LOCUS       BGC0001599              9373 bp    DNA     linear   BCT 16-APR-2015
DEFINITION  Burkholderia cenocepacia H111 chromosome 2, complete genome.
ACCESSION   BGC0001599
VERSION     BGC0001599
KEYWORDS    .
SOURCE      Burkholderia cenocepacia H111
  ORGANISM  Burkholderia cenocepacia H111
            Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
            Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
COMMENT     On Apr 25, 2014 this sequence version replaced HG938371.1.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:48:41
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9373
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1347)
                     /EC_number="2.6.1.18"
                     /NRPS_PKS="Domain: Aminotran_3 (24-379). E-value: 1.2e-101.
                     Score: 331.9. Matches aSDomain:
                     nrpspksdomains_I35_4188_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GOA:G7H9M8"
                     /db_xref="InterPro:IPR005814"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/TrEMBL:G7H9M8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 437.7;
                     E-value: 6.9e-133)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="I35_4188"
                     /old_locus_tag="I35_0526"
                     /product="Omega-amino acid--pyruvate aminotransferase"
                     /protein_id="CDN62024.1"
                     /sec_met_domain="Aminotran_3 (E-value: 5.8e-101, bitscore:
                     327.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYSESRFWHPRQHPLAASRPPVRITRGEGCYLYDDTGRPYLDAV
                     ASLFNVYVGHGRREIKEAIVRQLDELEYHPVFAGFSHPRAEELSARLIDMLQPEDMSRV
                     IFGSGGSDAVEAALMIARQYWKVSGQPERTKFIALRQAYHGSHFGGSSVTGNTVYRRNY
                     EPTLAGCFHVETPWIYRNPFTHDPEELGRLCASLVEREILFQGPDTVAAFIAEPVQATG
                     GIIVPPANYWPLVREVCDRHGVLLIADEVVTGFGRTGAAFGSRGWGVAPDIMCLAKGVS
                     SGYLPLGATVVNRRIENAFASNPGGIGTLMHGYTYSGHPIVCAAALANLQIIVDEDLAG
                     NAAREGAYLLERLQPLVDRYPVVGDVRGKGLLVGIDLVKDKVTRESIDPSDGYAAALAD
                     AARDAGVLIRSLGNRLAIAPPLVIGREDVDRIVHAIEHAFEAVPRWTAR"
     protocluster    1..9373
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[5262:8829]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5263..8829
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..9373
                     /SMILES="NC(CC(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..9373
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001599"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9373
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1347)
                     /locus_tag="I35_4188"
                     /old_locus_tag="I35_0526"
     aSDomain        complement(211..1275)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I35_4188_Aminotran_3.1"
                     /evalue="1.20E-101"
                     /label="I35_4188_Aminotran_3.1"
                     /locus_tag="I35_4188"
                     /protein_end="379"
                     /protein_start="24"
                     /score="331.9"
                     /tool="antismash"
                     /translation="ITRGEGCYLYDDTGRPYLDAVASLFNVYVGHGRREIKEAIVRQLD
                     ELEYHPVFAGFSHPRAEELSARLIDMLQPEDMSRVIFGSGGSDAVEAALMIARQYWKVS
                     GQPERTKFIALRQAYHGSHFGGSSVTGNTVYRRNYEPTLAGCFHVETPWIYRNPFTHDP
                     EELGRLCASLVEREILFQGPDTVAAFIAEPVQATGGIIVPPANYWPLVREVCDRHGVLL
                     IADEVVTGFGRTGAAFGSRGWGVAPDIMCLAKGVSSGYLPLGATVVNRRIENAFASNPG
                     GIGTLMHGYTYSGHPIVCAAALANLQIIVDEDLAGNAAREGAYLLERLQPLVDRYPVVG
                     DVRGKGLLVGIDLVK"
     gene            complement(1404..2765)
                     /locus_tag="I35_4189"
                     /old_locus_tag="I35_0525"
     CDS             complement(1404..2765)
                     /NRPS_PKS="Domain: Condensation_Starter (6-308). E-value:
                     4.8e-72. Score: 234.6. Matches aSDomain:
