LOCUS       BGC0001595             28227 bp    DNA     linear   BCT 06-FEB-2017
DEFINITION  Fischerella sp. SAG 46.79 fischerindole biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0001595
VERSION     BGC0001595
KEYWORDS    .
SOURCE      Fischerella sp. SAG 46.79
  ORGANISM  Fischerella sp. SAG 46.79
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Hapalosiphonaceae; Fischerella.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:53:05
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 28227
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..28227
                     /country="Iceland"
                     /db_xref="taxon:1930929"
                     /isolation_source="freshwater"
                     /mol_type="genomic DNA"
                     /organism="Fischerella sp. SAG 46.79"
                     /strain="SAG 46.79"
     misc_feature    1..28227
                     /note="fischerindole biosynthetic gene cluster; fis"
     protocluster    1..28227
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[12686:13613]"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or bcpB or frbD or
                     mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      12687..13613
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LmbU or Neocarzinostat or bcpB or frbD or
                     mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /neighbourhood="20000"
                     /product="other"
                     /protocluster_number="1"
     cand_cluster    1..28227
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(LmbU or Neocarzinostat or bcpB or frbD
                     or mitE or vlmB or prnB or CaiA or bacilysin or
                     orf2_PTase)"
                     /kind="single"
                     /product="other"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..28227
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001595"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..28227
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="other"
                     /region_number="1"
                     /rules="(LmbU or Neocarzinostat or bcpB or frbD or mitE or
                     vlmB or prnB or CaiA or bacilysin or orf2_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(68..940)
                     /gene="fisB1"
     CDS             complement(68..940)
                     /codon_start=1
                     /gene="fisB1"
                     /note="2OG-Fe(II) oxygenase"
                     /product="FisB1"
                     /protein_id="APZ79607.1"
                     /transl_table=11
                     /translation="MSNNTVSTKPALHFLDINATEVKNYPTAIQDIIFNRRFDGMIIRG
                     VFPLDTIEQVARCLEEGNDGGMKSILNKNEEFGTKVAQIYGHAIVGQSPDLKDYFASSK
                     IFRQACRTMFQGSPDFEEQVESIFHSLSGLPVEIPTGPEGQSYTPATIRLLLEGREIAV
                     HVGNDFLLMPAANHLKTLLDLSDQLSYFIPLTIPEAGGELVVYSLEWNPEQASKYAQMQ
                     EYMDDVESKIKSNQSQSVAYAPGPGDMLLFNGGRYYHRVSEVIGNSPRRTIGGFLAFSK
                     ERDKIYYWS"
     gene            complement(1152..2222)
                     /gene="fisB2"
     CDS             complement(1152..2222)
                     /codon_start=1
                     /gene="fisB2"
                     /note="rieske oxygenase"
                     /product="FisB2"
                     /protein_id="APZ79608.1"
                     /transl_table=11
                     /translation="MVSYLENSVNPVIKSETQTGQTMNLAASWYVAMLSKELRKKPQAI
                     ELFGRSLVAWRDKAGKAVIMERFCSHLGASLAIGEVVDGCIQCPFHHWRYDSSGVCVHI
                     PKVAKPHTDQIPQTARQKIYVTEERYGYIWIWYGTATPLFDLPNFDTAESNRYMSYRFS
                     FPVKTSVRRVIENAFDHHHFVTLHNLSVTESVELILINDQDVELSELPITKEAWIGCVF
                     KAPIKSFLGVGAIAKFIGLNIETMLLRIDAWPSGFIGTFMSNKNQHKFKLFVNVTPVSE
                     NRTIWHVLITIKKTGNLWLDLISYIVFGWQNKAAALEDKLIYANISADTTGAFLKSDQP
                     VLKFRHFYQSWVAKVQ"
     gene            complement(2293..2979)
                     /gene="fisC"
     CDS             complement(2293..2979)
                     /codon_start=1
                     /gene="fisC"
                     /note="Stig cyclase"
                     /product="FisC"
                     /protein_id="APZ79609.1"
                     /transl_table=11
                     /translation="MKRNFIIAAIVLLVYICFGISISANAASAVSIPIKNAGFEEPSLT
                     VEDYYTIDTPPGWITYDPNGLVPAKRTRITSNNGVGYTGPNSAYYNHKAPEGRNVAYVY
                     LAQEIGSGIAGLEQTLDAVLKPNTKYTLTVDIGNSGGSFQGFPLDGFPGYRVELLAGDT
                     VLAADQNNLYIKEKDFKTTTVTFIATPESPYLGQHLGIRLINPLQGKFSGVDFDNVRLT
                     AEPAET"
     gene            complement(3051..4253)
                     /gene="fisE1"
     CDS             complement(3051..4253)
                     /codon_start=1
                     /gene="fisE1"
                     /note="4-hydroxy-3-methylbut-2-enyl diphosphate reductase"
                     /product="FisE1"
                     /protein_id="APZ79610.1"
                     /transl_table=11
                     /translation="MDTKALKRSLHNSNRYYRNGFGHKVEATERLHFEYQSDLIQQIRE
                     NGYKLQRGDVTIRLAEAFGFCWGVERVIALTYETRKQFPSERIWITNEIIHNPTVNQNL
                     GEMQIEFIPINEQGQKDFAVVTEQDVVILPAFGATIQEIQLLNTIGCTIVDTTCPWVSK
                     VWNSVEKHKKQSYTSIIHGKYKHEETIATSSYADKYLVILNLQQAEYVCDYILNCGDRE
                     EFLSKFAGSYSFGFDPDTDLERIGIANQTTMLKRETEQIGKLFERTLMRKYGPNQINNH
                     FLSFNTICDATQERQDAMFKLVQEKIDLMVVVGGFNSSNTTHLQEIALERGIPSYHIDS
                     VERLGPGNRIQHKKLHSSLEVVEDWLPPGQIVVGITSGASTPDNIVSNVIEKIFEIKAA
                     R"
     gene            complement(4318..5379)
                     /gene="fisE2"
     CDS             complement(4318..5379)
                     /codon_start=1
                     /gene="fisE2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 223.4; E-value:
                     5.5e-68)"
                     /gene_kind="biosynthetic-additional"
                     /note="polyprenyl synthetase"
                     /product="FisE2"
                     /protein_id="APZ79611.1"
                     /transl_table=11
                     /translation="MKNHIFYEELSQMSIKNSEKTNLNYEQYRDQKSSQETRIVDTYLR
                     SSTLKDTNTYLTEAAFNLSDYIAQRREQVEAVLESSITSGYPEKLYESMRYSLMAGGKR
                     LRPILCLASCELSGGVVEMAMPTACALEMLHTMSLMHDDLPALDNDDYRRGKLTNHKVY
                     GENIAILAGDALLPYAFEYIVVQTKGVPADRLLKVIAKLSHAVGARGLAGGQVADLESE
                     KLQNLDLATLNFIHSHKTGALLEACVVSGALLVGANDEILRRLSHYARNIGLAFQIIDD
                     VLDVTATKEELGKTPGKDEKAQKATYPSLLGINESRYQAEKLIEEAKKELAPFEEKAIP
                     LISLADYIITRSY"
     gap             5448..5547
                     /estimated_length=unknown
     gene            5609..6373
                     /gene="fisM"
     CDS             5609..6373
                     /NRPS_PKS="Domain: oMT (39-145). E-value: 9e-12. Score:
                     35.6. Matches aSDomain: nrpspksdomains_fisM_oMT.1"
                     /codon_start=1
                     /gene="fisM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 67.3; E-value:
                     2.4e-20)"
                     /gene_kind="biosynthetic-additional"
                     /note="methyltransferase"
                     /product="FisM"
                     /protein_id="APZ79612.1"
                     /transl_table=11
                     /translation="MSVFPILTPHTPLFSAFYDYFLTIISLESSWKEFQKNFLESIPLH
                     SRLLGVGCGSSQCAINIVQNRPDLHITGLDSSPEKVKQAQIMIHKLGLEKQVKFIERMT
                     LELPTDEENFDYVYTIDSVKYWKDKEKNITEFLHVLKPGGKIFVIEVDQSYYYQDAFNW
                     INQNHVLLQIKPILEIYYQAYIENRSITLDDAQELWSTLPLINKNAPHRILGTPVLVMS
                     GTKQHYNYQVSEVELRVDNDVAHNFWCGKLLD"
     aSDomain        5726..6043
