BGC0001582: ecumicin biosynthetic gene cluster from Nonomuraea sp. MJM5123
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Location: 1 - 74,009 nt. (total: 74,009 nt).
This entry is originally from NCBI GenBank KJ144825.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001582
Short description ecumicin biosynthetic gene cluster from Nonomuraea sp. MJM5123
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KJ144825.1
via
Compounds
  • ecumicin
Species Nonomuraea sp. MJM5123 [taxonomy]
References
Chemical products information
ecumicin Evidence:
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C83H134N14O17
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIW58896.1
 9374 - 10717 (+) cytochrome P450 monooxygenase
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    • AIW58897.1
    		 10723 - 11829 (-) hypothetical protein
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      • AIW58898.1
      		 11855 - 12856 (-) O-methyltransferase
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        • AIW58899.1
        		 13040 - 13870 (-) putative ABC transporter
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          • AIW58900.1
          		 13867 - 14742 (-) hypothetical protein
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            • AIW58901.1
            		 14826 - 15527 (-) hypothetical protein
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              • AIW58902.1
              		 15596 - 16891 (-) hypothetical protein
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                • AIW58895.1
                		 16933 - 18021 (-) putative ATPase AAA
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                  • AIW58894.1
                  		 18118 - 18354 (-) hypothetical protein
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                    • AIW58893.1
                    		 18452 - 18670 (-) MbtH-like protein
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                      • AIW58892.1
                      		 18667 - 64446 (-) non-ribosomal peptide synthetase
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                        • AIW58891.1
                        		 65017 - 67695 (+) putative serine/threonine protein kinase
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                          • AIW58890.1
                          		 67679 - 67879 (-) hypothetical protein
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                            • AIW58889.1
                            		 67997 - 68434 (-) hypothetical protein
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                              • AIW58888.1
                              		 68723 - 68926 (+) hypothetical protein
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                                • AIW58887.1
                                		 69086 - 69889 (+) LmbU and CloE-like protein
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                                  • AIW58884.1
                                  		 69991 - 70326 (+) hypothetical protein
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                                    • AIW58885.1
                                    		 70607 - 72433 (-) hypothetical protein
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                                      • AIW58886.1
                                      		 72433 - 73464 (-) hypothetical protein
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                                        Biosynthesis information

                                        Biosynthetic modules

                                        Name
                                        Unk01
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        valine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk02
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        valine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk03
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        allo-isoleucine, isoleucine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk04
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        threonine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk05
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        threonine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk06
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        valine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk07
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        leucine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk08
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        valine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk09
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        valine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk10
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        tryptophan (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk11
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        valine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk12
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        phenylalanine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk13
                                        Type
                                        nrps-type1
                                        Genes
                                        AIW58892.1
                                        Substrates
                                        valine (evidence: Structure-based inference [2])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Annotation changelog

                                        Entry version: 3

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-09-15
                                        Added NRP substrate specificities
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 2

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2019-10-16
                                        Migrated from v1.4
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2019-10-16
                                        Updated reference publication(s) (MIBiG Annotathon)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2019-10-16
                                        Updated compound(s) information (NPAtlas curation)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 1

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2018-08-06
                                        Submitted
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        Detailed domain annotation
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