BGC0001630: kasumigamide biosynthetic gene cluster from uncultured Candidatus Entotheonella sp.
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 36,804 nt. (total: 36,804 nt).
This entry is originally from NCBI GenBank LC160290.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001630
Short description kasumigamide biosynthetic gene cluster from uncultured Candidatus Entotheonella sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
LC160290.1
via
Compounds
  • kasumigamide
Species uncultured Candidatus Entotheonella sp. [taxonomy]
References
Chemical products information
kasumigamide Evidence:
Copy SMILES
C40H50N8O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAW32320.1
  • ORF1
 46 - 963 (+) putative transferase
    copy AA seq
    copy Nt seq
    • BAW32321.1
    • kasD
    		 1173 - 2762 (-) hydroxylase
      copy AA seq
      copy Nt seq
      • BAW32322.1
      • kasA
      		 3403 - 7548 (+) nonribosomal peptide synthetase
        copy AA seq
        copy Nt seq
        • BAW32323.1
        • kasB
        		 7582 - 18666 (+) hybrid cis-AT polyketide synthase - nonribosomal peptide synthetase
          copy AA seq
          copy Nt seq
          • BAW32324.1
          • kasC
          		 18901 - 29634 (+) nonribosomal peptide synthetase
            copy AA seq
            copy Nt seq
            • BAW32325.1
            • kasE
            		 29677 - 31299 (-) transporter
              copy AA seq
              copy Nt seq
              • BAW32326.1
              • kasF
              		 32208 - 32714 (-) transcriptional regulator
                copy AA seq
                copy Nt seq
                • BAW32327.1
                • kasG
                		 33330 - 33977 (+) methyltransferase
                  copy AA seq
                  copy Nt seq
                  • BAW32328.1
                  • kasH
                  		 34100 - 34612 (+) chorismate synthase
                    copy AA seq
                    copy Nt seq
                    • BAW32329.1
                    • kasI
                    		 34674 - 35699 (-) hypothetical protein
                      copy AA seq
                      copy Nt seq
                      • BAW32330.1
                      • ORF2
                      		 35872 - 36789 (-) putative transferase
                        copy AA seq
                        copy Nt seq
                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        Unk01
                        Type
                        nrps-type1
                        Genes
                        kasA
                        Substrates
                        phenylpyruvic acid (evidence: Structure-based inference, Homology)
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk02
                        Type
                        nrps-type1
                        Genes
                        kasB
                        Substrates
                        beta-alanine (evidence: Structure-based inference, Homology)
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk03
                        Type
                        nrps-type1
                        Genes
                        kasB
                        Substrates
                        tryptophan (evidence: Structure-based inference, Homology)
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk04
                        Type
                        nrps-type1
                        Genes
                        kasC
                        Substrates
                        arginine (evidence: Structure-based inference, Homology)
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk05
                        Type
                        nrps-type1
                        Genes
                        kasC
                        Substrates
                        R-beta-hydroxyphenylalanine (evidence: Structure-based inference, Homology)
                        Integrated Monomers
                        Domains
                        adenylation
                        Annotation changelog

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Added NRP substrate specificities
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2018-08-06
                        Submitted
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                        A domain glossary is available here, and an explanation of the visualisation is available here.
                        Selected features only
                        Show module domains
                        Similar known gene clusters from MIBiG 4.0
                        Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                        Click on reference genes to show details of similarities to genes within the current region.
                        Click on an accession to open that entry in the MiBIG database.