                     nrpspksdomains_I35_4189_Condensation_Starter.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR001242"
                     /db_xref="UniProtKB/TrEMBL:G7H9M7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     336.9; E-value: 3.8e-102)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="I35_4189"
                     /old_locus_tag="I35_0525"
                     /product="Enterobactin synthetase component F"
                     /protein_id="CDN62025.1"
                     /sec_met_domain="Condensation (E-value: 6.5e-30, bitscore:
                     93.2, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDSTLQLPLSAPQRDFWEAALAYPVPSTHIYAAEYFDIRGALDT
                     GAFERALRQVIREAQTLHTTRIVLDGDTPVRVLDAALADDWTLEHVALAGTKDAHAIAL
                     AGMRAHCTGAIELARGPFFRHTLYRIAPDHYYWYHGYAHILVDGYSGSLIATRAAELYN
                     AFASGAKAPPARFASLAELQLDEDAYRASEQFAHDRRYWLERFADQPRTVTLAGPARFP
                     ERDDGPDLRETRLATATESARLEAVARDLFTSTVPRLVTALTAAYLYLNTGAHDIVLSV
                     AAMARTSARERRTPAQCANMLPLRLHVEPGHTLDDLCRQANREMIALRQHQRYRMGDLH
                     RELTSLDNGQGVFGPEINIMAFDYDLRFGDCVTTSHNLSVGTTDDLMVNLTDRRNGEPL
                     RFDFDASPQYYSRDALNAHVGQFLTFMRVALDEPFATLGALESRLDFQPAALAG"
     CDS_motif       complement(1689..1799)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I35_4189_0004"
                     /evalue="1.40E-10"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="I35_4189"
                     /protein_end="359"
                     /protein_start="322"
                     /score="33.7"
                     /tool="antismash"
                     /translation="REMIALRQHQRYRMGDLHRELTSLDNGQGVFGPEINI"
     aSDomain        complement(1842..2747)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I35_4189_Condensation_Starter.1"
                     /domain_subtype="Condensation_Starter"
                     /evalue="4.80E-72"
                     /label="I35_4189_Condensation_Starter.1"
                     /locus_tag="I35_4189"
                     /protein_end="308"
                     /protein_start="6"
                     /score="234.6"
                     /tool="antismash"
                     /translation="QLPLSAPQRDFWEAALAYPVPSTHIYAAEYFDIRGALDTGAFERA
                     LRQVIREAQTLHTTRIVLDGDTPVRVLDAALADDWTLEHVALAGTKDAHAIALAGMRAH
                     CTGAIELARGPFFRHTLYRIAPDHYYWYHGYAHILVDGYSGSLIATRAAELYNAFASGA
                     KAPPARFASLAELQLDEDAYRASEQFAHDRRYWLERFADQPRTVTLAGPARFPERDDGP
                     DLRETRLATATESARLEAVARDLFTSTVPRLVTALTAAYLYLNTGAHDIVLSVAAMART
                     SARERRTPAQCANMLPLRLHV"
     CDS_motif       complement(1851..1940)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I35_4189_0003"
                     /evalue="2.50E-09"
                     /label="C5_starter_265-294"
                     /locus_tag="I35_4189"
                     /protein_end="305"
                     /protein_start="275"
                     /score="29.6"
                     /tool="antismash"
                     /translation="DIVLSVAAMARTSARERRTPAQCANMLPLR"
     CDS_motif       complement(2280..2339)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I35_4189_0002"
                     /evalue="1.80E-06"
                     /label="C3_starter_134-155"
                     /locus_tag="I35_4189"
                     /protein_end="162"
                     /protein_start="142"
                     /score="20.9"
                     /tool="antismash"
                     /translation="HILVDGYSGSLIATRAAELY"
     CDS_motif       complement(2574..2666)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I35_4189_0001"
                     /evalue="2.80E-12"
                     /label="C2_starter_024-063"
                     /locus_tag="I35_4189"
                     /protein_end="64"
                     /protein_start="33"
                     /score="39.2"
                     /tool="antismash"
                     /translation="AEYFDIRGALDTGAFERALRQVIREAQTLHT"
     gene            complement(2880..3146)
                     /locus_tag="I35_4190"
