BGC0001627 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001627 (Mycobacterium tuberculosis H37Rv)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	10,806	isonitrile lipopeptides	NRPS:Type I	100%

BGC0001627 - Region 1 - NRPS

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Location: 1 - 10,806 nt. (total: 10,806 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 10,807
Label		BGC0001627

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001627	1.00	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001574	0.25	NRP	diisonitrile antibiotic SF2768	Streptomyces thioluteus
BGC0002491	0.23	NRP	myxochelin B, myxochelin A, pseudochelin A	Pseudoalteromonas piscicida
BGC0001637	0.23	NRP	kleboxymycin	Klebsiella oxytoca
BGC0001758	0.22	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001085	0.22	NRP, Terpene	teleocidin B1	Streptomyces blastmyceticus
BGC0001833	0.22	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128	0.22	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641	0.22	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.22	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001627	1.00	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001574	0.58	NRP	diisonitrile antibiotic SF2768	Streptomyces thioluteus
BGC0002491	0.56	NRP	myxochelin B, myxochelin A, pseudochelin A	Pseudoalteromonas piscicida
BGC0001637	0.56	NRP	kleboxymycin	Klebsiella oxytoca
BGC0001758	0.55	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001085	0.55	NRP, Terpene	teleocidin B1	Streptomyces blastmyceticus
BGC0001833	0.55	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128	0.55	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641	0.55	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.55	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 10806:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Lys - Phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Rv0099

AMP-binding (20..430): X

nrpys: Pen, C4:0

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IGWCGGVCTK
Nearest Stachelhaus code(s):: Pen or C4:0 IGWCGGVCTK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Rv0101

Search NORINE for peptide: strict or relaxed

AMP-binding (472..829): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIEDVGSVVK
Nearest Stachelhaus code(s):: Lys DIEDVGSVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1498..1882): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTVAAICK
Nearest Stachelhaus code(s):: Phe DAWTVAAICK (100% 8Å match)
Stachelhaus code match:: 100% (strong)