LOCUS       BGC0001627             10806 bp    DNA     linear   BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv complete genome.
ACCESSION   BGC0001627
VERSION     BGC0001627
KEYWORDS    .
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
COMMENT     On or before Feb 1, 2013 this sequence version replaced BX842572.1,
            BX842573.1, BX842574.1, BX842575.1, BX842576.1, BX842577.1,
            BX842578.1, BX842579.1, BX842580.1, BX842581.1, BX842582.1,
            BX842583.1, BX842584.1, AL123456.2.
            On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 03:00:19
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10806
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[3267:10806]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3268..10806
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..10806
                     /SMILES="NC([*])C(=O)NC(Cc1ccccc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10806
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001627"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10806
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..870
                     /locus_tag="Rv0097"
     CDS             1..870
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv0097"
                     /db_xref="EnsemblGenomes-Tr:CCP42822"
                     /db_xref="GOA:P9WG83"
                     /db_xref="InterPro:IPR003819"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121:dioxygenase, TauD/TfdA (Score: 253.2; E-value:
                     4.5e-77)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PROSITE:PS00077"
                     /locus_tag="Rv0097"
                     /note="Rv0097, (MTCY251.16), len: 289 aa. Possible
                     oxidoreductase, equivalent to NP_302343.1|NC_002677
                     putative oxidoreductase from Mycobacterium leprae (289 aa).
                     Also highly similar to BAB69377.1|AB070955 putative
                     oxidoreductase from Streptomyces avermitilis (296 aa).
                     Contains PS00077 Cytochrome c oxidase subunit I, copper B
                     binding region signature."
                     /product="Possible oxidoreductase"
                     /protein_id="CCP42822.1"
                     /transl_table=11
                     /translation="MTLKVKGEGLGAQVTGVDPKNLDDITTDEIRDIVYTNKLVVLKDV
                     HPSPREFIKLGRIIGQIVPYYEPMYHHEDHPEIFVSSTEEGQGVPKTGAFWHIDYMFMP
                     EPFAFSMVLPLAVPGHDRGTYFIDLARVWQSLPAAKRDPARGTVSTHDPRRHIKIRPSD
                     VYRPIGEVWDEINRTTPPIKWPTVIRHPKTGQEILYICATGTTKIEDKDGNPVDPEVLQ
                     ELMAATGQLDPEYQSPFIHTQHYQVGDIILWDNRVLMHRAKHGSAAGTLTTYRLTMLDG
                     LKTPGYAA"
     gene            867..1418
                     /gene="fcoT"
                     /locus_tag="Rv0098"
     CDS             867..1418
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv0098"
                     /db_xref="EnsemblGenomes-Tr:CCP42823"
                     /db_xref="GOA:P9WM67"
                     /db_xref="InterPro:IPR022598"
                     /db_xref="PDB:2PFC"
                     /db_xref="PDB:3B18"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="fcoT"
                     /locus_tag="Rv0098"
                     /note="Rv0098, (MTCY251.17), len: 183 aa. FcoT, long-chain
                     fatty acyl CoA thioesterase type III (See Wang et
                     al.,2007), equivalent to CAC30948.1|AL583924 from
                     Mycobacterium leprae (183 aa). A core mycobacterial gene;
                     conserved in mycobacterial strains (See Marmiesse et al.,
                     2004)."
                     /product="Probable fatty acyl CoA thioesterase type III
                     FcoT"
                     /protein_id="CCP42823.1"
                     /transl_table=11
                     /translation="MSHTDLTPCTRVLASSGTVPIAEELLARVLEPYSCKGCRYLIDAQ
                     YSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVLRG
                     WSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCVIEF
                     WDENGGAASGEIELAALNIP"
     gene            1423..3045
                     /gene="fadD10"
                     /locus_tag="Rv0099"
     CDS             1423..3045
                     /NRPS_PKS="Domain: AMP-binding (20-430). E-value: 2.9e-80.
                     Score: 261.7. Matches aSDomain:
                     nrpspksdomains_Rv0099_AMP-binding.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv0099"
                     /db_xref="EnsemblGenomes-Tr:CCP42824"
                     /db_xref="GOA:P9WQ55"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="fadD10"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     337.7; E-value: 1.6e-102)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:PROSITE:PS00455"
                     /locus_tag="Rv0099"
                     /note="Rv0099, (MTCY251.18), len: 540 aa. Possible
                     fadD10,fatty-acid-CoA synthetase, similar to many. Contains
                     PS00455 putative AMP-binding domain signature. Contains
                     IPR000873 AMP-dependent synthetase/ligase domain. Belongs
                     to the ATP-dependent AMP-binding enzyme family."
                     /product="Possible fatty-acid-CoA ligase FadD10
                     (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
                     /protein_id="CCP42824.1"
                     /sec_met_domain="AMP-binding (E-value: 7.8e-83, bitscore:
                     266.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYR
                     ELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAA
                     IERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGN
                     ADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLP
                     ATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSA
                     NATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIE
                     AGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVL
                     IDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEI
                     PDEEFGALVGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQS
                     GKVMRASLAAAATADKARVVVRG"
     aSDomain        1483..2712
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv0099_AMP-binding.1"
                     /evalue="2.90E-80"
                     /label="Rv0099_AMP-binding.1"
                     /locus_tag="Rv0099"
                     /protein_end="430"
                     /protein_start="20"
                     /score="261.7"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSR
                     GSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVAPGSK
                     MASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDPLAMIFTSGTTGE
                     PKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGGLC
                     VTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGSRAIAA
                     DVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAATDG
                     IGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFY
                     IKGRSSEMIIC"
     CDS_motif       1942..1989
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0099_0001"
                     /evalue="5.70E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="Rv0099"
                     /protein_end="189"
                     /protein_start="173"
                     /score="19.0"
                     /tool="antismash"
                     /translation="MIFTSGTTGEPKAVLL"
     CDS_motif       2545..2616
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0099_0002"
                     /evalue="2.10E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="Rv0099"
                     /protein_end="398"
                     /protein_start="374"
                     /score="20.1"
                     /tool="antismash"
                     /translation="GTLWIKSPANMLGYWNNPERTAEV"
     gene            3050..3286
                     /locus_tag="Rv0100"
     CDS             3050..3286
                     /NRPS_PKS="Domain: PP-binding (2-69). E-value: 1.1e-11.