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_fisM_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="9.00E-12"
                     /label="fisM_oMT.1"
                     /locus_tag="fisM"
                     /protein_end="145"
                     /protein_start="39"
                     /score="35.6"
                     /tool="antismash"
                     /translation="ESIPLHSRLLGVGCGSSQCAINIVQNRPDLHITGLDSSPEKVKQA
                     QIMIHKLGLEKQVKFIERMTLELPTDEENFDYVYTIDSVKYWKDKEKNITEFLHVLKPG
                     GK"
     gene            6741..7319
                     /gene="fisG1"
     CDS             6741..7319
                     /codon_start=1
                     /gene="fisG1"
                     /note="dephospho-CoA kinase-like protein"
                     /product="FisG1"
                     /protein_id="APZ79613.1"
                     /transl_table=11
                     /translation="MIKIIAIVGMPGSGKSIVASYFKNHSLPIIWLGEIIISEVEKRGL
                     MLTPQNEQVVREEIRAKYGMDVCMQMALPLIQQKLLYHPLVIIDGLYSFSEYKTLKNFF
                     GNELLVVAIFTPKSLRYERLFLRKIRPLTAEEAELRDFMEIEKIEKGGPIAMADLTIVN
                     DGTQDQLDQKIEIILTKILHNSSLNPCSN"
     gene            7384..8604
                     /gene="fisE3"
     CDS             7384..8604
                     /codon_start=1
                     /gene="fisE3"
                     /note="1-deoxy-D-xylulose 5-phosphate reductoisomerase"
                     /product="FisE3"
                     /protein_id="APZ79614.1"
                     /transl_table=11
                     /translation="MKLISILGSTGSIGTQTLDIVTQYPNQFQVVGLAALKNVELLAQQ
                     IRKFQPAIAAIGDSQKLPELQAAIADVKPQPILLAGESGIIEVARFSTAKIVVTGIVGC
                     AGLLPTIAAIKAGKDIALANKETLIAGGPVVLPLVREYGVKLLPADSEHSAIFQCLQGV
                     PDQGLRRILLTASGGAFRDLPVEKLSNITVDDALKHPNWSMGRKITIDSATLMNKGLEV
                     IEAHWLFGIDYDHIDIVIHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIY
                     TDWQQLDLVKLKELTFCAPDHQKYPCMQLAYAAGRSGGCMPAVLNAANEQAVALFLEEK
                     IQFLDIPRLIEQVCDRYVIHNCSSPTLEDIIAADQWARQELMNASQVLEHSTITKVSSK
                     QKTLTLT"
     gene            9194..10153
                     /gene="fisH1"
     CDS             9194..10153
                     /codon_start=1
                     /gene="fisH1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DIT1_PvcA"
                     /gene_kind="biosynthetic-additional"
                     /note="Isonitrile synthase"
                     /product="FisH1"
                     /protein_id="APZ79615.1"
                     /sec_met_domain="DIT1_PvcA (E-value: 7.1e-78, bitscore:
                     252.4, seeds: 112, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAEQILRYIFQYRRLLSDTEACAKEPCSMCLAPHIPKIQSFIEH
                     NEPIHFILPAFPAKSPNPQKVLGPMPDMGERVALQFLQNLCNQISKVYPPGAKITICSD
                     GRVFTDLVAITDENVSLYRQGIERLLNEINADRIDTFCLENVFSRMSFDEMRKTLIKQY
                     SQPIESIQERVNSEDKHRQFFNGIYHLLFDDYLVLYPDKPRNQVEVECNVRAYEVIQRS
                     NAWTKLVGQHFPQSLRLSIHPQHYHSDKIGIHMIKTSDQWGTPWHNAPVFNGKEFLLMK
                     RRHIEDIGASLVWHDGYPSHYILSKQVSQALVTIDSKK"
     gene            10502..11548
                     /gene="fisH2"
     CDS             10502..11548
                     /codon_start=1
                     /gene="fisH2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DIT1_PvcA"
                     /gene_kind="biosynthetic-additional"
                     /note="Isonitrile synthase"
                     /product="FisH2"
                     /protein_id="APZ79616.1"
                     /sec_met_domain="DIT1_PvcA (E-value: 1.8e-84, bitscore:
                     274.0, seeds: 112, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRFLLNLSISTKHRFKMTQIINITQSKVISEQILKHVFRHRRLI
                     SNTEPCVHQPCSLCLAPHLEKVQYFVEHNEPIHFILPAFPAKSPNTQKVLGTMPDMGEL
                     VSLKFLQSLCNQISEIYAPGAKLTICSDGRVFSDLVAVTDENVTLYGQRIQALLKEMEA
                     DAINVFNLEDMYTDLSFDEMRQKLVKLYGQNIEAIKEAVKNDDHHCQMFNGIHRFLVED
                     YQVLEAHKSRNKIRLECKTRAYEVIQRSNAWSVLISELYPHSVRLSIHPQHYHSEKIGI
                     HMIKTLDQWGTPWHNATVFDGKEFMLMKRSHLESMGATLVCQNGHPSHFAWTEQPLETR
                     ITVQEAIQ"
     gene            11545..12366
                     /gene="fisH3"
     CDS             11545..12366
                     /NRPS_PKS="Domain: TauD (14-270). E-value: 8.7e-46. Score:
                     148.7. Matches aSDomain: nrpspksdomains_fisH3_TauD.1"
                     /codon_start=1
                     /gene="fisH3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121:dioxygenase, TauD/TfdA (Score: 75.8; E-value:
                     5.2e-23)"
                     /gene_kind="biosynthetic-additional"
                     /note="Isonitrile synthase"
                     /product="FisH3"
                     /protein_id="APZ79617.1"
                     /sec_met_domain="TauD (E-value: 3.6e-46, bitscore: 148.7,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMVSTSLGQSTQFSVKPLTPFGALLEATEYHSDIKQLSIEQLCEL
                     TWEHRLIVLRGFSLLEREELSTYCQRWGELLIWNFGTVLDLIVHESPENYLFTNGNVPF
                     HWDGAFAEAVPRFLFFQCLKAPEAGSGGESLFCDTVRILQNLSPQQREIWEKTEVSYKT
                     EKVAHYGGEIIKSLVSKHPITGLSTLRFAEPLNDASVHLNPLYVEVCNLPAEEQNQFLS
                     ELIENLYLPQNCFGHEWQEGDFLVADNHALLHGRNPFLSNSQRHLQRVHIL"
     aSDomain        11587..12354
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_fisH3_TauD.1"
                     /evalue="8.70E-46"
                     /label="fisH3_TauD.1"
                     /locus_tag="fisH3"
                     /protein_end="270"
                     /protein_start="14"
                     /score="148.7"
                     /tool="antismash"
                     /translation="VKPLTPFGALLEATEYHSDIKQLSIEQLCELTWEHRLIVLRGFSL
                     LEREELSTYCQRWGELLIWNFGTVLDLIVHESPENYLFTNGNVPFHWDGAFAEAVPRFL
                     FFQCLKAPEAGSGGESLFCDTVRILQNLSPQQREIWEKTEVSYKTEKVAHYGGEIIKSL
                     VSKHPITGLSTLRFAEPLNDASVHLNPLYVEVCNLPAEEQNQFLSELIENLYLPQNCFG
                     HEWQEGDFLVADNHALLHGRNPFLSNSQRHLQRV"
     gene            12687..13613
                     /gene="fisD"
     CDS             12687..13613
                     /codon_start=1
                     /gene="fisD"
                     /gene_functions="biosynthetic (rule-based-clusters) other:
                     orf2_PTase"
                     /gene_kind="biosynthetic"
                     /note="Aromatic prenyltransferase"
                     /product="FisD"
                     /protein_id="APZ79618.1"
                     /sec_met_domain="orf2_PTase (E-value: 1e-55, bitscore:
                     179.6, seeds: 90, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDVNRIHTDIVNVAKTFGAEYSEKVLDEVFQVFGEQFADNSFMI
                     RTSNKQPDKLGCYFRYHEEDESHLGLAWDIARKSGLLSDQGRPVDRLIPEICETFPIMA
                     DGVDFDVKHGLAKIWQSIKGVVPVQDAFNLSLPASVIAHADFLKNHHLDALYAFGVDYH
                     HSSVNLYFDTYHPKHHTSEYYKNLLQDLQFQPPSDELLELLANNGEIALTFNFASPRIE
                     RLCFYLPFLNREAVPQNLLTPLLKKYINEAPALVKNPGFILGWSFGPQGGKGTYTKVDV
                     DYHGRTVPLFIKVHSQPLPKAADFALA"
     gene            13849..15795
                     /gene="fisE4"
     CDS             13849..15795
                     /codon_start=1
                     /gene="fisE4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110:1-deoxy-D-xylulose-5-phosphate synthase (Score:
                     310.2; E-value: 1.8e-94)"
                     /gene_kind="biosynthetic-additional"
                     /note="1-deoxy-D-xylulose-5-phosphate synthase"
                     /product="FisE4"
