LOCUS       BGC0001625             22706 bp    DNA     linear   BCT 08-JAN-2017
DEFINITION  Streptomyces sp. CB01883 isofuranonaphthoquinone biosynthetic gene
            cluster, complete sequence.
ACCESSION   BGC0001625
VERSION     BGC0001625
KEYWORDS    .
SOURCE      Streptomyces sp. CB01883
  ORGANISM  Streptomyces sp. CB01883
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:56:34
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22706
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..765
                     /gene="ifq(-1)"
     CDS             1..765
                     /NRPS_PKS="Domain: PKS_KR (4-181). E-value: 4.3e-11. Score:
                     34.9. Matches aSDomain: nrpspksdomains_ifq_-1__PKS_KR.1"
                     /codon_start=1
                     /gene="ifq_-1_"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     191.5; E-value: 2.9e-58)"
                     /gene_functions="biosynthetic-additional (t2pks) KR (Score:
                     136.6; E-value: 2.8e-42)"
                     /gene_kind="biosynthetic-additional"
                     /product="dehydrogenase"
                     /protein_id="APR73624.1"
                     /transl_table=11
                     /translation="MTEIALVTGANKGLGKEIARRLAAKGLTVYLGARNEERGLGAARE
                     LERAGQAVPAGGDVRFVRLDVTMREQVDAAVRRIEEECGRLDVLVNNAGIVTEWGVPVE
                     EVTEDHLRRAFEVNLFGAVALTRACLPLLRRSKDPRVVNLSSPLGSLSLLSDPSGHPAA
                     SRGLLAYSSSKAALNAVTLMYAEALRAEGIRVNAANPGLVATDLNADSPFSRGTRTVEQ
                     GAEVPVRLALGAGGTGGFHGGMEGDVTERVPW"
     source          1..22706
                     /db_xref="taxon:1703943"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. CB01883"
                     /strain="CB01883"
     misc_feature    1..22706
                     /note="isofuranonaphthoquinone biosynthetic gene cluster"
     protocluster    1..22706
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[12103:14598]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="7 (Score: 714.1; E-value:
                     1e-217)"
                     /t2pks_molecular_weights="acetyl-CoA_7 (Da): 322.353"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
                     /tool="antismash"
     proto_core      12104..14598
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="7 (Score: 714.1; E-value:
                     1e-217)"
                     /t2pks_molecular_weights="acetyl-CoA_7 (Da): 322.353"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
     cand_cluster    1..22706
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..22706
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001625"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22706
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        13..543
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ifq_-1__PKS_KR.1"
                     /evalue="4.30E-11"
                     /label="ifq_-1__PKS_KR.1"
                     /locus_tag="ifq_-1_"
                     /protein_end="181"
                     /protein_start="4"
                     /score="34.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="ALVTGANKGLGKEIARRLAAKGLTVYLGARNEERGLGAARELERA
                     GQAVPAGGDVRFVRLDVTMREQVDAAVRRIEEECGRLDVLVNNAGIVTEWGVPVEEVTE
                     DHLRRAFEVNLFGAVALTRACLPLLRRSKDPRVVNLSSPLGSLSLLSDPSGHPAASRGL
                     LAYSSSKAALNAVT"
     CDS_motif       16..78
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ifq_-1__0001"
                     /evalue="2.50E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ifq_-1_"
                     /protein_end="26"
                     /protein_start="5"
                     /score="16.9"
                     /tool="antismash"
                     /translation="LVTGANKGLGKEIARRLAAKG"
     gene            complement(887..1198)
                     /gene="ifqA"
     CDS             complement(887..1198)
                     /NRPS_PKS="Domain: PP-binding (30-93). E-value: 3.2e-15.
                     Score: 48.3. Matches aSDomain:
                     nrpspksdomains_ifqA_PP-binding.1"
                     /codon_start=1
                     /gene="ifqA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 110.4; E-value:
                     5.4e-34)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 109.9; E-value: 1.1e-34)"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl carrier protein"
                     /protein_id="APR73625.1"
                     /sec_met_domain="PP-binding (E-value: 1.3e-15, bitscore:
                     48.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAARCPGPRHTHFEETTAMATLDIEDLRRILVDCAGEEEGAEVSG
                     ATLDTPFEELGYDSLALMETAAAIQDEYGIVLPDEDVSEARTPRNLLDLANGAVRTGG"
     aSDomain        complement(920..1108)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ifqA_PP-binding.1"
                     /evalue="3.20E-15"
                     /label="ifqA_PP-binding.1"
                     /locus_tag="ifqA"
                     /protein_end="93"
                     /protein_start="30"
                     /score="48.3"
                     /tool="antismash"
                     /translation="LVDCAGEEEGAEVSGATLDTPFEELGYDSLALMETAAAIQDEYGI
                     VLPDEDVSEARTPRNLLD"
     gene            1398..2168
                     /gene="ifqB"
     CDS             1398..2168
                     /codon_start=1
                     /gene="ifqB"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="APR73626.1"
                     /transl_table=11
                     /translation="MVPGGLGPLEPRRLVEHAEAALEVVVGAVGGPDTGRLGRIPADAV
                     GACYLDLWICDRLLRHDGGDRSAAAQCLVPLLLLEGVGGLAAALGAGLHRPEPASVEYR
                     RRRRVLVRAARERSPQVWGRLARRMDRLAAGEDRLAHPLTAVRHRALPPPLPELVGGLE
                     EERRRLATAVTREPAADVRYGPAERYALLTAAAACADGWRPHGAGVHDSTLGVGARRAR
                     LCGALCRLSVRLDLPVSESARTAWRADVLRCAVA"
     gene            2153..2887
                     /gene="ifqC"
     CDS             2153..2887
                     /NRPS_PKS="Domain: ACPS (131-193). E-value: 7.4e-14. Score:
                     43.6. Matches aSDomain: nrpspksdomains_ifqC_ACPS.1"
                     /codon_start=1
                     /gene="ifqC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 135;
                     E-value: 3.9e-41)"
                     /gene_kind="biosynthetic-additional"
                     /product="phosphopantetheinyl transferase"
                     /protein_id="APR73627.1"
                     /transl_table=11
                     /translation="MRRGVTPLVAVAPADSLGPVRAALARYGDVAVHADAADWAVDRAE
                     EAALWAGAERGRLTGPLPAPVRRRLVASRRLVRCVAGSVLGVDPLLLELTRDPGGRPRL
                     RGYAHLQVSLSHTGNRLALALGAGGVPVGVDVERADRPVRVETLARRICTPRERAVLAG
                     LPPAERPAVLLRLWTLKEAHAKALGAGLRLPFTGFGFRLLGRTAVLTDDRGQPVRPVES
                     RFTTHLTATGHLVSVAAGSPAG"
     aSDomain        2546..2731
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ifqC_ACPS.1"
                     /evalue="7.40E-14"
                     /label="ifqC_ACPS.1"
                     /locus_tag="ifqC"
                     /protein_end="193"
                     /protein_start="131"
                     /score="43.6"
                     /tool="antismash"
                     /translation="VGVDVERADRPVRVETLARRICTPRERAVLAGLPPAERPAVLLRL
                     WTLKEAHAKALGAGLRL"
     gene            3228..4052
                     /gene="ifqD"
     CDS             3228..4052
                     /codon_start=1
                     /gene="ifqD"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     298.2; E-value: 2.5e-90)"
                     /gene_kind="regulatory"
                     /product="SARP family transcriptional regulator"
                     /protein_id="APR73628.1"
                     /transl_table=11
                     /translation="MKFKLLGQFEVVLNNGRPTTLTRSKVSQLLGLLVVQNGESVGAHT
                     LIEELWGENVPRSALTTLQTYIYHARKLCGIGPGRQSVLVTRPAGYSIEVPGDSVDSVV
                     FEGLVNRARTALDQRDAQRAAGLLDQAFALWRGPVLAGMITGPVLDAHLTYINELRLSA
                     HELHIAACARLGRHQEIIPRLRLLVAENPLNESFHAQLIRALYKSARRAEAIQAYRNLC
                     RILDTELGIEPAPELQTLQQDLMTGIPAGQSADHSFGQVLLAEGAVPRRSYC"
     misc_feature    4014..4016
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4138..4722
                     /gene="ifqE"
     CDS             4138..4722
                     /codon_start=1
                     /gene="ifqE"
                     /product="FMN reductase"
                     /protein_id="APR73629.1"
                     /transl_table=11
                     /translation="MSENPVSVAIAYHSGYGHTTRMAEGVEEGIRSVAGAAVEVVKVDG
                     ITDEDWARLDAADAIIFGSPTYMGSASPAFHTFAAATSGRWYGLAWKDKVAAGFTTSGA
