BGC0001620: ilamycin B1 biosynthetic gene cluster from Streptomyces atratus
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Location: 5,862 - 63,617 nt. (total: 57,756 nt).
This entry is originally from NCBI GenBank KY173348.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001620
Short description ilamycin B1 biosynthetic gene cluster from Streptomyces atratus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
KY173348.1
5862 - 63617
via
Compounds
  • ilamycin B1
  • ilamycin B2
  • ilamycin C1
  • ilamycin C2
  • ilamycin D
  • ilamycin E1
Species Streptomyces atratus [taxonomy]
References
Chemical products information
ilamycin B1 Evidence:
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C54H77N9O10
Chemical database entries
PubCHEM
ilamycin B2 Evidence:
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C54H77N9O11
Chemical database entries
PubCHEM
ilamycin C1 Evidence:
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C54H75N9O12
Chemical database entries
PubCHEM
ilamycin C2 Evidence:
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C54H75N9O12
Chemical database entries
PubCHEM
ilamycin D Evidence:
(no structure information available)
ilamycin E1 Evidence:
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C54H75N9O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ASX95222.1
 5862 - 6143 (+) lactate permease
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    • ASX95223.1
    		 6524 - 6841 (+) IlaA
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      • ASX95224.1
      		 6952 - 8013 (+) IlaB
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        • ASX95225.1
        		 8087 - 8890 (-) IlaC
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          • ASX95226.1
          		 8930 - 10234 (+) IlaD
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            • ASX95227.1
            		 10374 - 24878 (+) IlaE
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              • ASX95228.1
              		 24895 - 25638 (+) IlaF
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                • ASX95229.1
                		 26173 - 26412 (+) IlaG
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                  • ASX95230.1
                  		 26412 - 27554 (+) IlaH
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                    • ASX95231.1
                    		 27632 - 28117 (+) IlaI
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                      • ASX95232.1
                      		 28125 - 29180 (+) IlaJ
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                        • ASX95233.1
                        		 29177 - 30010 (+) IlaK
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                          • ASX95234.1
                          		 30145 - 31353 (+) IlaL
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                            • ASX95235.1
                            		 31634 - 32896 (+) IlaM
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                              • ASX95236.1
                              		 32874 - 34058 (+) IlaN
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                                • ASX95237.1
                                		 34080 - 35201 (+) IlaO
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                                  • ASX95238.1
                                  		 35340 - 35756 (+) IlaP
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                                    • ASX95239.1
                                    		 35787 - 36677 (-) IlaQ
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                                      • ASX95240.1
                                      		 36889 - 38088 (+) IlaR
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                                        • ASX95241.1
                                        		 38204 - 62272 (+) IlaS
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                                          • ASX95242.1
                                          		 62391 - 63617 (-) IlaT
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                                            Biosynthesis information

                                            Biosynthetic modules

                                            Name
                                            Unk01
                                            Type
                                            nrps-type1
                                            Genes
                                            ASX95241.1
                                            Substrates
                                            1-(1,1-dimethylallyl)-tryptophan (evidence: Knock-out studies, Structure-based inference)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk02
                                            Type
                                            nrps-type1
                                            Genes
                                            ASX95241.1
                                            Substrates
                                            leucine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk03
                                            Type
                                            nrps-type1
                                            Genes
                                            ASX95241.1
                                            Substrates
                                            3-nitrotyrosine (evidence: Knock-out studies, Structure-based inference)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk04
                                            Type
                                            nrps-type1
                                            Genes
                                            ASX95241.1
                                            Substrates
                                            alanine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk05
                                            Type
                                            nrps-type1
                                            Genes
                                            ASX95241.1
                                            Substrates
                                            leucine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk06
                                            Type
                                            nrps-type1
                                            Genes
                                            ASX95241.1
                                            Substrates
                                            leucine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk07
                                            Type
                                            nrps-type1
                                            Genes
                                            ASX95241.1
                                            Substrates
                                            2S-amino-4-hexenoic acid (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Annotation changelog

                                            Entry version: 4

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Add iliamycin compound details
                                            • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Updated bioactivity data
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Added NRP substrate specificities
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2018-08-06
                                            Submitted
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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