                     /old_locus_tag="I35_0524"
     CDS             complement(2880..3146)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:G7H9M6"
                     /locus_tag="I35_4190"
                     /old_locus_tag="I35_0524"
                     /product="hypothetical protein"
                     /protein_id="CDN62026.1"
                     /transl_table=11
                     /translation="MSARASPLRRLPAPETVSGELPACRFRLAQQFQASMLNKLPICRL
                     FKTDILIFFPDQTTHPSTKAFTVMALTHYQQNRTELTAANRAV"
     gene            3162..3944
                     /locus_tag="I35_4191"
                     /old_locus_tag="I35_0523"
     CDS             3162..3944
                     /codon_start=1
                     /db_xref="InterPro:IPR016084"
                     /db_xref="InterPro:IPR024423"
                     /db_xref="UniProtKB/TrEMBL:G7H9M5"
                     /locus_tag="I35_4191"
                     /old_locus_tag="I35_0523"
                     /product="PROBABLE REMNANT OF A TRANSPOSASE GENE PROTEIN"
                     /protein_id="CDN62027.1"
                     /transl_table=11
                     /translation="MNQLEGLERKIGEQHERLAHHPVFGSIRTIDELRVFMEWHVFAVW
                     DFMSLVKRLQQDLTTVAVPWVAPRNANASRLINEIVLGEESDETPNGHMSHYDLYLHAM
                     RDVGASTSRIEEMVSLVRSGFSVSAALKAVDAPEPVIRFVEATMAACTSGATHQVLGNF
                     FYGRENVIPDMFRTLLDEWKIERSSIPLLVYYLDRHIEVDSGEHGPAARAMIREAADGD
                     AAKLEEALQAGLDAIDERMRLWDGLLAHLGQTRNVVPA"
     gene            3941..4330
                     /locus_tag="I35_4192"
                     /old_locus_tag="I35_0522"
     CDS             3941..4330
                     /codon_start=1
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR013096"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:G7H9M4"
                     /locus_tag="I35_4192"
                     /old_locus_tag="I35_0522"
                     /product="hypothetical protein"
                     /protein_id="CDN62028.1"
                     /transl_table=11
                     /translation="MNARGLSERIVDFAALEWEHPAAFDDGIDQVVLVDTLDEHAKRGI
                     RTRIVRFDPGAGTRVPFLHDYHEEVHLIDGDQSLVDVATREYRATYREGSYFVRPAGTP
                     HGPFRSDAGCLLLEIHYYGSPEDTR"
     gene            4327..5253
                     /locus_tag="I35_4193"
                     /old_locus_tag="I35_0521"
     CDS             4327..5253
                     /codon_start=1
                     /db_xref="InterPro:IPR025859"
                     /db_xref="UniProtKB/TrEMBL:G7H9M3"
                     /locus_tag="I35_4193"
                     /old_locus_tag="I35_0521"
                     /product="hypothetical protein"
                     /protein_id="CDN62029.1"
                     /transl_table=11
                     /translation="MTTAVTYVSHVDRWEARATVRSRPRRIVEDDELRYYPLERQPLCA
                     HPAIVDAGDAVRDFVLLQSFYKYIQDVIIFETEIVNATALRIARGRFAHPFPFACRQDA
                     MTVVIDEDYHAYVAMDYLRQVEEATGIAPLPPNSEIELSRAIPRAVERVGAQYRDGMEL
                     LCVAISENTVTAEVAAFSRDATLKRSVKGVMADHLADEGRHSAFWINLVKLYWSEIDEP
                     ARLALGEGLPCFLREYLSADLQLQFDRRLIDALDLPAAERARIADDMVGAYPITSQHPM
                     IVNIRQFFRMSGLLDHAPTRAALSDYL"
     gene            5263..8829
                     /locus_tag="I35_4194"
                     /old_locus_tag="I35_0520"
     CDS             5263..8829
                     /NRPS_PKS="Domain: AMP-binding (198-594). E-value: 1.4e-91.
                     Score: 298.9. Matches aSDomain:
                     nrpspksdomains_I35_4194_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (699-770). E-value: 2.5e-17. Score:
                     54.7. Matches aSDomain: nrpspksdomains_I35_4194_PCP.1"
                     /NRPS_PKS="Domain: TD (806-1049). E-value: 1.1e-69. Score:
                     226.2. Matches aSDomain: nrpspksdomains_I35_4194_TD.1"
                     /codon_start=1
                     /db_xref="GOA:G7H9M2"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="InterPro:IPR010080"