                     MSGDKLNTLQYFTVLAAQHGMHWVNLDLLPGDTENDLNRLGGWLGAMGQCPGDQGAESM
                     RKGDLLTAAHLGRRVAEHALLLRTARERTAA"
     gene            complement(4819..5757)
                     /gene="ifqF"
     CDS             complement(4819..5757)
                     /codon_start=1
                     /gene="ifqF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066:alpha/beta hydrolase domain-containing protein
                     (Score: 271.9; E-value: 1.1e-82)"
                     /gene_kind="biosynthetic-additional"
                     /product="esterase"
                     /protein_id="APR73630.1"
                     /transl_table=11
                     /translation="MPSPYDFDPELAPEAPGMRPLDYADPESARAVMRRVMAKQPHYEH
                     LDRVRVSDRVLPVDGGPRLTVRVYAPAARRGDPLPALLFPHWGGFVTGDLDTPRAFAAR
                     IADQVGAVVVSPDYRLAPEHPFPAGLDDCWAALEWTRAHAAELGVDPDRIGVGGFSAGG
                     ALAAGLALRARDTGGPRIRYQYLLFPQLDDRLETVSAREFTDTPVLDRAALVLSWKHYT
                     GSGPASPLAAPARAEDLSGLPPAFVGVCAYDPLRDEGIHFAHRLIKAGVSTELVHYPGT
                     FHASVGIGHADVSRRMVRDQIDALRRGLRAD"
     gene            complement(5892..6980)
                     /gene="ifqG"
     CDS             complement(5892..6980)
                     /codon_start=1
                     /gene="ifqG"
                     /product="hypothetical protein"
                     /protein_id="APR73631.1"
                     /transl_table=11
                     /translation="MSLSRRTALTVTAAALAGTALSAGPAAARGTTPSAGRRVLFEDDF
                     SGGFATSGPGARWTGIPFGGGVGEDAVADTSGRGLRLAAKGRNPRTGEPAYTLTLGQHE
                     PSGLPGSLDHVKWLSYPDQHTADGLLGFTAEPGRLLVAEARLSATTYGTAAHPFGSAVA
                     DPHDDLRLAMAGLPAEDQETGIAVDFFFTDRTVYAFYERLPNHRDTLGDYAAFTYAVPV
                     ARRPSPTAEHHVRIAYDRSRGVIRWYLEGREVFTVDRIGRLLPSRRHLLLDHGGTPATV
                     TPRQFTFGLGLFDALDGARPGVPGSGLVRLTTETGHYYDPVRGEPTAQSFLDDTSRPEN
                     RLWGQGAALGVRRFTVFTRNAG"
     gene            complement(7024..8223)
                     /gene="ifqH"
     CDS             complement(7024..8223)
                     /codon_start=1
                     /gene="ifqH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 328.8;
                     E-value: 5.9e-100)"
                     /gene_kind="biosynthetic-additional"
                     /product="hydroxylase"
                     /protein_id="APR73632.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 8.2e-10, bitscore:
                     30.0, seeds: 790, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPTPSTGPPQATTDAPPDRQALVAAARDVAQEAARCAAAAERER
                     RLAPDVVKAAVAAGFARHLVPAAHGGAEGTFLELGRAVSAVGEGCAATAWCVSLAAHVG
                     RMAAHLPLEGRREVWAEGPDAFLVASLTPLGTARPVPGGHRLSGTWRFVSAIDHADWAL
                     LAANPPAGSGPAGAPRVFAVPRGAWRTEDTWHNVGMAATGSHSVTVEDVFVPQARSVSR
                     EDLFTGRGAVDVAPRLAVPMQGTTMMFAAPALGAAKGALAAWRRHAERKIRAAARNPAP
                     ALPGMPSFNRVSWDVTLTRSAGEIDAAELLLERAARNADESGHGLTPARTMRGWRDCAM
                     ATDLLVGVANRLFRGVGTTGQSTAEPVQRFWRDVNSMAGHQGLQVESAATAYAYQSLGF
                     "
     gene            8454..9296
                     /gene="ifqJ"
     CDS             8454..9296
                     /NRPS_PKS="Domain: Polyketide_cyc2 (117-271). E-value:
                     1.4e-16. Score: 53.1. Matches aSDomain:
                     nrpspksdomains_ifqJ_Polyketide_cyc2.1"
                     /codon_start=1
                     /gene="ifqJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 176.8; E-value:
                     1.1e-53)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 123.7; E-value: 1.7e-38)"
                     /gene_kind="biosynthetic-additional"
                     /product="polyketide cyclase/aromatase"
                     /protein_id="APR73633.1"
                     /transl_table=11
                     /translation="MIIHTLVYRFADSVDESQRREFFTDLEKIARGSGLVTHFGHGPHH
                     RLPVDDHAAGTTANAVAQFACRDLDDLRAFSELPHVHEHIAGWRSRIAYEAAYANHDDL
                     LHVIAPALTKESPMHHTEHTVTVDAPAAIVWDVLVDVEGYARIFPPTEDVKILEESPEH
                     QIARLTVDVNGEVQSWISRRDIDAGRRVIAYRQLENAPMMGYMGGEWRALPIDEHTTQL
                     VLTHDFKPREPEDGLVAGKFTYEQADEMIKAAVERNSVADLGAVKDEAEKLAGEGAAE"
     aSDomain        8805..9266
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ifqJ_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.40E-16"
                     /label="ifqJ_Polyketide_cyc2.1"
                     /locus_tag="ifqJ"
                     /protein_end="271"
                     /protein_start="117"
                     /score="53.1"
                     /tool="antismash"
                     /translation="MHHTEHTVTVDAPAAIVWDVLVDVEGYARIFPPTEDVKILEESPE
                     HQIARLTVDVNGEVQSWISRRDIDAGRRVIAYRQLENAPMMGYMGGEWRALPIDEHTTQ
                     LVLTHDFKPREPEDGLVAGKFTYEQADEMIKAAVERNSVADLGAVKDEAE"
     gene            9293..10057
                     /gene="ifqK"
     CDS             9293..10057
                     /codon_start=1
                     /gene="ifqK"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C5-C14/C3-C16 (Score: 336.4; E-value: 2.5e-103)"
                     /gene_kind="biosynthetic-additional"
                     /product="polyketide cyclase"
                     /protein_id="APR73634.1"
                     /transl_table=11
                     /translation="MRRLVDLSVVTRHTPSEATPVTVELLDHVTGATVLGLTPEDFPDG
                     MAISNETVTLTTHTGTHMDAPLHYGPLSGGAPAKSIDQVPLEWCVGPGVRLDVRQVPPG
                     EGITVEHLRAALRAAGHTLRPGDIVLLWTGADALWGEAEYLTKYPGLTGEGTAFLVESG
                     VRVIGIDAWGLDRPMRSMIDDYRRTGDRKALWPAHVYGRTREYLQLEKLAQLAALPAPT
                     GFTVVCFPVAVAGAGAGWTRVVALLDDDPHAR"
     gene            10047..10427
                     /gene="ifqL"
     CDS             10047..10427
                     /codon_start=1
                     /gene="ifqL"
                     /product="lipocalin-like domain containing protein"
                     /protein_id="APR73635.1"
                     /transl_table=11
                     /translation="MRADDLVGVWHLVSFRELDGAGTPGVGPLGDAPRGRLVYTRDGHV
                     SVHMMRGPDPGPVPYMGYAGTWRLDGSRIVHRIEVTPRHDWIDTEQTREATLAGGRLTL
                     HARTRVDGVEHRRVLVWRRDRA"
     gene            complement(10548..11852)
                     /gene="ifqM"
     CDS             complement(10548..11852)
                     /codon_start=1
                     /gene="ifqM"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 57.9; E-value:
                     1.4e-17)"
                     /gene_kind="regulatory"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="APR73636.1"
                     /transl_table=11
                     /translation="MAYRDWGNPQRALTVAAALMQAPIKQVLSTLSDALSDLVAHEALV
                     MLTGDCPTSATWSHGDAELTEAVTAAEMAQLATHVDIGRPRFDRARLADASRPVLAVAS
                     APPGSAGALLAVLPVDGTAPDPEVLPVVQQLWDLAMLRVMALWPTVVPVNQTAPWMANS
                     ERARIVSDLTDSHASTLTSLIGLLRNRSLDDGTARRTAVDLAVSSLIELRSVGDTERVP
                     GEETAHDAFGRLTEMLGLLSRYGNVRLEFEGPVGEAAERLIPSVIAQTARTTARGTVLT
                     MLEQGGVSRVRISWHVEESEVRAVIRDDGPGTLAGDALAVHRLTDRAAAVSGAVDVDAV
                     PGWGTIVTVRLPLAAPERQRNDPLGELNPRELDVLELLVQGHRNRVIAGRLLISEHTVK
                     FHVAKILKKLDVSTRGEAAALALAAGFPTAPALTS"
     gene            12104..13372
                     /gene="ifqN"
     CDS             12104..13372
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (5-391). E-value:
                     1.7e-53. Score: 173.9. Matches aSDomain:
                     nrpspksdomains_ifqN_PKS_KS.1"
                     /codon_start=1
                     /gene="ifqN"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 488.5; E-value:
                     2.8e-148)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     762.6; E-value: 2.2e-232)"
                     /gene_kind="biosynthetic"
                     /product="beta-ketoacyl synthase alpha subunit"
                     /protein_id="APR73637.1"
                     /sec_met_domain="t2ks (E-value: 4.3e-240, bitscore: 787.3,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRTVITGMGVRTPGGNGVKAFWELLTSGRSAIRPISFFDPSPY
                     RSRIAGEADFDPVLEGLTPLEIRRMDRATQFTVVCARDAVADSGLGFERLDPGRVGVSL
                     GSAVAAATSLEQEYLVLSDSGRDWLMDTANLSPHMFDYLVPSVMPAEVAWTVGAEGPVA
                     MVSNGCTSGIDSVGHACRLIEEGSADVMLAGAGDTPVTPIVVACFDAIKATTSRNDEPE
                     RASRPFDRTRNGFVLAEGAAMFVLEEYEHARARGAHVYAEITGYATRCNAYHMTGLKAD
                     GREMAEAIRSALDEARTDATDIDYINAHGSGTKQNDRHETAAYKRSLGEHARRTPVSSI
                     KSMVGHSLGAIGSIEIAASALALENGVVPPTANLHEADPECDLDYVPLTARERGLRNVL