                     /protein_id="APZ79619.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 2.2e-110,
                     bitscore: 358.7, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-07, bitscore:
                     22.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLSQITHPNQLHGLSISQLEEIARQIREKHLQTVSTSGGHLGPG
                     LGVVELTLGLYQTLDLNRDKVIWDVGHQAYPHKLITGRCDRFHTLRQKNGVAGYLKRCE
                     SQFDHFGAGHASTSISAALGMALARDLKGENFKVVAVIGDGALTGGMALEAINHAGYLP
                     KTKLLVVLNDNEMSISPNVGALSSHLNQLRFSSPVQLLKQLEEQFEYLSPVSNFLAPEL
                     NRIKQGIKRLAVPKVGAVFEELGFTYMGPIDGHNLPELIAAFDQAHQQTGPVLVHVATI
                     KGKGYEFAEQERVGYHAQSKFNLATGKAIISSKPKPPSYSKVFGETLTKIAKSNSKVIG
                     ITAAMSTGTKLDILQKNLPEQYIDVGIAEQHGVTLAAGLACEGMRPVVAIYSTFLQRAY
                     DQIIHDVCIQNLPVFFSMDRSGVVGADGPTHQGMYDIAYLRCIPNMVLMAPKDEAELQQ
                     MLVTGVNYTDGPIAMRYPRGEGHGVPLMSEGWETLPIGKGEILRHGEDVLMVAYGSMVY
                     PALQAAAILNEHGIQATVINARFAKPLDTELIVPLAKQIGQVFTLEEGCLIGGFGSAVA
                     EALLEHRVIVPVIRLGVTDKLVEHATPEESLSELGLTAPKIADRILQEFQQQSNLDINV
                     LQNGSFEQKTRSW"
     gene            15855..17081
                     /gene="fisE5"
     CDS             15855..17081
                     /codon_start=1
                     /gene="fisE5"
                     /note="4-hydroxy-3-methylbut-2-en-1-yl diphosphate
                     synthase"
                     /product="FisE5"
                     /protein_id="APZ79620.1"
                     /transl_table=11
                     /translation="MQTLSTPIISNSPSQQTFTNTIIPRRKTRPVRVANVTVGGGFPVV
                     VQSMINEDTLDVKASVDAIRRLHEIGCEIVRVTVPSLAHAKAVAEIKQKLKETYQDVPL
                     VADVHHNGMKIALEVAKHVDKVRINPGLYVFEKPNTNRTEYSQAEFDEIGDKIRETLEP
                     LVLCLREQGKAMRIGVNHGSLAERMLFTYGDTPEGMVQSALEFIRICESLDFRNLVISL
                     KASRVPVMVAAYRLMALRMDELGMDYPLHLGVTEAGDGEYGRIKSTAGIATLLADGIGD
                     TIRVSLTEAPEKEIPVCYSILQALGLRKTMVEYVACPSCGRTLFNLEEVLHQVREATKH
                     LTGLDIAVMGCIVNGPGEMADADYGYVGKQPGYISLYRGREEIKKVPESQGVEELINLI
                     KADGRWVDP"
     gene            17292..18368
                     /gene="fisB3"
     CDS             17292..18368
                     /codon_start=1
                     /gene="fisB3"
                     /note="rieske oxygenase"
                     /product="FisB3"
                     /protein_id="APZ79621.1"
                     /transl_table=11
                     /translation="MVNVEKSVEAKITKLETQSENKVMDLAASWYIAMQSKELGKKPQA
                     IQLFGRPLVAWRDKLGKPVIMERFCSHMGASLAIGQIIDGCIQCPFHHWRYDSSGVCVD
                     IPKVATPTTDVIPSTARQHTYVTQEKYGYIWVWYGSVNPLFPLPKFDPAESDKHNYMSY
                     RFFSKTKTTVLRVLENSFDHHHVVVTHNLPIINQIKQTLLNKEDIKISELSIAKEAWFG
                     TVMEAQIKSYAGVGAIAKFLGLNVETWKTRLDAWPSGSLGTTSFNGQQKIRVLSGITPI
                     SENQTTWHLLFMIKKTGNLWLDLLSYIVFGWQNEVAVSADVVIWDTMSAKTGQAFIKPD
                     QPVLKFRQFYQSWVDKAQ"
     gene            18419..19879
                     /gene="fisB4"
     CDS             18419..19879
                     /codon_start=1
                     /gene="fisB4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 386.9; E-value:
                     2.2e-117)"
                     /gene_kind="biosynthetic-additional"
                     /note="monooxygenase"
                     /product="FisB4"
                     /protein_id="APZ79622.1"
                     /sec_met_domain="p450 (E-value: 1.8e-85, bitscore: 277.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKSYYYSTYCEDSFVVLNQMQQPNPLKAPSFIQSLQFILNPVGF
                     LEKVHQQYPDIFTAKIFGFTGIPVVVVQHPQAIQEILTNDRKKFVVPGHVNKILQPLLG
                     KHSLLMVSGEQHKRQRQLVMPSFHKERMQSYGQLIVNLTEKVMSQLSLNQVFSACSVMQ
                     EISLQVILQAVFGLYEGQRYEKLKHLLPLMLGLFRSPLYNSFLFFPFLQKDFGAWSPWG
                     RFVRIRQQIDELLYAEIAERRVQPNSDRIDILSLLMEATDEEGQPMTDKELRDELMTML
                     VGGFDSTAIAMAWELYWTHHLPEVGEKLRQELDTLGNSKNPMDIFRLPYLSAVCNETLR
                     IYPVGVMANVRFVQEPVELLGYHLEPGTAVIPCIYLTHHRKDLYQKPKQFLPERFLQHQ
                     YSPYEFLPFGGGVRRCIGDALAMFEMKLVLATILSHYKLALADHQPVTLQRQIMFVGPG
                     NGIKMVMTGRRTPFKIPQSTSKTTQSFY"
     gene            19887..20792
                     /gene="fisI1"
     CDS             19887..20792
                     /codon_start=1
                     /gene="fisI1"
                     /note="3-deoxy-D-arabinoheptulosonate-7-phosphate synthase"
                     /product="FisI1"
                     /protein_id="APZ79623.1"
                     /transl_table=11
                     /translation="MRVNKAFKLASREFHNGEPSEIFVSTPNEIVAFGQNHPIVQIAGP
                     CSVENEEMIIYTALQVKAVGAKFLRGGAYKPRTSPYAFQGHGESALGLLAIARQVTGLG
                     IVTEVMDTADLEKVASVADIIQIGARNMQNFSLLKQVGAINKPVLLKRGMSATIEEWLM
                     AAEYILTAGNPNVILCERGIRTFDQQYTRNTLDLSAIPVLRSLTHLPIVIDPSHGTGRA
                     EYVPAMAMAAIAAGADSLMIEVHPDPAKALSDGPQSLTPEQYGKLIQDMIGISKVFGRW
                     YQKYPISTGHLALPIHATNT"
     gene            20875..23079
                     /gene="fisI2"
     CDS             20875..23079
                     /codon_start=1
                     /gene="fisI2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 257.4; E-value:
                     5.7e-78)"
                     /gene_kind="biosynthetic-additional"
                     /note="anthranilate synthase subunit I"
                     /product="FisI2"
                     /protein_id="APZ79624.1"
                     /transl_table=11
                     /translation="MFLNNHDYITKGGVKVSRFVTETFIDTAIEHILLCIDSQRGGLFK
                     SSYEYPGRYKRWAIGFVNPPLELVTRENFFKLTAHNQRGKVILSYLAEFLDKHPQLQEI
                     DQDDQYITGYIKPKGSFFSEEERSKQPSVFSIIREILDVFESPEDEHLGLYGAFGYDLV
                     FQFESMEKLLPRSTDQQDLLLYLPDELFIIDYYLQRAFCLQYDFETKHGSTKGLFRSGE
                     IIDYRGKCLTPAQSSDHEPDEYAQQVCKALLYFRRGDLFEVVPSQSFYRQCQQSPAELF
                     RTLQQINPSPYGFILNLGGEYLIGASPEMFVRTEGKRVETCPISGTIRRGENAIDDAAQ
                     IQKLLNSGKDEAELTMCTDVDRNDKSRICEPGSVQVIGRRQIEIYSHLIHTVDHVEGLL
                     RPEFDALDAFLTHLWAVTVTGAPKKSAMQFLEQHERSSRRWYGGAVGYLTFKGDLNTGL
                     ILRTIQLKDSIAEVRVGATVLYDSDPQAEAQETLTKAAALFQTLYQTQQKTDNVVNNID
                     INQNFLKSKAEHSKQILLIDYEDSFVHTLANYIRQTGAVVKTLRHGFSESVFDMEKPDL
                     VVLSPGPGRPSDFHVVETIVACIKRQIPIFGVCLGLQSIVEAFGGKLGVLNYPQHGKVS
                     RISVMDSESVTFKNLPKSFEVGRYHSLFALLETLPTELKVTAISDDGVIMGIEHQTLPI
                     IGVQFHPESIMTLAGGVGLGIIKNIVGACTTKIPSSVVVA"
     gene            23251..24102
                     /gene="fisI3"
     CDS             23251..24102
                     /codon_start=1
                     /gene="fisI3"
                     /note="indole-3-glycerol-phosphate synthase"
                     /product="FisI3"
                     /protein_id="APZ79625.1"
                     /transl_table=11
                     /translation="MDAQKSISTIEINSVKPRHILEEIVWHKRKEVASMGEQLSFADLQ
                     TQISTAPPLRDFLDALRQNPNKPILIAEVKKASPSKGVIRADFDPVKIAQAYEQSGATC
                     LSVLTDQKFFQGSFENLRLIRKSVGLPLLCKEFIIDPYQIYFARVNGADAVLLIAAILS
                     NEILTDFLQIVQHLGMTALVEVHTLAELDRVLALSNVQLIGINNRNLQDFSVELETTQR
                     LLKERREQLSSARITVVSESGLYTSVDLAFVAEAGAEAVLIGESLVKQTDLERAVKKLM
                     DR"
     gene            24150..24974
                     /gene="fisI4"
     CDS             24150..24974
                     /codon_start=1
                     /gene="fisI4"
                     /note="tryptophan synthase subunit alpha"
                     /product="FisI4"
                     /protein_id="APZ79626.1"
                     /transl_table=11