                     Score: 37.0. Matches aSDomain:
                     nrpspksdomains_Rv0100_PP-binding.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv0100"
                     /db_xref="EnsemblGenomes-Tr:CCP42825"
                     /db_xref="InterPro:IPR009081"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="Rv0100"
                     /note="Rv0100, (MTCY251.19), len: 78 aa. Conserved
                     hypothetical protein, equivalent only to
                     CAC30950.1|AL583924 conserved hypothetical protein from
                     Mycobacterium leprae (78 aa). A core mycobacterial gene;
                     conserved in mycobacterial strains (See Marmiesse et
                     al.,2004)."
                     /product="Conserved hypothetical protein"
                     /protein_id="CCP42825.1"
                     /sec_met_domain="PP-binding (E-value: 9.7e-13, bitscore:
                     37.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDRILAAVCDVLYIDEADLIDGDETDLRDLGLDSVRFVLLMKQL
                     GVNRQSELPSRLAANPSIAGWLRELEAVCTEFG"
     aSDomain        3056..3256
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv0100_PP-binding.1"
                     /evalue="1.10E-11"
                     /label="Rv0100_PP-binding.1"
                     /locus_tag="Rv0100"
                     /protein_end="69"
                     /protein_start="2"
                     /score="37.0"
                     /tool="antismash"
                     /translation="DRILAAVCDVLYIDEADLIDGDETDLRDLGLDSVRFVLLMKQLGV
                     NRQSELPSRLAANPSIAGWLRE"
     gene            3268..10806
                     /gene="nrp"
                     /locus_tag="Rv0101"
     CDS             3268..10806
                     /NRPS_PKS="Domain: AMP-binding (472-829). E-value: 5.3e-44.
                     Score: 142.2. Matches aSDomain:
                     nrpspksdomains_Rv0101_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (937-998). E-value: 2.3e-09.
                     Score: 29.6. Matches aSDomain:
                     nrpspksdomains_Rv0101_PP-binding.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1020-1324). E-value:
                     2.3e-115. Score: 376.5. Matches aSDomain:
                     nrpspksdomains_Rv0101_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1498-1882). E-value:
                     1.4e-97. Score: 318.7. Matches aSDomain:
                     nrpspksdomains_Rv0101_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (1989-2058). E-value: 1.4e-22.
                     Score: 71.5. Matches aSDomain: nrpspksdomains_Rv0101_PCP.1"
                     /NRPS_PKS="Domain: TD (2109-2373). E-value: 1.5e-85. Score:
                     278.1. Matches aSDomain: nrpspksdomains_Rv0101_TD.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:Rv0101"
                     /db_xref="EnsemblGenomes-Tr:CCP42826"
                     /db_xref="GOA:Q10896"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="InterPro:IPR010080"
                     /db_xref="InterPro:IPR013120"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="PDB:4DQV"
                     /db_xref="UniProtKB/TrEMBL:Q10896"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /gene="nrp"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     336.8; E-value: 3e-102)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:PROSITE:PS00012"
                     /inference="protein motif:PROSITE:PS00017"
                     /inference="protein motif:PROSITE:PS00455"
                     /locus_tag="Rv0101"
                     /note="Rv0101, (MTCY251.20), len: 2512 aa. Probable
                     nrp,peptide synthetase, similar to others e.g.
                     AAD44234.1|AF143772_40|PstB peptide synthetase from
                     Mycobacterium avium (2552 aa); 7476034|S77657 cyclic
                     peptide synthetase from Mycobacterium leprae (1401
                     aa),FASTA scores: opt: 4268, E(): 0, (65.7% identity in
                     1091 aa overlap); part of CAB55600.1|AJ238027 peptide
                     synthetase from Mycobacterium smegmatis (5990). Also
                     similar to e.g. AAD56240.1|AF184977_1|AF184977 DhbF protein
                     from Bacillus subtilis (2378 aa); SRF1_BACSU|P27206
                     surfactin synthetase subunit 1 (3587 aa), FASTA scores:
                     opt: 1708, E(): 0,(30.6% identity in 1633 aa overlap): etc.
                     Contains PS00017 ATP/GTP-binding site motif A (P-loop), 2 x
                     PS00455 Putative AMP-binding domain signature, and PS00012
                     Phosphopantetheine attachment site. Belongs to the
                     ATP-dependent AMP-binding enzyme family. Thought to be not
                     involved in mycobactin biosynthesis (see citation below)."