                     TVGSGFGGFQSAMVLRHAPGGTA"
     aSDomain        12119..13276
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ifqN_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.70E-53"
                     /label="ifqN_PKS_KS.1"
                     /locus_tag="ifqN"
                     /protein_end="391"
                     /protein_start="5"
                     /score="173.9"
                     /tool="antismash"
                     /translation="VITGMGVRTPGGNGVKAFWELLTSGRSAIRPISFFDPSPYRSRIA
                     GEADFDPVLEGLTPLEIRRMDRATQFTVVCARDAVADSGLGFERLDPGRVGVSLGSAVA
                     AATSLEQEYLVLSDSGRDWLMDTANLSPHMFDYLVPSVMPAEVAWTVGAEGPVAMVSNG
                     CTSGIDSVGHACRLIEEGSADVMLAGAGDTPVTPIVVACFDAIKATTSRNDEPERASRP
                     FDRTRNGFVLAEGAAMFVLEEYEHARARGAHVYAEITGYATRCNAYHMTGLKADGREMA
                     EAIRSALDEARTDATDIDYINAHGSGTKQNDRHETAAYKRSLGEHARRTPVSSIKSMVG
                     HSLGAIGSIEIAASALALENGVVPPTANLHEADPECDLDYVPLTAR"
     gene            13369..14598
                     /gene="ifqO"
     CDS             13369..14598
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (5-367). E-value:
                     1.5e-27. Score: 88.4. Matches aSDomain:
                     nrpspksdomains_ifqO_PKS_KS.1"
                     /codon_start=1
                     /gene="ifqO"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 638; E-value:
                     8.8e-194)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 7
                     (Score: 714.1; E-value: 1e-217)"
                     /gene_kind="biosynthetic"
                     /product="beta-ketoacyl synthase beta subunit"
                     /protein_id="APR73638.1"
                     /sec_met_domain="t2clf (E-value: 3.3e-204, bitscore: 668.5,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSALVTGIGLIAPNADGPEPYWAATVEGRTGIGTLTRFDVSRHP
                     VRLAGEIRDFDASARLPGRLLPQTDVSTRYALVAAERALADAGIEPGAYADYDMGVVTG
                     NAQGGFEFTHREFRKLWSQGPEKVSVYESFAWFYAVNTGQISIRHRLRGPSSALVAEQA
                     GGLDAIGHARRTVRRGTPMVVTGGVDSAFDPWGWVSQISGGRLTTSGDPDRAYQPFGTH
                     ADGHVPGEGGAILVLEDPRTARERGARQVYGEIAGYASTFDPAPGSGRPPGLRRAAELA
                     LRDAGLPPSDIDVVFADAAGSPDLDRVEAEAVGGLFGPHGVPVTAPKALTGRLCSGGGP
                     LDVAAALLCLREGVIPPTYGTDEVPEEYGIDLVRGAPREVPVRAALVLARGKWGFNSAV
                     VVRAAGVGDD"
     aSDomain        13384..14469
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ifqO_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.50E-27"
                     /label="ifqO_PKS_KS.1"
                     /locus_tag="ifqO"
                     /protein_end="367"
                     /protein_start="5"
                     /score="88.4"
                     /tool="antismash"
                     /translation="VTGIGLIAPNADGPEPYWAATVEGRTGIGTLTRFDVSRHPVRLAG
                     EIRDFDASARLPGRLLPQTDVSTRYALVAAERALADAGIEPGAYADYDMGVVTGNAQGG
                     FEFTHREFRKLWSQGPEKVSVYESFAWFYAVNTGQISIRHRLRGPSSALVAEQAGGLDA
                     IGHARRTVRRGTPMVVTGGVDSAFDPWGWVSQISGGRLTTSGDPDRAYQPFGTHADGHV
                     PGEGGAILVLEDPRTARERGARQVYGEIAGYASTFDPAPGSGRPPGLRRAAELALRDAG
                     LPPSDIDVVFADAAGSPDLDRVEAEAVGGLFGPHGVPVTAPKALTGRLCSGGGPLDVAA
                     ALLCLREGVIPPTYGTDEVPEE"
     gene            14591..15097
                     /gene="ifqP"
     CDS             14591..15097
                     /codon_start=1
                     /gene="ifqP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160:flavin reductase domain protein FMN-binding
                     (Score: 130.7; E-value: 6.5e-40)"
                     /gene_kind="biosynthetic-additional"
                     /product="flavin reductase"
                     /protein_id="APR73639.1"
                     /transl_table=11
                     /translation="MTEGLKEVVETAGGLREAMARFPTGVAIATVCDERGLPHGLTVSS
                     FCSVSLDPPLVLLCVARSAQCFPVFARASEFAVSVLREHHAELAARFATAGAEKFGPGG
                     LGRTARGGVVVDDALAVVECLVEQRHDAGDHVIVVGRVVGTHLTESGAPAVYFNRRFAA
                     LGPAS"
     gene            15094..17043
                     /gene="ifqQ"
     CDS             15094..17043
                     /codon_start=1
                     /gene="ifqQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092:hypothetical
                     protein (Score: 422.3; E-value: 4.9e-128)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 23.9; E-value: 4.4e-08)"
                     /gene_kind="biosynthetic-additional"
                     /product="Baeyer-Villiger monooxygenase"
                     /protein_id="APR73640.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.5e-14, bitscore:
                     44.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSPDTSKVTHMAFSRPLRPIPDDETLRRHLAGADVPALLLTV
                     AHLTGDTALLRDDLRAPGWLFQPQGGLTAARQDEARRLAFEALTAWRDRGGTHEPPDPA
                     LLRTITTWAMGSDTGDLLDLLAEEIALPRDDPKAPGWTLEGLRPGADLDVAVIGAGFSG
                     LLAAHRLGQAGVPVVVYEKNEDVGGTWFENTYPGCRTDVASHLYNYSFAPRADWPDHFC
                     RRDTVLEYLRDFAKESGVADRIRFGTEVRELRWDERERRWHLTLDGPGGPRTVTHRMVI
                     SAVGQLNRPQLPAVDGLGSFTGPAFHSAAWDHTADLTGKRVAVVGTGASAYQIVPELAG
                     AASEVVVFQRNPPWLRPTPHYHQPLSGSTSWLCEHLPYYAQWYRFWLFAPGLRGILDGW
                     IVDRCYPPTERAVSALNEQLRASLLQAMEAQLTDAPELREKVVPRYPVGAKRVLRDDGT
                     WLATLKRDDVTLVTAPVERETPRGLVADGEEFEVDVIVYATGFQASRFLTPMKVTGERG
                     VDLHTHWDGAPRAHLGISVPGFPNLFCLYGPNTNLVGQGGSIVYFSECATRYVLDAIRL
                     LLTRDADAVQVREDVHDDYNAWVDAASADRAWVWSKVSGWYKDGSRSSTNWPFSAAEYW
                     TRTRRADPEHLRLR"
     gene            17083..18225
                     /gene="ifqR"
     CDS             17083..18225
                     /codon_start=1
                     /gene="ifqR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 314.5;
                     E-value: 1.4e-95)"
                     /gene_kind="biosynthetic-additional"
                     /product="hydroxylase"
                     /protein_id="APR73641.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6.6e-08, bitscore:
                     23.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6.1e-08, bitscore:
                     23.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDTAAGPLATAARDIAATAAGLAARMAEQRHIDAGLVTAMREAG
                     FMRHLAPARYGGAGGTLADLLDAVATLGEACPATAWCASLFASTPRFVPCFPEAGQKEF
                     WADGPDTAFVCSVLPFGEAVPDADGDGLRVSGRWPYMSAVEHADWVVVCARSTGAGGPR
                     LTLVAVPASAVRIEDTWDSVGMRATGSDTVVLENVPVPAGRYVDRDAVFAGRTADGTAI
                     APLAAVNGLTFVVPALGAAQGALAELTRYLAGRLTEVTPTPGMPGPGGSLATHEMTLAR
                     SAAEIDSARLLLTRIARLADEGGPFTGPAIARNMRDSAFTVELLLSAVNRVFRAAGTGG
                     QAARGPLERFWHDVNAVATHQAVQFEPAAHHYARALFTTP"
     gene            18236..19279
                     /gene="ifqS"
     CDS             18236..19279
                     /codon_start=1
                     /gene="ifqS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 251.9; E-value:
                     1.6e-76)"
                     /gene_functions="biosynthetic-additional (t2pks) MET
                     (Score: 273.2; E-value: 6.9e-84)"
                     /gene_kind="biosynthetic-additional"
                     /product="methyltransferase"
                     /protein_id="APR73642.1"
                     /transl_table=11
                     /translation="MKNTNPPPESAPSADRILETALAFQASKTLLSAVEVGVFTELARK
                     PADVHELRERLGLHPRGARDFFDALVALGFLRREDGVYHNTPESEAHLDRAKPGYGHVA
                     PMLEMAGSRLFGIWNRLSDALRTGLSQDESKDRDEDTYDALYADPDRLRTFLSSMTGIS
                     HRANLRIARQVPWEDYTTMADMGTAQGDLAVQVLLANPGLTGTGFDLPQAEPVFTEYAE
                     RHGLTDRLGFTGGDFFTDPFPRADVLTFGHILHNWDLERKKVLLRKAWEALPQGGAVVV
                     YDTLIDDDRSENAFALLMSLNMLAVTDGGFGYTGHECQEWMREAGFDRTWTEHLVGPDS
                     IVVGVKE"
     gene            19276..19665
                     /gene="ifqT"
     CDS             19276..19665
                     /codon_start=1
                     /gene="ifqT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /product="SnoaL-like domain protein"
                     /protein_id="APR73643.1"
                     /sec_met_domain="PF07366 (E-value: 7e-14, bitscore: 42.3,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAMKQNKELVAEYIRLFYNEKDFDRARELLTEGFVNHHHGVGAG
                     RDRTVETFRAAVSVMPEFSLTVRRVVAEGDQVWTHSVARAAPGAHPSVVVDIWRVEDGR
                     LAEHWDVGQPVPEGSALDAMIEDAG"
     gene            19662..20609
                     /gene="ifqU"
     CDS             19662..20609
                     /NRPS_PKS="Domain: PKS_ER (22-312). E-value: 7.4e-54.
