BGC0001585 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001585 (Escovopsis weberi)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	44,233	melinacidin IV	other:other	100%

BGC0001585 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 44,233 nt. (total: 44,233 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 44,234
Label		BGC0001585

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001585	0.81	Alkaloid	melinacidin IV	Escovopsis weberi
BGC0000321	0.41	NRP	chaetocin	Collariella virescens
BGC0002321	0.34	Other	pulcherriminic acid, pulcherrimin, cyclodileucine, compound 3	Metschnikowia aff. pulcherrima
BGC0001820	0.33	NRP	verticillin	Gliocladium sp.
BGC0001989	0.32	Other	pulcherrimin	Kluyveromyces lactis
BGC0002670	0.25	Other	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0002226	0.25	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0001315	0.23	Terpene	cucurbitacin	Cucumis sativus
BGC0001132	0.23	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001659	0.22	Terpene	mangicol A	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001585	1.00	Alkaloid	melinacidin IV	Escovopsis weberi
BGC0002321	0.67	Other	pulcherriminic acid, pulcherrimin, cyclodileucine, compound 3	Metschnikowia aff. pulcherrima
BGC0002219	0.66	Terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0002181	0.66	Terpene	pleuromutilin	Rhodocybe pseudopiperita
BGC0001989	0.65	Other	pulcherrimin	Kluyveromyces lactis
BGC0001990	0.64	Other	BU-4704, xanthocillin-X monomethylether, melanocin E, melanocin F, fumiformamide	Aspergillus fumigatus Af293
BGC0000798	0.64	Saccharide	dhurrin	Sorghum bicolor
BGC0000321	0.64	NRP	chaetocin	Collariella virescens
BGC0002670	0.61	Other	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000686	0.61	Terpene	helvolic acid	Aspergillus fumigatus Af293

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 11141 - 44233:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

EtpP

Search NORINE for peptide: strict or relaxed

AMP-binding (790..1175): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DYVTYTAICK
Nearest Stachelhaus code(s):: Trp DYVTYTAICK (94% 8Å match)
Stachelhaus code match:: 100% (strong)