LOCUS       BGC0001622             23603 bp    DNA     linear   BCT 15-APR-2017
DEFINITION  Streptomyces sp. strain Go66 isatropolone gene cluster, complete
            sequence.
ACCESSION   BGC0001622
VERSION     BGC0001622
KEYWORDS    .
SOURCE      Streptomyces sp
  ORGANISM  Streptomyces sp.
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 02:58:48
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 23603
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..762
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1171:transcriptional regulator, MerR family (Score:
                     122.2; E-value: 5.5e-37)"
                     /gene_kind="regulatory"
                     /note="transcriptional activator"
                     /product="IstA"
                     /protein_id="ARG41904.1"
                     /transl_table=11
                     /translation="MVWPIAEVARMSGVTARTLRHYDEIGLLPPAGTGSNGHRCYGEGE
                     LLRLQQILVLRALGLGLPEIGRILASQVDEVEALRGHHRRLLAERDRIDALAGTVSRTI
                     TELEDSRKDGGPMTAINRPENLFEGVRPSQYRDSLRDFPGLAGDIDRHTSTMSEEQIEA
                     GHRERTAQMIRLAELLVAGVPAEADPVQAEIEAQHRALTGLRAVSAEEYRAIGRSCVEN
                     EQWRAAYEAIAPGLAVYQRDAIEAYVSTRLS"
     source          1..23603
                     /db_xref="taxon:1931"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp."
                     /strain="Go66"
     misc_feature    1..23603
                     /note="isatropolone gene cluster"
     protocluster    1..23603
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[7675:10242]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="7 (Score: 676.5; E-value:
                     2.6e-206)"
                     /t2pks_molecular_weights="butyryl-CoA_7 (Da): 528.547"
                     /t2pks_molecular_weights="2-methylbutyryl-CoA_7 (Da):
                     542.573"
                     /t2pks_starter_units="butyryl-CoA (Score: 469.0; E-value:
                     5.21e-171)"
                     /t2pks_starter_units="2-methylbutyryl-CoA (Score: 211.0;
                     E-value: 1.49e-66)"
                     /tool="antismash"
     proto_core      7676..10242
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="7 (Score: 676.5; E-value:
                     2.6e-206)"
                     /t2pks_molecular_weights="butyryl-CoA_7 (Da): 528.547"
                     /t2pks_molecular_weights="2-methylbutyryl-CoA_7 (Da):
                     542.573"
                     /t2pks_starter_units="butyryl-CoA (Score: 469.0; E-value:
                     5.21e-171)"
                     /t2pks_starter_units="2-methylbutyryl-CoA (Score: 211.0;
                     E-value: 1.49e-66)"
     cand_cluster    1..23603
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..23603
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001622"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23603
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(832..1446)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 64.8; E-value: 2.2e-19)"
                     /gene_kind="regulatory"
                     /note="regulator"
                     /product="IstB"
                     /protein_id="ARG41905.1"
                     /transl_table=11
                     /translation="MSPRGVTTPDVRERLFAAAERVLERDGPGALTSRAIAAEAGCAKG
                     LLHAHFRGLDEFVAELVLDRFGRVARHADELRGRAGQGTVAENLLGIALALLSSAGPTV
                     AGLALARPVASAHIREALVGGAPGFDTVQDAITDYLDAERRGGRIAERADTAAAALALV
                     GTVHHLLMTGTHDRQRERERAGQLVVLLDAALRHGPGGIEG"
     CDS             1599..2444
                     /NRPS_PKS="Domain: oMT (38-147). E-value: 7e-12. Score:
                     35.9. Matches aSDomain: nrpspksdomains_ARG41906.1_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 110.1; E-value: 2e-33)"
                     /gene_functions="biosynthetic-additional (t2pks) MET
                     (Score: 32.2; E-value: 1.3e-10)"
                     /gene_kind="biosynthetic-additional"
                     /note="O-methyltransferase"
                     /product="IstC"
                     /protein_id="ARG41906.1"
                     /transl_table=11
                     /translation="MRHIANRDQDQAWNGYEGTFWAANQDRWDGVNGGFDEPLLAAAAI
                     TGGDRVLDIGCGAGRTTRLAARRAGDGRALGLDLSAPMLGRARESARGEGIGNVTFEQA
                     DIQVHPFGTGSFDVAISRFGVMFFADPVAAFANIGRALRPGGRIAFVCTARADRNEWLQ
                     AIRGLGDLLPVGGLGTSANPGMFSLADPETVRDVLSRAGYEAIGTTPAEAYGTWGRDAS
                     DAAAFLLDSGPGRHLLSRAGEDDRTRARQRLVDLLRPHEREGALRLRSAALLVTARRPG
                     "
     aSDomain        1713..2039
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARG41906.1_oMT.1"
                     /domain_subtype="oMT"
                     /evalue="7.00E-12"
                     /label="ARG41906.1_oMT.1"
                     /locus_tag="ARG41906.1"
                     /protein_end="147"
                     /protein_start="38"
                     /score="35.9"
                     /tool="antismash"
                     /translation="LLAAAAITGGDRVLDIGCGAGRTTRLAARRAGDGRALGLDLSAPM
                     LGRARESARGEGIGNVTFEQADIQVHPFGTGSFDVAISRFGVMFFADPVAAFANIGRAL
                     RPGGR"
     CDS             complement(2535..4007)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 388.8; E-value:
                     4.5e-118)"
                     /gene_kind="transport"
                     /note="drug resistance transporter"
                     /product="IstD"
                     /protein_id="ARG41907.1"
                     /transl_table=11
                     /translation="MTASAAPNAPADPRRWSALALIALAQFMVIMDTSIIGVALPRMQA
                     DLGFSQENLSWVFNAYVVAFGGLLLLGGRLSDLLGAKRLFSAGWIVLAAGSLTAGLAGE
                     VWVELTGRAVQGVGAALIAPSALTLLMTLFGSRPQELGKAFALYGAAAPAGGTAGVFLG
                     GVITQYASWPWVFYINIPVALVVLIATPAVMPSGAGRRGSIDLAGAVTVTAGLAAGVYA
                     IVRAPETGWGSAETWLVLLGGVVLIAAFVAIQAKRREPLMRLGIWRAPNLAGANIAQLL
                     MAAAWIPMWFFLNLYLQQVLGLDAFASGSALLPMTVAIMIMMIVLAPRLISRFGPKPLI
                     VLGLFALGAGMFWLSLARPDGNFWVDVLPASLLSAVGMSLAFIPSLGTALSSARPEEGG
                     LASGIVNTSYQVGSALGLAAMTAIAAAHGAREPGDPVALTDGFSAAFLGAAALAVIGGL
                     AALLTLRTTPAAEGAGNGDGEGGGGRPEKAAA"
     CDS             4279..5859
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 473.9;
                     E-value: 1.3e-143)"
                     /gene_kind="biosynthetic-additional"
                     /note="regulatorFAD-like oxidase"
                     /product="IstE"
                     /protein_id="ARG41908.1"
                     /transl_table=11
                     /translation="MAHVTRSAPHREGAVAERGGGSPASSTVYPGDPRYEDLALRRRNE
                     RFVQRPACFRVVRSTDEVVAAVQWAVDSGRPVSVRSGGHSLENSVGEHPDGVIIDMTGM
                     NAIHFDPDRRAVVLESGATLGEVYRTLYLTWGVTVPGGWCHSVCVGGHIQGGGYGSLSR
                     SHGSVVDHLYAVEVVVVDEAGRARAVLATRESGDPHHDLWWAHTGGGGGNFGVVTRYWL
                     RSPGAEGDDPADLLPRPPASLTGGVLMWSWADLPKESFRRLMRNHADWHENNSDPDSPG
                     TALHSTLMLSGRKEQDSPTDILIYALADGDGADGAALVEKYFDALSDGVGGTRHMIPAA
                     PWLYVLMPPNGDEESQRGSEYGRYKGKAGYLRKGFSAAQVDTVFDHLTTAPPMLDMARV
                     WLVSYGGKVNDVAPEATALVQRDSVLKAAYTATWLDPRDDEASLDWLRRFYRDVYRETG
                     GVPVPDGTNDGSYINYPDTDLADPDWNTSGVPWHDLYYKQNYPRLRRVKKRWDPRNVFR
                     HALSIQPAD"
     CDS             6305..7195
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     276; E-value: 1.3e-83)"
                     /gene_kind="regulatory"
                     /note="SARP regulator"
                     /product="IstF"
                     /protein_id="ARG41909.1"
                     /transl_table=11
                     /translation="MYFKVLGALDVSESTKDLTPSAPKLRSTLSLLLLRQGDIVRKDLF
                     VDELWGVNPPPNALTTLQTYVYQLRRTLPDPQTRRAGHRPRGHAWKEATAGPSHGPWLR
                     TTSSGYCASIPPETIDLCRFETLAAQGGTALRQGNVPRAAELLEEALTLWRGPLVSNVK
                     HGPVLEAHATGLTEERLRVVEQCVDTQLFLGRYHEVLTGLRGLLVEHPLAEGLWQRLLL
                     ALYRSGRRLEAIQEYRRLHRILGDGLGLEPSRSVQRLYEAVLASDPAPDLERIALSAWR
                     DRAVIRPGGVSRHVA"
     CDS             7365..7619
                     /NRPS_PKS="Domain: PP-binding (14-76). E-value: 6.9e-17.