                     Score: 174.8. Matches aSDomain:
                     nrpspksdomains_ifqU_PKS_ER.1"
                     /codon_start=1
                     /gene="ifqU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 294.7; E-value: 1.3e-89)"
                     /gene_kind="biosynthetic-additional"
                     /product="dehydrogenase/quinone reductase"
                     /protein_id="APR73644.1"
                     /sec_met_domain="ADH_N (E-value: 8.7e-12, bitscore: 35.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.8e-20, bitscore:
                     63.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALMRAVVQRAFGGPGVLEPARVPRPAPALNEVLVRVHAAGVNP
                     IDALVRSGELPLLGAPPFTVGWDVSGVVAGTAPGVTRFAVGDEVYGMPCIPRAAAAYAE
                     YVVAPSRQLARKPASVDHRTAAGLPLAGLTAWQALVETGWAGRGTRVLVHGGGGGVGHL
                     AVQIAKARGAEVIATASAGKAAFVHALGADRVIDYRAVDFAAEVRDVDVVLDGVGGETA
                     VRSLDVLRPGGALVTIVEMRNPELARLAEARGLRFHGVTAEPDHVGLAALADLVDAGLL
                     RPHIDRSLPLDEAAQAHRLLDAGALTGKVVLETA"
     aSDomain        19728..20597
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ifqU_PKS_ER.1"
                     /evalue="7.40E-54"
                     /label="ifqU_PKS_ER.1"
                     /locus_tag="ifqU"
                     /protein_end="312"
                     /protein_start="22"
                     /score="174.8"
                     /tool="antismash"
                     /translation="RVPRPAPALNEVLVRVHAAGVNPIDALVRSGELPLLGAPPFTVGW
                     DVSGVVAGTAPGVTRFAVGDEVYGMPCIPRAAAAYAEYVVAPSRQLARKPASVDHRTAA
                     GLPLAGLTAWQALVETGWAGRGTRVLVHGGGGGVGHLAVQIAKARGAEVIATASAGKAA
                     FVHALGADRVIDYRAVDFAAEVRDVDVVLDGVGGETAVRSLDVLRPGGALVTIVEMRNP
                     ELARLAEARGLRFHGVTAEPDHVGLAALADLVDAGLLRPHIDRSLPLDEAAQAHRLLDA
                     GALTGKVVL"
     CDS_motif       20103..20165
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ifqU_0001"
                     /evalue="2.90E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="ifqU"
                     /protein_end="168"
                     /protein_start="147"
                     /score="19.8"
                     /tool="antismash"
                     /translation="GTRVLVHGGGGGVGHLAVQIA"
     gene            complement(20628..22706)
                     /gene="ifq(+1)"
     CDS             complement(20628..22706)
                     /codon_start=1
                     /gene="ifq__1_"
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 332.8; E-value: 6.9e-101)"
                     /gene_kind="other"
                     /product="PAS sensor protein"
                     /protein_id="APR73645.1"
                     /transl_table=11
                     /translation="MTPASPGSRPADGPASGAVAPSGLMDLLNVAAVLLEADGRIDMWS
                     PQAEQLFGYARSEAVGQYAAPLLVHPEHQDAVIELFAEVMATGRDWAGAFPVRHKDGST
                     RMVEFRNMRLTDNLGDHYALGLAADRATVRHVERKVALSNRLVTQAPIGLAVLDPDMRY
                     LAINPALAAMHGVPESDHVGRRFREILPGAPFLGAETVMRHVLATGAPVVDQQVVGRTA
                     ADPDTDHAWAVSTYRLEDHHGDVLGLAYVVVDVTDRYRAAKKADEAQHRLRLLANASGR
                     IGTTLEVERTARELADVLVPDLADMVAVDLLDSVLQTGRADLDEGPALFRAVAVKTAYP
                     TDADRAIVPPGSLVTYHADHPASHCVRTRRPLMITHVSGDDLSRIAAGPEAARLLARAG
                     VHTDMAVPLIAREQIIGVMGLARARNPLPFDEDDLTLACEMASSAALSIDNAVLHQHIR
                     GAAETLQRSLLPQLPPGRPGLEVAARYRPAQAFSEVGGDWYDVIALDGDRTALAVGDVM
                     GSGVTAATTMGRLRTATSTLADLDLDPARILTHLDKITADLDYLATCLYAVYDPHRARL
                     HVASAGHLPPVLVRDGRQPELLRLPTGTPLGVRGVPFEVTTLALEPGDRLVLYTDGLVE
                     TRHDPIDERLDDLMRLLTPPDRSTEETCDRLLRELRHPAGHDDVALLIACVQPLAPA"
ORIGIN
        1 atgacggaga tcgcactggt gaccggggcc aacaaggggc tcggcaagga gatcgcgcgg
       61 cgtttggccg cgaagggcct gaccgtgtac ctcggggccc ggaacgagga gcggggcctc
      121 ggggcggcgc gggagctgga gcgggccggg caagcggtgc cggccggcgg ggacgtgcgg
      181 ttcgtccggc tcgacgtcac gatgcgcgag caggtcgacg cggccgtacg gcggatcgag
      241 gaggagtgcg ggcggctcga cgtcctggtc aacaacgcgg ggatcgtgac cgagtggggc
      301 gtgcccgtgg aggaggtgac cgaggaccac ctgcgccggg cgttcgaggt gaaccttttc
      361 ggcgcggtcg ccctgacccg ggcctgtctg ccgttgctgc ggcgctcgaa ggatccgcgg
      421 gtggtcaacc tgtccagccc gctgggctcg ttgagcctgc tgagcgatcc cagcggtcat
      481 ccggcggctt cccgcggtct gctcgcgtac agctcctcca aggcggcgct gaacgcggtg
      541 accctgatgt acgccgaggc cctgcgcgcg gaggggatcc gcgtcaacgc ggccaatccc
      601 ggtctggtcg ccacggacct gaacgccgac tcgccgttca gccggggcac gcgcacggtg
      661 gagcagggtg ccgaggtgcc cgtgaggctg gcgctgggcg cgggcggcac gggtggcttc
      721 cacggcggta tggaggggga cgtgaccgag cgggtgccct ggtgaccgcc ggcgcgggac
      781 ggcgcgcggg ctgaacgcgg cccgggcggg gcgggtcgcg cgtcgcgacg ggaacggccc
      841 ccggcgcgcc gggggccgtt cccgtcggag ggtgtgcccg ggccggtcag ccgccggtgc
      901 ggaccgcccc gttcgccagg tcgagcaggt tgcggggcgt gcgggcctcg gacacgtcct
      961 cgtcgggcag cacgatcccg tattcgtcct ggatcgccgc cgccgtctcc atgagcgcga
     1021 gcgagtcgta acccagctcc tcgaaagggg tgtcgagcgt ggcaccgctc acctcggcgc
     1081 cctcctcctc accggcgcag tccaccagga tgcggcgcag gtcctcgatg tccagggttg
     1141 ccatggcagt cgtctcctcg aagtgcgtgt gacgtggtcc cgggcatcgt gcggccaccg
     1201 tcttggaggc cgctggaagc ggtccagcgg cgctccggtg gcctcccagc cgcccgcgat
     1261 gccggtctcc cacgctgagg agcacccaac gggggctgtg gaaggggcgg tgggccatgg
     1321 gcacggacga ccggcgggca cgggcggccg gcgggggacc cgcacggacg ggaggcgccc
     1381 ggtcccacgg gctgagggtg gtgcccggtg ggctgggtcc gctggagccc cggcggctgg
     1441 tcgaacacgc ggaggcggcg ctggaggtcg tcgtcggggc cgtgggcggc ccggacaccg
     1501 gtcgcctcgg ccggatcccg gcggacgccg tgggcgcctg ctacctcgac ctgtggatct
     1561 gcgaccggct cctgcgccac gacgggggtg accggtcggc cgcggcccag tgcctggtcc
     1621 cgctgctgtt gctggagggc gtcggcgggt tggcggccgc tctcggggcc gggctgcacc
     1681 ggcccgagcc cgcgtcggtc gaataccggc gccggcggcg ggtgctggta cgggcggcgc
     1741 gggaacgttc gccgcaggtg tgggggcggc tcgcccggcg gatggaccgc ctcgcggcgg
     1801 gcgaggaccg tctggcccac ccgctcaccg ccgtacggca ccgcgcgctg ccgcctccgc
     1861 tgccggaact ggtcggcggg ctggaggagg agcggcgccg cctggccacc gccgtgaccc
     1921 gcgagccggc cgccgacgtg cggtacggtc ccgccgagcg gtacgccctg ctgaccgcag
     1981 cggccgcctg tgccgacggc tggcgccccc acggtgccgg tgtccacgac agcaccctcg
     2041 gcgtcggcgc ccgtcgcgcc cgcctgtgcg gggccctgtg ccggctctcc gtgcggctcg
     2101 atctgccggt gtccgagtcg gcgcgcacgg catggcgggc ggacgtgctg cgatgcgccg