                     /product="Probable peptide synthetase Nrp (peptide
                     synthase)"
                     /protein_id="CCP42826.1"
                     /sec_met_domain="Condensation (E-value: 5.5e-67, bitscore:
                     214.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.8e-106, bitscore:
                     343.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.7e-16, bitscore:
                     48.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 8.1e-63, bitscore:
                     200.2, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRLELARFLAA
                     LHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADEHLQSTWCSGILGKPLVR
                     HTVHTDPNGYVTGLDVHTHHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAKLRE
                     AHRRETAKVEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNA
                     FDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVATCLVN
                     SVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVEALTLNF
                     IREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWNRADLPACKTHPK
                     VAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQGDWPARQPSTPAWFLDSARGV
                     HQFLGRRRFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDTAD
                     EISVRTNAITEHGDGILVTVVDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTAY
                     IMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAHDTVLQCAPLTSDISVEEIFGGA
                     ACGARLVRSAAMKTGDLAALVDDLVARETTIVDLPTAVWQLLCADGDAIDAIGRSRLRQ
                     IVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATVVATFLPIVCDQTTMDGALLRL
                     GRPILPNTVFLAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDA
                     EGFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVWFKSQRTRE
                     GEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDNLPRLPQWSAAGLNTAE
                     TGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRILPETRRYLGWRLSLLDLIGA
                     DTAANLADYAPTPDAPTGEDRFRPLVAAQRPAAIPLSFAQRRLWFLDQLQRPAPVYNMA
                     VALRLRGYLDTEALGAAVADVVGRHESLRTVFPAVDGVPRQLVIEARRADLGCDIVDAT
                     AWPADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEHVLVAVAHHIAADGWSVAPLT
                     ADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAG
                     MPERLRLPTARPYPPVADQRGASLVVDWPASVQQQVRRIARQHNATSFMVVAAGLAVLL
                     SKLSGSPDVAVGFPIAGRSDPALDNLVGFFVNTLVLRVNLAGDPSFAELLGQVRARSLA
                     AYENQDVPFEVLVDRLKPTRALTHHPLIQVMLAWQDNPVGQLNLGDLQATPMPIDTRTA
                     RMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEAQAIDVLIERLRKVLVAVAAAPERTV
                     SSIDALDGTERARLDEWGNRAVLTAPAPTPVSIPQMLAAQVARIPEAEAVCCGDASMTY
                     RELDEASNRLAHRLAGCGAGPGECVALLFERCAPAVVAMVAVLKTGAAYLPIDPANPPP
                     RVAFMLGDAVPVAAVTTAGLRSRLAGHDLPIIDVVDALAAYPGTPPPMPAAVNLAYILY
                     TSGTTGEPKGVGITHRNVTRLFASLPARLSAAQVWSQCHSYGFDASAWEIWGALLGGGR
                     LVIVPESVAASPNDFHGLLVAEHVSVLTQTPAAVAMLPTQGLESVALVVAGEACPAALV
                     DRWAPGRVMLNAYGPTETTICAAISAPLRPGSGMPPIGVPVSGAALFVLDSWLRPVPAG
                     VAGELYIAGAGVGVGYWRRAGLTASRFVACPFGGSGARMYRTGDLVCWRADGQLEFLGR
                     TDDQVKIRGYRIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAPGAVDPA
                     GLRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYGDTNGYRAPAGPVEKT
                     VAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAAINTTLNADLPVRALLHASSTRGL
                     SQLLGRDARPTSDPRLVSVHGDNPTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTV
                     LLTGATGFLGRYLVLELLRRLDVDGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFK
                     ELAADRLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPNVAGT
                     AELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGYGTSK
                     WAGEVLLREANDLCALPVAVFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPRSF
                     YEPDSEGNRQRAHFDGLPVTFVAEAIAVLGARVAGSSLAGFATYHVMNPHDDGIGLDEY
                     VDWLIEAGYPIRRIDDFAEWLQRFEASLGALPDRQRRHSVLPMLLASNSQRLQPLKPTR
                     GCSAPTDRFRAAVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL"
     CDS_motif       3343..3405
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0001"
                     /evalue="6.80E+00"
                     /label="C2_dual_024-063"
                     /locus_tag="Rv0101"
                     /protein_end="46"
                     /protein_start="25"
                     /score="-0.6"
                     /tool="antismash"
                     /translation="YLIGKSYRFRRLELARFLAAL"
     CDS_motif       3634..3687
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0002"
                     /evalue="1.50E-02"
                     /label="C3_DCL_135-156"
                     /locus_tag="Rv0101"
                     /protein_end="140"
                     /protein_start="122"
                     /score="8.1"
                     /tool="antismash"
                     /translation="HHILLDGGATGTIEADLA"