                     Score: 53.6. Matches aSDomain:
                     nrpspksdomains_ARG41910.1_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 71.2; E-value:
                     9.3e-22)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 67.3; E-value: 2.1e-21)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl carrier protein"
                     /product="IstG"
                     /protein_id="ARG41910.1"
                     /sec_met_domain="PP-binding (E-value: 2.6e-17, bitscore:
                     53.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAFTLTEFRQVVEKCFQGEAGPLDETALDATFSDLGFDSLMVYE
                     VTVRIQDEYPVEITDDELDELRTPGAFIAFVDARLSVSG"
     aSDomain        7407..7592
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARG41910.1_PP-binding.1"
                     /evalue="6.90E-17"
                     /label="ARG41910.1_PP-binding.1"
                     /locus_tag="ARG41910.1"
                     /protein_end="76"
                     /protein_start="14"
                     /score="53.6"
                     /tool="antismash"
                     /translation="KCFQGEAGPLDETALDATFSDLGFDSLMVYEVTVRIQDEYPVEIT
                     DDELDELRTPGAFIAFV"
     CDS             7676..8935
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (4-391). E-value:
                     8.6e-57. Score: 184.7. Matches aSDomain:
                     nrpspksdomains_ARG41911.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 500.1; E-value:
                     8.9e-152)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     774.3; E-value: 6.3e-236)"
                     /gene_kind="biosynthetic"
                     /note="beta-ketosynthase"
                     /product="IstH"
                     /protein_id="ARG41911.1"
                     /sec_met_domain="t2ks (E-value: 4.9e-243, bitscore: 796.9,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERSVAITGIGVMAPGGVGKKAFWDLLVSGRTATRTISFFDPAPF
                     RSRMAAEIDFNPELHGLTARQCRRLDRAAQLAVISARESLADSGLEFDTVDPHRVGVCV
                     GSAVGGTTTLEQEYVVLSDSGKEWDVDPAYLSPHLFDAFVPSSLAAEVAWLVGAQGPAT
                     VVSTGCTSGLDSLGHARDLIAEGSADIMIAGATDTPISPIAVACFDAIKATSPRNDDPE
                     HASRPFDRTRNGFVIAEGSAMLVLEELEHARARGQHVYGVISGYGSRCNAYHMTGLRPD
                     GREMAEAIRYALDEAKRPPESVGYVNAHGSGTKQNDRHETAAFKRALGEHAYNVPVSSI
                     KSMVGHSLGAIGSIEIAACALAMEHGVVPPTANLHEPDPECDLDYVPNEARERRLDTVL
                     SVGSGFGGFQSAMVLTREGI"
     aSDomain        7688..8848
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARG41911.1_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="8.60E-57"
                     /label="ARG41911.1_PKS_KS.1"
                     /locus_tag="ARG41911.1"
                     /protein_end="391"
                     /protein_start="4"
                     /score="184.7"
                     /tool="antismash"
                     /translation="VAITGIGVMAPGGVGKKAFWDLLVSGRTATRTISFFDPAPFRSRM
                     AAEIDFNPELHGLTARQCRRLDRAAQLAVISARESLADSGLEFDTVDPHRVGVCVGSAV
                     GGTTTLEQEYVVLSDSGKEWDVDPAYLSPHLFDAFVPSSLAAEVAWLVGAQGPATVVST
                     GCTSGLDSLGHARDLIAEGSADIMIAGATDTPISPIAVACFDAIKATSPRNDDPEHASR
                     PFDRTRNGFVIAEGSAMLVLEELEHARARGQHVYGVISGYGSRCNAYHMTGLRPDGREM
                     AEAIRYALDEAKRPPESVGYVNAHGSGTKQNDRHETAAFKRALGEHAYNVPVSSIKSMV
                     GHSLGAIGSIEIAACALAMEHGVVPPTANLHEPDPECDLDYVPNEAR"
     CDS             8932..10242
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (82-382). E-value:
                     2.4e-24. Score: 77.8. Matches aSDomain:
                     nrpspksdomains_ARG41912.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 619.4; E-value:
                     3.9e-188)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 7
                     (Score: 676.5; E-value: 2.6e-206)"
                     /gene_kind="biosynthetic"
                     /note="chain length factor"
                     /product="IstI"
                     /protein_id="ARG41912.1"
                     /sec_met_domain="t2clf (E-value: 4.2e-196, bitscore: 641.8,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITAPGTAPAAAATRTAVVTGIGVVAPNGLGTEEWWSATLRGES
                     GIRPVPDHSTRPGQAPLIGLIPGFEAADHLPGRLLPQTDRVTRLALVASDWALADSGAD
                     PAALPEYGMGVVTSNATGGFEFTHREIRKLWTQGPQHVSVYESFAWFYAANTGQISIRH
                     GMRGPSNVLIAEQAGGLDALGHARRVLRKGGELVLTGGVESAFDPWGVVSHIAGGRVSR
                     SGHPDRAYLPFDTGASGHVPGEGGAILVVETATAAAERDAGQVYGEIAGYAATFDPPPG
                     SSAPPGLARTARLAMADAGVTPEDVDVVFADAAALPALDAAEAAAIEEIFGPYGVPVTA
                     PKTMTGRLAGGGPALDTAAALLAVRDSVLPPTVNVERPVPGRRIDLVRGEPREARVEVA
                     LILARGHHGFNSALVVLAPNRMAAAPAGVPAAVRHHT"
     aSDomain        9178..10077
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARG41912.1_PKS_KS.1"
                     /domain_subtype="Modular-KS"
                     /evalue="2.40E-24"
                     /label="ARG41912.1_PKS_KS.1"
                     /locus_tag="ARG41912.1"
                     /protein_end="382"
                     /protein_start="82"
                     /score="77.8"
                     /tool="antismash"
                     /translation="TDRVTRLALVASDWALADSGADPAALPEYGMGVVTSNATGGFEFT
                     HREIRKLWTQGPQHVSVYESFAWFYAANTGQISIRHGMRGPSNVLIAEQAGGLDALGHA
                     RRVLRKGGELVLTGGVESAFDPWGVVSHIAGGRVSRSGHPDRAYLPFDTGASGHVPGEG
                     GAILVVETATAAAERDAGQVYGEIAGYAATFDPPPGSSAPPGLARTARLAMADAGVTPE
                     DVDVVFADAAALPALDAAEAAAIEEIFGPYGVPVTAPKTMTGRLAGGGPALDTAAALLA
                     VRDSVLPPTVNVERPVPGR"
     CDS             10278..11069
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     251; E-value: 4.8e-76)"
                     /gene_kind="regulatory"
                     /note="SARP family regulator"
                     /product="IstJ"
                     /protein_id="ARG41913.1"
                     /transl_table=11
                     /translation="MGTRLRITVLGRLAVSRGALTAAPSAPKERKLLAMLLLGHGSPVP
                     VRQLVDELWGSSPPRTVRTALQTHVLNLRGMLARQLHIPGDRVRRELIVTGNEGYQFRV
                     GDADFDLHEYHRLAKLGESELRVGHHLGAAESLRTAESLWTGPILPDTKHGLPLQCEIT
                     RLELQRDMVQELRIESDLALGRHRELLSELTALTLARPFDERVHEYLMTALYRSGRTIQ
                     ALQVFQRLRTKMAQEMGLEPSRVIQDLQRRILGATAYESIP"
     CDS             11140..12297
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 265.7;
                     E-value: 1.4e-80)"
                     /gene_functions="biosynthetic-additional (t2pks) GT (Score:
                     314.7; E-value: 2.7e-96)"
                     /gene_kind="biosynthetic-additional"
                     /note="glycosyl transferase"
                     /product="IstK"
                     /protein_id="ARG41914.1"
                     /sec_met_domain="MGT (E-value: 4.1e-106, bitscore: 345.8,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILFCTYSTASDLFATIPFAWALRAAGHEILYAGGGEGMREVAK
                     AGLPYVDIATPGVDLAAPFARRAAQSREKGQLVWYRGGDLQEDEVRATSALFAELSELV
                     VPGAVRLARQWRPDLVVSPDHQGSGAVVAGLLSVPLIAMSNLFALVPDMVDRIRGEMAG
                     TYDRYGIDPGSSRTRLLRTTPPSLFRASGNHLAMRPVPYNGSYLELGTIPDWLLRSPDR
                     PRVCVTLGTFIPQYIGLSLIRDFVAELDTVDADFVFVLGDADRTELGTLPDNVRSHGWI
                     PLNTLLDSCDAIIHHGGTSTSLAAMSAGIRQIALPHGSDQPFNARLVAERGLGVTCAAA
                     ELTAKTITTVLEAPEIGTAAAQVREEIARLPSPSGVASALPDLVG"
     CDS             12534..13646
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 285.4;
                     E-value: 9e-87)"
                     /gene_kind="biosynthetic-additional"
                     /note="dehydrogenase"
                     /product="IstL"
                     /protein_id="ARG41915.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.9e-08, bitscore:
                     24.2, seeds: 790, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPHAHPTPGPDLTAEHLAALAAQHAATADNERRLAPDVAAALVD
                     AGFARHFVPADHGGTAGSFTALAEAVRTIARGCPAAGWSAMIMATSARLAGRLPRAGRK
                     DIWGQSADVPIAAALNPGGSARRVADGWVLSGQWFSLSGIDHAAWALLCVTAPEDGTQH
                     YCAVPASRFRIEDTWFTLGMRGTGSRSVVLDEVYVPGHLSAPRDLVWQGRADGPDDALS
                     APLPAAHPPLFAAPAVGAARAALDLWARAESRTGPDRDAVLTRSAAEIDTAALLVEQAC
                     LRLDAPGPVGGIDAARNGRDAALAADLARTATDRLFRARGSRAHAAQDSVQRLWRDVQT