                     /db_xref="InterPro:IPR013120"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="UniProtKB/TrEMBL:G7H9M2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 323;
                     E-value: 4.5e-98)"
                     /gene_kind="biosynthetic"
                     /locus_tag="I35_4194"
                     /old_locus_tag="I35_0520"
                     /product="Peptide synthetase"
                     /protein_id="CDN62030.1"
                     /sec_met_domain="AMP-binding (E-value: 4.2e-102, bitscore:
                     330.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.4e-16, bitscore:
                     48.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.7e-60, bitscore:
                     192.2, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIIIAIGGQTRLAARLASELEATGHTVCIADGRDGPLRDAADA
                     LLLPAPAPEPLRNAAEWSIVCGAPDPAVHCAHARPLHCEIVADAFPPREVRVAWLTDAA
                     PGDTRVLADATLAFGAALNGADLADEIAACAVDLMHEVASGIARELSDPNDAPRATPPG
                     PADIVLDLERLAGWHASNDTAAEWPCEPSLPELVSRAAAAAPDACALVAADGQLTYREL
                     VARARQVAARIAARPAAPRVVAVRLDKGVALYPALVGVLGAGATCVPLDPAFPPERART
                     ILRESGAQALVVDGAVEPALLDGFDLDVIDCGAHAKADADASPDALSGQWPLERDADRA
                     ARCAVAIYTSGSTGVPKGVMLSHRNIVQFCHWYRAHVSLDASSRVLQFSTVAFDASLLD
                     MFPTWLAGATLVAPSEAQRRELDALAALVADARITHAFLPPALLAALPDCDWPALAHLV
                     TGGDVCDPDTIARWSANRRLHNIYGPTECTVLATTGELRAGDSNRRIGRPIANARCHVL
                     AADGRPALTGEEGELCIAGAGVGLGYLGRPDLSAERFVADPYGTPGATMYRTGDIASWE
                     PDGTLRYVGRRDAQLKIRGFRVEPGEIETAALAAGLYRQCAVVPDERKRIRLFAAKPVD
                     AAATPDALRAVLAATLPDYMVPYDITALDVLPATPNGKIDRAALARLPVSRAGSDTRDA
                     PRGALEMRLAEMWATLLELAPDEIGRDASFFELGGHSLLVSRLMLAVKRELGGNAALAR
                     FMERPTIAALAALLTDESGERGANVPARVHDDRRLPDDVRLPADQPAGDGPGAVLLTGA
                     NGFLGSFILSELISRTNQIVYCVVRGDDDASARRRLDEAAFVNGLDHLCGHPRVRVLRG
                     DLGAPRLGLSDAVWQTLAAEVGAIHHNGAHVNHVYDYPYLHAENVGSTLELLRLCCSGR
                     RKALHFVSTLSAASATGPTGRLIEAAPSEAGPAFVNNGYNLTKWVSEHLVAEAAARGID
                     TTILRPGNITGHSRTGLCQPGRNRILLLLKGAVQLGCAPLASEGGLFDLSPVDYLARAI
                     VACTLDGARTERVFHLHNPRPLDWAGYLRALARRGYPLRFEAPEIWRERLLSIDESNAL
                     FDVVAFYLDDRQDDIGDMAVIDHARTEATLRRLGVTYPDKDDALLDAHFGYLAECGFMP
                     PPPEPAPRANDARRDAEPEPAW"
     aSDomain        5857..7044
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I35_4194_AMP-binding.1"
                     /evalue="1.40E-91"
                     /label="I35_4194_AMP-binding.1"
                     /locus_tag="I35_4194"
                     /protein_end="594"
                     /protein_start="198"
                     /score="298.9"
                     /specificity="consensus: leu"
                     /tool="antismash"
                     /translation="RAAAAAPDACALVAADGQLTYRELVARARQVAARIAARPAAPRVV
                     AVRLDKGVALYPALVGVLGAGATCVPLDPAFPPERARTILRESGAQALVVDGAVEPALL
                     DGFDLDVIDCGAHAKADADASPDALSGQWPLERDADRAARCAVAIYTSGSTGVPKGVML
                     SHRNIVQFCHWYRAHVSLDASSRVLQFSTVAFDASLLDMFPTWLAGATLVAPSEAQRRE
                     LDALAALVADARITHAFLPPALLAALPDCDWPALAHLVTGGDVCDPDTIARWSANRRLH
                     NIYGPTECTVLATTGELRAGDSNRRIGRPIANARCHVLAADGRPALTGEEGELCIAGAG
                     VGLGYLGRPDLSAERFVADPYGTPGATMYRTGDIASWEPDGTLRYVGRRDAQLKIR"
     aSModule        5857..8409
                     /complete
                     /domains="nrpspksdomains_I35_4194_AMP-binding.1"
                     /domains="nrpspksdomains_I35_4194_PCP.1"
                     /domains="nrpspksdomains_I35_4194_TD.1"
                     /final_module
                     /locus_tags="I35_4194"
                     /monomer_pairings="leu -> leu"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6037..6075
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I35_4194_0001"
                     /evalue="1.40E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="I35_4194"
