BGC0001584: C-1027 biosynthetic gene cluster from Streptomyces sp. CB02366
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 73,117 nt. (total: 73,117 nt).
This entry is originally from NCBI GenBank KU597647.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001584
Short description C-1027 biosynthetic gene cluster from Streptomyces sp. CB02366
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
KU597647.1
via
Compounds
  • C-1027
Species Streptomyces sp. CB02366 [taxonomy]
References
Chemical products information
C-1027 Evidence:
Copy SMILES
C43H42Cl1N3O13
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ANY94423.1
 121 - 1491 (+) glycerol phosphate ABC transporter
    copy AA seq
    copy Nt seq
    • ANY94424.1
    		 1631 - 3958 (-) UvrA-like drug resistance pump
      copy AA seq
      copy Nt seq
      • ANY94425.1
      		 4038 - 5423 (-) Na/H efflux pump
        copy AA seq
        copy Nt seq
        • ANY94426.1
        		 5410 - 6894 (-) alkylhalidase
          copy AA seq
          copy Nt seq
          • ANY94427.1
          		 7077 - 8144 (+) dNTP-glucose synthase
            copy AA seq
            copy Nt seq
            • ANY94428.1
            		 8277 - 8708 (-) apoprotein
              copy AA seq
              copy Nt seq
              • ANY94429.1
              		 8755 - 9987 (-) amino transferase
                copy AA seq
                copy Nt seq
                • ANY94430.1
                		 9984 - 10718 (-) N-methyl transferase
                  copy AA seq
                  copy Nt seq
                  • ANY94431.1
                  		 10718 - 11989 (-) C-methyltransferase
                    copy AA seq
                    copy Nt seq
                    • ANY94432.1
                    		 12095 - 13252 (-) epoxide hydrolase
                      copy AA seq
                      copy Nt seq
                      • ANY94433.1
                      		 13325 - 13987 (-) anthranilate synthase II
                        copy AA seq
                        copy Nt seq
                        • ANY94434.1
                        		 13984 - 15465 (-) anthranilate synthase I
                          copy AA seq
                          copy Nt seq
                          • ANY94435.1
                          		 15481 - 16935 (-) phenylacetyl CoA ligase
                            copy AA seq
                            copy Nt seq
                            • ANY94436.1
                            		 16932 - 17603 (-) 2-amino-4-deoxychorismate dehydrogenase
                              copy AA seq
                              copy Nt seq
                              • ANY94437.1
                              		 17622 - 18944 (-) 3-O-acyltransferase
                                copy AA seq
                                copy Nt seq
                                • ANY94438.1
                                		 19043 - 19621 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
                                  copy AA seq
                                  copy Nt seq
                                  • ANY94439.1
                                  		 19872 - 21218 (+) FAD-binding monooxygenase
                                    copy AA seq
                                    copy Nt seq
                                    • ANY94440.1
                                    		 21262 - 22644 (+) glycosyl transferase
                                      copy AA seq
                                      copy Nt seq
                                      • ANY94441.1
                                      		 22647 - 23639 (+) dNTP-glucose dehydratase
                                        copy AA seq
                                        copy Nt seq
                                        • ANY94442.1
                                        		 23683 - 25248 (+) transmembrane efflux protein
                                          copy AA seq
                                          copy Nt seq
                                          • ANY94443.1
                                          		 25331 - 26641 (+) coenzyme F390 synthase-like protein
                                            copy AA seq
                                            copy Nt seq
                                            • ANY94444.1
                                            		 26861 - 28444 (+) chlorophenol-4-monooxygenase
                                              copy AA seq
                                              copy Nt seq
                                              • ANY94445.1
                                              		 28529 - 29365 (-) hydrolase
                                                copy AA seq
                                                copy Nt seq
                                                • ANY94446.1
                                                		 29587 - 30009 (-) hypothetical protein
                                                  copy AA seq
                                                  copy Nt seq
                                                  • ANY94447.1
                                                  		 30236 - 31561 (+) citrate/shikimate transporter
                                                    copy AA seq
                                                    copy Nt seq
                                                    • ANY94448.1
                                                    		 31630 - 33012 (+) C-domain type II peptide synthetase
                                                      copy AA seq
                                                      copy Nt seq
                                                      • ANY94449.1
                                                      		 33057 - 33338 (+) type II PCP
                                                        copy AA seq
                                                        copy Nt seq
                                                        • ANY94450.1
                                                        		 33442 - 35061 (-) MIO-dependent tyrosine 2,3-aminomutase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • ANY94451.1
                                                          		 35130 - 37778 (-) A-domain type II peptide synthetase
                                                            copy AA seq
                                                            copy Nt seq
                                                            • ANY94452.1
                                                            		 37993 - 40101 (+) antibiotic transporter
                                                              copy AA seq
                                                              copy Nt seq
                                                              • ANY94453.1
                                                              		 40206 - 41255 (+) O-methyltransferase
                                                                copy AA seq
                                                                copy Nt seq
                                                                • ANY94454.1
                                                                		 41311 - 42573 (+) P450 hydroxylase
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • ANY94455.1
                                                                  		 42640 - 43821 (-) oxidoreductase
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • ANY94456.1
                                                                    		 44473 - 45501 (+) hypothetical protein
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • ANY94457.1
                                                                      		 45526 - 46446 (-) oxidoreductase
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • ANY94458.1
                                                                        		 46471 - 47022 (-) alkylhydroperoxidase
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • ANY94459.1
                                                                          		 47345 - 47962 (-) hypothetical protein
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • ANY94460.1
                                                                            		 48237 - 49478 (+) regulator
                                                                              copy AA seq
                                                                              copy Nt seq
                                                                              • ANY94461.1
                                                                              		 50018 - 51001 (+) oxidase
                                                                                copy AA seq
                                                                                copy Nt seq
                                                                                • ANY94462.1
                                                                                		 51055 - 51858 (-) hypothetical protein
                                                                                  copy AA seq
                                                                                  copy Nt seq
                                                                                  • ANY94463.1
                                                                                  		 52096 - 52566 (-) type II thioesterase
                                                                                    copy AA seq
                                                                                    copy Nt seq
                                                                                    • ANY94464.1
                                                                                    		 52706 - 54361 (-) oxidoreductase
                                                                                      copy AA seq
                                                                                      copy Nt seq
                                                                                      • ANY94465.1
                                                                                      		 54358 - 54948 (-) hypothetical protein
                                                                                        copy AA seq
                                                                                        copy Nt seq
                                                                                        • ANY94466.1
                                                                                        		 55206 - 56285 (+) regulatory protein
                                                                                          copy AA seq
                                                                                          copy Nt seq
                                                                                          • ANY94467.1
                                                                                          		 56311 - 57165 (+) AraC family transcriptional regulator
                                                                                            copy AA seq
                                                                                            copy Nt seq
                                                                                            • ANY94468.1
                                                                                            		 57053 - 58402 (-) cytochrome P450
                                                                                              copy AA seq
                                                                                              copy Nt seq
                                                                                              • ANY94469.1
                                                                                              		 58399 - 58947 (-) flavin reductase
                                                                                                copy AA seq
                                                                                                copy Nt seq
                                                                                                • ANY94470.1
                                                                                                		 59076 - 64895 (-) enediyne polyketide synthase
                                                                                                  copy AA seq
                                                                                                  copy Nt seq
                                                                                                  • ANY94471.1
                                                                                                  		 64892 - 66031 (-) hypothetical protein
                                                                                                    copy AA seq
                                                                                                    copy Nt seq
                                                                                                    • ANY94472.1
                                                                                                    		 66028 - 67896 (-) hypothetical protein
                                                                                                      copy AA seq
                                                                                                      copy Nt seq
                                                                                                      • ANY94473.1
                                                                                                      		 67953 - 68930 (-) hypothetical protein
                                                                                                        copy AA seq
                                                                                                        copy Nt seq
                                                                                                        • ANY94474.1
                                                                                                        		 69035 - 69979 (-) hypothetical protein
                                                                                                          copy AA seq
                                                                                                          copy Nt seq
                                                                                                          • ANY94475.1
                                                                                                          		 70224 - 70667 (-) HxlR family transcriptional regulator
                                                                                                            copy AA seq
                                                                                                            copy Nt seq
                                                                                                            • ANY94476.1
                                                                                                            		 70814 - 71377 (+) hypothetical protein
                                                                                                              copy AA seq
                                                                                                              copy Nt seq
                                                                                                              • ANY94477.1
                                                                                                              		 71382 - 71852 (+) hypothetical protein
                                                                                                                copy AA seq
                                                                                                                copy Nt seq
                                                                                                                • ANY94478.1
                                                                                                                		 71930 - 73117 (-) transcriptional regulator
                                                                                                                  copy AA seq
                                                                                                                  copy Nt seq
                                                                                                                  Biosynthesis information
                                                                                                                  Annotation changelog