                     ASSHAAVDAARSNSLFATTFRASLPDHEES"
     CDS             13646..14476
                     /NRPS_PKS="Domain: Polyketide_cyc (121-249). E-value:
                     1.8e-16. Score: 52.4. Matches aSDomain:
                     nrpspksdomains_ARG41916.1_Polyketide_cyc.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 163.1; E-value:
                     1.6e-49)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 122.3; E-value: 4.4e-38)"
                     /gene_kind="biosynthetic-additional"
                     /note="cyclase/aromatase"
                     /product="IstM"
                     /protein_id="ARG41916.1"
                     /transl_table=11
                     /translation="MICHTLIYKFAESVSAEDRDQFLKELSETVRSTGLSVGFDYRIHE
                     WLPVDEKAIGMTGSAIAQIVCEDSETMRKFSELTSTHEFIASWRSRISYEAAYANHPPL
                     TGVPADNPLHHAEHTVTVHAPVAVVWDILVDVEGYARIFPPTQDVKLLEESPTHQIARL
                     VVDVNGETNSWISRRDIDADNRVITYRQLEHAPIVGHMGGQWRALPLGDDTTQLVLTHE
                     FRAREAVDGKVAGRLTPQEADAALRAVVERNSVADLGAVKTTAEATAPGNGGTR"
     aSDomain        14009..14392
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARG41916.1_Polyketide_cyc.1"
                     /domain_subtype="Polyketide_cyc"
                     /evalue="1.80E-16"
                     /label="ARG41916.1_Polyketide_cyc.1"
                     /locus_tag="ARG41916.1"
                     /protein_end="249"
                     /protein_start="121"
                     /score="52.4"
                     /tool="antismash"
                     /translation="VHAPVAVVWDILVDVEGYARIFPPTQDVKLLEESPTHQIARLVVD
                     VNGETNSWISRRDIDADNRVITYRQLEHAPIVGHMGGQWRALPLGDDTTQLVLTHEFRA
                     REAVDGKVAGRLTPQEADAALRAV"
     CDS             14473..15222
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C5-C14/C3-C16 (Score: 325.5; E-value: 5.6e-100)"
                     /gene_kind="biosynthetic-additional"
                     /note="cyclase"
                     /product="IstN"
                     /protein_id="ARG41917.1"
                     /transl_table=11
                     /translation="MTRLVDLSVPTEQTDSEATPVKIDLLDHVAGATVLGLSPEDFPGG
                     MAISNETVTLTTHTGTHMDAPLHYGPLTGDAPARSIDQVPLEWCYGPGVRLDFRDVPPG
                     QGITVTMLEEEFSRIGHVPVAGDIVLLWTGADALWGSSDYLTTFAGLTGEGTVFLAEHG
                     VKVIGIDAWGLDRPIPHMIEDYRRTGDRSVLWPAHVAGRTHPYLQLEKLAHLGDLPGPT
                     GYMVACFPVPVTGAGAGWTRVVAICDA"
     CDS             15237..15836
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1159:dihydropteridine reductase (Score: 166; E-value:
                     1.4e-50)"
                     /gene_kind="biosynthetic-additional"
                     /note="reductase"
                     /product="IstO"
                     /protein_id="ARG41918.1"
                     /sec_met_domain="PF00881 (E-value: 1.6e-14, bitscore: 44.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGHPLALDEAAQDLLFREARTANTFAPTHIGDEHIEAIYDLVKW
                     GPTSMNQQPMRVVLVRSDESRRALLQHVLEGNRDKVASAPLVAVLAADLSFPDTLPRLF
                     PHAPNARHAYADENARRESAVFNTALQLGYFIIGIRAGGLAAGPIAGFDPEGVHKEFFP
                     GEPVLVTSIVNIGYPGPDAFSARLPRLGYREVVRSV"
     CDS             15883..17676
                     /NRPS_PKS="Domain: ACP (28-78). E-value: 3.9e-11. Score:
                     35.0. Matches aSDomain: nrpspksdomains_ARG41919.1_ACP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 423.2; E-value:
                     2.6e-128)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 67.8; E-value: 1.4e-21)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 389.5; E-value: 5.8e-119)"
                     /gene_kind="biosynthetic-additional"
                     /note="oxygenase"
                     /product="IstP"
                     /protein_id="ARG41919.1"
                     /sec_met_domain="PP-binding (E-value: 2.7e-10, bitscore:
                     31.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRPNQLLTVLADCSGNQELVGIGNDALDTDFDALGLDSLAVLE
                     SVARIGREHGIHISDEEVHDLGTPLALLNRLNQAQNDGDEDTDAEERLPVVVVGAGPVG
                     LALAGELAAHGIGVTVLERRATPETMVRAGSVGPLAVALLRRRGLADELDRAERETVER
                     YRAMADSAAGAVGHALPKEHLAGIEKVEHADASMRRMRVEQPALVDILLRHVAALGVDV
                     VWEHEVTAIEQDDRGVWVTVAAPGGERRLRAAYAVGCDGGDSTVRRLAGIPLTGTEATL
                     TGRQSVVEFEGEPPLEHGFRHTSGGLVAWGLGVNRVATLEFDGPPAPDAGPLTSGELQD
                     SLRRVTGTGVPISRMAAGGRFTDMAYQAAEYRRGRVFLAGDAAHVHAPFGGQGLNTGIT
                     DAANLGWKLAAALDGWAPPRLLDTYHAERHPVGARLLANVRAQTALMRPDPHSSALRDL
                     VGRMMDVPDVRRFVGALLSGTDEGYGTDGHPAVGTFLPDYEVTDRQEPASGRGLLLDFT
                     DCAALRTIGARWADRVDIVSAKTGRDDLAAVLLRPDGYVAWALATGDTPRARPLVRALR
                     TWFGTGRSPAGTPAAPAGARR"
     aSDomain        15967..16116
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARG41919.1_ACP.1"
                     /evalue="3.90E-11"
                     /label="ARG41919.1_ACP.1"
                     /locus_tag="ARG41919.1"
                     /protein_end="78"
                     /protein_start="28"
                     /score="35.0"
                     /tool="antismash"
                     /translation="LDTDFDALGLDSLAVLESVARIGREHGIHISDEEVHDLGTPLALL
                     NRLNQ"
     CDS             18196..19038
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 240.6; E-value: 4.1e-73)"
                     /gene_kind="other"
                     /note="dehydratase"
                     /product="IstQ"
                     /protein_id="ARG41920.1"
                     /transl_table=11
                     /translation="MTILVTGGRGHVGRSVTRKLLAAGERVRVGTSDPTDTSLSRDAEV
                     VELDLSRPQTLSAALRGVQRVFLYADPSTVDQQIEAMELAGVDHVTLLSTRSLTFRDAD
                     SNPIARLHVAVERALGQSRLPWSFLRAGTFATNTLQWARLIRSDNTVRAPYPQSHAAAV
                     HEDDIADVATLTLTRQGHAGAAYVMSGPESNTQREQVSLIGKAIGREIEFEEIEPETYR
                     QTLSRWGGGREEVINQLLTYLVTWNERPVPVVDALQQLTGKPGRPYAQWAVDHADDFR"
     CDS             19135..20127
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 320.4; E-value: 1.8e-97)"
                     /gene_functions="biosynthetic-additional (t2pks) KSIII
                     (Score: 390.2; E-value: 1.8e-119)"
                     /gene_functions="biosynthetic-additional (t2pks) KSIII
                     ACI88883.1_Alnumycin_butyryl-CoA (Score: 469.0; E-value:
                     5.21e-171)"
                     /gene_kind="biosynthetic-additional"
                     /note="synthase III"
                     /product="IstR"
                     /protein_id="ARG41921.1"
                     /sec_met_domain="fabH (E-value: 2.9e-97, bitscore: 316.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASAPTILASAPRHSALLGVGGYRPRRVVTNAEMCRSIDSTEEWI
                     ETRSGIVRRHFAGEDETLTMMAAAAAEQAMARAGTAPADIDLVLVASMSDLVQTPPLAV
                     RVAHELGADRAAGLDLSGACAGFCHALALASDTVRVRDAERVLVIGAERMTDIVEPTDR
                     TIAFLFADGAGAVVVGPAREPGIGPVVRRAYGAYGNALRMTGPWAGKGPRPWMRMDGRR
                     VFRWAMEEVAPAAGRALSAAGLAPADLAAFVPHQANLRMTELMAERLGLGEDTVLATDV
                     VRSGNTSAASIPLALDTLLAEGRVAAGSTALLAGFGAGLNFAAQTVLLP"
     CDS             complement(20208..21437)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 439.6; E-value:
                     1.6e-133)"
                     /gene_kind="biosynthetic-additional"
                     /note="P450 monooxygenase"
                     /product="IstS"
                     /protein_id="ARG41922.1"
                     /sec_met_domain="p450 (E-value: 3.6e-23, bitscore: 72.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCLEPQREYVMTTHAPRLPFERTTELGPPPEFAALRAEQPLRRVG
                     CPFGGDAWLATRYADVRKVYADPRFSRAATVNADVPRVSPAQTPPGGLFAMDPPEHSRL
                     RKLVAGTFTMKNVQRWRPRTEQIVDGLVAGMREHGSPVDLVHHFSVPLPVTVICELLGV
                     PATDRGYFERLSRLMLSTTAATGEEIDEAIGTLLDYLGRHVAERRARPSAQRSRDLLTD
                     LVEARDESDRLSEQELVQMGVDLLVAGHETTANQLSNFTFTLLDTGLWSRLLEEPELLD
                     TAVEELLRYVHLVNGGTTRIALEDVEFDGTVVRAGEAVIAAIGSANHDETVFEEPGRIK
                     LDRSPNPHVGFGHGVHHCLGAQLARLELRAGLGALLREFPTLRLAGEKRDVPWREGQFV
                     HGPTELMVAW"
     CDS             21620..22546
                     /NRPS_PKS="Domain: PKS_ER (18-217). E-value: 3.1e-41.