                     /protein_end="271"
                     /protein_start="258"
                     /score="9.2"
                     /tool="antismash"
                     /translation="GVLGAGATCVPLD"
     CDS_motif       6292..6351
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I35_4194_0002"
                     /evalue="5.50E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="I35_4194"
                     /protein_end="363"
                     /protein_start="343"
                     /score="28.1"
                     /tool="antismash"
                     /translation="AVAIYTSGSTGVPKGVMLSH"
     CDS_motif       6841..6924
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I35_4194_0003"
                     /evalue="3.40E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="I35_4194"
                     /protein_end="554"
                     /protein_start="526"
                     /score="41.7"
                     /tool="antismash"
                     /translation="GEEGELCIAGAGVGLGYLGRPDLSAERF"
     CDS_motif       7009..7074
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_I35_4194_0004"
                     /evalue="3.20E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="I35_4194"
                     /protein_end="604"
                     /protein_start="582"
                     /score="35.2"
                     /tool="antismash"
                     /translation="YVGRRDAQLKIRGFRVEPGEIE"
     aSDomain        7360..7572
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I35_4194_PCP.1"
                     /evalue="2.50E-17"
                     /label="I35_4194_PCP.1"
                     /locus_tag="I35_4194"
                     /protein_end="770"
                     /protein_start="699"
                     /score="54.7"
                     /tool="antismash"
                     /translation="EMRLAEMWATLLELAPDEIGRDASFFELGGHSLLVSRLMLAVKRE
                     LGGNAALARFMERPTIAALAALLTDE"
     aSDomain        7681..8409
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I35_4194_TD.1"
                     /evalue="1.10E-69"
                     /label="I35_4194_TD.1"
                     /locus_tag="I35_4194"
                     /protein_end="1049"
                     /protein_start="806"
                     /score="226.2"
                     /tool="antismash"
                     /translation="VLLTGANGFLGSFILSELISRTNQIVYCVVRGDDDASARRRLDEA
                     AFVNGLDHLCGHPRVRVLRGDLGAPRLGLSDAVWQTLAAEVGAIHHNGAHVNHVYDYPY
                     LHAENVGSTLELLRLCCSGRRKALHFVSTLSAASATGPTGRLIEAAPSEAGPAFVNNGY
                     NLTKWVSEHLVAEAAARGIDTTILRPGNITGHSRTGLCQPGRNRILLLLKGAVQLGCAP
                     LASEGGLFDLSPVDYLARAIV"
     gene            8885..9373
                     /locus_tag="I35_4195"
                     /old_locus_tag="I35_0519"
     CDS             8885..9373
                     /NRPS_PKS="Domain: Polyketide_cyc2 (22-159). E-value:
                     2.3e-22. Score: 71.7. Matches aSDomain:
                     nrpspksdomains_I35_4195_Polyketide_cyc2.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR019587"
                     /db_xref="InterPro:IPR023393"
                     /db_xref="UniProtKB/TrEMBL:G7H9M1"
                     /locus_tag="I35_4195"
                     /old_locus_tag="I35_0519"
                     /product="hypothetical protein"
                     /protein_id="CDN62031.1"
                     /transl_table=11
                     /translation="MLQRTATQPRPSTLVYAPQTPILSGSADLDVPARDAWRVVGDFAG
                     FSRFITGLDHTDMIGEGVRSLRIKHFADGNVVVEQLNSHDDEAMVMTWSLIHTSFDIGN
                     LWALMRVEPRGDHACTVTWDIAGEPSHGGAARQPEFDAFVTGFLDMAMTNLRALFKPQ"
     aSDomain        8951..9361
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_I35_4195_Polyketide_cyc2.1"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="2.30E-22"
                     /label="I35_4195_Polyketide_cyc2.1"
                     /locus_tag="I35_4195"
                     /protein_end="159"
                     /protein_start="22"