     aSDomain        4684..5754
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv0101_AMP-binding.1"
                     /evalue="5.30E-44"
                     /label="Rv0101_AMP-binding.1"
                     /locus_tag="Rv0101"
                     /protein_end="829"
                     /protein_start="472"
                     /score="142.2"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="AWLVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDTAD
                     EISVRTNAITEHGDGILVTVVDVAATQLAVVGHDELRKVVDERVTQVTHDALLATKTAY
                     IMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAHDTVLQCAPLTSDISVEEIFGGA
                     ACGARLVRSAAMKTGDLAALVDDLVARETTIVDLPTAVWQLLCADGDAIDAIGRSRLRQ
                     IVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATVVATFLPIVCDQTTMDGALLRL
                     GRPILPNTVFLAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDA
                     EGFPVFSGRKDAVVKIS"
     aSModule        4684..6261
                     /complete
                     /domains="nrpspksdomains_Rv0101_AMP-binding.1"
                     /domains="nrpspksdomains_Rv0101_PP-binding.1"
                     /locus_tags="Rv0101"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4771..4803
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0003"
                     /evalue="1.80E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="Rv0101"
                     /protein_end="512"
                     /protein_start="501"
                     /score="-0.1"
                     /tool="antismash"
                     /translation="ACHLAGCGYSV"
     CDS_motif       4990..5049
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0004"
                     /evalue="9.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="Rv0101"
                     /protein_end="594"
                     /protein_start="574"
                     /score="21.4"
                     /tool="antismash"
                     /translation="AYIMPTSGTTGQPKLVRISH"
     CDS_motif       5053..5091
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0005"
                     /evalue="1.10E+01"
                     /label="C3_LCL_132-143"
                     /locus_tag="Rv0101"
                     /protein_end="608"
                     /protein_start="595"
                     /score="-1.0"
                     /tool="antismash"
                     /translation="SLAVFCDAISRAY"
     CDS_motif       5437..5466
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0006"
                     /evalue="3.60E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="Rv0101"
                     /protein_end="733"
                     /protein_start="723"
                     /score="7.2"
                     /tool="antismash"
                     /translation="SYGPTEATVV"
     CDS_motif       5566..5613
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0007"
                     /evalue="5.20E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="Rv0101"
                     /protein_end="782"
                     /protein_start="766"
                     /score="9.3"
                     /tool="antismash"
                     /translation="GEVVIVGDLVADGYLG"
     CDS_motif       5719..5781
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0008"
                     /evalue="9.20E-05"
                     /label="NRPS-A_a8"
                     /locus_tag="Rv0101"
                     /protein_end="838"
                     /protein_start="817"
                     /score="15.2"
                     /tool="antismash"
                     /translation="FSGRKDAVVKISGKRVDIAEV"
     aSDomain        6079..6261
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv0101_PP-binding.1"
                     /evalue="2.30E-09"
                     /label="Rv0101_PP-binding.1"
                     /locus_tag="Rv0101"
                     /protein_end="998"
                     /protein_start="937"
                     /score="29.6"
                     /tool="antismash"
                     /translation="LSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRILPETRRYLGWRLS
                     LLDLIGADTAANLADY"
     aSDomain        6328..7239
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv0101_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="2.30E-115"
                     /label="Rv0101_Condensation_LCL.1"
                     /locus_tag="Rv0101"
                     /protein_end="1324"
                     /protein_start="1020"
                     /score="376.5"
                     /tool="antismash"
                     /translation="AAIPLSFAQRRLWFLDQLQRPAPVYNMAVALRLRGYLDTEALGAA
                     VADVVGRHESLRTVFPAVDGVPRQLVIEARRADLGCDIVDATAWPADRLQRAIEEAARH
                     SFDLATEIPLRTWLFRIADDEHVLVAVAHHIAADGWSVAPLTADLSAAYASRCAGRAPD
                     WAPLPVQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAGMPERLRLPTARPYPPVA
                     DQRGASLVVDWPASVQQQVRRIARQHNATSFMVVAAGLAVLLSKLSGSPDVAVGFPIAG
                     RSDPALDNLVGFFVNTLVLRVNL"
     aSModule        6328..10386
                     /complete
                     /domains="nrpspksdomains_Rv0101_Condensation_LCL.1"