                     Score: 133.3. Matches aSDomain:
                     nrpspksdomains_ARG41923.1_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 266.1; E-value: 6.9e-81)"
                     /gene_kind="biosynthetic-additional"
                     /note="quinoe reductase"
                     /product="IstT"
                     /protein_id="ARG41923.1"
                     /sec_met_domain="ADH_N (E-value: 5.1e-13, bitscore: 39.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.1e-16, bitscore:
                     49.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKKYRAVEFAEYGGPEVLRVVEREMPRPGPGQVLVEVRAAGVNP
                     LDWQLRSGAVAEMMPVEFPSVPGGDVAGVVADVGEDVTDFAVGDEVFGSIGSGSYAEFA
                     LAPAAQLARKPEGVSWEVAAGLPVAVNTAYQVLADLGVKSGETLVVDGAAGGVGSVAVQ
                     IARHLGATVIGTASERNHAYLRSLGAEPVTYGEGFAERARAVAEKGVDAAFDAAGKGSL
                     PALVELTGGPDRVVTIADHRAAEHGVRFAFAGPDAIRERLEQAAALVGNGELGLSVART
                     YSLSEAADAHRESAGGHVRGKLIIVPS"
     misc_feature    21674..21676
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        21674..22270
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARG41923.1_PKS_ER.1"
                     /evalue="3.10E-41"
                     /label="ARG41923.1_PKS_ER.1"
                     /locus_tag="ARG41923.1"
                     /protein_end="217"
                     /protein_start="18"
                     /score="133.3"
                     /tool="antismash"
                     /translation="LRVVEREMPRPGPGQVLVEVRAAGVNPLDWQLRSGAVAEMMPVEF
                     PSVPGGDVAGVVADVGEDVTDFAVGDEVFGSIGSGSYAEFALAPAAQLARKPEGVSWEV
                     AAGLPVAVNTAYQVLADLGVKSGETLVVDGAAGGVGSVAVQIARHLGATVIGTASERNH
                     AYLRSLGAEPVTYGEGFAERARAVAEKGVDAAFDAA"
     CDS_motif       22052..22114
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ARG41923.1_0001"
                     /evalue="4.50E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="ARG41923.1"
                     /protein_end="165"
                     /protein_start="144"
                     /score="12.9"
                     /tool="antismash"
                     /translation="GETLVVDGAAGGVGSVAVQIA"
     CDS             complement(22617..23603)
                     /NRPS_PKS="Domain: PKS_AT (9-290). E-value: 4e-59. Score:
                     192.2. Matches aSDomain:
                     nrpspksdomains_ARG41924.1_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 247.3; E-value: 5.8e-75)"
                     /gene_functions="biosynthetic-additional (t2pks) AT (Score:
                     363.9; E-value: 1.8e-111)"
                     /gene_functions="biosynthetic-additional (t2pks) AT
                     ADB23379.1_TLN-05220/TLN-05223_2-methylbutyryl-CoA (Score:
                     211.0; E-value: 1.49e-66)"
                     /gene_kind="biosynthetic-additional"
                     /note="malonyl-CoA acyltransferase"
                     /product="IstU"
                     /protein_id="ARG41924.1"
                     /sec_met_domain="PKS_AT (E-value: 1.5e-59, bitscore: 192.2,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRRVVLLLPGQGAQRVRMAAGLHGVQPEFTRWMDEMFTVFGAD
                     GDRLRDVWLDPGSAGAVDEAVVAQPLLFAVGHALGRAVRSAAGAPDVLLGHSVGELVAA
                     CLADVFAPAELATAMAGHVRRLDDTGRGGMLAVAATAEELSAELRTGAVVAADNGPRQT
                     VLAGSDSVLAAVRGQLERRDITLRTLGSGHAFHSPAMVPAARRFGQDLGRLRPGPPRAT
                     IMSTRTARPVSAEEAVDPAFWADQISLPVRYWPALRSLLDSEGLDPGLVLLDASADRSL
                     AVAARGHRAVLRGPSSVHPLLARSDRAGTAADAEAFAAAVAVLHSGT"
     aSDomain        complement(22734..23576)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ARG41924.1_PKS_AT.1"
                     /evalue="4.00E-59"
                     /label="ARG41924.1_PKS_AT.1"
                     /locus_tag="ARG41924.1"
                     /protein_end="290"
                     /protein_start="9"
                     /score="192.2"
                     /specificity="consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LPGQGAQRVRMAAGLHGVQPEFTRWMDEMFTVFGADGDRLRDVWL
                     DPGSAGAVDEAVVAQPLLFAVGHALGRAVRSAAGAPDVLLGHSVGELVAACLADVFAPA
                     ELATAMAGHVRRLDDTGRGGMLAVAATAEELSAELRTGAVVAADNGPRQTVLAGSDSVL
                     AAVRGQLERRDITLRTLGSGHAFHSPAMVPAARRFGQDLGRLRPGPPRATIMSTRTARP
                     VSAEEAVDPAFWADQISLPVRYWPALRSLLDSEGLDPGLVLLDASADRSLAVAARGHRA
                     "
     CDS_motif       complement(22842..22898)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ARG41924.1_0005"
                     /evalue="1.10E+01"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="ARG41924.1"
                     /protein_end="254"
                     /protein_start="235"
                     /score="0.2"
                     /tool="antismash"
                     /translation="EAVDPAFWADQISLPVRYW"
     CDS_motif       complement(23103..23141)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ARG41924.1_0004"
                     /evalue="1.30E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="ARG41924.1"
                     /protein_end="167"
                     /protein_start="154"
                     /score="15.1"
                     /tool="antismash"
                     /translation="AADNGPRQTVLAG"
     CDS_motif       complement(23271..23336)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ARG41924.1_0003"
                     /evalue="1.00E-12"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ARG41924.1"
                     /protein_end="111"
                     /protein_start="89"
                     /score="40.1"
                     /tool="antismash"
                     /translation="PDVLLGHSVGELVAACLADVFA"
     CDS_motif       complement(23352..23408)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ARG41924.1_0002"
                     /evalue="9.60E-03"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="ARG41924.1"
                     /protein_end="84"
                     /protein_start="65"
                     /score="9.4"
                     /tool="antismash"
                     /translation="VVAQPLLFAVGHALGRAVR"
     CDS_motif       complement(23532..23585)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ARG41924.1_0001"
                     /evalue="2.10E-04"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ARG41924.1"
                     /protein_end="24"
                     /protein_start="6"
                     /score="14.0"
                     /tool="antismash"
                     /translation="VLLLPGQGAQRVRMAAGL"
ORIGIN
        1 atggtctggc cgatcgcgga ggtcgcccgg atgtccggtg tgacggctcg gacgctgcgg
       61 cactacgacg agatcggtct gctgccgccc gcggggaccg gttccaacgg ccatcgctgc
      121 tacggggagg gcgagctgct ccggttgcag cagatcctcg tgctgcgggc gctgggcctg
      181 ggtctgcccg agatcgggcg gatcctggcc tcgcaggtcg atgaggtgga ggcgctgcgc
      241 ggccaccacc gccggctgct cgccgagcgc gaccggatcg acgcactggc cggcaccgtc
      301 tcccgcacga tcaccgaact ggaggattcc agaaaggacg gtggccccat gaccgccatc
      361 aaccgaccgg agaatctctt cgagggcgtc cggccctccc agtacaggga cagcctgcgc
      421 gacttccccg ggctggccgg ggacatcgac cggcacacct cgacgatgag cgaggagcag
      481 atcgaggccg gacaccgcga gcgcacggcg cagatgatcc ggctggccga gctgctggtg