                     /translation="MTSISHHFASLRASNQCALIPFVVAGDPNLEITAEALRVLDSSGA
                     DLIELGVPYSDPLADGPVIQAAATRALKRGTRLDNVLQMVQTVTPHLRSPIILFTYYNP
                     ILNLGTISFLEKAAASGIKGLVVPDLPLDEASNLLEVADTVGIEVTLLVTPTSSKERIE
                     AIARQSRGFIYLVSVTGVTGVRSHLQTRVKDVLQDIRSVTNKPIGVGFGISKSEQARQV
                     RDWGADAVIVGSAFVERLVESTPYQGLGAIKDFCRDLKTSIEGRTEEAESRR"
     gene            25031..26278
                     /gene="fisI5"
     CDS             25031..26278
                     /codon_start=1
                     /gene="fisI5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /note="tryptophan synthase subunit beta"
                     /product="FisI5"
                     /protein_id="APZ79627.1"
                     /sec_met_domain="PALP (E-value: 8.3e-50, bitscore: 160.4,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLNTQHNQAATQLLTQQPDPNGRFGQFGGKYVPETLMSALTELE
                     TAFQQYRADPLFQQELQALLRDYVGRSTPLYFAQRLTEHYAKPDGTGPQIYLKREDLNH
                     TGAHKINNALAQVLLAKRMGKQRIVAETGAGQHGVATATVCARFGLECVIYMGIHDMER
                     QALNVFRMRLMGAEVRSVEAGTGTLKDATSEAIRDWVTNVQTTHYILGSVAGPHPYPMM
                     VRDFHAIIGKETRAQAQEKWGGLPDILLACVGGGSNAIGLFHEFVNEPSVRLIGVEAAG
                     EGINTDKHAATLTKGRVGVLHGAMSYVLQDEDGQIVEAHSISAGLDYPGVGPEHSYLKE
                     IGRAEYYSVTDQQALQAFQRLSQLEGIIPALETAHAIAYLETLCPQLTGSPRIVINCSG
                     RGDKDVQTAIQFLNPA"
     gene            26318..27415
                     /gene="fisI6"
     CDS             26318..27415
                     /codon_start=1
                     /gene="fisI6"
                     /note="anthranilate phosphoribosyltransferase"
                     /product="FisI6"
                     /protein_id="APZ79628.1"
                     /transl_table=11
                     /translation="MVTTSVIETNSISHNSPNWSHLLQQLLDHQSLTTDQASELMYGWL
                     IDAIPPVLSGAILAAIQMKGVSAQELLGMVKVLYSQSLRPTLRDIVVGDSPLIDTCGTG
                     GDGASTFNISTAVAFVTAAAKVKVAKHGNRSASGKTGSADVLEALGVNLKASSKKVQEA
                     VDAVGITFLFAQDWHPTLKVCYPLRKTLKVRTVFNLLGPLINPLRPTGQVIGVNDPGLI
                     ETFALVLHQIGIRKAIVLHGREKLDEAGLADITDLAIVSKQHLRLLELAPEKLGINPAP
                     TTELRGGDAQENARILKAVLQGKGTQAQQDIVALNTALALFVGEAIPETGDDMSTFAKG
                     LTLAKDVIASGVAWTKLEQLVEFLR"
     gene            27440..28084
                     /gene="fisG2"
     CDS             27440..28084
                     /codon_start=1
                     /gene="fisG2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101:phosphoglycerate mutase (Score: 127; E-value:
                     1.1e-38)"
                     /gene_kind="biosynthetic-additional"
                     /note="phosphoglycerate mutase"
                     /product="FisG2"
                     /protein_id="APZ79629.1"
                     /transl_table=11
                     /translation="MAAENRLILVRHGASEWSNLGRYQGHQPVPLSPLGIEQVYALTEE
                     LRQYHPERIVSSDLQRARQTAEIIAKHLMLEIHYDARLRELDCGNWAGLTEKQIEVLDP
                     KAVVELRSGRDIPRGSGETMADLIVRTRAALADWVNDSFSGTLIFVAHAYVIREITQTL
                     LGGNLPNNQLPSLGSYTLLNYKTGGKWILEGYGIVPNSSSSLTTVNWLPTF"
ORIGIN
        1 gatataggat tcgtaagatt gtggttggga tttcaaaaga cgtttgattt agaaaatttg
       61 gtcaagttta actccagtaa taaatcttat cacgctcttt agagaaagct aaaaatccac
      121 cgatggttcg ccgtggagaa ttaccaatta cttcactaac ccgatggtag tatcgaccac
      181 cattgaacag tagcatgtct ccaggacctg gtgcataagc tacactctga gattggttag
      241 acttaatctt ggactctaca tcatccatat attcctgcat ttgagcatat ttgcttgctt
      301 gttctggatt ccattccaaa ctatagacta ctagctcacc accagcttca ggaatagtaa
      361 gggggatgaa gtaactaagc tgatcagata aatcaagcaa agttttcaga tggttagccg
      421 caggcattaa caggaaatca ttgcccacat ggactgcgat ttcgcgacct tcgagtaata
      481 gccggatagt agctggggta tagctttgtc cttctggtcc tgtaggaatt tctacaggca
      541 atccagaaag agagtgaaat attgactcta cttgttcctc aaagtcggga cttccttgaa
      601 acatagtacg acaagcctgc cggaaaattt ttgaagaagc aaagtagtct ttaagatcag
      661 gtgattgacc gacaatagca tgaccgtata tctgggctac tttggtgcca aactcttcat
      721 tcttattaag aattgatttc atcccaccgt catttccttc ttccaagcaa cgggcaactt
      781 gctcaatggt atccagggga aatactccgc gaatgatcat gccatcgaag cggcgattga
      841 aaattatatc ttgaatagca gtgggatagt tttttacttc tgttgcattg atatctaaaa
      901 aatgcaaagc aggctttgta gagacggtgt tattggacat agcttttcct ctgttatgat
      961 gagtcggtta ttgtgagtta tgttgccaat attcagaact tacacactgg ttgttgttta
     1021 ttaaattatg tagataagtt cctaatattt aattgctttt aaaagcctta tattacgtta
     1081 tatattaaag cttattacga ccaattatgt ttagttacat aagtactttt gtttaagagt
     1141 tatttatgcg cttactgtac cttagcaacc caactttgat aaaagtgtct aaattttaac
     1201 actggctggt cagacttgag aaatgcccca gttgtatctg cgcttatgtt agcgtagatt
     1261 aatttatctt ccaacgcagc agctttgttt tgccagccaa aaacaatgta tgaaattaga
     1321 tctagccaca agtttccagt tttcttaatt gtgatcaaaa catgccatat tgtccggttt
     1381 tcagaaacag gagtgacatt aacaaatagc ttaaacttgt gctgattttt gttactcata
     1441 aatgtaccta tgaatccact cggccaagca tctattcgga gcaacatagt ttcaatattt
     1501 aaccctataa acttggcgat cgcacctact ccaagaaaac tttttatcgg ggccttgaat
     1561 acacatccaa tccaagcttc ttttgtaatt ggtagttcgc taagttctac atcctgatca
     1621 ttaatcagaa tcagttcaac cgattcagtc accgacaaat tatgtagtgt aacgaaatga
     1681 tggtgatcaa atgcattttc aattacccgt cgcacactag ttttaactgg gaaggagaag
     1741 cgataagaca tatatctatt gctttctgcg gtatcaaaat taggtaaatc gaataaagga
     1801 gttgcagtac cataccaaat ccagatgtaa ccatatcttt cctcagttac ataaattttt
     1861 tgacgtgctg tttgtggaat ctgatctgtg tgaggttttg ccactttagg tatgtgtacg
     1921 catacaccag aactatcata gcgccagtga tgaaaaggac attgaatgca accatctact
     1981 acttctccta tagctagaga ggcacccaaa tgtgagcaga aacgctccat aataacagct
     2041 ttgccagctt tgtctcgcca tgcaactaag gagcgaccaa acaactcaat tgcttgaggc
     2101 ttttttctta gttcctttga cagcatggca acataccaac tagctgccaa attcattgtc
     2161 tgtccagttt gggtttccga ttttattact ggatttacgc tattttcaag ataactaacc
     2221 attcgtttgt tccttcttca atacaagaaa atccagattg atacactaca actgttactt
     2281 tgaaaaaaca gtttaagttt cagctggttc cgcagttaaa cggacattat caaaatcaac
     2341 acctgagaat tttccttgca aaggattgat aagtcgaatt cctaaatgtt gacccagata
     2401 aggagactca ggtgtagcaa tgaatgtcac tgttgtagtt ttgaagtctt tctctttgat
     2461 gtagaggtta ttctggtcag cagccaaaac tgtatcacct gccagcaatt ctacacgata
     2521 accaggaaaa ccatccaagg gaaaaccttg gaaactacct cctgaattgc cgatatcaac
     2581 tgtcaaggta tattttgtgt taggttttaa gactgcatca agcgtttgtt ccagaccagc
     2641 gataccgctt ccgatttctt gagcaagata aacataagct acattccgac cttccggagc
     2701 tttgtggtta tagtacgctg agtttggacc agtatacccc acaccattat ttgaagttat
     2761 tcttgttcgt tttgcaggta ctagaccatt gggatcgtat gttatccaac caggaggggt
     2821 atcaatagta taataatctt caactgtcaa gctcggttct tcaaatcctg catttttgat
     2881 aggaatagaa acagcacttg ccgcattggc agaaatacta attccaaagc aaatgtatac
     2941 taacaaaaca atggcagcaa tgatgaaatt tcgcttcata attttttact ctttttaata
     3001 aatgtcgtgt taagttaatt gttttttacg cagcagattt cagattttta ttatctagcc
     3061 gctttaattt caaaaatctt ctcaataaca ttggaaacga tattatctgg ggttgaagct
     3121 ccagaggtaa tccctactac aatttgacca ggtggtagcc agtcttcgac tacttctaag
     3181 ctagaatgca attttttatg ctgaattcga ttacctggcc ccaaacgctc tacactgtcg
     3241 atgtgatacg aaggaatacc acgctccaaa gcgatttcct gcaagtgagt tgtgttagag
     3301 gaattaaacc cacccaccac aaccatcaaa tctatctttt cttgcacaag tttgaacatt
     3361 gcatcctgac gctcttgagt tgcatcgcag atggtattga agctcaagaa atgattattg
     3421 atttggtttg ggccatactt acgcatgaga gtacgctcaa atagcttacc aatttgctca
     3481 gtttcccttt tgagcattgt tgtttgatta gcaataccta tgcgttctaa atcggtgtct
     3541 gggtcaaatc caaaagaata gctgccagca aatttactca agaattcttc acggtctcca
