BGC0001590: formicamycin A biosynthetic gene cluster from Streptomyces sp. KY5
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 43,083 nt. (total: 43,083 nt).
This entry is originally from NCBI GenBank KX859301.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001590
Short description formicamycin A biosynthetic gene cluster from Streptomyces sp. KY5
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II aromatic)
Loci
KX859301.1
via
Compounds
  • formicamycin A
  • formicamycin B
  • formicamycin C
  • formicamycin D
  • formicamycin E
  • formicamycin F
  • formicamycin G
  • formicamycin H
  • formicamycin I
  • formicamycin J
  • formicamycin K
  • formicamycin L
  • formicamycin M
  • fasamycin C
  • fasamycin D
  • fasamycin E
Species Streptomyces sp. KY5 [taxonomy]
References
Chemical products information
formicamycin A Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin B Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin C Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin D Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin E Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin F Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin G Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin H Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin I Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin J Evidence: NMR [1], Mass spectrometry [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin K Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin L Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
formicamycin M Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
fasamycin C Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
fasamycin D Evidence: NMR [1]
Copy SMILES
fasamycin E Evidence: NMR [1]
Copy SMILES
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • orf4
  • AQP25545.1
 11 - 931 (+) NAD-dependent epimerase/dehydratase
    copy AA seq
    copy Nt seq
    • orf3
    • AQP25546.1
    		 1334 - 2344 (+) marR family transcriptional regulator
      copy AA seq
      copy Nt seq
      • orf2
      • AQP25547.1
      		 3530 - 4129 (+) hypothetical protein
        copy AA seq
        copy Nt seq
        • orf1
        • AQP25548.1
        		 4048 - 4560 (-) transposase
          copy AA seq
          copy Nt seq
          • forQ
          • AQP25549.1
          		 5320 - 6588 (+) decarboxylase
            copy AA seq
            copy Nt seq
            • forP
            • AQP25550.1
            		 6601 - 7254 (+) metallo-beta-lactamase
              copy AA seq
              copy Nt seq
              • forO
              • AQP25551.1
              		 7285 - 8064 (+) exodeoxyribonuclease III
                copy AA seq
                copy Nt seq
                • forN
                • AQP25552.1
                		 8121 - 9893 (-) acylhydrolase
                  copy AA seq
                  copy Nt seq
                  • forM
                  • AQP25553.1
                  		 10140 - 10925 (+) methyltransferase
                    copy AA seq
                    copy Nt seq
                    • forL
                    • AQP25554.1
                    		 10960 - 11301 (+) PKS cyclase
                      copy AA seq
                      copy Nt seq
                      • forK
                      • AQP25555.1
                      		 11309 - 12745 (+) Na+/H+ exchanger
                        copy AA seq
                        copy Nt seq
                        • forJ
                        • AQP25556.1
                        		 12823 - 13272 (+) MarR-family regulator
                          copy AA seq
                          copy Nt seq
                          • forI
                          • AQP25557.1
                          		 13294 - 14661 (-) ACC biotin carboxylase
                            copy AA seq
                            copy Nt seq
                            • forH
                            • AQP25558.1
                            		 14643 - 16466 (-) ACC carboxyl transferase
                              copy AA seq
                              copy Nt seq
                              • forG
                              • AQP25559.1
                              		 16976 - 18067 (+) sensor histidine kinase
                                copy AA seq
                                copy Nt seq
                                • forF
                                • AQP25560.1
                                		 18075 - 18734 (+) luxR family response regulator
                                  copy AA seq
                                  copy Nt seq
                                  • forE
                                  • AQP25561.1
                                  		 18738 - 19253 (-) ACC biotin carboxy carrier protein
                                    copy AA seq
                                    copy Nt seq
                                    • forD
                                    • AQP25562.1
                                    		 19250 - 19711 (-) PKS cyclase/dehydratase
                                      copy AA seq
                                      copy Nt seq
                                      • forC
                                      • AQP25563.1
                                      		 19714 - 20004 (-) PKS ACP protein
                                        copy AA seq
                                        copy Nt seq
                                        • forB
                                        • AQP25564.1
                                        		 20001 - 21248 (-) KSB protein
                                          copy AA seq
                                          copy Nt seq
                                          • forA
                                          • AQP25565.1
                                          		 21245 - 22507 (-) KSA protein
                                            copy AA seq
                                            copy Nt seq
                                            • forR
                                            • AQP25566.1
                                            		 22504 - 22899 (-) cupin (cyclase/monooxygenase)
                                              copy AA seq
                                              copy Nt seq
                                              • forS
                                              • AQP25567.1
                                              		 22927 - 23247 (-) monooxygenase/cyclase
                                                copy AA seq
                                                copy Nt seq
                                                • forT
                                                • AQP25568.1
                                                		 23244 - 24272 (-) O-methyltransferase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • forU
                                                  • AQP25569.1
                                                  		 24393 - 24752 (+) monooxygenase/cyclase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • forV
                                                    • AQP25570.1
                                                    		 24745 - 26037 (+) halogenase
                                                      copy AA seq
                                                      copy Nt seq
                                                      • forW
                                                      • AQP25571.1
                                                      		 26034 - 27059 (+) O-methyltransferase
                                                        copy AA seq
                                                        copy Nt seq
                                                        • forX
                                                        • AQP25572.1
                                                        		 27069 - 28784 (+) monooxygenase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • forY
                                                          • AQP25573.1
                                                          		 28963 - 29910 (+) oxidoreductase