      541 gcgggcgtgc ccgccgaggc cgatccggtg caggccgaga tcgaggccca gcaccgggcc
      601 ctgaccgggc tgcgggcggt ctccgccgag gagtaccgcg cgatcggccg ttcctgtgtg
      661 gagaacgagc agtggcgcgc ggcgtacgag gcgatcgcgc ccggactggc cgtctaccag
      721 cgggacgcca tcgaggcgta cgtatcgacc cggctgagct gagcgggggc gagtggcagg
      781 ggtgccgccg cgggaacggt cccgcggcgg cactcttgcg ttcgtccctg ctcacccctc
      841 gatgccgccg ggcccgtgcc ggagtgcggc atcgagcagg accaccagtt gtccggcccg
      901 ctcccgctcc cgctgccggt cgtgcgtgcc ggtcatgagc aggtggtgga cggtcccgac
      961 cagggcgagg gccgcggcgg cggtgtcggc ccgttccgcg atccggccgc cccgccgttc
     1021 cgcgtccagg tagtcggtga tcgcgtcctg gaccgtgtcg aagcccggcg caccgcccac
     1081 cagggcttcg cggatgtgcg cggacgccac ggggcgggcg agcgccagcc cggcgacggt
     1141 ggggccggcc gaggacagca gcgcgagcgc gatgccgagc aggttctccg cgacggtgcc
     1201 ctgccccgcc cgcccccgga gttcgtcggc gtgccgggcc acccgcccga accggtccag
     1261 gaccagctcc gcgacgaact cgtccagtcc gcggaaatgg gcgtgcagca ggcccttcgc
     1321 gcagccggcc tcggcggcga tcgccctgct cgtcagggcc cccggcccgt cccgctccaa
     1381 cacccgctcc gcggcggcga agagccgctc acgtacgtcc ggagtcgtca caccacgcgg
     1441 agacaccgat tccctccctc tcgccctgtt tacagtatgg gcacttgccc ataccttgaa
     1501 tgggcgcccg cccatactag tcgtcccgat gtccgcgggc gccgcaacca gacggcgaac
     1561 aggccgagtt cgagcagcgt tcaggggaag cacaccgcat gcgacacatc gccaacagag
     1621 atcaggacca agcgtggaac ggttacgagg ggacgttctg ggccgccaac caggaccgct
     1681 gggacggggt gaacgggggc ttcgacgagc cactgctcgc cgccgccgcg atcaccggag
     1741 gtgaccgtgt cctcgacatc ggctgcgggg cggggcgcac cacccgcctc gccgcgcgac
     1801 gggccggcga cgggcgggcg ctgggcctgg acctgtcggc cccgatgctg ggccgcgcac
     1861 gggagtccgc gcgcggcgag ggcatcggca acgtgacgtt cgagcaggcg gacatccagg
     1921 tccacccgtt cgggaccggg tccttcgatg tcgcgatcag ccgtttcggg gtgatgttct
     1981 tcgccgatcc ggtcgccgcc ttcgccaaca tcggacgggc actgcgcccc ggcggccgta
     2041 tcgccttcgt ctgcaccgcg cgggccgacc ggaacgagtg gctccaggcc atccgggggc
     2101 tgggtgacct gctgcccgtc ggcggactgg gcacctccgc gaaccccggc atgttctcgc
     2161 tggcggaccc ggagaccgtg cgtgacgtgc tgtcccgcgc cgggtacgag gcgatcggca
     2221 ccacaccggc cgaggcgtac gggacctggg gccgggacgc ctccgacgcc gccgccttcc
     2281 tgctggactc cggccccggc cggcatctgc tgagccgggc cggggaggac gaccggaccc
     2341 gggcccggca gcggctcgtc gacctgctgc gcccccacga gcgggaaggc gcgctccgac
     2401 tgcgcagtgc cgccctgctg gtcaccgccc gacggcccgg gtgaacgagg gcggcgtccg
     2461 ctgccgaggg cggacaaccg tccccggcag cggacgccgc ccgaccacag ccctcgggga
     2521 acacccgccc cctttcaggc cgcggccttc tccggccggc caccaccgcc ctcaccgtca
     2581 ccgttgcccg cgccttcggc ggcgggtgtg gtgcgcaggg tcagcagggc ggcgagaccg
     2641 ccgatcaccg cgagggccgc ggcgccgagg aaggcggcgg agaagccgtc ggtgagggcc
     2701 accgggtcgc cgggctcacg ggcaccgtgc gcggcggcga tcgccgtcat ggcggcgagg
     2761 cccagcgcgg agccgacctg gtagctggtg ttgacgatcc ccgaggcgag accgccctcc
     2821 tccgggcggg cactggagag cgcggtgccg agcgacggga tgaacgccag cgacatgccc
     2881 accgcggaga gcagggaggc gggcagcacg tccacccaga agtttccgtc cgggcgggcg
     2941 agcgagagcc agaacatgcc cgccccgagc gcgaacagcc ccaggacgat gaggggcttg
     3001 ggcccgaacc gggagatcag acgcggcgcc agaacgatca tcatgatcat gatggcgacc
     3061 gtcatgggca gcagcgcgga gccggaggcg aaggcgtcga gccccaggac ctgctggagg
     3121 tagaggttga ggaagaacca catgggtatc cacgcggcgg ccatgagcag ctgagcgatg
     3181 ttggcaccgg ccaggttggg cgcccgccag atgcccagcc gcatcagcgg ctcgcgccgc
     3241 ttggcctgga tcgcgacgaa cgcggcgatc agcaccacgc cgcccaggag gaccagccag
     3301 gtctcggccg aaccccagcc ggtctcggga gcacggacga tggcgtagac gccggcggcg
     3361 agacccgccg tgacggtgac cgcgccggcc aggtcgatcg agccgcgccg ccccgcgccc
     3421 gagggcatga cggcgggcgt ggcgatcagg acgacgaggg cgacggggat gttgatgtag
     3481 aacacccagg gccagctggc gtactgggtg atgaccccgc cgaggaagac tccggcggtg
     3541 ccaccggccg gggcggccgc gccgtacagg gcgaacgcct tccccagctc ctggggccgg
     3601 gagccgaaca gggtcatcag cagcgtgagg gcggacggcg cgatcagcgc ggcacccacc
     3661 ccctggacgg cccgcccggt cagctcgacc cagacctcac ccgcgaggcc cgcggtcagg
     3721 gaacccgcgg cgaggacgat ccatccggcg ctgaagaggc gcttggcgcc gagcaggtcg
     3781 gacagccgcc cgccgagcag caacagccca ccgaaggcga cgacgtaggc gttgaacacc
     3841 caggacaggt tctcctggga gaagcccagg tcggcctgca tccggggcag ggccacgccg
     3901 atgatcgacg tgtccatgat gaccatgaac tgggccaggg cgatcagggc gagcgcggac
     3961 catctccgcg gatccgccgg tgcgttcggt gcggctgatg cagtcatcgc aggcactcct
     4021 atacgggagg ggggtatcga ggtatcgacg cgtgcaatat accccccagg ggtatctacg
     4081 gccagtccgg atgttcggaa ggttcctgac gtcgcgaccg cgccgcgccg gggcacgccc
     4141 cggtcgtccg gtgttggtgt ccgggaaacg gcacggttca gcgggaattc agcgagtccg
     4201 gaccggtcga gtggaagttc gagaggtctc ggctccgaag agccgggacc gatcgagcgg
     4261 acacggagga tccacccgat ggcccatgtg acccgtagtg ccccgcaccg ggaaggcgca
     4321 gtcgcggagc gcggcggcgg gagtccggcg tcgtcgaccg tgtaccccgg cgacccgcgt
     4381 tacgaggacc tcgccctgcg ccgccgtaac gagcggttcg tccagcgccc cgcctgcttc
     4441 cgggtggtgc gctccaccga cgaggtggtg gcggcggtgc agtgggcggt cgattccggt
     4501 cggccggtct cggtgcgcag cggcggtcac tcgctggaga actccgtggg cgagcacccc
     4561 gacggcgtga tcatcgacat gaccgggatg aacgcgatcc acttcgaccc cgaccggcgc
     4621 gccgtggtcc tggagtcggg cgcgacgctg ggcgaggtgt accgcacgct ctacctgacc
     4681 tggggagtga ccgttcccgg cggttggtgc cactcggtct gtgtgggcgg gcacatccag
     4741 ggcggcggct acggatcgct ctcgcgcagc cacggttccg tcgtcgacca cctgtacgcc
     4801 gtcgaggtcg tcgtcgtgga cgaggcgggc cgggcccgtg ccgtgctggc cacccgcgaa
     4861 agcggcgatc cccatcacga cctgtggtgg gcacacaccg gcggcggggg cggcaacttc
     4921 ggtgtggtga cccggtactg gctgcggtcg cccggcgcgg agggggacga tccggcggat
     4981 ctgctgccca ggccgcccgc ttccctgacg gggggcgtcc tcatgtggtc gtgggcggat
     5041 ctgccgaagg agtcgttccg gcggctgatg cgcaaccacg ccgactggca cgagaacaac
     5101 agcgatcccg actcgcccgg cacggcgctg cactccacgc tgatgctctc cggccgcaag
     5161 gagcaggaca gcccgacgga catcctgatc tacgccctgg ccgacggcga cggcgcggac
     5221 ggggcggcgc tggtggagaa gtacttcgat gccttgagcg acggcgtcgg cggcacccgc
     5281 cacatgattc ccgccgcacc ctggctgtac gtgctgatgc cgccgaacgg cgacgaggag
     5341 tcgcaacgcg ggtccgagta cggccgctac aagggcaagg cgggatatct gcgcaagggg
     5401 ttcagcgccg cgcaggtcga caccgtcttc gatcacctga ccacggcacc acccatgctg
     5461 gacatggccc gcgtctggct cgtctcctac ggcggcaagg tcaatgacgt cgctccggag
     5521 gccaccgcgc tggtgcagcg cgactccgtc ctgaaggccg cctacaccgc gacgtggctg
     5581 gatccccgcg acgacgaggc gtccctcgac tggcttcggc gcttctaccg cgacgtctac
     5641 cgcgaaaccg gcggggtgcc ggtgcccgac gggacgaacg acggctcgta catcaactat
     5701 ccggacaccg atctcgccga cccggactgg aacacgtccg gcgtcccctg gcacgacctc
     5761 tactacaagc agaactaccc caggctgcgg cgggtcaaga agcgatggga cccgcgcaac
     5821 gtcttccgcc acgccctgtc catccagccg gccgactgaa acggaacacg ccatgtccca
     5881 tgccgaccag aacaccacaa cgcagaccga tgtcgcggtg cgcgaactgc tggaccggtt
     5941 ccagagcgcc tggacctcga acgacgccga cgccgtcgcc gagatgtaca ccgaggacgc
     6001 gaccctggtc atgaccggcc tggtcctcga cagcaaggac gccatccggg agttcatgcg
     6061 cgcggcgttc gacggaccga tgcggggaag ccgcccgctc aacgagcccc gcatcatccg
     6121 ccgcaccgga gcggacaccg cggtcgtggt gagcgacctc ggcatcctcc tcgacggaca
     6181 gaccgagctg gccgagagcg acaagcgggt cgcgaccttc gtgctcgccc gggccgacgg
     6241 cgtctggcgg gtcacggcgt atcacaactg ccccgcctga cgggcggccc caggaggagg