                     /domains="nrpspksdomains_Rv0101_AMP-binding.2"
                     /domains="nrpspksdomains_Rv0101_PCP.1"
                     /domains="nrpspksdomains_Rv0101_TD.1"
                     /final_module
                     /locus_tags="Rv0101"
                     /monomer_pairings="phe -> phe"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6394..6510
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0009"
                     /evalue="5.20E-16"
                     /label="C2_LCL_024-062"
                     /locus_tag="Rv0101"
                     /protein_end="1081"
                     /protein_start="1042"
                     /score="51.0"
                     /tool="antismash"
                     /translation="PVYNMAVALRLRGYLDTEALGAAVADVVGRHESLRTVFP"
     CDS_motif       6724..6786
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0010"
                     /evalue="4.40E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="Rv0101"
                     /protein_end="1173"
                     /protein_start="1152"
                     /score="28.8"
                     /tool="antismash"
                     /translation="HHIAADGWSVAPLTADLSAAY"
     CDS_motif       6835..6873
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0011"
                     /evalue="2.30E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="Rv0101"
                     /protein_end="1202"
                     /protein_start="1189"
                     /score="13.8"
                     /tool="antismash"
                     /translation="QYVDYTLWQREIL"
     CDS_motif       7141..7230
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0012"
                     /evalue="7.90E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="Rv0101"
                     /protein_end="1321"
                     /protein_start="1291"
                     /score="47.2"
                     /tool="antismash"
                     /translation="DVAVGFPIAGRSDPALDNLVGFFVNTLVLR"
     CDS_motif       7279..7398
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0013"
                     /evalue="2.60E-18"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="Rv0101"
                     /protein_end="1377"
                     /protein_start="1337"
                     /score="58.4"
                     /tool="antismash"
                     /translation="RARSLAAYENQDVPFEVLVDRLKPTRALTHHPLIQVMLAW"
     aSDomain        7762..8913
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv0101_AMP-binding.2"
                     /evalue="1.40E-97"
                     /label="Rv0101_AMP-binding.2"
                     /locus_tag="Rv0101"
                     /protein_end="1882"
                     /protein_start="1498"
                     /score="318.7"
                     /specificity="consensus: phe"
                     /tool="antismash"
                     /translation="AAQVARIPEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGE
                     CVALLFERCAPAVVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSR
                     LAGHDLPIIDVVDALAAYPGTPPPMPAAVNLAYILYTSGTTGEPKGVGITHRNVTRLFA
                     SLPARLSAAQVWSQCHSYGFDASAWEIWGALLGGGRLVIVPESVAASPNDFHGLLVAEH
                     VSVLTQTPAAVAMLPTQGLESVALVVAGEACPAALVDRWAPGRVMLNAYGPTETTICAA
                     ISAPLRPGSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRRAGLT
                     ASRFVACPFGGSGARMYRTGDLVCWRADGQLEFLGRTDDQVKIR"
     CDS_motif       7948..7986
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0014"
                     /evalue="2.20E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="Rv0101"
                     /protein_end="1573"
                     /protein_start="1560"
                     /score="14.6"
                     /tool="antismash"
                     /translation="AVLKTGAAYLPID"
     CDS_motif       8167..8226
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0015"
                     /evalue="5.90E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="Rv0101"
                     /protein_end="1653"
                     /protein_start="1633"
                     /score="28.0"
                     /tool="antismash"
                     /translation="AYILYTSGTTGEPKGVGITH"
     CDS_motif       8572..8598
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0016"
                     /evalue="1.40E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="Rv0101"
                     /protein_end="1777"
                     /protein_start="1768"
                     /score="8.3"
                     /tool="antismash"
                     /translation="YGPTETTIC"
     CDS_motif       8704..8793
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0017"
                     /evalue="3.30E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="Rv0101"
                     /protein_end="1842"
                     /protein_start="1812"
                     /score="41.8"
                     /tool="antismash"
                     /translation="PAGVAGELYIAGAGVGVGYWRRAGLTASRF"
     CDS_motif       8878..8940
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0018"
                     /evalue="1.90E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="Rv0101"