     3601 caattgagaa tataatcgca gacatactct gcctgttgta aattgaggat aactaaatat
     3661 ttgtctgcat aggaactagt tgcaattgtt tcttcgtgct tatatttacc gtggataata
     3721 gaagtgtaac tttgtttttt gtgcttttca acactattcc aaactttaga aacccacgga
     3781 caagttgtat ctactattgt acagcctatt gtatttaata gttgaatttc ctgaattgta
     3841 gctccaaaag caggtagaat tactacgtcc tgctcagtaa caaccgcaaa atccttctgt
     3901 ccctgctcat taattggaat aaattcaatt tgcatttctc cgagattttg attcactgta
     3961 gggttgtgaa taatctcgtt ggtaatccaa attcgctcac taggaaattg cttacgtgtt
     4021 tcataagtta aggcaatcac ccgctccacc ccccagcaaa atccaaatgc ttctgctagt
     4081 ctaatggtga catcacctcg ttgtaatttg tagccattct ctcggatctg ttggattaaa
     4141 tcactctgat actcaaaatg caatctttca gttgcttcta ctttatgtcc aaacccatta
     4201 cggtaatagc gattggaatt atggagcgat cgctttagag cttttgtatc catctgtcta
     4261 aaaagtgaga attagggtgt aagagtaagg ctttggggaa aatcttgatt ttcataccta
     4321 gtaacttcta gtgatgatat agtctgcaag acttattaga ggaatagcct tctcttcaaa
     4381 cggagcgagt tctttcttgg cttcctcaat taatttttct gcctggtatc tggattcatt
     4441 aattcctaac aaactaggat aagttgcttt ctgtgctttt tcgtctttgc ctggtgtttt
     4501 acctagttct tcttttgttg cagtaacatc cagcacatca tcaataatct gaaaggcaag
     4561 accaatattg cgagcataat gagaaagcct tcgtaaaatc tcatcatttg ctcctactaa
     4621 caatgctcct gaaacaacac aagcttctaa taacgcacct gttttgtgag agtgaataaa
     4681 gttgagagtt gctagatcaa gattttgcaa tttctctgat tcaagatcag caacttgacc
     4741 acccgctaaa ccccttgctc caaccgcatg gcttaactta gcaatgactt ttaacaagcg
     4801 atcggctgga actccttttg tttgaaccac tatgtattca aaggcatagg gcaaaagtgc
     4861 atcaccagcc agtatggcaa tattttcgcc atagacttta tgatttgtta gcttacctcg
     4921 acgatagtcg tcattatcta aagcaggtaa gtcgtcatgc attaaagaca ttgtgtgaag
     4981 catttccaat gcacaagcag tgggcatagc catttctact acgcccccgg ataattcaca
     5041 gctggcaaga cataaaattg ggcgcagacg ttttccccca gccattaagg aataacgcat
     5101 agattcgtat agcttttctg gataacctga agtgatagag ctttcgagta ctgcttcaac
     5161 ttgctctcgg cgttgtgcaa tatagtctga caaattaaaa gcagcttctg taagataggt
     5221 atttgtatct ttcaaagttg atgaacgcaa ataggtatct acaattcttg tttcttgact
     5281 acttttttga tctcgatatt gttcataatt taggtttgtt ttttcagaat ttttaatact
     5341 catttggctt aattcctcat aaaaaatatg atttttcatt ctattaaatt cgattcataa
     5401 taaatcatta tttttcttga aaaaaatgat tgtaaaaagt aatttcannn nnnnnnnnnn
     5461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5521 nnnnnnnnnn nnnnnnnnnn nnnnnnnaag ttgggcatga ttttaaaaac tgacttatgt
     5581 aaaacaggag aggagctaag tattaaatat gtctgtattt ccaatattga caccccatac
     5641 tccacttttc tctgcattct atgattattt tctaactata atatctttag aaagttcatg
     5701 gaaggaattc caaaaaaatt ttttagaatc gatccccttg cattctcgtc ttttaggcgt
     5761 gggttgtggt agcagtcaat gtgctattaa tattgtgcaa aatcgaccag atctccatat
     5821 tactggtttg gattcatcac ctgaaaaagt caaacaagcc caaataatga ttcataaatt
     5881 aggcttggag aaacaagtta aatttatcga gaggatgaca ttagagttac ctactgatga
     5941 ggaaaatttt gattatgtat acactataga ctctgtaaaa tattggaagg ataaggaaaa
     6001 aaatatcaca gaatttctgc acgtgctaaa gccaggaggc aaaatttttg tcatagaagt
     6061 tgatcaaagc tattactatc aagatgcttt taactggata aatcaaaatc acgtgctgct
     6121 tcaaataaag cctattctcg aaatttacta tcaagcatat atagagaatc ggtctattac
     6181 tttagatgat gctcaagaat tatggagtac tttgcctttg attaataaaa atgctcctca
     6241 cagaatttta ggaactcctg ttttagttat gagtgggaca aagcaacatt ataattatca
     6301 agtgagtgaa gtagagctaa gagtagataa tgatgtcgca cacaactttt ggtgtggcaa
     6361 gttactcgat taattaaata caaatcaggc aacaaaaata agtaattact gcatatataa
     6421 tttttgggaa atttaacaac agttagataa cttataccaa tttagatttt agattttgga
     6481 ctaacaatct ttaccattag aaagtttcag aaatttcaaa caattctatc gtcacaattt
     6541 tataccaatt taaaaacatc tatagaacgc cctacgaaga gatctgtatt attctttctt
     6601 caaattagta ttagtccatt gaagcggact ctttgcagta ccaatattct caaatataca
     6661 tctttataag ttcatagaat atatccttga ttagttgaaa atataataag ttaactttca
     6721 atgtttagat agaagcattt atgattaaaa ttattgctat tgttggtatg cctggttcag
     6781 gtaagagtat agttgctagt tactttaaaa atcatagttt acctataatt tggttgggtg
     6841 aaattattat atctgaagtt gaaaagagag gtttaatgct cacaccacaa aatgagcagg
     6901 tcgtgagaga agaaattaga gccaaatatg gaatggatgt atgtatgcaa atggctttac
     6961 cacttattca acaaaagctg ttatatcatc cattagttat tattgatggt ctttatagct
     7021 ttagtgaata taaaactctc aaaaatttct ttggtaatga attgttggtg gtagctattt
     7081 ttactcccaa atctcttaga tacgaacgac tatttttgag aaaaattaga cctttgacag
     7141 cagaagaagc tgagttaagg gacttcatgg aaattgagaa aattgaaaag ggagggccaa
     7201 ttgctatggc agacttaact atagtcaatg atggaacaca agaccagtta gatcaaaaaa
     7261 tagaaataat cttaacaaaa atattgcata attcttcttt gaatccctgt agtaattaac
     7321 aggacagatt taatatttta gaaaattagg gcaatctaga taatttgtag gaattttact
     7381 accgtgaaac taatttctat ccttggttcg acaggttcta ttggtactca aactctggat
     7441 attgttaccc aatatcctaa tcagtttcag gttgtgggat tagcagctct taaaaatgta
     7501 gaattactag ctcaacagat ccgcaaattt caaccagcga tcgcagctat cggtgattca
     7561 caaaaattac cagaattaca ggctgcgatc gctgatgtta aaccccaacc tattctgctt
     7621 gcgggtgaat caggaatcat cgaggttgct cgattcagca ctgccaagat tgtagtcaca
     7681 ggtattgttg gttgtgcagg tttattacct acaattgctg caatcaaagc aggcaaagat
     7741 attgctttgg ccaacaaaga aactctcatt gctgggggac cagttgtctt acctttagta
     7801 cgtgaatatg gggtaaaact gttacctgct gattccgaac attcagcaat tttccagtgt
     7861 ttacagggag tacccgatca aggactgcga cgaattctac tgactgcttc tgggggcgct
     7921 ttccgtgatt tgccagttga gaaattatcc aatattactg tagatgatgc tttgaagcac
     7981 cctaactggt caatgggtcg taaaataacc attgattctg ccaccttaat gaataaagga
     8041 ttagaagtca tagaggctca ctggcttttt ggtattgact atgaccatat tgatattgtc
     8101 atacaccctc aaagcataat tcattcatta attgagctac aagatacctc tgtgttagca
     8161 caattaggct ggcctgatat gcgcctacca ctgctgtatg ctttatcttg gccagagcga
     8221 atttacacag attggcaaca gttagattta gtaaaactca aagagttaac cttttgcgcc
     8281 ccagaccatc aaaagtatcc ttgtatgcaa ctagcttatg cagcaggtcg atctgggggt
     8341 tgtatgccgg cagtcctgaa tgcagctaat gaacaagctg tagctttatt cctggaagaa
     8401 aaaattcagt ttcttgatat ccctcgtttg attgaacaag tctgcgatcg ctacgttatc
     8461 cacaactgtt ctagcccaac tcttgaagac atcattgcag cagatcaatg ggctagacaa
     8521 gaactcatga atgcaagtca agttttagag cattcgacta taactaaagt ttcatccaaa
     8581 caaaaaactt taacgcttac ctaaatattg tccaatctaa tactttgtca catcaacttt
     8641 aaatggttcg tagtgaggac tttagtcctt tttaagagga tgtttaaaag ggttttttga
     8701 tgtcatgcag acctgctttg tacggtttcc cgtttgccgt caggcgttca cgcagggtag
     8761 agggttctgt tggcgtagcc gccctgaaag ggctaggtag ggtaagtaga cgattctgcg
     8821 gctactcaca tattgcacca ataaaaattg atgtagttta atactgagta attaaactac
     8881 aacccttgat ttagtgataa aaaccaataa aaatcaggta accttatcgc ctatttcttt
     8941 agtttgtctg ggattgtact taaaagtgca agatgtgaaa aatttaaatt attgttcaaa
     9001 taagtacttg tgtaactatc agtttttgta acaacaagtt aaattaaaca aagaaatgaa
     9061 attaataatt tctcaatata aattactcta agtatgattt ttgatcgact aacttataaa
     9121 ttaaaaacaa tgtcaagaaa acagtttatt gacatacttg gcgaattaaa caaatgatta
     9181 tatagaaatc aaaatgattg ctgaacaaat tctcagatat atattccaat accgtcgttt
     9241 gctgtcagat acagaagctt gtgctaaaga accctgttca atgtgtctgg ctcctcatat
     9301 tccaaaaata cagtcattta ttgaacataa tgaaccaatt cattttatcc tcccagcatt
     9361 tcctgcaaaa tcacctaatc ctcaaaaagt tttaggacca atgccagata tgggagaacg
     9421 agttgcactc caattccttc agaatttgtg caatcagatc tctaaagtat atcctcctgg
     9481 ggcaaaaata accatttgtt ctgatggtcg agtatttaca gatctagttg ctattacaga
     9541 tgagaatgta agtctgtacc gtcaaggaat tgaacggcta ctcaatgaaa tcaatgcaga
     9601 tagaattgat accttctgtc ttgaaaacgt cttcagtaga atgagctttg atgagatgag
     9661 aaaaacactt atcaaacaat attctcaacc aattgaaagt atccaagagc gggtaaacag
     9721 tgaagataaa catcgtcaat ttttcaatgg tatttatcac ttgctgtttg atgattatct
