BGC0001620: ilamycin B1 biosynthetic gene cluster from Streptomyces atratus
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Location: 5,862 - 63,617 nt. (total: 57,756 nt).
This entry is originally from NCBI GenBank KY173348.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001620
Short description ilamycin B1 biosynthetic gene cluster from Streptomyces atratus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: KY173348.1
Compounds
  • ilamycin B1
  • ilamycin B2
  • ilamycin C1
  • ilamycin C2
  • ilamycin D
  • ilamycin E1
Species Streptomyces atratus [taxonomy]
References
Chemical products information
ilamycin B1
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C54H77N9O10
Chemical database entries
PubCHEM
ilamycin B2
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C54H77N9O11
Chemical database entries
PubCHEM
ilamycin C1
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C54H75N9O12
Chemical database entries
PubCHEM
ilamycin C2
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C54H75N9O12
Chemical database entries
PubCHEM
ilamycin D
(no structure information available)
ilamycin E1
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C54H75N9O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ASX95222.1
 5862 - 6143 (+) lactate permease
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  • ASX95223.1
 6524 - 6841 (+) IlaA
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  • ASX95224.1
 6952 - 8013 (+) IlaB
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  • ASX95225.1
 8087 - 8890 (-) IlaC
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  • ASX95226.1
 8930 - 10234 (+) IlaD
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  • ASX95227.1
 10374 - 24878 (+) IlaE
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  • ASX95228.1
 24895 - 25638 (+) IlaF
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  • ASX95229.1
 26173 - 26412 (+) IlaG
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  • ASX95230.1
 26412 - 27554 (+) IlaH
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  • ASX95231.1
 27632 - 28117 (+) IlaI
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  • ASX95232.1
 28125 - 29180 (+) IlaJ
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  • ASX95233.1
 29177 - 30010 (+) IlaK
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  • ASX95234.1
 30145 - 31353 (+) IlaL
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  • ASX95235.1
 31634 - 32896 (+) IlaM
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  • ASX95236.1
 32874 - 34058 (+) IlaN
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  • ASX95237.1
 34080 - 35201 (+) IlaO
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  • ASX95238.1
 35340 - 35756 (+) IlaP
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  • ASX95239.1
 35787 - 36677 (-) IlaQ
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  • ASX95240.1
 36889 - 38088 (+) IlaR
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  • ASX95241.1
 38204 - 62272 (+) IlaS
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  • ASX95242.1
 62391 - 63617 (-) IlaT
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ASX95241.1
Module ?
Specificity: 1-(1,1-dimethylallyl)-tryptophan
Evidence for specificity:
  • Knock-out studies
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 3-nitrotyrosine
Evidence for specificity:
  • Knock-out studies
  • Structure-based inference
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 2S-amino-4-hexenoic acid
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: SJG3CBEHSM6A3I74YXLH6GLA, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Add iliamycin compound details
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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