                                                            copy AA seq
                                                            copy Nt seq
                                                            • forZ
                                                            • AQP25574.1
                                                            		 29867 - 30385 (-) marR family transcriptional regulator
                                                              copy AA seq
                                                              copy Nt seq
                                                              • forAA
                                                              • AQP25575.1
                                                              		 30474 - 32015 (+) MFS family transporter
                                                                copy AA seq
                                                                copy Nt seq
                                                                • forBB
                                                                • AQP25576.1
                                                                		 32025 - 32687 (-) LuxR family response regulator
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • forCC
                                                                  • AQP25577.1
                                                                  		 32684 - 33937 (-) sensor histidine kinase
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • orf6
                                                                    • AQP25578.1
                                                                    		 34060 - 35025 (+) ABC transporter
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • orf7
                                                                      • AQP25579.1
                                                                      		 35022 - 35876 (+) ABC transporter permease
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • orf8
                                                                        • AQP25580.1
                                                                        		 36034 - 37623 (+) glutamate synthase
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • orf9
                                                                          • AQP25581.1
                                                                          		 37613 - 38113 (-) hypothetical protein
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • orf10
                                                                            • AQP25582.1
                                                                            		 38113 - 38724 (-) hypothetical protein
                                                                              copy AA seq
                                                                              copy Nt seq
                                                                              • orf11
                                                                              • AQP25583.1
                                                                              		 39031 - 39525 (+) hypothetical protein
                                                                                copy AA seq
                                                                                copy Nt seq
                                                                                • orf12
                                                                                • AQP25584.1
                                                                                		 39640 - 40383 (+) glutamate ABC transporter
                                                                                  copy AA seq
                                                                                  copy Nt seq
                                                                                  • orf13
                                                                                  • AQP25585.1
                                                                                  		 40394 - 41326 (+) ABC transporter substrate binding protein
                                                                                    copy AA seq
                                                                                    copy Nt seq
                                                                                    • orf14
                                                                                    • AQP25586.1
                                                                                    		 41336 - 41980 (+) ABC transporter permease
                                                                                      copy AA seq
                                                                                      copy Nt seq
                                                                                      • orf15
                                                                                      • AQP25587.1
                                                                                      		 41977 - 42846 (+) ABC transporter permease
                                                                                        copy AA seq
                                                                                        copy Nt seq
                                                                                        Biosynthesis information
                                                                                        Annotation changelog

                                                                                        Entry version: next

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2024-05-14
                                                                                        MIBiG v4 annotathon
                                                                                        • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                                                        • (ID: MGLE5JJ3S32DQA3YR5WPYH4W)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 4

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-10-07
                                                                                        Update chemical activity to schema version 2.11
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 3

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-09-15
                                                                                        Updated bioactivity data
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 2

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2019-10-16
                                                                                        Migrated from v1.4
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 1

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2018-08-06
                                                                                        Submitted
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        Detailed domain annotation
                                                                                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                                        A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                                        Selected features only
                                                                                        Show module domains
                                                                                        Similar known gene clusters from MIBiG 4.0
                                                                                        Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                                        Click on reference genes to show details of similarities to genes within the current region.
                                                                                        Click on an accession to open that entry in the MiBIG database.