                     /score="71.7"
                     /tool="antismash"
                     /translation="LSGSADLDVPARDAWRVVGDFAGFSRFITGLDHTDMIGEGVRSLR
                     IKHFADGNVVVEQLNSHDDEAMVMTWSLIHTSFDIGNLWALMRVEPRGDHACTVTWDIA
                     GEPSHGGAARQPEFDAFVTGFLDMAMTNLRALF"
ORIGIN
        1 tcagcgggcg gtccagcgcg gcaccgcttc gaacgcatgc tcgatcgcat gcacgatccg
       61 gtcgacgtcc tcgcgaccga tcacgagcgg cggcgcgatc gcgagccggt tgccgagcga
      121 gcggatcagc acgccggcat cgcgcgccgc gtcggccagt gcggccgcat agccgtccga
      181 cggatcgatc gattcgcgcg tgaccttgtc cttcacgagg tcgatgccga ccagcaggcc
      241 cttgccgcgc acgtcgccga ccaccggata gcggtcgacc agcggctgca gccgttccag
      301 caggtacgcg ccttcgcgcg ccgcgttgcc ggcgagatcc tcgtcgacga tgatctgcag
      361 gttcgcgagc gcggccgcgc agacgatcgg gtggcccgag taggtgtagc cgtgcatcag
      421 cgtgccgatg ccgcccgggt tggacgcgaa cgcgttctcg atgcgacggt tgacgacggt
      481 cgcgccgagc ggcagatacc ctgacgacac gcccttcgcc aggcacatga tgtcgggcgc
      541 gacgccccag ccgcggctgc cgaacgccgc gccggtccgg ccgaagccgg tcaccacctc
      601 gtcggcgatc agcagcacgc cgtggcggtc gcacacttcg cgcaccagcg gccagtagtt
      661 cgcgggcggc acgatgatgc cgcccgtcgc ctgcaccggt tcggcgatga aggcggccac
      721 ggtatcggga ccctggaaca ggatctcgcg ctcgacgagc gacgcgcaca ggcggccgag
      781 ttcttccggg tcgtgcgtga acgggttgcg atagatccac ggcgtctcga cgtggaagca
      841 gccggcgagc gtcggctcgt agttgcggcg gtagacggtg ttgcccgtga cggagctgcc
      901 gccgaagtgc gagccgtgat aggcctggcg cagcgcgatg aacttggtgc gctcgggctg
      961 cccggacacc ttccagtact gccgcgcgat catcagcgcg gcctcgaccg cgtccgagcc
     1021 gccggagccg aagatcacgc ggctcatgtc ttccggctgg agcatgtcga tcagccgcgc
     1081 cgacagttct tccgcacgcg gatggctgaa cccggcaaac accgggtgat attcgagctc
     1141 gtcgagctgc cggacgatcg cttccttgat ttcccgccgg ccgtggccga cgtacacgtt
     1201 gaacagcgac gcgactgcgt cgagatacgg ccggccggtg tcgtcgtaca gatagcagcc
     1261 ttcgccgcgc gtgatgcgga ccggcgggcg cgacgcggcg agcggatgtt gccggggatg
     1321 ccagaagcgc gattccgaat aggacatgac aggactccgt agtgattcgg tttgacgggg
     1381 caacacggtg acgcaggtgg cgcttagccg gcgagcgccg ccggttgaaa gtcgagccgg
     1441 ctctcgagcg cgccgagcgt cgcgaacggt tcgtcgagcg cgacacgcat gaaagtcagg
     1501 aactggccga cgtgggcgtt cagcgcatca cggctgtagt actgcggact cgcgtcgaag
     1561 tcgaagcgca gcggctcgcc gttgcggcgg tcggtcaggt tcaccatcag gtcgtcggtg
     1621 gtgccgacgg acaggttgtg cgacgtcgtc acgcagtcgc cgaaccgcag gtcgtagtcg
     1681 aacgccatga tgttgatctc ggggccgaac acgccctggc cattgtcgag cgacgtcagc
     1741 tcgcggtgca ggtcgcccat ccggtagcgc tggtgctggc gcagcgcgat catctcgcgg
     1801 ttcgcctggc ggcacagatc gtcgagcgtg tggcccggct cgacgtgcag gcgcagcggc
     1861 agcatgttcg cgcactgcgc cggcgtgcgg cgctcgcgcg ccgacgtgcg cgccatcgcg
     1921 gcgaccgaca gcacgatgtc gtgcgcgccg gtgttcaggt acaggtacgc ggcggtcagc
     1981 gcggtgacga gccgcggcac cgtcgacgtg aagagatccc tggcgaccgc ctcgaggcgt
     2041 gcgctttcgg ttgcggtggc gaggcgcgtc tcgcgcaggt cgggcccgtc gtcgcgctcg
     2101 ggaaagcgtg cggggccggc gagcgtgacc gtgcgcggct ggtccgcgaa gcgctcgagc
     2161 cagtagcggc gatcgtgcgc gaactgttcg gacgcgcggt acgcgtcttc gtccagttgc
     2221 agctccgcga gcgacgcgaa gcgcgcaggc ggcgccttgg cgcccgaggc gaatgcgttg
     2281 tacagctcgg cggcgcgcgt ggcgatcagg ctgcccgaat agccgtcgac caggatgtgc
     2341 gcgtagccgt gataccagta gtagtgatcc ggcgcgatgc ggtacagcgt atggcggaag
     2401 aacggcccgc gcgccagctc gatcgcgccc gtgcagtgtg cgcgcatgcc ggcgagcgcg
     2461 atggcgtgcg cgtctttcgt gccggcgagg gcgacgtgtt cgagcgtcca gtcgtcggcg
     2521 agcgcagcat cgagcacgcg cacgggcgtg tcgccatcca gcacgatccg cgtcgtgtgc
     2581 agcgtctgcg cctcgcggat cacctgccgc agcgcgcgtt cgaatgcgcc ggtgtcgagc
     2641 gcgccgcgaa tgtcgaaata ctcggccgcg tagatatgcg tcgacgggac gggatacgcg
     2701 agcgcggcct cccagaaatc ccgctgcggc gcggacagcg gcaattgaag cgtcgaatcg
     2761 gtcacgtcgt ttctcctgga aaacttattc cggtggatga attaaatgcg cgtatttgtt
     2821 taataaaaaa tacatattcg catcgtgcat ttcatttttg atgaatcgca attcttatcc
     2881 tagacagccc gatttgcggc tgtcaattcc gtgcgatttt gttggtaatg cgtcaaagcc