     6301 acccatgtac ttcaaggtgc tcggcgcgct ggatgtatcg gagagtacga aggatctgac
     6361 gccgtcggcg ccgaaactgc gcagcaccct gtcgctgttg ctgctgcggc agggggacat
     6421 cgtgcgcaag gacctgttcg tcgacgaact ctggggcgtc aacccgccgc ccaacgcact
     6481 gaccacgctg cagacctacg tgtaccagct ccgtcgtacg ctgcccgacc cgcagacccg
     6541 gcgggccgga caccggcccc ggggacatgc ctggaaggag gccaccgccg gcccgtcgca
     6601 cgggccgtgg ctgcgcacca cctcctccgg gtactgcgcg agcatccccc cggagacgat
     6661 cgacctctgc cggttcgaga ccctggccgc acagggcggt accgcgctca ggcaggggaa
     6721 cgtaccccgg gccgccgaac tgctcgaaga ggcactgacg ttgtggcgcg gcccgctggt
     6781 ctccaatgtg aagcacggcc cggtcctgga ggcgcacgcg acgggactga ccgaggagcg
     6841 gctgcgcgtc gtggagcagt gcgtcgacac gcagctcttc ctcggcaggt accacgaggt
     6901 gctcaccggg ctgcgcgggc tgctcgtgga acacccgctg gccgagggcc tgtggcagcg
     6961 gctgctgctc gccctctacc ggtccggcag gcgccttgag gcgatccagg agtaccggcg
     7021 gctgcaccgg atactcggcg acggactcgg gctagaaccc tcacgctcgg tgcagcggct
     7081 gtacgaggcc gtcctggctt ccgatccggc gcccgatctc gaacgcatcg cgctgtccgc
     7141 atggcgcgac cgggccgtca tccgcccggg gggcgtgtcc cggcacgtcg cctgaacccg
     7201 acgaaccgga cgtatagaca cggcacgtcc atccccctcg attcgtgctg gaggagccgg
     7261 aaggggcgtc tggagcggct ccccatcgac gcaccatgcc cggcgccgac agtccaacgg
     7321 tccgtccgca ccggatcggc caccggcccg acgaaaggaa atccgtgccc gcctttaccc
     7381 tcaccgaatt ccggcaggtc gtggagaagt gcttccaggg ggaggccgga cccctcgacg
     7441 aaaccgcgct ggacgcgacc ttctccgacc tcggcttcga ctcgctcatg gtctacgagg
     7501 tcaccgtccg catccaggac gagtaccccg tggagatcac cgacgacgaa ctcgacgagt
     7561 tgcggacacc gggcgcgttc atcgccttcg tcgacgccag gctctccgtt tccggctgaa
     7621 ccaccgcgcg aaccacttgg tccaccgcgg acaatccgtc agagaggttt ccatcgtgga
     7681 gcggtctgtc gccatcaccg gcatcggggt catggccccg ggcggggtcg gcaagaaagc
     7741 gttctgggac cttctggtct cgggccgcac cgccacccgc accatctcct tcttcgaccc
     7801 ggcgccgttc cggtcgagga tggccgccga gatcgacttc aatcccgagc tgcacgggct
     7861 gaccgcccgc cagtgccgca ggctcgacag ggccgcgcaa ctggccgtga tcagcgcacg
     7921 tgagagcctc gccgacagcg ggctggagtt cgacacggtg gacccccacc gggtcggagt
     7981 ctgcgtcggc agcgccgtcg gcggcacgac cacgctggag caggagtacg tggtcctgag
     8041 cgacagcggc aaggagtggg atgtcgaccc ggcgtacctg tccccgcacc tgttcgacgc
     8101 cttcgtgccc agttcgctgg cggccgaggt cgcctggctg gtgggtgcgc aggggccggc
     8161 cacggtggtc tccaccggct gcacctccgg tctcgactcg ctcgggcacg cacgggacct
     8221 gatcgcggag ggcagcgccg acatcatgat cgccggcgcg accgacacac cgatctcacc
     8281 catcgcggtg gcctgcttcg acgcgatcaa ggcgacctcg ccgcgcaacg acgaccccga
     8341 gcacgcctcg cgccccttcg accgcacccg caacggcttc gtcatcgccg agggctcggc
     8401 gatgctcgtc ctggaagagc tggagcacgc cagggcgcgg ggccagcacg tctacggtgt
     8461 catctccgga tacggctcgc gctgcaacgc ctaccacatg accggactgc ggcccgacgg
     8521 gcgggagatg gccgaggcca tccgctacgc gctggacgag gcgaagcgcc cgccggagtc
     8581 ggtcggctac gtcaacgccc atggttccgg caccaagcag aacgaccggc acgagaccgc
     8641 ggcgttcaaa cgcgcgctcg gcgagcacgc ctacaacgtg ccggtcagtt ccatcaagtc
     8701 catggtcggg cactcgctcg gcgcgatcgg ctcgatcgag atcgcggcct gcgcactggc
     8761 catggaacac ggtgtggtgc cgcccacggc caacctgcac gagccggacc cggagtgcga
     8821 cctcgactac gtgcccaacg aggcccggga acggcgcctt gacaccgtac tcagcgtggg
     8881 cagcggcttc ggcggcttcc agagcgccat ggtcctcacc cgggagggca tatgacgatc
     8941 accgcacccg gcaccgcacc cgccgcggcc gccaccagga ccgcggtcgt caccggcatc
     9001 ggtgtcgtcg cgcccaacgg gctcggcacc gaggagtggt ggagcgccac cctccgcggg
     9061 gagtcgggca tccgcccggt cccggaccac tccacccggc ccggccaggc gccgctgatc
     9121 ggcctgatcc ccggattcga agcggccgac cacctcccgg gcaggctgct gccgcagacc
     9181 gaccgggtga cccggctggc cctcgtggcc tcggactggg ccctggccga ctccggggcc
     9241 gacccggccg cactgcccga gtacggcatg ggcgtggtga cctccaacgc gacggggggc
     9301 ttcgagttca cccaccgcga gatccgcaag ctgtggaccc agggccccca gcacgtcagc
     9361 gtctacgagt ccttcgcctg gttctacgcg gccaacaccg gccagatctc gatccgtcac
     9421 gggatgcgcg gccccagcaa tgtgctgatc gccgagcagg ccggcggcct cgacgcgctc
     9481 gggcacgcac ggcgggtact gcgcaagggc ggcgaactgg tcctcaccgg cggggtggag
     9541 tcggcgttcg acccgtgggg cgtggtctcc cacatcgcgg gcgggcgggt gtcgcggtcg
     9601 ggccacccgg accgcgccta cctccccttc gacaccgggg cgtccggaca cgtaccgggt
     9661 gagggcggcg cgatcctggt cgtggagacg gccaccgccg cggccgaacg cgacgccggt
     9721 caggtctacg gcgaaatcgc cggctacgcg gccacgttcg acccccctcc cgggtcgtcg
     9781 gccccgccgg ggctggcccg gacggcacgg ctggcgatgg cggacgccgg ggtgactccc
     9841 gaggacgtgg acgtggtgtt cgccgacgcg gcggccctcc ccgcgctcga cgccgcggag
     9901 gccgccgcca tcgaggagat cttcggcccg tacggcgtac cggtcaccgc accgaagacg
     9961 atgacgggac ggctcgccgg cggcggacct gccctggaca ccgcggccgc cctgctcgcc
    10021 gtgcgcgact cggtcctgcc accgacggtc aacgtcgaac ggccggtccc gggccggcgg
    10081 atcgacctgg tgcgcggcga gccgcgcgag gcccgggtcg aggtggcgct gatcctggcg
    10141 cgcggccacc acggcttcaa ctcggcgctg gtggtgctcg ccccgaaccg gatggcagcg
    10201 gctccggccg gggtgccggc cgccgtacgc caccacacct gacctccaca cagtgaccgg
    10261 cgacggaagg acgagcggtg gggacacgac tgaggatcac cgtgctcggc aggctggcgg
    10321 tgtcccgcgg cgcgctgacg gcggcgccca gcgcgccgaa ggaacgcaag ctgctggcca
    10381 tgctcctgct cggtcacggc agcccggtcc cggtacggca gctggtggac gagctgtggg
    10441 gcagcagccc gccgcgcacc gtacggacgg cgttgcagac ccatgtgctc aacctgcgcg
    10501 gcatgctcgc ccgtcagctg cacatccctg gggaccgggt ccgcagggaa ctgatcgtca
    10561 ccgggaacga ggggtaccaa ttccgggtcg gtgatgccga cttcgacctg cacgaatacc
    10621 accggctggc aaaactcggg gaatcggaac tccgggtggg tcaccatctc ggggcggccg
    10681 aatcgctccg tacggcggag tcactgtgga cggggccgat actcccggac acgaaacacg
    10741 gccttccgct ccaatgcgag ataacccggc tcgaactgca gcgggacatg gtccaggagc
    10801 tgcggatcga gagcgatctg gcactgggcc ggcaccggga gctgctcagc gaactgaccg
    10861 cgctcactct cgcccgcccc ttcgacgaac gggttcatga gtacctgatg accgcgctgt
    10921 accggtcggg ccgcaccatc caggcactcc aggtgttcca gcgactgcgc acgaagatgg
    10981 ctcaggagat gggcctggag ccgtcccggg tgatccagga cctccagcga agaattctgg
    11041 gcgcgaccgc ctacgaatcg atcccgtgac cgccacagcc cgcgacaaga gtccccgaga
    11101 aggccggaac ccataaacgg aaaaggcgtg ttctgaggca tgagaattct cttctgcacc
    11161 tactcgacgg caagcgacct gttcgccacc attcccttcg cctgggcact gcgcgcggcc
    11221 ggtcacgaaa tcctctacgc cggtggcggc gagggcatgc gggaagtcgc caaggccggt
    11281 ctgccctacg tggacatcgc cacgccgggc gtcgatctcg cggcaccgtt cgcgcgcagg
    11341 gccgcacagt cccgggagaa gggacaactc gtctggtatc gcggcggcga cctccaggag
    11401 gacgaggtac gggcgacgtc cgcgctgttc gccgaactct ccgagctggt cgtgcccggt
    11461 gcggtgcggc tcgcacggca gtggcgtccc gacctggtgg tgagcccgga ccaccagggt
    11521 tccggtgccg tcgtggccgg gctgctgtcc gtaccgctga tcgccatgtc caacctcttc
    11581 gcgctggtcc ccgacatggt cgaccggata cgcggggaga tggccggcac ctacgaccgc
    11641 tacggcatcg accccggctc ctcccgcacc cggctgctcc gtacgacacc gcccagcctg
    11701 ttccgggcat ccggcaacca cctggccatg cgccccgtgc cctacaacgg ctcctacctg
    11761 gagctcggca cgattcccga ctggctgttg cgctccccgg accggccccg ggtctgcgtc
    11821 accctgggca ccttcatccc ccagtacatc ggactcagcc tgatccgcga cttcgtcgcc
    11881 gaactggaca cggtcgacgc cgacttcgtg ttcgtgctcg gcgacgccga ccgtacggaa
    11941 ctgggcaccc tgccggacaa cgtccgctca cacggatgga tcccgctgaa cacactgctc
    12001 gactcgtgcg acgcgatcat ccatcacggc ggcaccagca cctcgctggc cgccatgtcc