                     /protein_end="1891"
                     /protein_start="1870"
                     /score="35.9"
                     /tool="antismash"
                     /translation="FLGRTDDQVKIRGYRIELGEV"
     aSDomain        9235..9441
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv0101_PCP.1"
                     /evalue="1.40E-22"
                     /label="Rv0101_PCP.1"
                     /locus_tag="Rv0101"
                     /protein_end="2058"
                     /protein_start="1989"
                     /score="71.5"
                     /tool="antismash"
                     /translation="EKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMRVIAAINTTLN
                     ADLPVRALLHASSTRGLSQLLGRD"
     aSDomain        9595..10386
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Rv0101_TD.1"
                     /evalue="1.50E-85"
                     /label="Rv0101_TD.1"
                     /locus_tag="Rv0101"
                     /protein_end="2373"
                     /protein_start="2109"
                     /score="278.1"
                     /tool="antismash"
                     /translation="VLLTGATGFLGRYLVLELLRRLDVDGRLICLVRAESDEDARRRLE
                     KTFDSGDPELLRHFKELAADRLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVN
                     AFPYHELFGPNVAGTAELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVISPT
                     RTVDGGWAGGYGTSKWAGEVLLREANDLCALPVAVFRCGMILADTSYAGQLNMSDWVTR
                     MVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLPVTFVAEAIA"
     CDS_motif       10528..10548
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Rv0101_0019"
                     /evalue="6.20E+00"
                     /label="C4_LCL_164-176"
                     /locus_tag="Rv0101"
                     /protein_end="2427"
                     /protein_start="2420"
                     /score="0.2"
                     /tool="antismash"
                     /translation="DFAEWLQ"
ORIGIN
        1 atgacgctta aggtcaaagg cgagggactc ggtgcgcagg tcacaggggt cgatcccaag
       61 aatctggacg atataaccac cgacgagatc cgggatatcg tttacacgaa caagctcgtt
      121 gtgctaaaag acgtccatcc gtctccgcgg gagttcatca aactcggcag gataattgga
      181 caaatcgttc cgtattacga acccatgtac catcacgaag accacccgga gatctttgtc
      241 tcctccactg aggaaggtca gggggtccca aaaaccggcg cgttctggca tatcgactat
      301 atgtttatgc cggaaccttt cgcgttttcc atggtgctgc cgctggcggt gcctggacac
      361 gaccgcggga cctatttcat cgatctcgcc agggtctggc agtcgctgcc cgccgccaag
      421 cgagacccgg cccgcggaac cgtcagcacc cacgaccctc gacgccacat caagatccga
      481 cccagcgacg tctaccggcc catcggagag gtatgggacg agatcaaccg gaccacgccc
      541 ccaataaagt ggcctacggt catccggcac ccaaagaccg gccaagagat cctctacatc
      601 tgcgcgacgg gcaccaccaa gatcgaggac aaggacggca atccggttga tccggaggtg
      661 ctgcaagaac tcatggccgc gaccggacag ctcgatcctg agtaccagtc gccgttcata
      721 catactcagc actaccaggt tggcgacatc atcttgtggg acaaccgggt tctcatgcac
      781 cgagcgaagc acggcagcgc cgcgggcact ctgacgacct accgcctgac catgcttgat
      841 ggcctcaaga cgccgggata cgcggcatga gccacaccga cttgacgccc tgcacacggg
      901 tgctggcatc cagcggcacg gttccgatcg cagaggaact gctggccaga gtgctcgagc
      961 cctactcctg caaaggatgt cgctacctca tcgacgcaca gtacagcgcc accgaggatt
     1021 cggttcttgc ctatggcaac ttcacgatcg gtgagtccgc ctatattcga agcacggggc
     1081 acttcaacgc ggtcgaactg attctgtgtt tcaatcagct cgcctacagc gccttcgctc
     1141 cggccgtcct caacgaggaa atccgggtgc ttcgcggctg gtcgatcgac gactactgcc
     1201 aacaccagct ctctagcatg ctgatcagga aggcatcatc gcggttcaga aaaccgctga
     1261 acccgcaaaa gttctctgcc cgcctcctgt gtcgagatct gcaggtcatc gaacgaacct
     1321 ggcgctatct caaggtcccg tgcgtcatcg agttctggga cgagaacggc ggggcggcgt
     1381 ccggtgagat cgaactagcg gccctcaaca ttccgtaatc caatgggagg aaagaagttt
     1441 caagctatgc ctcagttgcc atctaccgtg ctggaccggg tcttcgagca ggcacggcag
     1501 cagccggaag caatcgcctt gcgtcgctgc gacggcacta gcgcactgcg gtaccgtgaa
     1561 ctcgtcgccg aagttggtgg ccttgccgcg gatttgcgtg cccagtcggt tagccggggt
     1621 tctagggtgc tggtcatttc cgacaatgga cccgagacgt acctgtcggt gctggcgtgt
     1681 gcaaagctcg gggcgatcgc cgtcatggcc gacggcaatc ttccgatcgc agccatcgaa
     1741 cgattctgtc agatcaccga ccccgcagcg gctctcgtcg caccagggag caagatggca
     1801 tcttccgccg ttcccgaggc gctgcactcg ataccagtga tcgcggtcga catagccgct
     1861 gttacacggg aatccgagca ttccttggat gcagccagcc tcgccgggaa cgcggaccag
     1921 gggagcgagg atccgctggc gatgatcttc accagcggta ccacgggcga gcccaaggct
     1981 gtgctactgg ccaaccgcac cttcttcgcc gtcccggaca tcttgcaaaa agagggtttg
     2041 aactgggtca cttgggtcgt cggcgaaacc acctactcgc cgctgccggc gacgcacatc
     2101 ggtggactgt ggtggatact tacctgcctg atgcacggcg ggttgtgtgt caccggcggc
     2161 gagaatacga catcgttgct ggagattctc accacgaacg cggtggcgac gacgtgccta
     2221 gtgccaacgc ttctttcgaa gttagtttct gaactgaagt ccgccaacgc gacggttccc
     2281 tcgctgcgcc tagttggata cggtggttcg cgggcgatcg cggccgatgt gcggtttatc
     2341 gaagctaccg gcgtgcgcac cgcacaggtc tacggattga gcgagaccgg ttgcacggct
     2401 ttgtgtttgc cgaccgatga cggctcgatc gtcaagatcg aagcaggtgc tgttggccgt
     2461 ccgtaccctg gcgtggacgt ctatcttgcc gctaccgatg gcatcggccc taccgccccc
