BGC0001628: JBIR-78 biosynthetic gene cluster from Kibdelosporangium sp. AK-AA56
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Location: 1 - 35,856 nt. (total: 35,856 nt).
This entry is originally from NCBI GenBank LC217607.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001628
Short description JBIR-78 biosynthetic gene cluster from Kibdelosporangium sp. AK-AA56
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
LC217607.1
via
Compounds
  • JBIR-78
  • JBIR-95
Species Kibdelosporangium sp. AK-AA56 [taxonomy]
References
Chemical products information
JBIR-78 Evidence:
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C40H55N7O12
Chemical database entries
NPAtlas
JBIR-95 Evidence:
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C39H55N7O13S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAX89995.1
  • orf1
 443 - 2476 (-) pyruvate dehydrogenase complex, E1 beta and E2 units
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    • BAX89996.1
    • orf2
    		 2547 - 3485 (-) pyruvate dehydrogenase complex, E1 alpha unit
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      • BAX89997.1
      • orf3
      		 3914 - 5191 (+) cysteic acid synthase
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        • BAX89998.1
        • orf4
        		 5223 - 12920 (+) Non-ribosomal peptide synthetase
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          • BAX89999.1
          • orf5
          		 12917 - 20539 (+) Non-ribosomal peptide synthetase
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            • BAX90000.1
            • orf6
            		 20600 - 32077 (+) Non-ribosomal peptide synthetase
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              • BAX90001.1
              • orf7
              		 32077 - 32286 (+) MbtH domain protein
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                • BAX90002.1
                • orf8
                		 32308 - 33528 (+) Cytochrome P450
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                  • BAX90003.1
                  • orf9
                  		 34091 - 34762 (-) hypothetical protein
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    Unk01
                    Type
                    nrps-type1
                    Genes
                    orf4
                    Substrates
                    valine (evidence: Structure-based inference, Heterologous expression)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk02
                    Type
                    nrps-type1
                    Genes
                    orf4
                    Substrates
                    aspartic acid, cysteic acid (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk03
                    Type
                    nrps-type1
                    Genes
                    orf5
                    Substrates
                    alanine (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk04
                    Type
                    nrps-type1
                    Genes
                    orf5
                    Substrates
                    leucine (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk05
                    Type
                    nrps-type1
                    Genes
                    orf6
                    Substrates
                    glycine (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk06
                    Type
                    nrps-type1
                    Genes
                    orf6
                    Substrates
                    alanine (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk07
                    Type
                    nrps-type1
                    Genes
                    orf6
                    Substrates
                    phenylalanine (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    adenylation
                    Annotation changelog

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Added NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2019-10-16
                    Updated compound(s) information (NPAtlas curation)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2018-08-06
                    Submitted
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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