BGC0001621: imizoquin A biosynthetic gene cluster from Aspergillus flavus NRRL3357
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Location: 25,905 - 53,073 nt. (total: 27,169 nt).
This entry is originally from NCBI GenBank NW_002477244.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001621
Short description imizoquin A biosynthetic gene cluster from Aspergillus flavus NRRL3357
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NW_002477244.1
25905 - 53073
via
Compounds
  • imizoquin A
  • imizoquin B
  • imizoquin C
  • imizoquin D
  • TMC-2A
  • TMC-2B
Species Aspergillus flavus NRRL3357 [taxonomy]
References
Chemical products information
imizoquin A Evidence:
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C28H30N4O9
Chemical database entries
PubCHEM
imizoquin B Evidence:
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C28H30N4O10
Chemical database entries
PubCHEM
imizoquin C Evidence:
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C28H32N4O10
Chemical database entries
PubCHEM
imizoquin D Evidence:
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C28H28N4O10
Chemical database entries
PubCHEM
TMC-2A Evidence:
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C28H34N4O9
Chemical database entries
NPAtlas
TMC-2B Evidence:
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C28H34N4O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFLA_064240
  • XP_002379984.1
 29095 - 35391 (-) nonribosomal peptide synthase, putative
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    • AFLA_064250
    • XP_002379985.1
    		 36311 - 37102 (+) phenol 2-monooxygenase, putative
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      • AFLA_064260
      • XP_002379986.1
      		 38582 - 40510 (-) oligopeptide transporter, putative
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        • AFLA_064270
        • XP_002379987.1
        		 41154 - 42314 (+) gibberellin 2-oxidase, putative
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          • AFLA_064280
          • XP_002379988.1
          		 42851 - 44016 (+) N-methyltransferase, putative
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            • AFLA_064290
            • XP_002379989.1
            		 44443 - 45186 (-) O-methyltransferase, putative
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              • AFLA_064300
              • XP_002379990.1
              		 45453 - 46964 (-) fructosyl amino acid oxidase, putative
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                • AFLA_064310
                • XP_002379991.1
                		 47408 - 47725 (+) hypothetical protein
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                  • AFLA_064320
                  • XP_002379992.1
                  		 47758 - 50991 (+) oligopeptide transporter, putative
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                    • AFLA_064330
                    • XP_002379993.1
                    		 51418 - 53073 (-) conserved hypothetical protein
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      AFLA_064240
                      Substrates
                      tryptophan (evidence: Sequence-based prediction, Structure-based inference, Mass spectrometry)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      AFLA_064240
                      Substrates
                      tyrosine (evidence: Sequence-based prediction, Structure-based inference, Mass spectrometry)
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Added missing compound details
                      • (ID: YQF4634PJETKNUL6ADZ4RRW4)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2018-08-06
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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