     9781 cgttctatat cctgataaac ctcgtaatca ggttgaagtt gaatgtaacg tacgagctta
     9841 tgaagtcatc caaagaagta atgcttggac taaattggtt gggcaacatt ttccccaatc
     9901 tttacgtttg tctatccatc ctcaacatta tcactcagat aagattggta ttcatatgat
     9961 taaaacctca gatcagtggg gaactccatg gcacaatgct ccggtgttta atggtaaaga
    10021 gtttttgctg atgaaacgta gacatattga agatataggt gcttcactag tttggcatga
    10081 tggttatcct agtcactaca tcttatctaa acaagtatcc caagctttgg tcactattga
    10141 cagtaagaaa taaagcatca ggttactcgc ctcaatgagc aattactcta caaaatacac
    10201 attgaacaac ctcaaaaatt gctaagaaaa aatatgtggg gatagtgtaa ctgagtaaca
    10261 tattggtctc caaaaccaaa gaatctaggt tcaaatccta gtccccacgc tagagcatga
    10321 ggttgctcac caacaccagc agttctaaat aataaatgca tacatcttta aatagtattt
    10381 catcaattaa aaattgatga gtgcaacaac cagaaaaata aaagggaaaa aataagggat
    10441 aaaatacctt tttcctttac cctattaatg aacttggaac tagtgcagca atgcatttcc
    10501 aatgcagaga tttttgctca atttaagtat tagcacaaaa cataggttta aaatgactca
    10561 aattataaat atcactcaat caaaggtgat tagtgaacag attctaaagc atgtatttcg
    10621 tcatcgtcgt ttaatctcaa atacagagcc ttgtgtacat caaccctgtt cattgtgtct
    10681 agctcctcat cttgaaaaag ttcaatattt tgttgaacat aacgaaccaa ttcattttat
    10741 tctcccagca tttcctgcaa aatcacctaa tactcaaaaa gttctaggca ctatgccaga
    10801 tatgggagaa ctagtttcac ttaaatttct tcaatctctt tgtaatcaga tcagtgaaat
    10861 atatgctcct ggagctaaat taacaatttg ctctgatggt cgggttttta gtgatcttgt
    10921 cgctgtcaca gatgaaaatg taactttata tggtcaaaga attcaagcgc tgctgaaaga
    10981 aatggaggca gatgcaatca atgtcttcaa tctggaagat atgtatactg acctcagttt
    11041 tgatgagatg agacagaaac ttgttaagct ctatggtcaa aacattgaag ctatcaaaga
    11101 agctgtgaaa aacgatgatc atcactgtca aatgttcaac ggtattcatc gttttctggt
    11161 tgaagattat caggtattag aagctcataa aagtcgtaac aaaattcgac ttgaatgtaa
    11221 gacaagagct tatgaagtaa ttcaacgcag taatgcttgg agtgtactaa tttcagagct
    11281 ttaccctcac tcagtacgct tatctattca tcctcaacat tatcattcag aaaaaattgg
    11341 tatccacatg atcaaaacat tagatcaatg ggggactcca tggcacaatg ctacagtctt
    11401 tgatggaaaa gaattcatgc tcatgaagcg aagccatcta gaaagtatgg gtgctacctt
    11461 agtttgccaa aatggtcatc ctagtcattt tgcgtggact gaacagccat tagaaactcg
    11521 tattaccgtt caggaggcta ttcaatgatg gtttctactt ctcttgggca atcaacacaa
    11581 tttagtgtca aaccattaac tccttttggt gcattgcttg aagcaactga ataccactca
    11641 gatattaagc aactgtcgat tgaacagtta tgtgaattaa cttgggaaca tcggttgatt
    11701 gttctgcgtg gtttttcact cttagagcgt gaagaattat caacctactg ccagcgttgg
    11761 ggtgagttat taatttggaa ttttggtaca gttcttgatt taattgttca cgaaagtcct
    11821 gagaactatt tatttacaaa tggaaatgta ccgtttcatt gggatggagc ttttgctgaa
    11881 gctgtaccac gctttctatt ttttcaatgt ctgaaggcac cagaagcagg aagtggtggt
    11941 gaaagcttat tttgcgatac agtacggatt ttgcaaaatc taagccccca acaacgcgaa
    12001 atttgggaaa agactgaggt tagttataaa actgaaaaag ttgctcacta tggtggagag
    12061 attatcaaat ctcttgtgag taagcatccc attactggtc tttcaacgct tcgttttgca
    12121 gaaccattaa acgatgcaag cgtacacctc aacccgttgt atgttgaagt ttgtaatcta
    12181 ccagccgaag aacaaaacca atttctcagt gagctaatag aaaatcttta cctaccgcaa
    12241 aattgttttg gacacgaatg gcaagaagga gattttttgg tagctgacaa tcatgcgctg
    12301 ctacatggtc gcaatccctt tctttccaat tcacagagac atttgcaacg ggtacatatt
    12361 ttataaattt tggcagtgat cggtcttgct cgctattatg tgatctccgc ttaaacacct
    12421 gtcattcagg ctgacgggaa gaagtgggaa cgcagatata ggaagaggta ctgatagtgc
    12481 gggtaattta ctggaatttt cattcaagta attcccgcca ctctcaatca aaaatgtggg
    12541 gatagtgtaa ctggataaca cattggtctc caaaaccaaa gattctgggt tcaaatccta
    12601 gtccccacgc tagagcaaca gtttgaaatc cgtctgctct catcacagtt catgattatc
    12661 taacttaaaa ttgaggtaag tagaaaatga acgacgttaa ccgtatacac actgatatag
    12721 tcaatgtagc taaaactttt ggagcagaat attctgaaaa agttttggac gaagtattcc
    12781 aagtttttgg tgagcaattt gccgataact cattcatgat tcggactagt aacaaacaac
    12841 cagataaatt aggttgctat ttccgttatc atgaggaaga tgaaagccat ttaggtcttg
    12901 catgggatat tgccagaaaa tccggtctgt tatctgatca aggtcgtcca gtagatcgac
    12961 tgataccaga aatttgtgaa acttttccaa taatggcaga tggtgtagat tttgacgtta
    13021 aacacggatt agcaaaaatc tggcagagta ttaaaggagt tgtccctgta caagatgctt
    13081 ttaatttatc tttgccagca agtgttattg ctcacgcaga ttttctcaaa aatcaccatc
    13141 ttgatgctct ctatgctttt ggagttgact atcaccatag ttcagtcaat ctgtatttcg
    13201 acacttatca tccaaaacat cacacatccg aatattacaa aaatcttttg caggatttac
    13261 aatttcaacc tccttctgat gaacttcttg aactactagc aaataatgga gaaattgcac
    13321 tgacatttaa ttttgcatct cctcggattg agcggttgtg tttttatctt ccctttttaa
    13381 atcgtgaagc tgtacctcaa aatcttttga ctccattact caaaaaatat attaacgagg
    13441 ctccagcatt agtcaaaaat ccaggtttta ttttgggttg gtcatttggc ccacaaggag
    13501 gaaagggaac atatactaaa gttgacgtag actaccatgg tcgaactgta cctttattta
    13561 taaaagtaca cagccaacca ttacctaaag ctgctgattt tgctcttgct taataaattc
    13621 agggtataaa aataagagta aaactactct ttgctaaaga taaaaaagag cgattaaata
    13681 cactgaagtt caagtttatg ggtgggtcaa taaaagctca cccactactt tgattgttga
    13741 aataaaaccg tacattttct ggcccctatt cccggtcttc atgagtaaat tcataaatca
    13801 aaccggattc ctatagctag ttattttact tataacgtaa ttattcttat gaaactgagc
    13861 caaattactc atccaaatca attacacgga ctgtcaattt cgcaattgga agaaattgca
    13921 cgtcagattc gagaaaagca tctacaaaca gtatctacta gtggaggtca tcttggtcca
    13981 ggtttaggtg tggttgaact gaccttagga ctttaccaga ctttagatct caatcgggat
    14041 aaagtgattt gggatgtggg tcatcaagct tacccacata agttgataac tggacggtgc
    14101 gatcgctttc atactctgcg acaaaagaat ggtgttgcag gttatctcaa acgctgcgaa
    14161 agtcagtttg atcattttgg tgcaggtcat gcttctacca gtatctctgc ggctttagga
    14221 atggctcttg ccagagacct aaaaggagaa aatttcaaag ttgttgcagt cattggtgat
    14281 ggtgcattga caggaggaat ggctctagaa gcaattaacc atgctggtta cttgcccaaa
    14341 actaaattgt tagttgtact caacgacaat gagatgtcga tttctccaaa tgtcggggcg
    14401 ctttcttctc acctcaatca actgcgcttt agctctccag tccagttgct caaacaactg
    14461 gaagaacagt ttgagtatct atcacctgta agtaattttc tagcaccaga attgaaccgg
    14521 attaaacaag gtataaaacg tctggcagtc ccaaaggtag gggcggtatt tgaagaatta
    14581 ggctttacct atatgggccc aatcgacggt cataatttgc cagaactgat agctgccttt
    14641 gaccaagcac atcaacaaac tggcccagtg ttagtgcatg tagcaacgat caaaggcaaa
    14701 ggctatgaat tcgctgaaca agaaagagtt ggctatcatg cccaatctaa attcaatttg
    14761 gctacaggca aagcaatcat ctctagcaag cctaaaccac caagttattc taaagtcttt
    14821 ggtgaaactc tcactaaaat tgccaagagt aactccaaag tcatcggcat cacggcagct
    14881 atgtccactg ggacaaagtt ggatatctta cagaaaaatc tacctgagca atatattgat
    14941 gtggggattg ccgaacagca tggagtaaca ctagcagcag gtttagcgtg cgagggtatg
    15001 cgtcctgttg ttgccatcta ctcgaccttc ttgcaacgag cgtatgatca aatcatccat
    15061 gatgtctgca ttcaaaattt gcctgtcttc ttcagcatgg atcgatctgg tgtagttgga
    15121 gcagatggcc ccacccatca aggaatgtac gacatcgcct atttacgttg cattcctaat
    15181 atggtgttaa tggctcccaa agatgaagcc gaactccagc aaatgttagt cactggcgtc
    15241 aactacactg atggccctat tgctatgcga tatccgcgtg gtgaaggtca cggagttccc
    15301 ctgatgtcag aaggctggga gaccctaccc attggcaaag gagaaatcct tcgtcacgga
    15361 gaagatgtgc taatggtagc ttatggctct atggtatatc cagcactgca agctgctgct
    15421 attttgaatg aacacggtat ccaagcaact gtaattaatg ctcgatttgc caagccttta
    15481 gatactgaat taatcgtgcc tcttgctaaa caaattggtc aagtctttac tttggaagaa
    15541 ggttgtttaa taggtggctt tggttcagca gttgctgaag ctctacttga acatcgtgtg
    15601 attgttccgg ttattcgtct gggtgtaaca gacaagttag ttgaacatgc tactcccgaa
    15661 gaatctctat cagaactagg tttaactgct ccaaagattg ccgatcgcat ccttcaagaa
    15721 tttcaacaac aatccaattt ggatataaat gtattgcaaa acggctcctt tgagcaaaaa
    15781 acccgttcat ggtaatttgt gatttttcat tagttttact gcttttctgt tgtaggcgtc
    15841 aaaaataaca acatatgcaa actctttcaa ctcccatcat ctccaattct ccttctcagc
    15901 agacattcac gaataccatt atcccccgca ggaaaactcg cccagtgcgt gtggctaatg