     2161 tggcgtgacg ccgctggtag ccgtggcgcc ggcggactcc ttgggaccgg tgcgggcggc
     2221 gctcgcccgg tacggcgatg tggccgtgca cgcggatgcc gctgactggg ccgtggaccg
     2281 ggcggaggag gccgcgctgt gggccggcgc cgagcgcggg cggctgaccg gaccgcttcc
     2341 cgcgccggtg cggcggcggc tcgtggcgtc ccggcggctg gtcagatgcg tggcggggtc
     2401 cgtcctcggg gtcgatccgc tactcctgga actcacccgt gatccgggcg gccggccccg
     2461 gctgcgcggg tacgcccacc tccaggtgag tctgagtcac accgggaacc ggctggcgct
     2521 cgcgctcggt gcgggcggcg tgccggtggg ggtggacgtg gagcgtgcgg accggccggt
     2581 gcgggtggag acactcgcgc gccgtatctg tacaccccgc gaacgggcag tgctggcggg
     2641 tctgccgccg gccgaacgtc ccgccgtact gctgcggttg tggaccctga aagaagcgca
     2701 cgccaaggcg ctcggggccg gactgcggct gccgttcacc ggcttcggat tccgcttgct
     2761 gggccgtacg gcggtgctga ccgacgaccg ggggcagccg gtgcggcccg tggagtcgcg
     2821 gttcacgacc catctcaccg ccaccggaca tctggtcagc gtcgcggcgg gttcccccgc
     2881 gggctgattc cgcttggcgg acgggaaccg agcggaaatt cgtacgcctt ttcgtcgata
     2941 ttttgtgaag accgttccgg gcgccggtga atccacccgt caatgagagc agttcacggc
     3001 tagtgtgacg ccgatcactt ctgagccgct ggcattgatt gcgtttgctc ttataccgtt
     3061 caaaatagac gtggactgga ccaccaggtg tacgcggacg gccgcacggg ggcaccgcga
     3121 agcattctcg ccacatccga cgtcacctcc atcatccata gtggacggag atcgtttgca
     3181 cgattcggcg gaccatttcg cgcgctcgaa aaacaggggg aaagaaattg aagttcaaac
     3241 tgctgggaca gttcgaagta gtactgaaca atggccggcc gacgaccctg accaggtcga
     3301 aagtcagcca gctcctggga ctgctggtcg tgcagaacgg cgagtccgtc ggggcccaca
     3361 cactgatcga ggagctgtgg ggggagaacg taccgcgcag cgcgctgacg accctgcaga
     3421 cgtacatcta ccacgcccgc aagctctgcg gcatcggccc cggccgccag tccgtcctgg
     3481 tgacccggcc ggccggctac agcatcgagg tgcccggcga ctccgtcgac agcgtcgtct
     3541 tcgagggcct ggtcaaccgc gcgcgtaccg cgctcgacca gcgtgacgcg cagagggccg
     3601 ccgggctgct cgaccaggcc ttcgctctgt ggcgcggccc ggtgctggcc ggaatgatca
     3661 cggggccggt gctcgacgcc cacctgacct acatcaacga gctgcgactg tccgcgcacg
     3721 agctgcacat cgcggcctgc gcgcggctgg gccgccacca ggagatcatc ccgcgcctgc
     3781 gcctgctggt cgcggagaac ccgctcaacg agagtttcca cgcccagttg atcagggccc
     3841 tctacaaaag cgcacggcgg gccgaggcca tccaggccta ccgaaatctc tgtcgcatac
     3901 tcgacacgga actgggcatc gaacccgcac cggaactgca gacgctgcaa caggacctca
     3961 tgaccggaat tccggcgggc cagtccgccg accactcctt cgggcaggtt ctgttagccg
     4021 aaggagcagt cccccggcgc agctattgct gacagcctgg aagcgtgccc gggccgcggc
     4081 agcggagatc gggcgggtat tcacccacac aattcttggc tgtccggagg gaaacgcatg
     4141 tccgagaacc cggtatccgt cgccatcgct tatcacagcg ggtacgggca caccacgaga
     4201 atggccgagg gggtcgagga gggcatcagg tccgtggcgg gcgccgcggt cgaggtggtc
     4261 aaggtcgacg gcatcaccga cgaggactgg gcccggctcg acgccgccga cgcgatcatc
     4321 ttcggatcac ccacctacat gggttcggcg agccccgcct tccacacctt cgccgcggcc
     4381 accagcgggc gctggtacgg gctggcgtgg aaggacaagg tggcggccgg gttcaccacg
     4441 tccggcgcga tgagcggcga caagctgaac acgctccagt acttcacggt gctcgccgca
     4501 cagcacggta tgcactgggt gaacctcgac ctgctgcccg gtgacacgga gaacgacctg
     4561 aaccggctgg gcggctggct gggcgccatg ggccagtgcc cgggcgacca gggtgcggag
     4621 tccatgcgca agggcgacct gctcaccgcg gcccacctcg ggcgccgggt ggcggaacac
     4681 gccctgctgc tgcgcaccgc gcgggagcgc acggccgcct gacaccggca cggcgcacga
     4741 agagggtgcc ccggggactc gcatccccgg ggcaccctct tctctcttcc tgcacgcgtc
     4801 ctcgtacgcc gggtccgctc agtcggcccg cagtccgcgg cgcagcgcgt cgatctggtc
     4861 gcgcaccatc cggcgggaca cgtcggcgtg cccgatgccg acggaggcgt ggaacgtccc
     4921 ggggtagtgg accagttcgg tggacacgcc cgccttgatc agccggtgcg cgaagtggat
     4981 tccctcgtcc ctcagcgggt cgtacgcgca caccccgacg aacgcgggcg gcagccccga
     5041 caggtcctcc gcacgggccg gggcggcgag gggggaggcc ggtccggagc cggtgtagtg
     5101 cttccagctg agcaccagcg cggcccggtc cagcaccggg gtgtccgtga actcccgtgc
     5161 ggagacggtc tccaggcggt cgtcgagctg cgggaagagc aggtactggt agcggatgcg
     5221 cggaccgccg gtgtcgcggg cgcgcagtgc cagacccgcc gccagcgcac cgcccgcgct
     5281 gaacccgccc acaccgatcc ggtccgggtc gacgcccagt tcagcggcgt gcgcgcgggt
     5341 ccactccagt gcggcccagc agtcgtccag gccggccggg aaggggtgtt cgggggcgag
     5401 ccggtagtcg ggcgagacca ccaccgcgcc cacctggtcc gcgatccggg cggcgaacgc
     5461 gcgcggggtg tccaggtctc cggtgacgaa cccgccccag tgcgggaaga ggagcgcggg
     5521 cagcgggtca cccctccggg ctgccggggc gtacacccgc acggtgaggc gggggccgcc
     5581 gtcgacgggc agcacccggt cgctcacccg gacccggtcg aggtgctcgt agtgcggctg
     5641 cttggccatc acccggcgca tgaccgcccg ggccgactcg ggatcggcgt agtccagcgg
     5701 ccgcatcccc ggtgcttccg gggcgagttc ggggtcgaag tcataagggg acggcatgac
     5761 gcaactcctc ggggacggcg agggacggcg tcggcggccc ggccggctgc gccgggccgc
     5821 cgacgccgtc ggggggggtg ggacggtggt cggtggtggt gccgccccgg agcgacggcg
     5881 ggcggcaccc gtcaaccggc gttccgggtg aagacggtga acctgcggac gccgagggcc
     5941 gcgccctgac cccacagacg gttctccgga cggctcgtgt cgtcgaggaa gctctgagcg
     6001 gtgggctcgc cgcgcaccgg gtcgtagtag tgccccgtct ccgtggtcag ccggaccaga
     6061 cccgagccgg gcacgccggg ccgggccccg tcgagggcgt cgaacaggcc gagcccgaag
     6121 gtgaactggc gcggcgtcac cgtggccggt gtacccccgt ggtcgagcag caggtggcgg
     6181 cgggagggca gcagccggcc gatccggtcg acggtgaaca cctcgcgtcc ctccaggtac
     6241 cagcggatca cgccccggga gcggtcgtac gcgatgcgga cgtggtgttc ggcggtgggc
     6301 gaggggcggc gggcgaccgg cacggcgtag gtgaaggccg cgtagtcacc gagggtgtcg
     6361 cggtggttgg ggaggcgctc gtagaacgcg tacaccgtcc tgtcggtgaa gaagaagtcg
     6421 accgcgatgc cggtctcctg gtcctccgcg ggcagtccgg ccatggcgag ccgcaggtcg
     6481 tcgtgcggat cggcgaccgc ggagccgaac gggtgggccg ccgtaccgta cgtggtggca
     6541 ctcagccgcg cctcggcgac caggaggcgg ccgggctcgg cggtgaagcc cagcaggccg
     6601 tcggcggtgt gctggtccgg gtacgacagc cacttgacgt ggtcgagcga gccgggcagg
     6661 ccgctcggct cgtgctggcc gagggtcagg gtgtaggcgg gctcgccggt gcgcgggttg
     6721 cggcccttcg ccgcgaggcg caggccgcgc cccgacgtgt cggccacggc gtcctcgccg
     6781 acgccgccgc cgaaggggat cccggtccag cgggcgcccg ggccgctggt ggcgaagccg
     6841 ccggagaagt cgtcctcgaa caggacgcgc cggccggcgg acggggtggt gcccctcgcc
     6901 gcggccggtc cggccgacag ggcggtaccg gcgagggcgg cggcggtgac ggtgagtgcc
     6961 gtgcggcggc tcagggacat acgggttcct ttccggaggg cgtgcgcggg gtcggtgggc
     7021 tgatcagaag ccgagcgact ggtaggcgta ggcggtggcg gcggactcca cctggaggcc
     7081 ctggtggccg gccatcgagt tgacgtcccg ccagaagcgc tgcaccggtt cggccgtgga
     7141 ctggccggtg gtgccgacgc cgcggaagag ccggttggcg acgccgacca ggaggtcggt
     7201 ggccatggcg cagtcgcgcc agccgcgcat ggtccgggcc ggggtgaggc cgtggccgct
     7261 ctcgtcggcg ttgcgggcgg cgcgctccag gagcagctcg gccgcgtcga tctcgccggc
