BGC0001627: isonitrile lipopeptides biosynthetic gene cluster from Mycobacterium tuberculosis H37Rv
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Location: 106,734 - 117,539 nt. (total: 10,806 nt).
This entry is originally from NCBI GenBank AL123456.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001627
Short description isonitrile lipopeptides biosynthetic gene cluster from Mycobacterium tuberculosis H37Rv
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AL123456.3
106734 - 117539
via
Compounds
  • isonitrile lipopeptides
Species Mycobacterium tuberculosis H37Rv [taxonomy]
References
Chemical products information
isonitrile lipopeptides Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Rv0097
  • CCP42822.1
 106734 - 107603 (+) Possible oxidoreductase
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    • Rv0098
    • CCP42823.1
    • fcoT
    		 107600 - 108151 (+) Probable fatty acyl CoA thioesterase type III FcoT
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      • Rv0099
      • CCP42824.1
      • fadD10
      		 108156 - 109778 (+) Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
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        • Rv0100
        • CCP42825.1
        		 109783 - 110019 (+) Conserved hypothetical protein
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          • Rv0101
          • CCP42826.1
          • nrp
          		 110001 - 117539 (+) Probable peptide synthetase Nrp (peptide synthase)
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            Biosynthesis information

            Biosynthetic modules

            Name
            Unk01
            Type
            nrps-type1
            Genes
            fadD10
            Substrates
            butyric acid, pentanoic acid, isovaleric acid, hexanoic acid, 2-hexenoic acid, octanoic acid, 2-octenoic acid (evidence: ACVS assay, X-ray crystallography, Heterologous expression)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk02
            Type
            nrps-type1
            Genes
            nrp
            Substrates
            lysine (evidence: Sequence-based prediction, Homology)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk03
            Type
            nrps-type1
            Genes
            nrp
            Substrates
            phenylalanine (evidence: Sequence-based prediction, Homology)
            Integrated Monomers
            Domains
            adenylation
            Annotation changelog

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Added NRP substrate specificities
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2018-08-06
            Submitted
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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