    12061 gccggtatcc ggcagatcgc gctgccgcac ggttccgacc agcccttcaa cgcgcgcctc
    12121 gtggccgaac gcgggctggg agtcacctgc gcggcggccg aactgaccgc gaagaccatc
    12181 accaccgtgc tggaggcgcc ggagatcggc accgccgccg cgcaggtacg ggaggagatc
    12241 gcccgcctgc cgtcgccctc cggcgtggcc tccgcactgc cggatctcgt gggctgagcc
    12301 gtccgggaga ccccgcggca cacccgtcat gccctgagag gctctcggct gacctctgat
    12361 cgggcggcca cgccctggca cgcacgcttc cggcgttgcc gaaatgccct agtagctccg
    12421 ctacgaggac atctcggcgc cttggaatcg cacgcaccag accgcgtccg ctttccgatc
    12481 gaaggccacc caacagcctc tgacaccgca cccggttctg gaggattccc gaagtggccc
    12541 cgcacgcaca cccaacgccc ggcccggacc tgaccgcaga gcacctggcg gcactcgcgg
    12601 cacaacacgc cgccaccgcc gacaacgaac gccgcctcgc ccccgacgtc gccgccgcgc
    12661 tggtggacgc cggattcgcc cgccacttcg tgccggccga ccacggcggt acggcgggct
    12721 ccttcaccgc actggccgag gcggtgcgca ccatcgcgcg gggctgcccc gcggccggct
    12781 ggtccgccat gatcatggcc acgtccgcgc ggctggccgg ccggctgccg cgggccggcc
    12841 ggaaggacat ctgggggcag tcggccgacg tgccgatcgc cgccgcgctg aacccggggg
    12901 gctcggcacg gcgggtcgcg gacggatggg tcctgtcggg gcagtggttc tcgctgtccg
    12961 gcatcgacca cgcggcctgg gcactgctgt gcgtgaccgc gcccgaggac gggacgcagc
    13021 actactgcgc cgttccggcg agccggttcc gtatcgagga cacctggttc accctcggca
    13081 tgcggggtac gggaagccgc agcgtggtgc tcgacgaggt gtacgtcccc ggccatctct
    13141 cggccccccg ggacctggtg tggcaagggc gcgccgacgg ccccgacgac gccctctccg
    13201 ctcccctgcc ggccgcgcat ccaccgctgt tcgccgcccc cgccgtgggc gccgcccggg
    13261 cggccctcga cctgtgggca cgggccgagt cccgcaccgg ccccgaccgc gacgccgtac
    13321 tgacccgctc ggcggccgag atcgacaccg cggccctgct cgtcgagcag gcatgcctgc
    13381 gcctcgacgc cccgggcccg gtcggcggca tcgacgccgc gcgcaacggc cgggacgccg
    13441 cactcgccgc ggacctggcc cgcaccgcca ccgaccgtct cttccgcgcc cgaggaagcc
    13501 gcgcccacgc cgctcaggac tccgtccagc ggctctggcg cgacgtacag acggcgtcct
    13561 cgcacgcggc cgtcgacgcc gcgcggagca actcgctgtt cgcaaccacc ttccgggcat
    13621 ccctgcccga ccacgaggag agctgatgat ctgccacacc ctgatctaca agttcgccga
    13681 atccgtctcg gccgaggacc gtgatcagtt cctgaaggag ctcagtgaga cggtccggag
    13741 caccgggctg tccgtcggct tcgactaccg gatccacgag tggctgcccg tggacgagaa
    13801 ggcgatcggc atgaccggct ccgcgatcgc ccagatcgtg tgcgaggaca gcgagacgat
    13861 gcggaagttc tcggagctga cctccacgca cgagttcatc gcctcctggc gctccaggat
    13921 cagctacgaa gccgcctacg ccaaccaccc gccgctgacc ggcgtccccg cggacaaccc
    13981 tctgcaccac gcggagcaca ccgtcaccgt gcacgccccc gtggccgttg tctgggacat
    14041 cctggtcgat gtcgagggct acgccaggat cttcccgccc acccaggacg tgaagctcct
    14101 ggaggagtcg ccgacgcacc agatcgccag gctcgtggtc gacgtcaacg gcgagaccaa
    14161 ctcctggatc tcccggcgcg acatagacgc cgacaaccgg gtcatcacct accggcagct
    14221 ggagcacgcg ccgatcgtcg gccacatggg cggccagtgg cgggccctgc ccctgggcga
    14281 cgacaccaca cagctggtgc tgacccatga gttcagggcc cgggaggcgg tcgacggcaa
    14341 ggtcgcgggc aggctcaccc cgcaggaggc cgacgccgcg ctgcgggccg tggtggagcg
    14401 caacagcgtc gccgatctcg gcgcggtcaa gacgacggcg gaggccaccg caccgggcaa
    14461 cggcggcacc cgatgacccg gctggtggac ctcagcgtgc ccaccgagca gaccgacagc
    14521 gaagcgacgc cggtgaagat cgatctgctc gaccacgtgg cgggcgccac cgtgctgggg
    14581 ctctctccgg aggacttccc cggcgggatg gccatctcca acgagaccgt caccctgacc
    14641 acacacaccg gcacgcacat ggacgcgccc ctgcactacg gcccgctcac cggggacgcc
    14701 ccggccagga gcatcgacca ggtcccgctg gagtggtgct acggacccgg cgtacggctc
    14761 gacttccgtg acgtcccgcc cgggcagggc atcaccgtga cgatgctgga ggaggagttc
    14821 agccgcatcg ggcacgtacc ggtcgccggc gacatcgtgc tgctgtggac cggcgcggac
    14881 gccctgtggg gaagcagcga ctacctgacc acgttcgcgg gactgaccgg cgagggcacc
    14941 gtcttcctgg ccgagcacgg tgtgaaggtg atcgggatcg acgcctgggg cctggaccgg
    15001 ccgattccgc acatgatcga ggactaccgg cgcaccggcg accgctcggt gctctggccc
    15061 gcgcacgtcg ccggacgcac ccacccctac ctccagctgg agaaactggc ccacctgggc
    15121 gatctgccgg gccccacggg ctacatggtg gcgtgcttcc cggtcccggt caccggtgcg
    15181 ggcgcgggct ggacccgtgt cgtggccatc tgcgacgcgt gaccgggagg gacggcatgg
    15241 ccggtcatcc gttggccctg gacgaagcgg cacaggatct gctgttccgg gaggcgagaa
    15301 ccgcgaacac gttcgccccg acccacatcg gcgacgagca catcgaagcg atctacgacc
    15361 tggtcaagtg gggcccgacc tcgatgaacc agcagcccat gcgggtcgtg ctggtccgct
    15421 ccgacgagtc gagacgtgcg ctgctgcagc acgtcctgga ggggaaccgg gacaaggtcg
    15481 cctcggcccc cctggtcgcg gtcctggcgg cggacctgag cttccccgac acactgcccc
    15541 gtctctttcc gcacgccccg aacgcccggc acgcctatgc cgacgagaac gcccgccgtg
    15601 agtccgcggt gttcaacacg gccctgcaac tgggctattt catcatcggg atccgggcgg
    15661 gcggcctggc ggcggggccg atcgcaggct tcgaccccga gggcgtccac aaggagttct
    15721 tcccgggcga accggtgctc gtcaccagca tcgtcaacat cggctacccc ggcccggacg
    15781 ccttctccgc ccggctgccc cgcctgggct accgagaagt cgtccgcagc gtgtgatgtc
    15841 tccgcgccgt caccgcacca cagcctcatg gaaggagaag agatgagcat ccgaccgaat
    15901 cagctgctga ccgttctcgc cgactgctcc ggcaatcagg aactcgtcgg catcgggaac
    15961 gacgcactcg acacggactt cgacgccctg ggtctcgatt ctctggcggt actggaatcg
    16021 gtggcccgga tcgggcggga acacggaatc cacatatccg acgaggaggt tcatgacctg
    16081 ggcaccccgc tggcgctgct gaaccggctc aaccaggcgc agaacgacgg cgacgaggac
    16141 accgacgccg aggagcggct gcccgtggtg gtggtcgggg ccggcccggt cggcctcgcg
    16201 ctggcgggcg aactggccgc tcatggcatc ggggtgaccg tgctcgaacg gcgggccacc
    16261 cccgagacga tggtcagggc cggttcggtc ggaccgctcg cggtggcgct gctgcgcagg
    16321 cgcgggctgg ccgacgagct ggaccgggcc gagcgggaga ccgtggagcg ctaccgcgcg
    16381 atggccgaca gcgccgcggg cgcggtcggg cacgccctgc cgaaggagca tctcgccggc
    16441 atcgagaagg tcgagcatgc cgacgcctcg atgcgccgga tgcgggtgga gcagccggcc
    16501 ctcgtcgaca tcctgctgcg gcacgtcgcc gcactcggcg tcgacgtggt gtgggagcac
    16561 gaggtgaccg cgatcgagca ggacgaccgg ggagtgtggg tcactgtggc cgcacccggc
    16621 ggcgagcgac gcctccgcgc ggcctacgcg gtcggctgcg acggcggcga cagcacggtg
    16681 cgcaggctcg ccggcatccc gctgaccggc accgaagcga ccctgaccgg ccggcagtcg
    16741 gtcgtcgagt tcgagggcga accaccgctc gaacacggct tccgccacac ctccggcggg
    16801 ctcgtcgcgt ggggtctcgg cgtcaaccgg gtcgccaccc tggagttcga cgggcccccg
    16861 gccccggacg ccgggccgct gacgtccggt gaactccagg acagtctccg gcgtgtgacg
    16921 gggaccggcg ttccgatctc gcggatggcc gccgggggcc ggttcaccga catggcgtac
    16981 caggcggcgg agtaccgcag gggccgggtc ttcctggccg gtgacgcggc ccatgtgcac
    17041 gccccgttcg gcggtcaggg cctgaacacc ggcatcaccg acgccgccaa cctcggctgg
    17101 aagctcgccg ccgccctcga cggctgggca ccgccccggc tgctcgacac gtaccacgcg
    17161 gaacggcatc cggtgggtgc ccggctgctg gccaacgtcc gggcccagac ggctctgatg
    17221 cggcccgatc cgcacagcag cgccctgcgc gacctcgtcg gccggatgat ggacgtgccg
    17281 gacgtgcgcc gcttcgtcgg tgccctgctc agcggaaccg acgaggggta cggcacggac
    17341 gggcacccgg cggtcggcac cttcctgccg gactacgaag tgacggaccg ccaggagccc
    17401 gcctcgggaa ggggcctgct gctcgacttc accgactgcg ccgcgctgcg caccatcggg
    17461 gcgaggtggg cggaccgggt ggacatcgtg tccgcgaaga ccgggcgcga cgatctggcc
    17521 gcggtcctgc tccggcccga cggctatgtc gcctgggcac tggcgaccgg ggacaccccg
    17581 agggcccggc cgctggtgcg ggctctgcgc acctggttcg gtaccggccg ctcccccgcc
    17641 ggtacgcccg cggctccggc cggagcccga cggtgaaccc cgccgatctc atcggtgtgt
    17701 ggacgctcga ttccttccac gacatcgacg ccacgggcac ccgcgccgaa ggaccgctgg
    17761 gcgccgcccc tcgcggcacc ctcatctaca ccgcggacgg gcgtgtgtcg gtgcacatga