     7321 gctccgcgtc agggtcacgt cccagctgac gcggttgaag gacggcatgc cgggcagcgc
     7381 gggagcgggg ttccgcgccg ccgcgcggat cttccgctcg gcgtgccgcc gccaggccgc
     7441 gagcgcgccc ttggcggcgc ccagagcggg ggccgcgaac atcatggtcg tgccctgcat
     7501 cgggaccgcc aggcgcggcg cgacgtcgac ggcgccccgc ccggtgaaca ggtcctcacg
     7561 gctgacggag cgtgcctggg gcacgaacac gtcctcgacg gtgacggagt ggctgccggt
     7621 cgcggccatg ccgacgttgt gccaggtgtc ctcggtgcgc caggcgcccc ggggcaccgc
     7681 gaagacacgg ggggcgcccg ccgggccgga accggccggc gggttcgccg cgagcagcgc
     7741 ccagtcggcg tggtcgatcg cgctgacgaa gcgccaggta ccgctgagcc gatggccgcc
     7801 ggggacgggg cgcgcggtgc cgagcggtgt gagggaggcg acgaggaacg cgtcgggccc
     7861 ctcggcccac acctcccggc ggccctccag cggcagatga gccgccatcc ggccgacgtg
     7921 cgcggcgagc gagacgcacc aggcggtcgc cgcgcagccc tcgccgacgg cgctcacggc
     7981 ccgcccgagt tcgaggaagg tcccctcggc gccgccgtgt gccgcgggca ccaggtgccg
     8041 cgcgaatccg gccgccacgg ccgccttgac gacgtccggc gccaggcgcc gctcccgctc
     8101 cgcggcggcg gcacaccggg cggcctcctg ggccacgtcc cgggcggccg ccaccagcgc
     8161 ctgacggtcc ggcggtgcgt cggtcgtcgc ctgcgggggg ccggtgctcg gtgtcggggc
     8221 catgctggtc tctcctcgac tcgtacggtg gaccgccccg ggcgctgtcg cagccgggcg
     8281 cggccggtcg gcgaccggga gcctcgccgc cgccgcccgt atttcgcttg gccggcgctt
     8341 ggacgtgcct ggcgcggtgc gcgccggaca ccagcggcct cccagccgac tgcgaggcac
     8401 cgccggaacg ctgtggcccg tcaccgcatc ccgtgcgcct cggaggagag tccgtgatca
     8461 tccacaccct cgtctaccgg ttcgcggact cggtcgacga gtcccagcgc cgcgagttct
     8521 tcaccgacct ggagaagatc gcgcgcggct cgggcctcgt cacgcacttc ggccacggtc
     8581 cgcaccaccg gctgccggtc gacgaccacg ccgccgggac gaccgcgaac gccgtggccc
     8641 agttcgcctg ccgcgacctc gacgacctgc gggcgttctc ggagcttccg cacgtgcacg
     8701 agcacatcgc cggctggcgg tcccgcatcg cgtacgaggc ggcctacgcc aaccacgacg
     8761 acctgctcca cgtcatcgcg cccgcactca cgaaggagag tcccatgcac cacaccgaac
     8821 acaccgtcac cgtcgacgcc ccggccgcga tcgtctggga cgtcctcgtc gacgtcgagg
     8881 gctacgcgcg catcttcccg cccacggagg acgtgaagat cctcgaggag tcgcccgagc
     8941 accagatcgc ccggctgacc gtcgacgtca acggcgaggt gcagtcctgg atctcccggc
     9001 gggacatcga cgccggccgc cgtgtcatcg cctaccggca gctggagaac gccccgatga
     9061 tgggttacat gggcggcgag tggcgggccc tgcccatcga cgagcacacc acccagctgg
     9121 tcctgaccca cgacttcaag ccccgtgagc cggaggacgg cctggtcgcc ggaaagttca
     9181 cgtacgagca ggccgacgag atgatcaagg cggcggtgga gcgcaacagc gtggcggacc
     9241 tcggcgcggt caaggacgag gcggagaagc tcgccggtga gggcgccgcc gagtgaggcg
     9301 cctcgtcgac ctgagcgtgg tcacccggca cacgccgagc gaggcgacac ccgtcacggt
     9361 ggaactcctc gaccacgtca ccggcgccac cgtcctcggt ctgacgcccg aggacttccc
     9421 ggacgggatg gcgatctcca acgagacggt gacgctgacc acccacaccg gcacgcacat
     9481 ggacgcgccg ctgcactacg gcccgctcag cggcggcgcg cccgccaaga gcatcgacca
     9541 ggtgccgctg gagtggtgcg tgggtccggg cgtacggctg gacgtgcgcc aggtgccgcc
     9601 cggcgagggc atcacggtcg agcacctgcg cgcggcactg cgcgcggccg gacacaccct
     9661 gcggccaggc gacatcgtcc tgctgtggac cggtgccgac gcgctgtggg gcgaggccga
     9721 gtacctgacg aagtatccgg gactgaccgg cgagggcacg gcgttcctcg tggagtccgg
     9781 ggtacgggtg atcggcatcg acgcctgggg cctggaccgg cccatgcggt cgatgatcga
     9841 cgactaccgc cgcaccggcg acaggaaggc cctgtggccc gcgcacgtct acggccgcac
     9901 gcgcgagtac ctccagttgg agaagctcgc gcaactggcc gcgctgcccg cgccgacggg
     9961 cttcaccgtg gtctgcttcc cggtggcggt cgccggggcg ggggcgggct ggacccgggt
    10021 ggtggccctt ctcgacgacg accctcatgc gcgctgacga cctggtcggg gtgtggcacc
    10081 tggtgtcgtt ccgggaactg gacggcgccg gcacccccgg cgtcggtccc ctgggcgacg
    10141 cgccccgggg ccggctcgtc tacacccgcg acgggcacgt ctcggtgcac atgatgcgcg
    10201 gtccggaccc cggccccgtc ccgtacatgg gctacgccgg aacctggcgc ctggacggct
    10261 cccggatcgt gcaccggatc gaggtcaccc cccggcacga ctggatcgac accgaacaga
    10321 cccgggaggc gacgctggcc gggggccgtc tgacgctcca cgcccgcacc cgcgtcgacg
    10381 gggtggagca ccgcagggtc ctcgtctggc gcagggaccg cgcctagtag tgctttgttg
    10441 ggttctggac tgtctgccga tactccgagg gccgcgacca cggacgggtg gtcgcggccc
    10501 tcaggtccgc cgtacggcgt ccgtacgacg acgtcggtgg accaggacta cgacgtcagc
    10561 gccggcgcgg tcgggaaccc cgccgccagg gccagtgccg ccgcctcgcc ccgcgtgctg
    10621 acgtccagct tcttcaggat cttcgccacg tggaacttca ccgtgtgctc gctgatcagc
    10681 agacgcccgg cgatgacgcg gttgcggtgg ccctggacga gcagttccag gacgtcgagc
    10741 tcgcgcgggt tgagctcgcc gagcgggtcg ttgcgctgcc gttccggcgc ggccagcggc
    10801 agccggacgg tgacgatcgt gccccatccc ggcaccgcgt cgacgtccac ggccccgctg
    10861 acggccgccg cccggtcggt gagccggtgc acggcgagcg cgtcaccggc cagggtgccg
    10921 gggccgtcgt cccggatcac cgcgcgcacc tcggactcct cgacgtgcca gctgatccgg
    10981 acccggctca ccccgccctg ctccagcatg gtcagcacgg tgccgcgggc cgtcgtccgc
    11041 gccgtctggg cgatcaccga ggggatcagc cgctcggccg cctctcccac cggaccctcg
    11101 aactccaggc gcacgttgcc gtaccgggac agcagtccga gcatctcggt gagccgtccg
    11161 aaggcgtcgt gggccgtctc ctcccccggt acccgctcgg tgtcacccac cgagcgcagc
    11221 tcgatcagcg aggacaccgc caggtcgacg gcggtccggc gggccgtgcc gtcgtcgagg
    11281 ctgcggttgc gcagcagccc gatcagcgag gtgagcgtcg aggcgtggga gtccgtcaga
    11341 tcggagacga tgcgtgcgcg ttcgctgttc gccatccagg gcgcggtctg gttgacgggg
    11401 acgacggtgg gccacagggc catcacccgc agcatcgcca gatcccacaa ctgctggacg
    11461 acgggcagga cttcggggtc gggtgcggtg ccgtccaccg gcagtaccgc gagcagcgcg
    11521 cccgccgagc cgggtggcgc cgaggccacc gcgagcaccg ggcgcgaggc gtcggcgagt
    11581 ctcgcccggt cgaaccgcgg cctgccgatg tcgacgtgcg tggcgagctg ggccatctcg
    11641 gccgcggtga ccgcctcggt cagctcggcg tccccgtggc tccaggtcgc cgacgtcggg
    11701 cagtcgccgg tcagcatcac cagggcctcg tgcgccacca ggtcggacag cgcgtcagag
    11761 agcgtggaca gtacctgctt gatgggtgcc tgcatcagcg cggccgcaac cgtcagggca
    11821 cgctgcgggt tcccccagtc ccgatatgcc atgtctttca tgctacgggc ccggtgtccg
    11881 cttcccactc gccgaatggc tggtagtgac cgcccgttcg ggtggtccgc cgggccccgg
    11941 cggacgcccc accatcctcc cagcgccgtc ccagcggccc gtagggcggt gtcggtcatg
    12001 ttgggcgcgg cgcacggcac atggccggac gccgtcagct tcggcacgaa gggggccaca
    12061 aggtgaacga gtcagcagcg gctcggcaga cgggcgggac gcgatgaccc gccgcacggt
    12121 gatcaccggc atgggggtgc ggacgcccgg cgggaacggg gtgaaggcgt tctgggagct
    12181 gctgacctcc ggccgcagcg ccatccgccc catctccttc ttcgatccgt cgccctatcg
    12241 gtcgcggatc gccggcgagg ccgacttcga ccccgtgctg gaggggctga cgcccctgga
    12301 gatccggcgc atggaccggg ccacgcagtt caccgtggtc tgcgcgcggg acgcggtcgc
    12361 cgacagcggg ctcggcttcg agcggctgga tcccggccgg gtcggggtga gcctgggcag
