BGC0001621 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001621 (Aspergillus flavus NRRL3357)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	27,169	imizoquin A/imizoquin B/imizoquin C/imizoquin D/TMC-2A/TMC-2B	NRPS:Type I	100%

BGC0001621 - Region 1 - NRPS

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Location: 1 - 27,169 nt. (total: 27,169 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 27,170
Label		BGC0001621

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001621	1.00	NRP	imizoquin A, imizoquin B, imizoquin C, imizoquin D, TMC-2A, TMC-2B	Aspergillus flavus NRRL3357
BGC0001527	0.31	Other	basidioferrin	Gelatoporia subvermispora
BGC0000457	0.28	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000342	0.26	NRP	enniatin	Fusarium equiseti
BGC0000313	0.26	NRP	beauvericin	Beauveria bassiana
BGC0001261	0.25	NRP	AM-toxin	Alternaria alternata
BGC0002157	0.24	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001166	0.24	NRP	HC-toxin	Alternaria jesenskae
BGC0002135	0.24	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.24	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001621	1.00	NRP	imizoquin A, imizoquin B, imizoquin C, imizoquin D, TMC-2A, TMC-2B	Aspergillus flavus NRRL3357
BGC0001527	0.64	Other	basidioferrin	Gelatoporia subvermispora
BGC0000457	0.61	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000342	0.60	NRP	enniatin	Fusarium equiseti
BGC0000313	0.60	NRP	beauvericin	Beauveria bassiana
BGC0001261	0.59	NRP	AM-toxin	Alternaria alternata
BGC0002157	0.58	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001166	0.58	NRP	HC-toxin	Alternaria jesenskae
BGC0002135	0.57	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.57	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 27169:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp - Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFLA_064240

Search NORINE for peptide: strict or relaxed

AMP-binding (229..622): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIEMHGGVVK
Nearest Stachelhaus code(s):: Trp DIEMHGGVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1335..1740): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVDDKGIVVK
Nearest Stachelhaus code(s):: Tyr DVDDKGIVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)