BGC0001597: fluvirucin B2 biosynthetic gene cluster from Actinomadura fulva subsp. indica
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Location: 1 - 71,515 nt. (total: 71,515 nt).
This entry is originally from NCBI GenBank LC095592.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001597
Short description fluvirucin B2 biosynthetic gene cluster from Actinomadura fulva subsp. indica
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
LC095592.1
via
Compounds
  • fluvirucin B2
Species Actinomadura fulva subsp. indica [taxonomy]
References
Chemical products information
fluvirucin B2 Evidence:
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C25H48N2O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAV55985.1
 178 - 666 (+) hypothetical protein
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    • BAV55986.1
    		 702 - 1127 (+) hypothetical protein
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      • BAV55987.1
      		 1269 - 3059 (+) FAD-linked oxidase
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        • BAV55988.1
        		 3368 - 3793 (-) hypothetical protein
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          • BAV55989.1
          • flvA
          		 3809 - 4507 (-) 4'-phosphopantetheinyl transferase
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            • BAV55990.1
            • flvB
            		 4504 - 5331 (-) metallophosphoesterase
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              • BAV55991.1
              • flvC
              		 5328 - 6068 (-) thioesterase
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                • BAV55992.1
                • flvS1
                		 6120 - 7007 (-) dTDP-1-glucose synthase
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                  • BAV55993.1
                  • flvR1
                  		 7205 - 9550 (-) PbsX family transcriptional regulator
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                    • BAV55994.1
                    • flvS2
                    		 9607 - 10590 (-) dTDP-glucose 4,6-dehydratase
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                      • BAV55995.1
                      • flvE1
                      		 11006 - 12436 (+) propionyl-CoA carboxylase subunit beta
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                        • BAV55996.1
                        • flvE2
                        		 12511 - 13581 (+) 3-oxoacyl-ACP synthase
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                          • BAV55997.1
                          • flvE3
                          		 13581 - 14441 (+) 3-hydroxybutyryl-CoA dehydrogenase
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                            • BAV55998.1
                            • flvS3
                            		 14475 - 15086 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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                              • BAV55999.1
                              • flvS4
                              		 15118 - 16227 (+) NDP-sugar aminotransferase
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                                • BBD71108.1
                                • flvK
                                		 16224 - 17195 (+) aminoacyl-ACP:ACP aminoacyltransferase
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                                  • BAV56000.1
                                  • flvL
                                  		 17253 - 17501 (-) acyl carrier protein
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                                    • BAV56002.1
                                    • flvM
                                    		 17640 - 19151 (+) ATP-dependent ligase
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                                      • BAV56003.1
                                      • flvD
                                      		 19194 - 20195 (-) esterase
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                                        • BAV56004.1
                                        • flvE4
                                        		 20266 - 21030 (-) short-chain dehydrogenase
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                                          • BAV56005.1
                                          • flvE5
                                          		 21099 - 22436 (-) crotonyl-CoA reductase
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                                            • BAV56006.1
                                            • flvP1
                                            		 22509 - 34280 (-) PKS (ACP-KS-AT-DH-ER-KR-ACP-KS-AT-KR-ACP)
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                                              • BAV56007.1
                                              • flvO
                                              		 34371 - 35645 (-) PLP-dependent decarboxylase
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                                                • BAV56008.1
                                                • flvJ
                                                		 35816 - 36769 (-) amidohydrolase
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                                                  • BAV56009.1
                                                  • flvR2
                                                  		 37222 - 38142 (+) transcriptional regulator
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                                                    • BAV56010.1
                                                    • flvS5
                                                    		 38335 - 39636 (+) glycosyltransferase
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                                                      • BAV56011.1
                                                      • flvP2
                                                      		 39704 - 52564 (+) PKS (KS-AT-DH-ER-KR-ACP-KS-AT-DH-ER-KR-ACP)
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                                                        • BAV56012.1
                                                        • flvP3
                                                        		 52628 - 60070 (+) PKS (KS-AT-DH-ER-KR-ACP-TE)
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                                                          • BAV56013.1
                                                          • flvR3
                                                          		 60169 - 61092 (-) TetR family transcriptional regulator
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                                                            • BAV56014.1
                                                            • flvT1
                                                            		 61349 - 62869 (+) MFS transporter
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                                                              • BAV56015.1
                                                              • flvE
                                                              		 63078 - 63923 (+) methyltransferase
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                                                                • BAV56016.1
                                                                • flvR4
                                                                		 63940 - 66783 (-) LuxR-family transcriptional regulator
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                                                                  • BAV56017.1
                                                                  • flvN
                                                                  		 68111 - 69685 (+) ATP-dependent b-aminoacyl-ACP synthetase
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                                                                    • BAV56018.1
                                                                    • flvR5
                                                                    		 69900 - 70598 (+) LexA-family transcriptional regulator
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                                                                      • BAV56019.1
                                                                      		 70696 - 71067 (-) hypothetical protein
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                                                                        • BAV56020.1
                                                                        		 71118 - 71501 (+) hypothetical protein
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                                                                          Biosynthesis information
                                                                          Annotation changelog

                                                                          Entry version: 3

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-09-15
                                                                          Added AMP-binding domain substrate specificities
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2019-10-16
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2019-10-16
                                                                          Updated compound(s) information (NPAtlas curation)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2018-08-06
                                                                          Submitted
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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