    15961 tcacagttgg tggtggtttc cctgtagtag tccagtcaat gattaatgaa gatactttag
    16021 atgtgaaagc atctgtagat gctattcgtc gcttgcatga aattggctgt gaaattgttc
    16081 gtgttaccgt acctagtctg gctcacgcta aagctgtagc tgaaatcaag caaaagctaa
    16141 aagaaactta ccaagatgtt cctttagtag ctgatgtcca ccacaatggc atgaagattg
    16201 ctttagaagt ggcaaaacat gtcgataaag taaggattaa tcctggattg tatgtctttg
    16261 aaaagcccaa cactaaccgt accgaataca gccaagctga atttgatgaa attggcgata
    16321 aaattcgtga aactttagag cctttagtcc tctgtttgcg cgagcaggga aaagccatgc
    16381 gtattggtgt caatcacggt tcgctggcag agagaatgtt atttacctac ggtgatactc
    16441 ctgaaggtat ggtacagtct gctcttgaat ttattcgcat ttgtgaatct cttgacttcc
    16501 gcaacctagt gatttccctc aaagcctcca gagttcctgt aatggttgct gcctatcgtt
    16561 tgatggctct acggatggat gaattgggta tggactaccc cttacacctt ggtgtcaccg
    16621 aagcaggcga tggagaatat ggtcgcatta aatccactgc tggaattgca actcttttag
    16681 ctgatggtat tggtgataca atccgcgtct ctttaacaga agcaccagaa aaagaaattc
    16741 ctgtttgcta cagtattctg caagccctgg gattacgtaa aaccatggta gagtatgtag
    16801 cttgtccctc ctgtggtcgc accttgttta atttagaaga ggtgttacat caagtgcgag
    16861 aagctaccaa acaccttaca ggtttagaca ttgctgttat gggctgcata gtcaacggtc
    16921 ctggagaaat ggcagatgca gactacggtt atgttggtaa gcaacccggc tatatctctt
    16981 tatatcgtgg gcgagaagaa attaaaaaag taccagaatc ccagggagtt gaagaactga
    17041 ttaatttgat taaagcagac ggtcgttggg ttgatcctta aagggagaca agacttcttc
    17101 ctctctcata agctactgtg tacacataca cataaataat ttaattactc aaaactcgtt
    17161 atgtagaatg tgttgtgcca caggctaacg cacctaaaat taatggtgcg ttagaagtag
    17221 tggtaaagaa aaaaatggtc tttttgagtg tgtaaatctg gattttcctg tcctaattta
    17281 aagaacaaac aatggttaat gttgaaaaga gcgtagaggc aaaaataaca aaattagaaa
    17341 ctcaatctga aaataaagta atggatctgg cagctagttg gtatattgcc atgcaatcga
    17401 aggaactagg taaaaagcca caagcaatcc agttatttgg tagaccttta gttgcatggc
    17461 gagacaaact tggcaaacca gtgattatgg agcgtttctg ctcacacatg ggtgcatctt
    17521 tagcaatcgg ccagatcata gatggttgca ttcaatgtcc ttttcatcac tggcggtacg
    17581 atagttccgg tgtgtgcgtg gatataccaa aggtagcaac accgacaaca gatgtaattc
    17641 cgtcaacagc gcgtcaacac acttatgtga cccaagaaaa atatggttac atttgggttt
    17701 ggtatggttc tgtaaaccct ttgtttccct tgcccaagtt tgatcctgcc gaaagcgaca
    17761 agcataacta tatgtcttac cgtttcttta gcaaaactaa aactactgtg ttacgggtac
    17821 ttgaaaattc atttgatcat caccatgttg ttgtaacaca taatctaccg ataattaatc
    17881 aaattaaaca aaccctcctt aataaagaag atataaaaat tagtgaacta tcgattgcaa
    17941 aagaagcctg gtttggaaca gtaatggaag ctcagattaa aagttatgct ggtgtaggtg
    18001 cgatcgctaa gtttttaggg ttaaatgttg aaacttggaa gacccgactg gatgcttggc
    18061 cgagtggcag cttaggcaca accagcttta atggacaaca gaaaataaga gtactctctg
    18121 gtatcactcc aatttctgaa aaccagacaa catggcactt gttgttcatg atcaaaaaaa
    18181 ctggtaactt gtggctggat ctactttcct acattgtttt tggctggcaa aacgaagttg
    18241 ctgtatcggc agatgtagtc atctgggata ccatgagcgc aaaaacaggg caagcattta
    18301 tcaagcctga ccagccagta ttaaaattta gacaatttta tcaaagttgg gttgataagg
    18361 cacagtaaaa caaagttagg tgtaaacaag ataaatacgc atactcaaaa tcctatcaat
    18421 gcgtaagtcc tactattatt caacctattg tgaagacagc tttgtcgtgc taaatcaaat
    18481 gcaacaaccc aatccactaa aagctccctc gtttattcaa tcacttcagt ttattcttaa
    18541 tccagtagga tttttggaaa aagtgcatca gcagtatcct gatattttca ctgctaaaat
    18601 ttttggtttt acgggtatcc cagttgtagt tgtacagcat cctcaagcaa ttcaagaaat
    18661 attaaccaat gacagaaaaa agtttgtagt tccaggtcat gtcaacaaaa tcttgcaacc
    18721 cttgttaggt aagcattcac ttttaatggt atcgggagaa cagcacaaac gtcagcgtca
    18781 acttgtgatg ccctcgtttc ataaagagcg gatgcaatcc tatgggcaac ttattgttaa
    18841 tctgactgaa aaagtcatga gtcagttgtc acttaatcaa gtattctcag cttgtagtgt
    18901 catgcaggaa atttccttac aagttatttt acaggctgtg tttggcttat acgaagggca
    18961 aagatacgaa aaactaaagc atttactacc cttgatgttg ggtcttttta gatccccact
    19021 gtacaatagt ttcctatttt ttcctttcct acaaaaagat tttggagcat ggagtccttg
    19081 gggaagattt gtacgcattc gccagcagat agatgaattg ttatacgctg agattgctga
    19141 acgtcgtgta caacccaatt cagatcgtat tgatatcctc tcgttattga tggaagcaac
    19201 agatgaagaa ggtcaaccaa tgacagataa ggagttgcgc gatgagttga tgactatgtt
    19261 agttggtgga tttgacagta cagcaatagc aatggcttgg gaattatatt ggactcatca
    19321 tttaccagaa gttggtgaaa aacttcgcca agaactagat accctgggta attcaaaaaa
    19381 tccaatggat atttttcggc tgccttattt gagtgctgtt tgtaatgaaa ctttgcgtat
    19441 ttatcctgta ggagtaatgg cgaatgttag atttgtgcaa gaacctgtcg aactgctggg
    19501 gtatcactta gagcctggta cggcagtgat tccttgtatc tatctgactc atcatcgtaa
    19561 ggatttatat caaaagccca agcagtttct gccagaacgc tttctacaac atcaatattc
    19621 tccctacgaa ttcctgccgt ttggtggagg tgtccgtcgt tgtattggcg atgctttagc
    19681 tatgtttgaa atgaagttag tcttggcaac tatcctgtca cactataaac tagcactggc
    19741 agatcatcaa ccagtaacac ttcagcggca aatcatgttt gttgggcctg gaaatggaat
    19801 caagatggtt atgacaggac gacgtacgcc ctttaagatt ccacagtcta caagtaaaac
    19861 aactcagtcc ttttattgag aatattatgc gggtaaataa agcttttaaa cttgctagtc
    19921 gagaatttca caatggagag ccaagtgaaa tttttgtctc aacacctaat gaaattgtag
    19981 cttttggtca aaatcatccg attgttcaaa tagctggccc ctgctctgta gaaaatgaag
    20041 aaatgattat ttatactgct ttgcaagtca aggcagttgg tgctaagttt ttgcgaggtg
    20101 gagcttataa gccccgtact tctccttatg cttttcaagg tcatggtgaa agtgctttgg
    20161 gtttgcttgc gatcgctcgt caagttacag gtttgggtat tgtgacggaa gtcatggata
    20221 cagctgacct tgagaaagtt gcttctgtcg cagacattat ccaaatcggt gcgcgtaaca
    20281 tgcaaaattt ctcactttta aagcaagtgg gagcaataaa taaaccagtt ttgctgaagc
    20341 gaggcatgtc tgccactatt gaagaatggt taatggcagc tgagtacata ctgacagcag
    20401 ggaacccaaa tgttattttg tgcgaacgag gaattcgcac gtttgaccaa cagtatacac
    20461 gtaacacatt ggatctaagt gctataccag tgctgcgatc gctcactcac ttaccgattg
    20521 taattgaccc cagtcatggc acaggtcgag cagagtatgt acctgcaatg gctatggctg
    20581 ctatagcagc tggcgctgat tcactgatga ttgaagttca ccctgatcca gccaaagcgc
    20641 tttctgatgg ccctcaatct ttaacgccag agcaatatgg caagttaatt caggacatga
    20701 ttggaattag taaagttttt ggtcgttggt atcaaaaata tcctatatct acaggacatc
    20761 ttgctttacc aatacatgct accaacacat gatatgcaga caaggggaac aaaggggaca
    20821 aggagctaat gcaaaattag gaaatttgct tcaagttatt ggagataatt attaatgttt
    20881 ttgaataatc atgattacat aactaaaggt ggggttaagg tatctcgctt cgttactgag
    20941 actttcatag atactgcgat cgaacatatt ttattgtgta ttgattctca acgtggagga
    21001 ttgttcaaaa gcagctatga atatccagga agatataaaa gatgggcgat tggctttgtt
    21061 aatccaccct tagaacttgt tactcgtgag aactttttta aactcaccgc tcataatcaa
    21121 cgaggcaaag taatactttc gtatttggca gaatttttag ataagcaccc acaactgcaa
    21181 gaaatagacc aggatgatca gtatatcact ggttatatca aaccaaaagg aagtttcttt
    21241 tcagaggaag aaagaagtaa gcaaccatca gttttcagta tcattcgcga aattttagat
    21301 gtttttgaaa gtcctgaaga tgagcattta ggactttatg gtgcctttgg ttatgatttg
    21361 gtttttcaat ttgaatctat ggaaaaactg ctcccacgtt ctacagatca gcaagattta
    21421 ttactttatt taccagatga attattcatc atagattatt atttgcaacg tgcattttgt
    21481 ttacaatatg attttgaaac caagcatggt agtactaagg gactttttcg cagtggtgaa
    21541 ataattgatt acagaggtaa gtgtcttact cctgctcaat cttcagatca tgaacctgat
    21601 gaatatgcac agcaagtttg taaagcactc ttatatttcc gtcgtggtga cttgtttgaa
    21661 gttgttccga gtcaaagctt ttatagacaa tgtcaacagt ctccggcaga attatttcgc
    21721 actttacaac aaatcaatcc tagcccctat ggattcattt tgaatttagg tggagagtat
    21781 ctgattggtg catctccaga aatgtttgtc cgaactgaag gcaaacgtgt agaaacttgc
    21841 ccaattagtg gtacgattcg tcggggagaa aatgcaattg atgatgctgc tcaaattcag
    21901 aagcttctca actcaggtaa ggatgaagct gaactgacca tgtgtactga tgtggatcgc
    21961 aatgataagt cacgcatatg tgaaccaggt tcagtacaag taattggtcg tcgtcaaatt
    22021 gagatataca gccatttaat ccacactgta gatcatgtgg aaggcttatt aagacctgag