    12421 cgcggtggcc gcggcgacca gcctggaaca ggagtacctg gtgctgtcgg acagcggacg
    12481 cgactggctg atggacaccg ccaacctgtc cccgcacatg ttcgactacc tggtgccgag
    12541 cgtgatgccg gccgaggtgg cctggacggt gggcgccgag ggcccggtgg ccatggtctc
    12601 caacggctgc acctccggga tcgactccgt cggccacgcc tgccggctca tcgaggaggg
    12661 cagcgccgac gtgatgctcg ccggtgccgg cgacactccg gtcacgccga tcgtcgtggc
    12721 ctgcttcgac gccatcaagg cgaccacctc gcgcaacgac gaacccgagc gggcctcccg
    12781 gccgttcgac cgcacccgca acggcttcgt cctcgccgag ggcgccgcga tgttcgtcct
    12841 ggaggagtac gagcacgccc gggcccgcgg cgcgcacgtc tacgccgaga tcaccggcta
    12901 cgccacgcgc tgcaacgcct atcacatgac cgggctgaag gcggacggcc gtgagatggc
    12961 cgaggcgatc cgctcggctc tcgacgaggc gcgcaccgac gccacggaca tcgactacat
    13021 caacgcgcac ggctcgggca ccaagcagaa cgaccgccac gagaccgccg cctacaagcg
    13081 cagcctgggc gagcacgccc ggcgcacccc cgtcagttcc atcaagtcga tggtgggtca
    13141 ctcgctgggc gcgatcgggt cgatcgagat cgccgcctcg gccctcgccc tggagaacgg
    13201 cgtggtcccg cccacggcca acctgcacga ggcggacccc gagtgcgacc tggactacgt
    13261 gccgctcacg gcgcgcgagc gcggtctgcg caacgtcctg accgtcggca gcggcttcgg
    13321 cggcttccag tccgccatgg tgctccggca cgcccctgga ggtaccgcgt gagcagcgca
    13381 ctcgtcaccg gaatcggcct gatcgcaccg aacgccgacg gcccggagcc ctactgggcg
    13441 gccacggtcg aggggcggac cggcatcggc accctgaccc gcttcgacgt gtcccgccat
    13501 ccggtccggc tggccggtga gatccgggac ttcgacgcct ccgcccggct gccgggaagg
    13561 ctgctgccgc agacggacgt ctccacccga tacgcgctgg tcgccgccga gcgggcgctc
    13621 gccgacgcgg ggatcgagcc cggcgcctac gccgactacg acatgggcgt ggtcaccggc
    13681 aacgcgcagg gcggcttcga gttcacccac cgcgagttcc gcaagctgtg gtcgcagggc
    13741 ccggagaagg tcagcgtgta cgagtcgttc gcctggttct acgcggtgaa caccggccag
    13801 atctccatcc gccaccggct gcgcggcccc agcagcgccc tggtcgccga gcaggccggc
    13861 ggtctggacg cgatcgggca cgcccggcgt acggtccggc gcggcacgcc gatggtcgtg
    13921 acggggggcg tcgactcggc gttcgacccc tggggctggg tgtcgcagat ctccggcggg
    13981 cggctgacca cctccggcga cccggaccgg gcctaccagc cgttcggcac gcacgccgac
    14041 ggccatgtgc ccggcgaggg cggtgcgatc ctcgtcctgg aggacccgcg gacggcgcgg
    14101 gagcggggtg cccggcaggt gtacggggag atcgccggct acgcctccac cttcgacccg
    14161 gcgccgggct cgggccggcc gcccggcctg cgcagggcgg ccgaactcgc cctgcgtgac
    14221 gcggggttgc caccctccga catcgacgtg gtgttcgcgg acgcggccgg cagcccggac
    14281 ctcgaccggg tggaggcgga ggccgtcggc gggctgttcg gtccgcacgg cgtgccggtc
    14341 accgcgccca aggccctgac cggccggctg tgctccggcg gcggtccgct ggacgtggcc
    14401 gccgcgctgc tctgcctgcg cgagggcgtg atcccgccga cgtacggcac ggacgaggtg
    14461 cccgaggagt acggcatcga cctggtgcgc ggcgcgcccc gcgaggtccc ggtccgggcg
    14521 gcgctggtgc tggcgcgcgg caagtggggc ttcaactcgg cggtcgtcgt gcgcgccgcg
    14581 ggggtcggcg atgactgagg gactcaagga ggtcgtggag acggccggcg ggctccggga
    14641 ggccatggcc cggttcccga cgggggtcgc catcgccacc gtgtgcgacg agcgcggact
    14701 gccgcacgga ctgaccgtca gctccttctg ctcggtctcc ctggacccgc cgctggtcct
    14761 gctctgcgtc gccaggtcgg cgcagtgctt cccggtgttc gcgcgtgcct ccgagttcgc
    14821 ggtgagcgtg ctgcgcgagc accacgcgga gctggccgcg cggttcgcga cggcgggggc
    14881 cgagaagttc gggcccggcg gactggggcg caccgcgcgg ggaggcgtgg tcgtcgacga
    14941 cgccctcgcc gtcgtggagt gcctggtgga gcagcggcac gacgcgggcg accacgtgat
    15001 cgtcgtcggc agggtcgtcg gtacgcacct caccgagtcg ggcgcacccg ccgtgtactt
    15061 caaccgccgg ttcgccgccc tcggcccggc ctcatgacga ccccctctcc ggacacttcg
    15121 aaggtgacgc acatggcgtt cagccggccg ctgcggccga ttcccgacga cgagaccctg
    15181 cgccgccacc tggcgggcgc ggacgtgccc gcgctgttgc tgacggtggc ccacctgacg
    15241 ggggacaccg ccctgctccg cgacgacctt cgcgcaccgg gctggctgtt ccagccgcag
    15301 ggcggcctga ccgccgcgcg gcaggacgag gcacgccggc tcgccttcga ggcgctgacc
    15361 gcgtggcggg accggggcgg cacccacgag ccgccggacc ccgcgctgct gcggacgatc
    15421 accacctggg cgatgggttc cgacaccggt gatctgctgg acctgctcgc cgaggagatc
    15481 gcgctgccgc gggacgaccc caaggcgccc ggctggacgc tggaggggct gcgccccggc
    15541 gccgatctgg acgtggccgt gatcggtgcc gggttcagcg ggctgctggc cgcccaccgg
    15601 ctcggccagg ccggagtgcc ggtcgtggtg tacgagaaga acgaggacgt cggaggcacc
    15661 tggttcgaga acacctatcc gggctgccgc accgacgtgg ccagccatct gtacaactac
    15721 tccttcgcgc cccgcgccga ctggccggac cacttctgcc gccgcgacac ggtcctggag
    15781 tacctgcggg acttcgcgaa ggagtcgggg gtcgccgacc gcatccggtt cggcaccgaa
    15841 gtacgggagc tgcgctggga cgaacgcgag cgccgctggc acctcaccct ggacggcccc
    15901 ggcggcccac ggacggtcac gcaccggatg gtgatcagcg ccgtgggcca gctcaaccgg
    15961 ccgcagctgc cggccgtcga tggcctcggc agcttcaccg ggcccgcctt ccactccgcc
    16021 gcctgggacc acacggcgga cctcaccggc aagcgggtcg cggtcgtcgg cacgggcgcc
    16081 agcgcctacc agatcgtgcc cgaactggcc ggcgccgcct ccgaggtggt cgtcttccag
    16141 cgcaatccgc cctggctgcg gcccaccccg cactaccacc agccgctgtc cggcagcacc
    16201 tcctggctct gcgagcacct gccgtactac gcgcagtggt accgcttctg gctgttcgcg
    16261 cccggactgc gcggcatcct cgacggctgg atcgtggacc gctgctaccc gcccaccgag
    16321 cgtgccgtct ccgccctcaa cgagcagctg cgcgcctccc tccttcaggc catggaggcc
    16381 cagctcaccg acgcccccga gctgcgcgag aaggtcgtgc cgcgctaccc ggtcggcgcc
    16441 aagcgggtac tgcgggacga cggcacctgg ctggccaccc tcaagcggga cgacgtgacg
    16501 ctggtgaccg ccccggtgga acgggagaca ccgcgcggac tggtcgcgga cggcgaggag
    16561 ttcgaggtgg acgtcatcgt ctacgccacc gggttccagg cctcccggtt cctcaccccg
    16621 atgaaggtga ccggcgagcg gggcgtggac ctgcacaccc actgggacgg ggcaccccgt
    16681 gcgcacctgg gcatcagcgt ccccggcttc cccaacctgt tctgcctgta cggaccgaac
    16741 accaatctcg tcggacaggg cggcagcatc gtctacttct ccgagtgcgc cacccggtac
    16801 gtcctggacg cgatccgtct gctgctcacg cgggacgcgg acgcggtcca ggtccgcgag
    16861 gacgtgcacg acgactacaa cgcgtgggtc gacgcggcga gcgccgaccg ggcctgggtc
    16921 tggtcgaagg tgagcggctg gtacaaggac ggctcccgtt cctccaccaa ctggcccttc
    16981 tccgcggccg agtactggac acgcacccgg cgcgccgacc ccgagcacct ccgactgcgc
    17041 tgacatccga cagcttccgc gaaccgagga cgggacacac acatggtgga cacagccgcc
    17101 ggcccgctgg ccacggcagc ccgcgacatc gcggcgacgg ccgccgggct cgccgcccgc
    17161 atggccgagc agcggcacat cgacgccggc ctggtgacgg cgatgcgcga ggccggcttc
    17221 atgaggcacc tggcacccgc gcggtacggc ggcgccgggg gcaccctcgc cgacctgctg
    17281 gacgcggtgg cgaccctggg cgaggcctgc ccggcgaccg cgtggtgcgc ctcgctgttc
    17341 gcgagcacac cccggttcgt gccctgcttc cccgaggccg ggcagaagga gttctgggcc
    17401 gacggtccgg acaccgcgtt cgtctgctcg gtgctgccct tcggcgaggc ggtcccggac
    17461 gccgacggcg acgggctgcg cgtcagcgga cggtggccgt acatgagcgc cgtggagcac
    17521 gcggactggg tcgtcgtctg cgcccggagc accggcgccg gcggcccccg gctcacgctg