     2941 atgacggtaa aggctttggt ggatgggtga gtagtctggt ccggaaagaa tatgagaatg
     3001 tccgttttga ataggcggca aattggcagc ttatttagca tcgacgcctg aaattgctgc
     3061 gcaagccgaa aacggcatgc aggcaattcg ccggaaacgg tttccggcgc cggaagccgg
     3121 cgcagtgggc tggcgcgagc ggacattact aggagagtcc cgtgaatcaa ctggaagggc
     3181 tggagcgaaa aatcggcgag cagcacgagc ggctcgcgca tcatccggtg ttcggatcga
     3241 tccgtaccat cgacgagctg cgcgtgttca tggaatggca cgtattcgcc gtgtgggatt
     3301 tcatgtcgct cgtgaagcgg ctgcagcagg acctgaccac cgtcgcggtg ccgtgggtcg
     3361 cgccgcgcaa cgcgaacgcg tcgcgcctga tcaacgagat cgtgctcggc gaggaatcgg
     3421 acgaaacgcc gaacggccac atgagccact acgacctgta cctgcacgcg atgcgcgatg
     3481 tcggcgcgtc gacctcgcgc atcgaggaaa tggtgtcgct ggtgcgctcg ggcttctcgg
     3541 tgtcggccgc gctgaaggcc gtcgatgcgc cggagccggt gatccgcttc gtcgaggcga
     3601 cgatggccgc gtgcacgtcg ggcgcgacgc accaggtgct cggcaacttc ttctacggcc
     3661 gcgagaacgt gattcccgac atgttccgca cgctgctcga cgaatggaag atcgagcgct
     3721 cgtcgatccc gctgctcgtg tattacctcg accgccacat cgaagtggat tcgggcgagc
     3781 acgggccggc ggcgcgcgcg atgatccgcg aggcggccga cggcgacgcg gcgaagctcg
     3841 aggaagcgct gcaggccggg ctcgatgcga tcgacgagcg catgcgtctg tgggacgggc
     3901 tgctcgcgca tctcggccag acccgcaacg tggtgccggc atgaacgcgc gcgggctgtc
     3961 ggagcgcatc gtcgatttcg cggcgctcga gtgggagcac ccggcggcgt tcgacgacgg
     4021 catcgaccag gtcgtgctcg tcgatacgct ggacgagcac gcgaagcgcg gcatccgaac
     4081 ccggatcgtg cggttcgatc ccggcgcggg cacgcgcgtg ccgttcctgc acgactacca
     4141 cgaggaagtg cacctgatcg acggcgacca gagcctggtc gacgtcgcga cgcgcgagta
     4201 tcgcgcgacg tatcgggaag gcagctactt cgtgcgtccg gccggcacgc cgcatggccc
     4261 gttccgcagc gacgcgggct gcctgctgct cgaaatccat tactacggtt ccccggagga
     4321 cacgcgatga cgaccgccgt cacctacgtg agccacgtcg atcgctggga ggcgcgcgcg
     4381 accgtgcgat cgcgcccgcg gcggatcgtc gaggacgacg aactgcgcta ctacccgctc
     4441 gaacgccagc cgctgtgcgc gcacccggcg atcgtcgacg cgggcgatgc ggtgcgcgat
     4501 ttcgtcctgc tgcaaagctt ctacaagtac atccaggacg tgatcatctt cgagacggag
     4561 atcgtcaacg ccaccgcgtt gcggatcgcg cgcggccgct tcgcgcaccc gtttccgttc
     4621 gcatgccggc aggatgcgat gaccgtcgtg atcgacgagg actaccacgc gtacgtcgcg
     4681 atggactacc tgcggcaggt cgaggaggcc accggcatcg cgccgctgcc gccgaacagc
     4741 gagatcgagc tgtcgcgggc gattccgcgc gcggtcgagc gggtcggcgc gcagtatcgc
     4801 gacggcatgg agctgctgtg cgtcgcgatc tcggagaaca cggtcacggc ggaagtcgcg
     4861 gcgttctcgc gcgacgcgac gctcaagcgc tcggtgaagg gcgtgatggc cgatcacctc
     4921 gcggacgaag gccgtcactc ggcgttctgg atcaatctcg tgaagctgta ctggtcggag
     4981 atcgacgaac ccgcgcggct cgcgctcggc gaagggctgc cgtgcttcct gcgcgaatac
     5041 ctgagcgccg acctgcaact gcagttcgat cgccgcctga tcgatgcgct cgatctgccg
     5101 gccgccgagc gtgcgcggat cgcggacgac atggtcggcg cgtatccgat cacgagccag
     5161 catccgatga tcgtcaacat ccggcagttc ttccggatga gcggcctgct cgatcacgcg
     5221 ccgacccgcg cggccttgtc cgactacctg tgagtcacgt cgatgaaagc gatcatcatt
     5281 gcgatcggcg ggcagacccg tctcgccgca cggctggcgt ctgaactcga ggcgaccggt
     5341 cataccgtct gtatcgccga cggacgcgac ggcccgctgc gcgacgcggc cgatgcgctg
     5401 ctgttgccgg cgccggcgcc cgaaccgttg cgcaacgcgg ccgagtggtc gatcgtctgc
     5461 ggcgcgccgg accccgccgt gcactgcgcg cacgcacggc cgctgcattg cgagatcgtc
     5521 gccgatgcat ttccgccgcg cgaggtacgc gtcgcgtggc tgaccgacgc ggcgccgggc
     5581 gacacgcgcg tgctggccga cgcgacgctc gcgttcggcg cggcgctcaa cggcgccgat
     5641 ctcgcggacg agatcgccgc gtgcgcggtc gatctgatgc acgaagtcgc gagcgggatc
     5701 gcccgcgagc tgagcgaccc gaacgacgcg ccgcgcgcga cgccgcccgg gccggccgac
     5761 atcgtgctcg atctcgaacg gctggccggc tggcatgcgt cgaacgacac ggcggccgaa
     5821 tggccgtgcg agccgtcgct gccggagctc gtgtcgcgtg cggcggccgc cgcgccggac
     5881 gcctgcgcgc tcgtcgcggc cgatggccaa ctgacctatc gcgagctggt cgcgcgtgcc
     5941 cgccaggttg ccgcgcgcat tgccgcgcgg cccgctgcgc cgcgcgtggt cgcggtgcgg
     6001 ctcgacaagg gcgtcgcgct gtatccggcg ctcgtcggcg tgctgggcgc cggcgcgacc
     6061 tgcgtgccac tcgatccggc gtttccgccc gaacgggccc gcacgatcct gcgtgaatcg
     6121 ggggcgcagg cgctcgtcgt cgacggtgcg gtcgagccgg cgctgctcga cggattcgac
     6181 ctcgacgtga tcgactgcgg cgcgcacgcg aaagcggacg cggacgcctc gcccgatgcg
     6241 ctgtccggcc agtggccgct cgaacgcgat gcggatcgcg ctgcgcgctg cgcggtcgcg
     6301 atctacacgt cggggtcgac cggcgtgccg aagggcgtga tgctgtcgca ccggaacatc
     6361 gtgcagttct gccactggta tcgcgcgcac gtgtcgctcg atgcgtcgtc gcgcgtgctg
     6421 cagttctcga cggtcgcgtt cgatgcgtcg ctgctcgaca tgttcccgac ctggctcgcc
     6481 ggcgcgacgc tggtcgcgcc gagcgaggcg cagcgccgcg aactcgacgc gctcgcggcg
     6541 ctcgtcgccg acgcgcgcat cacgcacgcg ttcctgccgc ccgcgctgct cgcggcgctg
     6601 ccggattgcg actggcccgc gctcgcgcat ctcgtcacgg gcggcgacgt gtgcgacccc
     6661 gacacgatcg cacgctggag cgcgaaccgg cggctgcaca acatctacgg gccgaccgaa
     6721 tgcacggtgc tcgcgacgac gggcgaactg cgcgccggcg acagcaaccg gcgcatcggc
     6781 cggccgatcg cgaacgcgcg ctgccatgtg ctcgcggccg acggccgtcc ggcgctcacc
     6841 ggcgaggaag gcgagctgtg catcgccggc gcgggcgtcg ggctcggcta tctcggccgg
     6901 cccgacctga gcgccgagcg tttcgtcgcc gatccgtacg gcacgccggg cgcgacgatg
     6961 taccggaccg gcgacatcgc gagctgggag ccagacggca cgctgcgtta cgtgggccgc
     7021 cgcgacgcgc aactgaagat tcgcggtttt cgcgtcgagc cgggcgagat cgagacggcc
     7081 gcgctggcgg cggggttgta ccgccagtgc gcggtggtgc ccgacgagcg caagcgcatc
     7141 cgcctgttcg ccgcgaagcc ggtcgacgcg gcggcgacgc ccgacgcgct gcgcgccgtg
     7201 ctggccgcca cgctgcccga ctacatggtg ccgtacgaca tcacggcgct cgacgtattg
     7261 cccgcgacgc cgaacggcaa gatcgaccgg gctgcgctgg cgcgcctgcc ggtgtcgcgt
     7321 gcgggaagcg acacccgcga cgccccgcgc ggcgcgctgg agatgcgtct cgccgagatg
     7381 tgggccacgt tgctcgaact cgcgccggac gagatcggcc gcgatgcgtc gttcttcgaa
     7441 ctgggcggcc attcgttgct ggtgtcgcgg ctgatgctgg cggtgaagcg cgagctgggc
     7501 ggcaacgcgg cgctcgcgcg tttcatggag cggccgacca tcgccgcgct cgcggcgctg
     7561 ctgaccgacg agtcgggcga gcgcggcgcg aacgtgccgg cgcgcgtgca cgacgaccgc
     7621 cgcctgcccg acgacgtgcg actgccggcc gaccagccgg cgggcgacgg ccccggcgcg
     7681 gtgctgctga ccggcgcgaa cggcttcttg ggcagcttca tcctcagcga actgatcagc
     7741 cgcacgaacc agatcgtcta ttgcgtggtg cgcggcgacg acgatgcgag cgcgcgccgg
     7801 cggctcgacg aagcggcgtt cgtcaacggg ctcgaccatc tgtgcgggca tccgcgcgtg
     7861 cgggtgctgc gcggcgatct cggcgcaccg cgcctcgggc tgtcggatgc ggtgtggcag
     7921 acgctcgcgg ccgaggtcgg cgcgattcat cataacggcg cacacgtgaa tcacgtgtac
     7981 gactacccgt acctgcacgc ggagaacgtc ggctcgacgc tcgaactgct ccgcctgtgc
     8041 tgcagcggcc gccgcaaggc gctgcatttc gtatcgacgc tatccgcggc gagcgcgacg
     8101 ggcccgacgg gccgcctgat cgaggcggcc ccgtcggagg ccggccctgc cttcgtcaac
     8161 aacggctaca acctgacgaa gtgggtgtcc gagcatctcg ttgccgaagc ggctgcgcgc
     8221 gggatcgaca cgacgatcct gcggcccggc aacatcacgg gccattcgcg cacggggctg
     8281 tgccagccgg gacgcaaccg gatcctgctg ctgctcaagg gtgcggtgca gctcggctgc
     8341 gcgccgctcg cgagcgaggg cgggctgttc gacctgagcc cggtcgacta cctggcgcgg
     8401 gcgatcgtcg cgtgcacgct cgacggtgcg cgcaccgagc gcgtgttcca tctgcacaac
     8461 ccgcgtccgc tcgactgggc cggctatctg cgcgcactcg cgcggcgcgg ctatccgctg
     8521 cgtttcgagg cgcccgagat ctggcgcgag cggctgttgt cgatcgacga atcgaatgcg
     8581 ctgttcgacg tcgtcgcgtt ctatctcgac gaccggcagg acgatatcgg cgacatggcc
     8641 gtgatcgatc acgcgcgcac cgaggcgacg ctgcgccggc tcggcgtcac gtatccggac
     8701 aaggacgacg cgctgctcga tgcgcatttc ggctatctcg ccgaatgcgg cttcatgccg
     8761 ccgccgcccg aaccggcgcc gcgcgcgaac gacgcccgcc gcgacgccga gcccgaaccc
     8821 gcgtggtgaa gacgtacccc gtttgatcaa tcgctgtcat cgcatcattc atcaaggagg
     8881 catcatgctg caacgtactg caacgcaacc ccgtccgtcc acgctcgtct acgcgccgca
     8941 aacgccgatc ctgtccggct cggccgatct cgacgtgccg gcgcgcgacg cgtggcgcgt
     9001 ggtcggcgat ttcgccggct tctcgcgctt catcacgggg ctcgaccata ccgacatgat
     9061 cggtgaaggc gtgcgctcgc tgcgcatcaa gcatttcgcg gacggcaacg tcgtcgtcga
     9121 acagctcaac agccacgacg acgaagcgat ggtgatgacg tggagcctga tccatacgtc
     9181 gttcgacatc ggcaatctgt gggcgctgat gcgcgtcgaa ccgcgcggcg accacgcctg
     9241 cacggtgacg tgggatatcg ccggcgaacc gtcgcacggc ggcgccgcgc gccagccgga
     9301 attcgacgcg ttcgtcaccg gctttctcga catggcgatg acgaacctgc gcgcgctgtt
     9361 caagccgcag taa
//