     2521 ggcgccggcc cgtccgcctc gttcggcacg ctatggatta agtcaccggc caacatgctg
     2581 ggctactgga acaatcccga acgcaccgca gaggtgctga ttgacggctg ggtgaacacc
     2641 ggtgacctgc tggagcgccg cgaggacggc ttcttctaca tcaagggaag atcctcggag
     2701 atgatcatct gtggtggcgt gaacattgcg cccgacgagg tcgatcgcat cgcggagggc
     2761 gtgtcgggcg tccgcgaggc cgcgtgctac gagattcctg acgaagagtt cggcgcgctg
     2821 gtgggcctgg ccgtggtcgc atcggcagag cttgacgagt cggcagcccg ggcgctcaag
     2881 cacacgattg cggctcgttt tcgacgggag tccgagccga tggcgcggcc gtcgacaatt
     2941 gtgatcgtca ccgacattcc acgaacgcag tccggcaagg tcatgcgggc ctcgcttgca
     3001 gcggcggcaa cagcagacaa ggccagagtg gtcgttcgtg gctgagccgg tgcgggaccg
     3061 aatcctcgcc gccgtctgcg acgtgttgta tatcgacgag gcggatctca ttgatggcga
     3121 cgaaacggat ctccgcgacc tcgggctgga ctctgttcgg tttgttctgc tgatgaagca
     3181 gctaggcgtg aaccgacaat ccgaactgcc gtcccgattg gccgcgaacc cgtcgattgc
     3241 gggttggctt cgcgagctgg aggctgtgtg caccgagttc ggttaagccg ctcgcagcgc
     3301 aacctctaca acggcgtgcg ccaggataac aatcccgcgt tatatctgat cggcaagagc
     3361 tatcggttcc gccggttgga gctggcgaga ttcctggccg ctctgcacgc aacggtactg
     3421 gacaaccccg tgcaactttg cgtcctggag aattcggggg cagactatcc ggatctggtg
     3481 ccgcggctac ggttcggcga catcgtgcgg gtggggtcag ccgatgagca cctgcagagc
     3541 acatggtgtt cgggcatcct gggcaagcca ctggtgcggc atacggtgca caccgacccg
     3601 aacgggtatg tgaccggtct ggacgttcac acccaccaca tcctgctgga cggcggcgcg
     3661 accgggacga tcgaagctga cctggcgcgt tacctgacca ccgacccggc gggcgaaacc
     3721 cccagtgtcg gtgcgggtct agccaagctc agggaggcgc accgtcgtga gacggccaag
     3781 gtggaagaat cgcgggggcg cctgtcggct gtcgtgcagc gtgaactcgc cgacgaagca
     3841 taccacggcg ggcacgggca cagcgttagc gacgctcccg ggaccgcggc caagggcgtc
     3901 ctgcacgaat cggcaacgat ctgcggcaac gcgtttgatg ccatcctgac cctttcggaa
     3961 gcgcagcggg tcccgcttaa tgtgctggtg gctgcggcgg ccgtcgcggt ggacgcgagc
     4021 cttcggcaga acaccgaaac cctcttggtg cacacggtgg acaaccggtt cggagattct
     4081 gatctgaatg tcgcgacctg tttggtcaat tcggttgccc agaccgtccg gtttccccca
     4141 tttgcgtcgg tgtccgatgt cgttcgaacg cttgaccgcg gctatgtcaa ggcggtaaga
     4201 cgccggtggc ttcgtgagga gcattaccgc cgaatgtatt tggcgatcaa ccggacatct
     4261 cacgtggagg cgttgacgct aaatttcatt cgcgagccat gcgcacctgg cctgcgcccg
     4321 ttcttgtcgg aggtcccgat tgccacggat atcggtccgg tcgagggcat gacggtggcg
     4381 tctgttctgg acgaagaaca gcgcacactg aacctagcca tctggaaccg agccgatctg
     4441 cccgcgtgca agacacaccc caaggtcgcg gaacggatag cggcagcgtt ggaatcgatg
     4501 gcggcgatgt gggatcggcc gatcgccatg atcgtcaacg actggttcgg gatcggcccg
     4561 gacgggactc gctgccaagg cgattggcca gcccgtcagc cgtcgacgcc cgcgtggttt
     4621 ctcgattccg caaggggcgt ccaccaattt ctcggcaggc gccgcttcgt ctacccgtgg
     4681 gtcgcgtggt tggtgcaacg cggcgccgca ccgggtgatg ttctggtgtt caccgacgac
     4741 gacaccgaca agaccattga cctgctcatc gcgtgtcacc ttgcgggttg cgggtacagc
     4801 gtctgcgaca ccgctgacga aatttccgtg cggaccaatg cgattaccga gcacggcgat
     4861 ggcatcttgg tgacagtggt cgacgtggcc gccacccagc tggcggttgt cggccatgac
     4921 gagctgcgga aggtcgttga cgagcgcgtc acacaggtga cacacgacgc actgctggcc
     4981 accaagaccg cctacatcat gccgacctcg ggaactaccg gacaacccaa gctggtgcga
     5041 atctcacacg gctcgctcgc ggttttctgt gatgcgatca gccgcgccta cggttgggga
     5101 gcccacgaca ccgttctgca gtgcgctccg ttgacatcgg acatcagcgt cgaggagatt
     5161 ttcggtggcg cggcctgtgg cgcgcgactg gtgcgatccg cggctatgaa aaccggcgac
     5221 ctggcggcgc tggttgacga tctcgtcgcc cgcgagacga caatcgtcga cctgccgacc
     5281 gccgtctggc agctgttgtg cgccgacggc gacgccattg acgcgatcgg ccgctcgcgc
     5341 ctgcggcaga tcgtaatcgg cggtgaagcc atccgctgta gcgccgtgga caagtggctt
     5401 gaatcggctg cttcacaagg gatctcgctg ctctcgagct atggtccaac agaagccacg
     5461 gtcgtcgcca ccttcttgcc gatcgtttgc gaccagacca ccatggacgg cgcactgctc
     5521 aggctcggcc ggccgatcct accgaacacg gtgttcctcg cgttcggtga agtcgtcatt
     5581 gtcggggatt tagtcgccga cggctacctc gggatcgacg gcgacggctt cggcaccgtg
     5641 acggccgcag acggttcccg acgccgtgcc tttgccactg gcgaccgggt gaccgtcgac
     5701 gccgaaggat ttccggtctt ctccggacgc aaagacgccg tcgtcaagat ctccggcaag
     5761 cgtgtcgata tcgctgaggt aaccaggcgc atcgccgaag accccgcggt gtcagatgtc
     5821 gccgtcgagt tgcacagcgg aagcctcgga gtgtggttca agagccaacg gacccgcgag
     5881 ggcgaacaag acgctgccgc ggcgacccgg atcaggctcg tcctcgtgag tctgggagtg
     5941 tcgtcgtttt tcgttgtcgg cgtgccgaat atcccgagga agcccaacgg gaagatcgac
     6001 agcgacaacc tgccgaggct gcctcagtgg tcagctgctg ggctaaacac cgccgagacg
     6061 ggtcagcgag cggccggcct ctcgcagatc tggagccggc agctcggccg ggcaatcggg
     6121 ccggactcgt cgctgcttgg tgagggcatc ggctcgttgg atctcatcag aatactgccc
     6181 gagacgcgta ggtatctggg gtggcgcctc tcgctgctgg atctgatcgg tgccgatacc
     6241 gccgccaatc tggccgatta cgcgccaacg cccgacgcgc cgacgggcga agatcggttt
     6301 aggccgctgg tggccgcgca acggcccgcg gcgattccgt tgtcgtttgc ccagcggcga
     6361 ctatggtttc tcgaccagtt acagcgaccc gctccggtct acaacatggc ggtggcgttg
     6421 cggctgcgcg ggtatctcga taccgaggcg ttgggcgcgg cggtcgccga tgtcgtgggc
     6481 cgccacgaaa gcctacggac ggtgtttccg gcggtcgacg gggtccctcg gcagctggtc
     6541 atcgaagcgc ggcgggcaga tcttggctgc gacatcgtcg atgccaccgc atggccggct
     6601 gaccggctgc aacgggccat cgaggaggcg gcgcgccaca gcttcgattt ggcaaccgag