    17581 gtggcggtgc ccgcgtcggc cgtccgcatc gaggacacct gggacagcgt ggggatgcgc
    17641 gccaccggca gcgacacggt ggtcctggag aacgtgcccg tccccgcagg ccggtacgtc
    17701 gaccgggacg cggtgttcgc ggggcggacc gccgacggaa ccgccatcgc cccgctcgcc
    17761 gccgtgaacg ggctgacgtt cgtcgtgccc gcgctcggcg cggcgcaggg cgccctggcc
    17821 gagctcaccc ggtacctggc gggcaggctg accgaggtga cgccgacgcc gggcatgccc
    17881 ggacccgggg gcagcctggc cacccacgag atgaccctgg cccgctcggc cgccgagatc
    17941 gacagcgccc gtctgctgct cacccgcatc gcccgactcg ccgacgaggg cggcccgttc
    18001 accgggccgg cgatcgcgcg gaacatgcgc gacagcgcct tcaccgtcga gttgctgctc
    18061 tccgccgtca accgcgtctt ccgcgccgcg ggcacgggcg ggcaggcggc gcgcggcccg
    18121 ctggagcgct tctggcacga cgtcaacgcc gtcgccaccc accaggccgt gcagttcgag
    18181 ccggccgcgc accactacgc gcgcgccctg ttcaccaccc cttgaggagg acgtcatgaa
    18241 gaacacgaac ccgcccccgg agtccgcccc ctcggccgac cgcatcctgg agacggccct
    18301 ggccttccag gcgtcgaaga cgctgctcag cgcggtcgag gtcggcgtct tcaccgagct
    18361 ggccaggaag ccggccgacg tccacgagct gcgggagcgg ctcggcctgc acccgcgcgg
    18421 cgcccgggac ttcttcgacg cgctggtcgc gctgggcttc ctgcgccgcg aggacggcgt
    18481 ctaccacaac acccccgagt ccgaggccca cctggaccgc gccaagcccg gttacggaca
    18541 cgtggcaccg atgctggaga tggccgggtc ccggttgttc ggcatctgga accggctgtc
    18601 ggacgccctg cgcacgggcc tctcccagga cgagtcgaag gacagggacg aggacaccta
    18661 cgacgccctg tacgcggacc cggaccgcct gcggacgttc ctctcgtcga tgacgggcat
    18721 cagccatcgc gccaatctcc gcatcgcacg gcaggtgccc tgggaggact acacgacgat
    18781 ggccgacatg ggcaccgcgc agggcgacct cgcggtgcag gtgctgctcg ccaacccggg
    18841 gctgaccggc accggtttcg acctgcccca ggcggagccg gtgttcaccg agtacgccga
    18901 gcggcacggc ctgacggacc ggctcggctt caccggcggt gacttcttca ccgacccctt
    18961 cccgcgggcc gacgtgctga ccttcggcca catcctgcac aactgggacc ttgagcggaa
    19021 gaaggtcctg ctgcgcaagg cgtgggaggc gctgccgcag ggcggcgcgg tggtggtgta
    19081 cgacaccctc atcgacgacg accggtccga gaacgcgttc gccctgctca tgagcctgaa
    19141 catgctggcc gtcacggacg gcggcttcgg ctacacgggc cacgagtgcc aggagtggat
    19201 gcgggaggcc ggtttcgacc gcacctggac ggaacacctc gtggggcccg actcgatcgt
    19261 ggtaggggtc aaggaatgaa cgcgatgaag cagaacaagg aactggtcgc cgaatacatc
    19321 cggctgttct acaacgagaa ggacttcgac cgggcccggg agctgctgac cgagggcttc
    19381 gtcaaccacc accacggcgt cggcgccggc cgggaccgta ccgtcgagac gttccgggcc
    19441 gccgtctcgg tgatgcccga gttctcgctc accgtgcggc gcgtggtcgc ggagggcgac
    19501 caggtgtgga cccacagcgt ggccagggcg gcgccggggg cgcacccgtc ggtcgtcgtg
    19561 gacatctggc gcgtcgagga cggccggctg gccgagcact gggacgtcgg ccagccggtg
    19621 ccggagggtt cggccctgga cgcgatgatc gaggacgccg gatgaccgct ctgatgcggg
    19681 ccgtcgtcca gcgcgccttc ggcgggccgg gtgtcctgga gcccgcccgg gtgccccggc
    19741 cggccccggc gctcaacgag gtgctggtcc gcgtgcacgc ggccggggtg aacccgatcg
    19801 acgccctcgt ccggtcgggg gaacttcccc tgctgggcgc accgcccttc accgtcggct
    19861 gggacgtctc cggtgtcgtg gccgggaccg ctccgggcgt gacccggttc gccgtcgggg
    19921 acgaggtcta cggcatgccg tgcatcccgc gtgcggcggc cgcctacgcc gagtacgtcg
    19981 tggcgccctc ccgccagctc gcccgcaaac cggcgtccgt cgatcaccgt acggcggcgg
    20041 ggctgccgct ggccgggctg acggcgtggc aggcgctggt cgagaccggc tgggcggggc
    20101 gcggcacgcg ggtgctggtg cacggcgggg gcggcggcgt gggccatctc gccgtgcaga
    20161 tcgccaaggc ccgcggggcc gaggtgatcg ccacggcgag cgcgggcaag gcggccttcg
    20221 tacatgccct gggcgccgac cgggtgatcg actaccgggc ggtcgacttc gccgccgagg
    20281 tccgggacgt cgacgtggtc ctcgacggcg tcggcggcga gaccgccgta cgctcgctcg
    20341 acgtgctgcg gccgggtggc gcgctggtga cgatcgtgga gatgcggaac ccggagctgg
    20401 cccggctggc cgaggcgcgc gggctgcgtt tccacggcgt cacggcggaa ccggaccacg
    20461 tgggtctggc ggccctcgcg gacctggtcg acgccggtct gctgcgcccg cacatcgacc
    20521 gctcgctgcc gctggacgag gcggcgcagg cccaccggct gctggacgcg ggcgcgctga
    20581 ccgggaaggt cgtgctggag acggcctgac ctcgcggacc ggcgcggtca ggcgggcgcg
    20641 agcggttgga cgcaggcgat gaggagggcg acgtcgtcgt ggccggcggg gtgccgcagc
    20701 tcccgcagga gccggtcgca ggtctcctcc gtcgaccggt ccggcggtgt caggaggcgc
    20761 atcaggtcgt ccagccgctc gtcgatggga tcgtgccggg tctccacgag tccgtcggtg
    20821 tacaggacga ggcggtcgcc gggctccaga gcgagggtcg tcacctcgaa ggggaccccc
    20881 cgcacgccca gcggcgtgcc ggtgggcagc cggagcagtt ccggctgccg gccgtcccgc
    20941 accaggaccg ggggcagatg gccggctgat gccacgtgca gccgggcgcg gtgcgggtcg
    21001 tacaccgcgt acaggcaggt ggcgaggtag tccagatcgg cggtgatctt gtcgaggtgg
    21061 gtgaggatcc gcgccgggtc gaggtccagg tcggcgaggg tggaggtggc ggtgcgcagc
    21121 cggcccatgg tggtggcggc ggtgacaccg ctgcccatga cgtcgcccac cgcgagggcg
    21181 gtccggtcgc cgtcgagggc gatcacgtcg taccagtcgc cgcccacctc gctgaaggcc
    21241 tgggcgggcc ggtagcgggc ggcgacctcc aggccgggac ggccgggcgg gagctgcggg
    21301 aggaggctgc gctgcagcgt ctccgcggca ccccggatgt gctggtgcag cacggcgttg
    21361 tcgatgctca gcgcggcgga cgaggccatc tcgcaggcga gggtgaggtc gtcctcgtcg
    21421 aacggcaggg ggttgcgggc ccgggccagg cccatgacgc cgatgatctg ttcgcgggcg
    21481 atcagcggaa cggccatgtc ggtgtgcacc cccgcccggg ccagcaggcg ggcggcctcg
    21541 gggccggcgg cgatacggct cagatcgtcg ccgctcacat gggtgatcat gaggggccgg
    21601 cgggtgcgca cgcagtggga cgccggatgg tcggcgtggt acgtgacgag gctgccgggc
    21661 ggcacgatgg cccggtcggc gtcggtgggg taggcggtct tcaccgcgac ggcacggaac
    21721 agggccggcc cctcgtcgag gtccgcccgg cccgtctgca ggaccgagtc caggaggtcc
    21781 acggcgacca tgtcggcgag gtcgggcacc aggacgtcgg ccagttcccg ggccgtgcgc
    21841 tccacctcca gggtggtgcc gatccggccc gaggcgttgg cgaggagacg cagccggtgc
    21901 tgggcctcgt cggccttctt cgccgcccgg taccggtcgg tgacgtcgac gaccacgtag
    21961 gcgaggccca ggacgtcacc gtggtggtcc tccaggcggt acgtcgacac cgcccacgcg
    22021 tggtcggtgt ccgggtcggc ggcggtgcgc cccaccacct gctggtccac cacgggggcg
    22081 ccggtcgcca gcacgtgccg catcacggtc tccgctccca ggaagggggc gccgggcagg
    22141 atctcgcgga acctgcggcc cacgtggtcg gactcgggga cgccgtgcat cgccgccagg
    22201 gccgggttga tggccaggta ccgcatgtcg gggtcgagga cggcaagccc gatgggtgcc
    22261 tgggtgacca ggcggttgga cagggccacc ttgcgctcga catgccgcac cgtggcccgg
    22321 tcggcggcga gcccgagggc gtagtggtcg cccaggttgt cggtcagccg catgttgcgg
    22381 aactcgacca tccgggtgct gccgtccttg tgccggacgg ggaaggcccc ggcccagtcc
    22441 cggccggtcg ccatcacctc ggcgaacagt tcgatcaccg cgtcctggtg ctccgggtgg
    22501 acgagcagcg gtgcggcgta ctgcccgacc gcctcactgc gggcgtagcc gaacagctgc
    22561 tcggcctggg ggctccacat gtcgatcctg ccgtcggcct ccagcagcac cgcggcgacg
    22621 ttcagcaggt ccatcagccc gctcggggcc accgcgccgc tcgccggacc gtccgccggc
    22681 cgcgagcccg ggctcgctgg cgtcat
//
