BGC0001627: isonitrile lipopeptides biosynthetic gene cluster from Mycobacterium tuberculosis H37Rv
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Location: 106,734 - 117,539 nt. (total: 10,806 nt).
This entry is originally from NCBI GenBank AL123456.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001627
Short description isonitrile lipopeptides biosynthetic gene cluster from Mycobacterium tuberculosis H37Rv
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AL123456.3
Compounds
  • isonitrile lipopeptides
Species Mycobacterium tuberculosis H37Rv [taxonomy]
References
Chemical products information
isonitrile lipopeptides
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Rv0097
  • CCP42822.1
 106734 - 107603 (+) Possible oxidoreductase
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  • Rv0098
  • CCP42823.1
  • fcoT
 107600 - 108151 (+) Probable fatty acyl CoA thioesterase type III FcoT
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  • Rv0099
  • CCP42824.1
  • fadD10
 108156 - 109778 (+) Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
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  • Rv0100
  • CCP42825.1
 109783 - 110019 (+) Conserved hypothetical protein
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  • Rv0101
  • CCP42826.1
  • nrp
 110001 - 117539 (+) Probable peptide synthetase Nrp (peptide synthase)
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
fadD10
Module ?
Specificity: butyric acid / pentanoic acid / isovaleric acid / hexanoic acid / 2-hexenoic acid / octanoic acid / 2-octenoic acid
Evidence for specificity:
  • ACVS assay
  • X-ray crystallography
  • Heterologous expression
nrp
Module ?
Specificity: lysine
Evidence for specificity:
  • Sequence-based prediction
  • Homology
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Sequence-based prediction
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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