                                                                                                                  Entry version: 4

                                                                                                                  Date
                                                                                                                  Changes
                                                                                                                  Submitters
                                                                                                                  Reviewers
                                                                                                                  2022-10-07
                                                                                                                  Update chemical activity to schema version 2.11
                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                  Entry version: 3

                                                                                                                  Date
                                                                                                                  Changes
                                                                                                                  Submitters
                                                                                                                  Reviewers
                                                                                                                  2022-09-15
                                                                                                                  Updated bioactivity data
                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                  Entry version: 2

                                                                                                                  Date
                                                                                                                  Changes
                                                                                                                  Submitters
                                                                                                                  Reviewers
                                                                                                                  2019-10-16
                                                                                                                  Migrated from v1.4
                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                  Entry version: 1

                                                                                                                  Date
                                                                                                                  Changes
                                                                                                                  Submitters
                                                                                                                  Reviewers
                                                                                                                  2018-08-06
                                                                                                                  Submitted
                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                  Detailed domain annotation
                                                                                                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                                                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                                                                  Selected features only
                                                                                                                  Show module domains
                                                                                                                  Similar known gene clusters from MIBiG 4.0
                                                                                                                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                                                                  Click on reference genes to show details of similarities to genes within the current region.
                                                                                                                  Click on an accession to open that entry in the MiBIG database.