    22081 tttgatgctt tagatgcatt tctaactcat ctgtgggctg ttacagttac aggagcgcca
    22141 aaaaaatcag caatgcagtt tcttgaacag catgaacgca gttctcgacg ttggtatggt
    22201 ggagcagttg gttacttaac cttcaaagga gatttgaata caggtctgat tctgcgaaca
    22261 atccagctta aggactcaat tgctgaagtg cgagtgggtg cgacagttct ttacgattca
    22321 gatccacaag cagaagctca agaaactctc actaaagctg ctgctctgtt tcaaacactt
    22381 taccagactc aacaaaagac tgataatgtt gtcaacaaca tcgacatcaa tcaaaacttt
    22441 ctcaaatcta aagctgaaca tagtaaacaa atattattga tagactatga agattcattt
    22501 gttcacactc tagcaaacta cattcgtcaa actggtgctg tcgtcaaaac attacgccat
    22561 ggcttttccg aatcagtctt tgatatggaa aagcctgatc ttgttgtctt atctcctggg
    22621 cccggtagac ctagcgattt tcatgtagta gagacaatcg tagcttgtat aaaacgacag
    22681 attcccatct ttggtgtttg tttaggattg cagtccattg ttgaagcgtt tggaggtaaa
    22741 ctgggagttc taaattatcc tcaacatggt aaggtatccc ggatttctgt tatggattca
    22801 gaatctgtta ctttcaaaaa tttacccaaa tcatttgaag ttggtagata tcactcatta
    22861 tttgctttac ttgagactct ccccacagaa ttaaaagtga cagcaatctc agatgatggc
    22921 gtaattatgg gtatcgaaca tcaaacatta ccgattatcg gcgttcaatt ccacccagaa
    22981 tcaatcatga ctttagctgg aggagttggt ctaggcatta ttaagaatat agttggtgca
    23041 tgtacaacta aaataccttc ttcagttgtc gttgcataaa tatcttttta gatatgcctc
    23101 tagtgtccca ttaattttga tgagttacat aagtaattaa tttaataatt aatcattttt
    23161 tcctcttttc ttggcacact tagcatctac cctccgggaa ccccctgaca gttcattttc
    23221 tacagttact atcaatcatc cccatctcat atggatgcac aaaagagtat ctccactatt
    23281 gaaataaact cagtaaaacc gcgtcatatt ctcgaagaga ttgtatggca caaacgaaaa
    23341 gaagttgcat ctatgggtga gcaactgtct tttgcagact tacaaactca gattagtact
    23401 gctcctcctt tacgagattt cctggatgct ttgcgccaga atccgaataa accgatctta
    23461 attgctgaag ttaagaaagc ttcacctagc aagggagtga ttcgtgccga ttttgatcca
    23521 gtcaagattg ctcaggcgta tgaacaaagt ggtgctacct gtctatcagt actaactgac
    23581 caaaaattct tccaaggcag ttttgagaat ctacggttaa ttagaaaaag cgtaggatta
    23641 cctttattgt gtaaggagtt tattattgac ccttaccaaa tttattttgc aagagtcaat
    23701 ggagcagatg cagtattact gattgctgcc attttatcta atgaaattct tacggatttt
    23761 ctacagattg ttcagcattt aggtatgact gctttagtag aggtgcatac tttggctgaa
    23821 cttgatcgag tactggcact atcaaatgtc caattaatag ggattaataa ccgtaatctt
    23881 caagacttta gcgttgaact agaaacaact caacgtttat tgaaagagcg tcgagaacaa
    23941 ttaagtagtg caagaatcac tgtggtaagt gagtctggtt tgtatacatc agttgactta
    24001 gcttttgttg cagaagcagg agccgaagca gtcttgattg gagaatctct ggtaaagcaa
    24061 acagatttag aacgggctgt aaaaaagcta atggatagat aaaatctgtg gagtcaattc
    24121 aaaatctaaa atccaaaatc taaaatcgaa tgacctctat ttctcatcac tttgcatctt
    24181 tacgagccag taatcagtgc gctttgattc cctttgtagt agctggtgat cctaatttgg
    24241 aaatcacagc agaagcttta cgagttttag attctagcgg tgctgatttg attgaattgg
    24301 gagttcccta ctcagatcca ttagcagatg gaccagtgat tcaagcagcc gctacccgtg
    24361 ctttgaaacg gggaacccgt ttagataatg ttttacaaat ggttcaaaca gttacacctc
    24421 acttgcgatc gcctattatt ctttttactt actacaaccc aattctaaat ttaggcacaa
    24481 tttcgtttct agaaaaagcc gcagcatcag gaattaaggg attagtagta cctgatttac
    24541 ctttggatga ggcaagtaat ttgttagagg ttgctgatac tgtgggaatt gaggtgactt
    24601 tgttagtaac tcctacaagt tcaaaagaac gcatagaggc gatcgctcgt caatctcgtg
    24661 gatttattta cttagtgagt gtaacaggtg ttactggtgt gcgctctcat ctgcaaacac
    24721 gggttaagga tgtgctgcaa gacatccgca gtgttacaaa caaacctatt ggtgttggtt
    24781 ttggcatatc taaatcagaa caagctcgtc aagttagaga ttggggcgca gatgctgtga
    24841 tcgtcggtag tgcctttgta gagcgtttag tggaaagtac accatatcaa ggactgggag
    24901 ctattaaaga tttctgtcgt gatttgaaga catcaataga aggcagaaca gaggaagcag
    24961 aaagcagaag ataagagatt taatccttca aactctaaat attgtataac agtatttttg
    25021 tgtaaaactt atgttattaa atacacaaca taatcaagct gcaactcaac tactcactca
    25081 acaacctgac ccaaatggca ggtttggtca atttggtggt aagtatgtac ctgaaacttt
    25141 aatgtcagca ctgactgaat tagaaaccgc ctttcagcaa taccgtgctg atccactatt
    25201 ccaacaagag cttcaagcac tgctacggga ctatgttgga cgttctactc ccctttactt
    25261 tgctcaaaga ctaactgaac attatgctaa acctgatggt acggggccac aaatttatct
    25321 taaacgtgaa gacctaaacc acacaggagc gcacaaaatt aacaatgctc tggcgcaagt
    25381 actgttagcc aaacgcatgg gtaaacagcg cattgtggcg gaaacgggag caggtcaaca
    25441 tggtgttgct actgctactg tgtgcgctcg ttttggccta gaatgcgtaa tttacatggg
    25501 tatccatgac atggaacggc aagccctaaa tgtattccgg atgcggttga tgggggcaga
    25561 ggttcgatct gtagaagcag gaacaggaac cctcaaagat gcgacatctg aggcaattcg
    25621 ggattgggta acaaacgtcc aaacaactca ttatattctc ggttcggttg cggggccaca
    25681 tccttacccg atgatggtgc gggactttca tgcaataatt ggtaaagaaa ctcgcgctca
    25741 ggcacaagag aaatggggag gactaccgga tattcttttg gcttgtgtgg gtggaggttc
    25801 caatgcaatc ggactgttcc atgaatttgt aaatgaacct tcggtgcgcc taattggtgt
    25861 tgaagcggct ggtgaaggta ttaacacaga taaacatgca gcaaccctga caaaaggacg
    25921 agtcggagtt ttgcatggcg caatgagtta tgtactacaa gatgaagatg gtcaaattgt
    25981 tgaggcccac tctatcagtg ctgggttaga ttatccaggc gttggccctg aacatagtta
    26041 tttgaaagaa atagggcgtg ctgaatatta cagtgtgaca gatcaacagg cgctacaagc
    26101 atttcaacgc ctttcacaac tagaaggaat tattccagcg ctggaaacag cacatgcgat
    26161 cgcatattta gaaactcttt gcccacaact tacaggtagc ccgcgaattg tcatcaactg
    26221 ttccggacgt ggtgataaag atgtacaaac agctatccaa tttttaaacc cagcttaaag
    26281 gaagacaaag taatttagta aaaattttta cttaaatatg gttacaacat ctgtaattga
    26341 aacaaattca atatctcata actcccctaa ttggagtcat ttattacaac aattgttaga
    26401 tcatcaatcg ctgacaactg atcaagccag tgaattaatg tacggctggc tcatagatgc
    26461 tattcctcct gtattatctg gtgcgatttt ggcagcaatt cagatgaagg gtgtctctgc
    26521 acaagaattg ctgggtatgg tgaaggtttt atactcccag tcattacgac caacattacg
    26581 agatatagtt gtcggtgatt cacccctcat tgatacctgt ggtactggtg gagatggagc
    26641 atcaacattt aatatttcca cagcggttgc ctttgtaaca gctgctgcca aggtaaaagt
    26701 tgcaaaacat ggtaatcgtt ctgcatctgg taaaaccgga tcagcagatg ttttggaagc
    26761 tttgggagtt aatttgaaag caagtagtaa aaaagttcaa gaggctgttg atgcagttgg
    26821 tataactttt ctatttgcac aagattggca tccaactttg aaagtttgtt acccactgcg
    26881 gaaaacacta aaagtacgta cagtttttaa cctgcttggc cccctgatta acccattgcg
    26941 accaacagga caggtcatag gtgttaatga tccaggactg attgagacct ttgctctggt
    27001 cttgcatcaa ataggaattc gtaaagcgat cgtgcttcac ggacgagaga aattagatga
    27061 agcaggttta gctgatatta ctgacttagc gatcgtatca aagcaacatt tgcgcttgct
    27121 tgaacttgct cctgaaaaac taggaataaa cccggctcca actacagaac taaggggtgg
    27181 cgatgctcag gaaaatgcca gaattctcaa agcagttctt caaggtaaag gtactcaagc
    27241 acagcaagat atagtagcct taaatacagc tttagcactc tttgttggcg aagcaattcc
    27301 tgaaacagga gatgacatga gtacctttgc aaaaggtctg actcttgcta aagacgttat
    27361 tgcaagcggg gttgcttgga caaagttaga acagcttgtt gaatttctgc gctagaaagt
    27421 ttcaaaggag gactgcttca tggctgctga aaaccgacta attttggtac gtcacggtgc
    27481 tagtgaatgg agtaatctgg ggcgttatca gggacaccaa cctgtgccat tgagtcctct
    27541 aggaatagag caagtttatg ctttaacaga ggaactgcgt cagtatcacc cagagcgaat
    27601 tgttagtagt gacttgcaaa gagcgcgaca aactgcggag attatagcca agcatctgat
    27661 gctggaaatt cattatgatg cacgattgcg tgagctagac tgtggaaatt gggctggatt
    27721 aactgagaag cagattgaag tattagatcc taaagctgtt gtcgagttgc gttctggccg
    27781 cgatattcct agaggttctg gtgagacgat ggcagattta atagtgcgta cccgtgctgc
    27841 attggctgat tgggtaaatg atagtttctc cggcacacta atatttgttg cccatgccta
    27901 tgtcattcga gaaattacgc aaactctctt aggtggaaat ttacctaata atcagttacc
    27961 tagtttaggc tcttatactt tactcaatta caaaacagga ggtaaatgga tactagaggg
    28021 gtatggaatt gttcctaata gcagttcttc tttaactact gtaaattggt tgccaacatt
    28081 ctgaaagaat actagtggtt catcgcatta attatgaggt gttatagatt cccgacttct
    28141 tcaagaagtc ggggatctga acacccacga ctcatcaaag tttacgtgac agaatactaa
    28201 caaggtatca caacgcttac aacagtt
//