     6661 atacctttgc ggacgtggct tttccggatc gccgacgacg aacatgtgct ggtggcggtt
     6721 gcacaccata tcgccgccga cggctggtcg gtggctccgc tgacggccga tctgagtgcg
     6781 gcatatgcca gccgttgtgc gggtcgggca ccggactggg cgccattgcc agtgcagtat
     6841 gtcgattaca cgctgtggca gcgggaaatc ctcggtgatc tcgacgacag cgacagcccg
     6901 atcgccgcgc agctggccta ctgggaaaat gcgttggccg gtatgccgga acggctgcgg
     6961 ctgcccaccg ctcggcccta tccaccggtt gccgatcagc gcggcgccag tttggtggtg
     7021 gattggccgg cgtcggtgca acagcaggtg cgtcggatcg cccgccagca caacgcgacc
     7081 agcttcatgg tggtagctgc cgggcttgcc gtgctgctgt cgaaactcag cggaagcccc
     7141 gatgtggcgg tcggatttcc catcgccggc cgcagcgatc ctgcgctgga taacttggtg
     7201 ggcttttttg tcaacacctt ggtgttgcgg gtcaacctgg ccggtgatcc cagcttcgcc
     7261 gaactgctgg ggcaggtgcg agcgcgcagc ctggccgcct acgaaaatca agacgtacct
     7321 ttcgaggtgc tcgttgatcg cctcaaaccc actcgagccc tgacccatca cccgctgatc
     7381 caggtgatgt tggcctggca ggacaatccg gttggacagc tgaatttggg tgatctgcag
     7441 gccaccccga tgccgatcga cacccgcacc gcccgcatgg acttggtgtt ttcgttagcg
     7501 gaacgcttca gcgagggtag cgaacctgcc gggatcggcg gagcggtgga ataccgcacc
     7561 gatgtgtttg aagcccaagc aatcgacgtg cttatcgagc ggttgcggaa ggtgttggtg
     7621 gcggtggccg ctgctccgga acggacggtg tcgtcgatcg atgcgctgga tgggaccgag
     7681 cgtgcccggt tggatgagtg gggtaaccgc gctgtgctga ctgcgcccgc gcccacgccg
     7741 gtgtcgatcc cgcagatgtt ggccgcccag gtggcacgta tccccgaagc ggaggcggtg
     7801 tgttgcgggg acgcgtcgat gacgtatcgg gaactcgacg aggcgtccaa ccggttagcg
     7861 catcggctgg caggttgtgg ggccggcccg ggcgagtgtg tggcgctgct gttcgagcgg
     7921 tgcgcgccgg cggtcgtggc gatggtggca gtgctcaaaa ccggggcggc gtatctgccg
     7981 atcgatccgg cgaatcctcc gccgcgggtg gcgttcatgc tcggcgacgc ggtgcccgtg
     8041 gccgcggtca ccacggctgg gctgcgctcc cggttggcgg gacacgactt gccgatcatc
     8101 gatgtcgtcg atgctttagc ggcatatccg ggcacgcccc cacccatgcc ggccgcagtg
     8161 aacctcgcct acatcctgta cacctcgggc actaccggcg agcccaaagg cgtggggatc
     8221 acccatcgca acgtcaccag gctgttcgca tcactgccgg cacgcttgtc ggcggcgcag
     8281 gtgtggtcgc agtgtcattc ctatggcttc gacgcctcgg cgtgggagat ctggggcgcg
     8341 ttgctaggtg gtgggcgact ggtgatcgtg cccgagtcgg tggcggcctc gccgaacgac
     8401 tttcatgggc tgctcgtggc cgaacacgtc agcgtgctga ctcagactcc ggctgcggtg
     8461 gcaatgttgc cgacgcaggg tttggagtcg gtggcgttgg tggtggccgg tgaggcatgt
     8521 ccggcagcgc tggtggatcg gtgggcgccc gggcgggtga tgctaaatgc ttatggccca
     8581 accgagacca cgatctgtgc ggcgataagt gcgccgttgc gaccgggttc ggggatgccg
     8641 ccgattggtg ttccggtgtc gggggcggcg ttgtttgtgc tggatagctg gttgcgcccg
     8701 gtaccggccg gggtggccgg agagttgtac attgccggtg cgggcgtcgg tgttgggtat
     8761 tggcgtcggg cggggctgac cgcgtcacgg tttgtggcct gcccattcgg cggttccggg
     8821 gcacgcatgt atcgcaccgg ggatctggtg tgttggcgcg ccgatggcca gttggagttc
     8881 ctggggcgca ccgacgatca ggtcaagatc cgcgggtatc gcatcgagct cggcgaggtt
     8941 gcgaccgcgc tggccgagct ggctggggta ggtcaagcgg ttgtaatcgc ccgtgaagac
     9001 cgccctgggg acaagcgcct agtcgggtat gccaccgaaa ttgcccccgg ggcagtggac
     9061 ccggccgggc tgcgggcgca actagcccag cgattgcccg gttacctggt gccagccgcg
     9121 gtggtagtga tcgatgcgct tccgttgacg gtcaacggca aacttgatca tcgtgcgttg
     9181 ccggcaccgg aatacggtga taccaacgga tatcgcgctc cggccgggcc ggttgagaag
     9241 accgtggccg gcatctttgc ccgggttctt gggcttgagc gggtcggcgt cgacgactcg
     9301 ttcttcgagc tcggcggcga ttcgctggcg gcaatgcggg ttatcgccgc gatcaacacc
     9361 accctaaacg ccgatctgcc ggtgcgcgcg ttgctgcacg cgtcgtcgac gagaggttta
     9421 agccagctgt tggggcgaga tgcccgaccg accagcgatc cgcgcttggt gtctgtgcac
     9481 ggcgacaacc ccaccgaggt gcatgccagc gacctcacgc tggaccggtt catcgacgcc
     9541 gacacgctgg ccaccgccgt caacctgccg ggcccgagcc ccgagctacg gacggtcctg
     9601 ctgacgggcg cgacgggttt cctcggacgg tatctggtcc ttgaattgct gcggcggctg
     9661 gacgtcgacg gcaggctgat ctgtttggtg cgggcggagt ccgacgagga tgcgcggcgt
     9721 cgtctggaga agaccttcga tagcggtgac ccggaattgc tgcggcactt caaggagctt
     9781 gccgccgacc ggctggaggt cgtcgcaggc gacaagagcg aacccgacct gggcctggac
     9841 caaccgatgt ggcggcggct ggccgaaacc gtggatttga ttgtcgattc cgcggcgatg
     9901 gtcaacgcgt ttccctacca cgaattgttc gggcccaacg tcgcgggcac cgccgagctg
     9961 atccgaatcg cgcttaccac caagctcaaa cccttcacct acgtgtcaac cgccgacgtg
    10021 ggtgctgcga tcgagccgtc ggcgttcacc gaggacgccg acatccgggt aatcagcccc
    10081 acccgcaccg tcgacggcgg ctgggctggc ggctacggca ccagcaagtg ggccggtgag
    10141 gtgctgctgc gcgaggccaa cgacctgtgc gcgctgccgg tcgcggtgtt tcgctgcggg
    10201 atgatcctgg ccgacaccag ctatgccgga cagctcaaca tgtcggactg ggtcacccgg
    10261 atggtgttga gcttgatggc taccggcatc gcgcctcgtt cgttctacga accggactcc
    10321 gagggcaatc ggcaacgcgc gcacttcgac gggctgccag tcaccttcgt tgccgaggcg
    10381 atcgcggtgc tgggcgcgcg ggtggccggc tcatcgttgg cgggatttgc gacctatcac
    10441 gtgatgaacc cgcacgacga cggtatcggg ctcgatgagt atgtggactg gctgattgag
    10501 gccggctacc cgatacgccg catcgatgac tttgcggagt ggttgcagcg gtttgaggcc
    10561 agcctgggcg ctctgccgga tcggcaacgc cggcactcgg tgctgccgat gctgctggcg
    10621 agcaattccc agcgattgca gccgcttaag ccgaccaggg ggtgctccgc gccgaccgac
    10681 cgattccgtg ccgcggtgcg agcggcgaaa gtcggctccg acaaggacaa tccagacatc
    10741 ccgcacgtgt cggcgccgac catcatcaac tacgtcacca acctacaact gctcggactg
    10801 ctgtag
//
