BGC0001585 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001585 (Escovopsis weberi)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	44,233	High	melinacidin IV	other:other

BGC0001585 - Region 1 - NRPS

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Location: 1 - 44,233 nt. (total: 44,233 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 44,234
Label		BGC0001585

Tailoring functions

Oxidoreductases: oxygenase reductase

EtpB: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

EtpC: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

EtpE: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

EtpT: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: aminotransferase methyltransferase sulfotransferase

EtpG: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

EtpI: aminotransferase

smcogs: SMCOG1019: aminotransferase

EtpM: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: ligase

EtpP: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001585.3	0.91	other (other)	melinacidin IV	Escovopsis weberi
BGC0000321.4	0.71	NRPS	chaetocin	Collariella virescens
BGC0001820.3	0.65	NRPS	verticillin	Gliocladium sp.
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001585.3	0.99	other (other)	melinacidin IV	Escovopsis weberi
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000321.4	0.63	NRPS	chaetocin	Collariella virescens
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001820.3	0.56	NRPS	verticillin	Gliocladium sp.

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 11141 - 44233:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

EtpP: Trp

Search NORINE for peptide: strict or relaxed

AMP-binding (790..1175): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DYVTYTAICK
Nearest Stachelhaus code(s):: Trp DYVTYTAICK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor