BGC0001600 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001600 (Fusarium graminearum (Gibberella zeae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS-like,T1PKS	1	58,806	High	fusarielin H	PKS

BGC0001600 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 58,806 nt. (total: 58,806 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 58,807
Label		BGC0001600

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

FGRAMPH1_01T08157: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

FGRAMPH1_01T08159: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: ligase synthase

FGRAMPH1_01T08155: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FGRAMPH1_01T08165: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001600.3	2.00	PKS	fusarielin H	Fusarium graminearum
BGC0002192.3	0.90	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.90	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.80	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001160.5	0.58	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.58	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001600.3	1.00	PKS	fusarielin H	Fusarium graminearum
BGC0002192.3	0.75	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.75	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.72	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 58806:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 43460:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 10582 - 58806:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FGRAMPH1_01T08155: X

AMP-binding (72..332): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFGTSGTILK
Nearest Stachelhaus code(s):: Ser DFDTFGGILK (29% 8Å match)
Stachelhaus code match:: 60% (weak)

FGRAMPH1_01T08165: pk

PKS_AT (565..888): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 68.5
Methoxymalonyl-CoA: 54.8
Ethylmalonyl-CoA: 41.9
Propionyl-CoA: 24.4
Isobutyryl-CoA: 24.1
fatty_acid: 20.7
Benzoyl-CoA: 16.0
trans-1,2-CPDA: 11.9
2-Methylbutyryl-CoA: 10.3
CHC-CoA: 9.5
3-Methylbutyryl-CoA: 8.9
Acetyl-CoA: 8.7
Malonyl-CoA: 4.2
inactive: 0.0

Link to PARAS substrate predictor