BGC0001614: hassallidin E biosynthetic gene cluster from Planktothrix serta PCC 8927
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Location: 1 - 47,882 nt. (total: 47,882 nt).
This entry is originally from NCBI GenBank LT546031.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001614
Short description hassallidin E biosynthetic gene cluster from Planktothrix serta PCC 8927
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: LT546031.1
Compounds
  • hassallidin E
Species Planktothrix serta PCC 8927 [taxonomy]
References
Chemical products information
hassallidin E
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C64H103N11O24
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PL8927_110032
  • CZT62779.1
  • hasK
 1 - 1320 (+) major facilitator transporter, involved in Hassallidin biosynthesis
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  • PL8927_110033
  • CZT62780.1
  • hasF
 1352 - 2992 (+) membrane hypothetical protein, involved in Hassallidin biosynthesis
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  • PL8927_110034
  • CZT62781.1
 2968 - 3087 (+) hypothetical protein
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  • PL8927_110035
  • CZT62782.1
 3041 - 4153 (+) membrane protein with putative acyltransferase activity
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  • PL8927_110036
 4228 - 4764 (+)
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  • PL8927_110037
  • CZT62784.1
  • hasO
 4811 - 15850 (-) Non-ribosomal peptide synthase, involved in Hassallidin biosynthesis
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  • PL8927_110038
  • CZT62785.1
  • hasN
 15874 - 24963 (-) Non-ribosomal peptide synthase, involved in Hassallidin biosynthesis
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  • PL8927_110039
  • CZT62786.1
  • hasM
 24979 - 25557 (-) Aspartyl/asparaginyl beta-hydroxylase family protein, involved in Hassallidin biosynthesis
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  • PL8927_110040
  • CZT62787.1
  • hasL
 25753 - 26517 (+) 3-oxoacyl-(Acyl-carrier-protein) reductase, involved in Hassallidin biosynthesis
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  • PL8927_110041
  • CZT62788.1
  • hasT
 26539 - 27273 (+) Glycosyltransferase DXD motif-containing protein, involved in Hassallidin biosynthesis
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  • PL8927_110042
  • CZT62789.1
  • hasA
 27319 - 28971 (-) ABC-type uncharacterized transport system, permease and ATPase components, involved in Hassallidin biosynthesis
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  • PL8927_110043
  • CZT62790.1
  • hasZ
 29031 - 30317 (+) major facilitator superfamily transporter, involved in Hassallidin biosynthesis
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  • PL8927_110044
  • CZT62791.1
  • hasU
 30314 - 30544 (-) conserved hypothetical protein, MbtH-like, involved in Hassallidin biosynthesis
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  • PL8927_110045
  • CZT62792.1
  • hasV
 30541 - 36987 (-) non-ribosomal peptide synthase involved in Hassallidin biosynthesis
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  • PL8927_110046
  • CZT62793.1
  • hasB
 37058 - 39079 (-) glycosyl hydrolase, involved in Hassallidin biosynthesis
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  • PL8927_110047
  • CZT62794.1
  • hasY
 39402 - 47882 (-) Non-ribosomal peptide synthase involved in Hassallidin biosynthesis
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
hasO
Module ?
Specificity: 2,3-dihydroxyhexadecanoic acid
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Sequence-based prediction
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Sequence-based prediction
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Sequence-based prediction
hasN
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Sequence-based prediction
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Sequence-based prediction
hasV
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Sequence-based prediction
Module ?
Specificity: glutamine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Sequence-based prediction
hasY
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Sequence-based prediction
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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