    17821 tgcgtgcgcc ggacgccgac ccggtccccg ggagcaacga ctacatgggg tacacgggca
    17881 cctggcgggt gacggggtcc cgggtgacgc acgccatcga gatcacgcca cgtcgcccat
    17941 gggtcggcac cgagcagacc cgcggggcgc gtctcgaagg cgaccgcctg acactggacg
    18001 gctcggtccc ggtgaacggc cttgagcagc gacgggtgct ggagtggcgg cgcacttccg
    18061 cccacggcac gacgaggcac tgaccgaacg ccacaccgtg cccgtccgta cgttccggcg
    18121 gcaccccgag gcgatccgca ccaccgatcc acaccaccga tacgcactac cgatccgcac
    18181 tactgaggag acactgtgac cattctggta accgggggcc gcggacatgt cggccgcagc
    18241 gtcacgcgaa agctgctcgc ggcgggagag agggtgcggg tgggcaccag cgaccccacg
    18301 gacacctcgc tgtcccgcga cgcggaggtc gtggagctgg atctgtccag gccgcagacg
    18361 ctgagcgcgg cactgcgcgg cgtacagcgg gtgttcctgt acgccgaccc ctcgacggtc
    18421 gaccagcaga tcgaggccat ggagctggcc ggggtggacc atgtgaccct gctctccacc
    18481 aggtcgctga ccttccggga cgccgacagc aaccccatcg cccggctgca cgtcgcggtg
    18541 gagcgcgcac tgggccagtc ccggctgccg tggtccttcc tgcgcgcggg gacgttcgcc
    18601 acgaacacac tgcagtgggc ccgcctcatc cgctcggaca acaccgtgcg ggcgccctac
    18661 ccgcagtcgc acgccgccgc ggtgcacgag gacgacatcg ccgatgtggc cacgctgacc
    18721 ctgacccggc aggggcacgc cggtgccgcc tatgtgatga gtggtcccga gtccaacacc
    18781 cagcgcgagc aggtatcgct gatcgggaag gccatcggcc gtgagatcga gttcgaggag
    18841 atcgagccgg agacgtaccg gcagacgctc agccgctggg gcggcgggcg cgaagaggtc
    18901 atcaaccagc tcctcaccta cctggtgacc tggaacgagc gtccggtgcc cgtggtggac
    18961 gcgttgcagc agctcaccgg caagccgggc cggccctacg cgcagtgggc cgtcgaccac
    19021 gccgatgact tccgctgacc ggaccggtca ggtgctcccg gggcggccct gcggggccgc
    19081 cccggggggt cccgggcact ccccccgtcg acgcgtaccg agagaaggag cacgatggcg
    19141 tccgcaccca cgatccttgc gtccgccccc cggcacagcg ccctgctcgg cgtcgggggc
    19201 taccgcccgc ggcgggtggt gacgaatgcc gagatgtgcc ggtcgatcga ttccacggag
    19261 gagtggatcg agacccgcag cggcatcgtc cggcggcatt tcgccggcga ggacgagacg
    19321 ctgacgatga tggccgcggc ggccgcggaa caggccatgg cgcgggccgg cactgctccg
    19381 gccgatatcg acctggtgct ggtcgccagc atgtccgacc tggtccagac accgccgctc
    19441 gcggtccgcg tggcccacga actcggggcc gaccgggccg cgggcctcga tctgtcgggg
    19501 gcctgcgcgg gcttctgcca cgccctcgcg ctcgcctccg acaccgtacg ggtccgcgat
    19561 gccgagcggg tcctggtgat cggtgccgag cggatgaccg acatcgtgga acccaccgac
    19621 cgcacgatcg cgttcctgtt cgcggacggg gcgggcgccg tggtggtcgg accggcgcgg
    19681 gaaccgggca tcggtcccgt ggtgcgccgg gcgtacggcg cgtacggcaa cgcccttcgg
    19741 atgaccgggc cctgggccgg gaagggtccg cgcccctgga tgcgcatgga cggccggagg
    19801 gtcttccgct gggccatgga ggaggtggcg ccggccgcgg gccgggctct ctcggcggcg
    19861 ggtctggcac cggccgacct ggccgcgttc gtgccgcacc aggccaacct gcggatgacc
    19921 gagctgatgg ccgagcggct cggcctgggc gaggacaccg tgctggccac cgatgtggtc
    19981 aggtccggca acacctcggc cgcctcgata ccgctcgctc tggacaccct gctggccgag
    20041 gggcgggtgg ccgcgggcag tacggccctg ctggccggtt tcggggccgg cctgaacttc
    20101 gccgctcaga cggtcctgct gccctgaggg gccgcgacac gggagccgga ccactcgaac
    20161 caccggtggt ccggctcccg cactgccgtg tacggctcac cggcaggtca ccaggcgacc
    20221 atcagctccg tggggccgtg cacgaactgc ccctcccgcc agggaacgtc ccgcttctcc
    20281 ccggccagcc ggagcgtggg gaactcgcgc agcagcgccc cgagcccggc ccgtagttcc
    20341 aggcgggcca gctgcgcacc gagacagtgg tgcacgccgt gcccgaatcc gacgtgcggg
    20401 ttcggggacc ggtccagctt gatgcggccg ggctcctcga agaccgtctc gtcgtggttg
    20461 gccgatccga tggccgcgat caccgcctcg cccgcgcgca ccaccgtgcc gtcgaactcc
    20521 acgtcctcca gggcgatgcg cgtggtccca ccgttgacga gatggacgta ccgcagcagt
    20581 tcctcgaccg cggtgtcgag cagttcgggc tcttcgagga gccgggacca caggccggtg
    20641 tccagcaggg tgaaggtgaa gttggagagc tggttggccg tggtctcgtg cccggcgacg
    20701 agcaggtcga cgcccatctg caccagctcc tgctcgctga gccggtccga ctcgtcccgc
    20761 gcctccacca ggtcggtcag caggtcgcgg gagcgttggg ccgagggccg tgcgcggcgt
    20821 tccgccacgt gccggccgag atagtccagc agggtgccga tcgcctcgtc gatctcctcg
    20881 ccggtcgccg cggtggtgct cagcatgagc cgggacagcc gctcgaagta gccgcggtcg
    20941 gtcgccggca cgcccagcaa ttcgcagatc acggtcaccg gcagcggtac cgagaagtgg
    21001 tgcaccaggt cgacggggga tccgtgctcc cgcattccgg ccacgagtcc gtcgacgatc
    21061 tgttccgtcc ggggccgcca gcgctgcacg ttcttcatgg tgaacgtgcc cgccacgagc
    21121 ttgcgcagcc tgctgtgctc cggcgggtcc atggcgaaca gtccgccggg cggggtctgc
    21181 gccgggctca cccgcggcac gtccgcgttg accgtcgcgg cccgggagaa cctcggatcc
    21241 gcgtagacct tccgcacatc ggcgtaccgg gtggccagcc acgcgtcgcc accgaaggga
    21301 cacccgaccc gccgcagcgg ttgctccgcg cgcagcgcgg cgaactccgg tggcggaccc
    21361 agctcagtgg tccgctcaaa cggaagccgc ggggcatgtg ttgtcatgac gtactccctt
    21421 tgcggttcca ggcacattcc atcgctccga agctacgggg gcccgcaccc cgactcactc
    21481 aaggaccgct catacaaacg gtagttggcc gaaccccgat ggcctgctga gctgtagttc
    21541 gatagtttgc gcatgggact tgacagaacg tcagtgatcc ctttcgacct ggtaaaacct
    21601 acatagacaa agggtaaaaa tggtaaagaa atatcgcgct gtggagttcg ccgagtacgg
    21661 gggccccgag gtcttacgtg tggtggagcg cgagatgccc cggcccggtc ccgggcaggt
    21721 gctggtggag gtccgcgccg ccggggtgaa tccgctggac tggcagctgc gcagcggggc
    21781 cgtcgcggag atgatgccgg tggagttccc ttcggtgccc ggcggtgatg tcgccggtgt
    21841 cgtcgcggac gtcggtgagg acgtgaccga cttcgccgtg ggcgacgagg tcttcggctc
    21901 gatcggctcc ggcagctacg ccgagttcgc gctcgcgccc gcggcacagc tcgcgcggaa
    21961 gcccgaaggt gtgtcctggg aggtcgcggc cgggctgccg gtggccgtca acacggcgta
    22021 ccaggtgctc gcggacctcg gggtgaagtc cggggagacc ctggtcgtgg acggcgccgc
    22081 cggtggcgtc gggtccgtgg ccgtgcagat cgccaggcat ctcggcgcga cggtgatcgg
    22141 tacggcgagc gagcgcaacc acgcgtacct gcgctcgctc ggcgccgaac ccgtgacgta
    22201 cggggagggg ttcgccgagc gggcccgcgc cgtcgccgag aagggggtgg acgcggcgtt
    22261 cgacgccgcc gggaagggct cgctaccggc cctggtcgaa ctgaccggcg gcccggaccg
    22321 cgtggtcacc atcgccgatc accgggcggc ggagcacggt gtgcgcttcg cgttcgccgg
    22381 ccccgacgcg atccgtgagc gcctggagca ggcggccgcg ctggtcggga acggcgaact
    22441 cggcctgtcc gtggcccgga cgtactctct gtccgaggcg gccgacgccc accgggagag
    22501 cgcgggcggc catgtacgcg gcaagctgat catcgtaccc agctgacgcc ggtccatcac
    22561 gtcccggtgc gtcacgtccc ggtgcgtcat gtgtcggtgc gtcatgtgcc ggtgcgtcat
    22621 gtgccggagt ggagcaccgc gacggccgcc gcgaaggctt cggcgtccgc ggcggtgccc
    22681 gcccgatcac tccgggccag cagcgggtga acactgctcg ggccgcgcag gacggcccgg
    22741 tgtccgcgtg cggcgaccgc gaggctgcgg tccgcgctcg cgtcgagcag tacgagcccg
    22801 gggtcgaggc cctcggagtc gagcagtgag cgcagtgcgg gccagtaccg tacggggagc
    22861 gatatctggt cggcccagaa ggcggggtcg acggcctctt cggcgctcac cgggcgtgcg
    22921 gtcctcgtgg acatgatggt cgcccgcggc ggcccgggcc ggagccggcc caggtcctgc
    22981 ccgaaccgcc gggcggccgg aaccatcgcc gggctgtgga aggcgtgccc cgatcccagt
    23041 gtgcgcagcg tgatgtcgcg gcgctccagt tgtccgcgca ccgccgcgag gacgctgtcg
    23101 gaaccggcga gcacggtctg ccgggggccg ttgtcggccg cgacgacggc ccccgtacgc
    23161 agctccgcgg acagctcctc cgcagtggcc gcgacggcca gcatgccgcc gcgtccggtg
    23221 tcgtccagcc gccggacgtg gccggccatg gccgtcgcga gttccgccgg ggcgaagacg
    23281 tcggccaggc acgccgcgac gagttcgccc acgctgtgcc ccagcagcac gtccggcgcc
    23341 ccggcggcgg accgcaccgc gcgtccgagc gcgtggccga cggcgaacag cagcggctgg
    23401 gcgacgacgg cctcgtccac cgcaccggcg gaaccgggat ccagccagac gtcccgcagc
    23461 ctgtccccgt cggcgccgaa caccgtgaac atctcgtcca tccagcgggt gaactccggt
    23521 tgcacgccat ggagtcccgc cgccatccgg acgcgctgcg ccccctgtcc cggcagcagc
    23581 aggacgactc gtcgccgtgt cac
//
