BGC0001623: ishigamide biosynthetic gene cluster from Streptomyces sp. MSC090213JE08
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Location: 1 - 37,581 nt. (total: 37,581 nt).
This entry is originally from NCBI GenBank LC269948.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001623
Short description ishigamide biosynthetic gene cluster from Streptomyces sp. MSC090213JE08
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
LC269948.1
via
Compounds
  • ishigamide
Species Streptomyces sp. MSC090213JE08 [taxonomy]
References
Chemical products information
ishigamide Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAX64242.1
  • iga1
 462 - 758 (+) LuxR family regulator
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    • BAX64243.1
    • iga2
    		 891 - 1649 (+) SARP family transcriptional regulator
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      • BAX64244.1
      • iga3
      		 1735 - 9360 (-) NRPS
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        • BAX64245.1
        • iga4
        		 9697 - 10734 (+) cysteine synthase
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          • BAX64246.1
          • iga5
          		 10753 - 18882 (+) NRPS
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            • BAX64247.1
            • iga6
            		 18879 - 26222 (+) NRPS
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              • BAX64248.1
              • iga7
              		 26237 - 26479 (+) MbtH-like protein
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                • BAX64249.1
                • iga8
                		 26482 - 27447 (+) ABC transporter
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                  • BAX64250.1
                  • iga9
                  		 27444 - 28286 (+) ABC transporter
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                    • BAX64251.1
                    • iga10
                    		 28389 - 28640 (+) ACP
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                      • BAX64252.1
                      • iga11
                      		 28670 - 29899 (+) ketosynthase
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                        • BAX64253.1
                        • iga12
                        		 29900 - 31036 (+) ketosynthase
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                          • BAX64254.1
                          • iga13
                          		 31033 - 31761 (+) ketoreductase
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                            • BAX64255.1
                            • iga14
                            		 31761 - 33488 (+) flavin-dependent oxidoreductase
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                              • BAX64256.1
                              • iga15
                              		 33544 - 34575 (+) alanine dehydrogenase
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                                • BAX64257.1
                                • iga16
                                		 34687 - 35163 (+) MaoC dehydratase
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                                  • BAX64258.1
                                  • iga17
                                  		 35295 - 36614 (+) histidine kinse
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                                    • BAX64259.1
                                    • iga18
                                    		 36578 - 37222 (+) LuxR family regulator
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      Unk01
                                      Type
                                      nrps-type1
                                      Genes
                                      iga3
                                      Substrates
                                      glycine (evidence: Sequence-based prediction, Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk02
                                      Type
                                      nrps-type1
                                      Genes
                                      iga3
                                      Substrates
                                      leucine (evidence: Sequence-based prediction, Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk03
                                      Type
                                      nrps-type1
                                      Genes
                                      iga5
                                      Substrates
                                      serine (evidence: Sequence-based prediction, Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk04
                                      Type
                                      nrps-type1
                                      Genes
                                      iga5
                                      Substrates
                                      serine (evidence: Sequence-based prediction, Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk05
                                      Type
                                      nrps-type1
                                      Genes
                                      iga6
                                      Substrates
                                      threonine (evidence: Sequence-based prediction, Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk06
                                      Type
                                      nrps-type1
                                      Genes
                                      iga6
                                      Substrates
                                      isoleucine (evidence: Sequence-based prediction, Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Annotation changelog

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Added NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2018-08-06
                                      Submitted
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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