class
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2018-08-06
            Submitted
            • (ID: ZMZXFLPDGFEHMQPX76IB4OQ3)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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